P2X7 receptor is critical in α-synuclein–mediated microglial NADPH oxidase activation

The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology

Bedard, K., & Krause, K.-H. (2007) · Physiological Reviews · doi:10.1152/physrev.00044.2005 · Cited by 6,989 · see citing works

Statistical Methods

Dhamu Kp Ramamoorthy, K. (2016) · Cited by 2,952 · see citing works

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

Butovsky, O., Jedrychowski, M. P., Moore, C. S., Cialic, R., Lanser, A. J., Gabriely, G., Koeglsperger, T., Dake, B., Wu, P. M., Doykan, C. E., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3599 · Cited by 2,543 · see citing works

Oxidative stress in Parkinson's disease

Jenner, P. (2003) · Annals of Neurology · doi:10.1002/ana.10483 · Cited by 2,053 · see citing works

Aggregated α‐synuclein activates microglia: a process leading to disease progression in Parkinson's disease

Zhang, W., Wang, T., Pei, Z., Miller, D. S., Wu, X., Block, M. L., Wilson, B., Zhang, W., Zhou, Y., Hong, J.-S., et al. (2005) · The FASEB Journal · doi:10.1096/fj.04-2751com · Cited by 1,265 · see citing works

Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia

Kim, C., Ho, D.-H., Suk, J.-E., You, S., Michael, S., Kang, J., Joong Lee, S., Masliah, E., Hwang, D., Lee, H.-J., et al. (2013) · Nature Communications · doi:10.1038/ncomms2534 · Cited by 856 · see citing works

Amyloid β protein forms ion channels: implications for Alzheimer's disease pathophysiology

LIN, H., Bhatia, R., & Lal, R. (2001) · The FASEB Journal · doi:10.1096/fj.01-0377com · Cited by 641 · see citing works

Synuclein activates microglia in a model of Parkinson's disease

Su, X., Maguire-Zeiss, K. A., Giuliano, R., Prifti, L., Venkatesh, K., & Federoff, H. J. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.04.006 · Cited by 474 · see citing works

NOX Enzymes in the Central Nervous System: From Signaling to Disease

Sorce, S., & Krause, K. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2578 · Cited by 472 · see citing works

Neuroinflammation and Oxidation/Nitration of α-Synuclein Linked to Dopaminergic Neurodegeneration

Gao, H., Kotzbauer, P. T., Uryu, K., Leight, S., Trojanowski, J. Q., & Lee, V. M. ‐. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0143-07.2008 · Cited by 435 · see citing works

Microglial inflammation in the parkinsonian substantia nigra: relationship to alpha-synuclein deposition

Croisier, E., Moran, L. B., Dexter, D. T., Pearce, R. K., & Graeber, M. B. (2005) · Journal of Neuroinflammation · doi:10.1186/1742-2094-2-14 · Cited by 414 · see citing works

Brilliant Blue G Selectively Blocks ATP-Gated Rat P2X7Receptors

Jiang, L., Mackenzie, A. B., North, R. A., & Surprenant, A. (2000) · Molecular Pharmacology · doi:10.1124/mol.58.1.82 · Cited by 401 · see citing works

Activation of Microglia by Amyloid β Requires P2X7 Receptor Expression

Sanz, J. M., Chiozzi, P., Ferrari, D., Colaianna, M., Idzko, M., Falzoni, S., Fellin, R., Trabace, L., & Di Virgilio, F. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803612 · Cited by 293 · see citing works

Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impair LTP Via NMDA-Receptor Activation

Diógenes, M. J., Dias, R. B., Rombo, D. M., Miranda, H. V., Maiolino, F., Guerreiro, P. S., Näsström, T., Franquelim, H. G., Oliveira, L. M. A., Castanho, M. A. R. B., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0234-12.2012 · Cited by 268 · see citing works

The changing phenotype of microglia from homeostasis to disease

Luo, X., & Chen, S. (2012) · Translational Neurodegeneration · doi:10.1186/2047-9158-1-9 · Cited by 232 · see citing works

Curcumin Ameliorates the Neurodegenerative Pathology in A53T α-synuclein Cell Model of Parkinson’s Disease Through the Downregulation of mTOR/p70S6K Signaling and the Recovery of Macroautophagy

Jiang, T., Zhang, Y., Zhou, H., Wang, H., Tian, L., Liu, J., Ding, J., & Chen, S. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-012-9431-7 · Cited by 220 · see citing works

Oxidized CaMKII causes cardiac sinus node dysfunction in mice

Dominic, P. S., Purohit, A., Soni, S., Voigt, N., Singh, M. V., Glukhov, A. V., Gao, Z., He, B. J., Luczak, E. D., Joiner, M.-L. A., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57833 · Cited by 213 · see citing works

Requirement of Reactive Oxygen Species-dependent Activation of ASK1-p38 MAPK Pathway for Extracellular ATP-induced Apoptosis in Macrophage

Noguchi, T., Ishii, K. J., Fukutomi, H., Naguro, I., Matsuzawa, A., Takeda, K., & Ichijo, H. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m708402200 · Cited by 193 · see citing works

Akt signal transduction dysfunction in Parkinson's disease

Timmons, S., Coakley, M. F., Moloney, A. M., & Neill, C. O. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.09.055 · Cited by 192 · see citing works

TNF-α-induced mitochondrial oxidative stress and cardiac dysfunction: restoration by superoxide dismutase mimetic Tempol

Mariappan, N., Soorappan, R. N., Haque, M., Sriramula, S., & Francis, J. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00376.2007 · Cited by 171 · see citing works

Microglial PHOX and Mac‐1 are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant alpha‐synuclein

Zhang, W., Dallas, S., Zhang, D., Guo, J., Pang, H., Wilson, B. C., Miller, D. S., Chen, B., Zhang, W., McGeer, P. L., et al. (2007) · Glia · doi:10.1002/glia.20532 · Cited by 161 · see citing works

Exosomes of BV-2 cells induced by alpha-synuclein: Important mediator of neurodegeneration in PD

Chang, C., Lang, H., Geng, N., Wang, J., Li, N., & Wang, X. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.06.009 · Cited by 156 · see citing works

Rab11a and HSP90 Regulate Recycling of Extracellular α-Synuclein

Liu, J., Zhang, J., Shi, M. Y., Quinn, T. J., Bradner, J. M., Beyer, R., Chen, S., & Zhang, J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.6202-08.2009 · Cited by 133 · see citing works

The NADPH Oxidase Pathway Is Dysregulated by the P2X7 Receptor in the SOD1-G93A Microglia Model of Amyotrophic Lateral Sclerosis

Apolloni, S., Parisi, C., Pesaresi, M. G., Rossi, S., Carrı̀, M. T., Cozzolino, M., Volonté, C., & D’Ambrosi, N. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203262 · Cited by 128 · see citing works

P2X7 receptors stimulate AKT phosphorylation in astrocytes

Jacques-Silva, M. C., Rodnight, R., Lenz, G., Liao, Z., Kong, Q., Tran, M., Kang, Y., Gonzalez, F. A., Weisman, G. A., & Neary, J. T. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705685 · Cited by 121 · see citing works

Resolvin D1-mediated NOX2 inactivation rescues macrophages undertaking efferocytosis from oxidative stress-induced apoptosis

Lee, H., & Surh, Y. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.07.002 · Cited by 119 · see citing works

P2X7 Receptor Signaling Pathway as a Therapeutic Target for Neurodegenerative Diseases

Takenouchi, T., Sekiyama, K., Sekigawa, A., Fujita, M., Waragai, M., Sugama, S., Iwamaru, Y., Kitani, H., & Hashimoto, M. (2010) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-010-0069-y · Cited by 116 · see citing works

Uridine 5′-Diphosphate Induces Chemokine Expression in Microglia and Astrocytes through Activation of the P2Y6 Receptor

Kim, B., Jeong, H., Kim, J.-H., Lee, S. Y., Jou, I., & Joe, E. (2011) · Journal of Immunology · doi:10.4049/jimmunol.1000212 · Cited by 115 · see citing works

Low-level laser therapy regulates microglial function through Src-mediated signaling pathways: implications for neurodegenerative diseases

Song, S., Zhou, F., & Chen, W. R. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-219 · Cited by 110 · see citing works

Impaired CD200-CD200R-mediated microglia silencing enhances midbrain dopaminergic neurodegeneration: roles of aging, superoxide, NADPH oxidase, and p38 MAPK

Wang, X.-J., Zhang, S., Yan, Z.-Q., Zhao, Y.-X., Zhou, H.-Y., Wang, Y., Lu, G.-Q., & Zhang, J.-D. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.01.032 · Cited by 108 · see citing works

Expression of mutant alpha-synuclein modulates microglial phenotype in vitro

Rojanathammanee, L., Murphy, E. J., & Combs, C. K. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-44 · Cited by 106 · see citing works

On the role of P2X7 receptors in dopamine nerve cell degeneration in a rat model of Parkinson’s disease: studies with the P2X7 receptor antagonist A-438079

Marcellino, D., Suárez-Boomgaard, D., Sánchez-Reina, M. D., Aguirre, J. A., Yoshitake, T., Yoshitake, S., Hagman, B., Kehr, J., Agnati, L. F., Fuxe, K., et al. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0400-0 · Cited by 97 · see citing works

Rotenone induces neuronal death by microglial phagocytosis of neurons

Emmrich, J., Hornik, T. C., Neher, J. J., & Brown, G. C. (2013) · FEBS Journal · doi:10.1111/febs.12401 · Cited by 93 · see citing works

Microglial MAC1 receptor and PI3K are essential in mediating β-amyloid peptide-induced microglial activation and subsequent neurotoxicity

Zhang, D., Hu, X., Li, Q., Chen, S., Zhou, H., Wilson, B. C., Miller, D. S., & Hong, J. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-3 · Cited by 87 · see citing works

Mitochondrial neuronal uncoupling proteins: a target for potential disease-modification in Parkinson's disease

Ho, P. W., Ho, J. W.-M., Liu, H., So, D. H. ‐., Tse, Z. H., Chan, K., Ramsden, D. B., & Ho, S. (2012) · Translational Neurodegeneration · doi:10.1186/2047-9158-1-3 · Cited by 80 · see citing works

Phosphoinositide 3-kinase couples NMDA receptors to superoxide release in excitotoxic neuronal death

Brennan, A., Shen, Y., Benna, J. E., & Swanson, R. A. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.111 · Cited by 80 · see citing works

Identification of Proteins Involved in Microglial Endocytosis of α-Synuclein

Liu, J., Zhou, Y. F., Wang, Y., Fong, H. K., Murray, T. M., & Zhang, J. (2007) · Journal of Proteome Research · doi:10.1021/pr0701512 · Cited by 74 · see citing works

Microglia Proliferation Is Controlled by P2X7 Receptors in a Pannexin-1-Independent Manner during Early Embryonic Spinal Cord Invasion

Rigato, C., Swinnen, N., Buckinx, R., Couillin, I., Mangin, J., Rigo, J., Legendre, P., & Corronc, H. L. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1042-12.2012 · Cited by 73 · see citing works

Induction of Tumor Cell Apoptosis by a Proteasome Deubiquitinase Inhibitor Is Associated with Oxidative Stress

Brnjic, S., Mazurkiewicz, M., Fryknäs, M., Sun, C., Zhang, X., Larsson, R. L., D’Arcy, P., & Linder, S. T. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5322 · Cited by 73 · see citing works

Erratum: Phosphoinositide 3-kinase couples NMDA receptors to superoxide release in excitotoxic neuronal death

Brennan, A., Shen, Y., Benna, J. E., & Swanson, R. A. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.164 · Cited by 69 · see citing works

Mycoplasma hyopneumoniae-derived lipid-associated membrane proteins induce apoptosis in porcine alveolar macrophage via increasing nitric oxide production, oxidative stress, and caspase-3 activation

Bai, F., Ni, B., Liu, M., Feng, Z., Xiong, Q., Xiao, S., & Shao, G. (2013) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2013.07.004 · Cited by 69 · see citing works

Differentiation of adipose-derived stem cells into Schwann cell phenotype induces expression of P2X receptors that control cell death

Faroni, A., Rothwell, S. W., Grolla, A. A., Terenghi, G., Magnaghi, V., & Verkhratsky, A. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.268 · Cited by 65 · see citing works

Increased reactive oxygen species production and p47phox phosphorylation in neutrophils from myeloproliferative disorders patients with JAK2 (V617F) mutation

Hurtado-Nédelec, M., Csillag-Grange, M.-J., Boussetta, T., Belambri, S. A., Fay, M., Cassinat, B., Gougerot‐Pocidalo, M., Dang, P. M., & Benna, J. E. (2013) · Haematologica · doi:10.3324/haematol.2012.082560 · Cited by 64 · see citing works

P2X7 receptor-NADPH oxidase axis mediates protein radical formation and Kupffer cell activation in carbon tetrachloride-mediated steatohepatitis in obese mice

Chatterjee, S., Rana, R., Corbett, J. T., Kadiiska, M. B., Goldstein, J. A., & Mason, R. P. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.02.010 · Cited by 58 · see citing works

P2X7 Cell Death Receptor Activation and Mitochondrial Impairment in Oxaliplatin-Induced Apoptosis and Neuronal Injury: Cellular Mechanisms and In Vivo Approach

Massicot, F., Hache, G., David, L., Chen, D., Leuxe, C., Garnier-Legrand, L., Rat, P., Laprévôte, O., & Coudoré, F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066830 · Cited by 57 · see citing works

Activation of Trimeric P2X2 Receptors by Fewer than Three ATP Molecules

Stelmashenko, O., Lalo, U., Yue, Y., Bragg, L., North, R. A., & Compan, V. (2012) · Molecular Pharmacology · doi:10.1124/mol.112.080903 · Cited by 50 · see citing works

Effect of genetic deletion and pharmacological antagonism of P2X7 receptors in a mouse animal model of migraine

Gölöncsér, F., & Sperlágh, B. (2014) · The Journal of Headache and Pain · doi:10.1186/1129-2377-15-24 · Cited by 49 · see citing works

Reactive oxygen species induce apoptosis in bronchial epithelial BEAS-2B cells by inhibiting the antiglycation glyoxalase I defence: involvement of superoxide anion, hydrogen peroxide and NF-κB

Antognelli, C., Gambelunghe, A., Talesa, V. N., & Muzi, G. (2013) · APOPTOSIS · doi:10.1007/s10495-013-0902-y · Cited by 45 · see citing works

NADPH oxidase is a novel target of delphinidin for the inhibition of UVB ‐induced MMP ‐1 expression in human dermal fibroblasts

Lim, T., Jung, S. K., Kim, J.-E., Kim, Y., Lee, H. J., Jang, T. S., & Lee, K. W. (2013) · Experimental Dermatology · doi:10.1111/exd.12157 · Cited by 41 · see citing works

Toxicity of extracellular secreted alpha-synuclein: Its role in nitrosative stress and neurodegeneration

Wilkaniec, A., Strosznajder, J. B., & Adamczyk, A. (2013) · Neurochemistry International · doi:10.1016/j.neuint.2013.02.004 · Cited by 37 · see citing works

Serum Amyloid A Differentially Activates Microglia and Astrocytes via the PI3K Pathway

Yu, Y., Liu, J., Li, S.-Q., Lei, P., & Ye, R. D. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130818 · Cited by 35 · see citing works

Association of P2X7 receptor gene polymorphisms with sporadic Parkinson's disease in a Han Chinese population

Liu, H., Han, X., Li, Y., Zou, H., & Xie, A. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.04.049 · Cited by 32 · see citing works

TEMPOL protects human neuroblastoma SH-SY5Y cells against ß-amyloid-induced cell toxicity

Chonpathompikunlert, P., Han, J., Toh, K., Isoda, H., & Nagasaki, Y. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.10.028 · Cited by 28 · see citing works

DJ-1 can inhibit microtubule associated protein 1 B formed aggregates

Wang, Z., Zhang, Y., Shi, Z., Guo, Q., Tan, Y., Wang, X., Xiong, R., Ding, J., & Chen, S. (2011) · Molecular Neurodegeneration · doi:10.1186/1750-1326-6-38 · Cited by 23 · see citing works

Lymphocyte-derived microparticles induce apoptosis of airway epithelial cells through activation of p38 MAPK and production of arachidonic acid

Qiu, Q., Xiong, W., Yang, C., Dai, X., Dan, X., Yang, Z., Jiao, Y., Xiang, Y., Liu, G., & Hardy, P. (2014) · APOPTOSIS · doi:10.1007/s10495-014-0993-0 · Cited by 23 · see citing works

Alpha-synuclein: Pathology, mitochondrial dysfunction and neuroinflammation in Parkinson’s disease

Rocha, E. M., Miranda, B. D., & Sanders, L. H. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.04.004 · Cited by 769 · see citing works

Oxidative stress: A major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson’s disease and Alzheimer’s disease

Jiang, T., Sun, Q., & Chen, S. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.07.005 · Cited by 594 · see citing works

The P2X7 Receptor in Inflammatory Diseases: Angel or Demon?

Savio, L. E. B., de Andrade Mello, P., da Silva, C. G., & Coutinho-Silva, R. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00052 · Cited by 437 · see citing works

NADPH oxidase in brain injury and neurodegenerative disorders

Ma, M. W., Wang, J., Zhang, Q., Wang, R., Dhandapani, K. M., Vadlamudi, R. K., & Brann, D. W. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0150-7 · Cited by 432 · see citing works

Microglia and astrocyte dysfunction in parkinson's disease

Kam, T., Hinkle, J. T., Dawson, T. M., & Dawson, V. L. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105028 · Cited by 399 · see citing works

Microglia Mediated Neuroinflammation in Parkinson’s Disease

Işık, S., Yeman-Kıyak, B., Akbayır, R., Şeyhali-Abutayeh, R., & Arpaci, T. (2023) · Cells · doi:10.3390/cells12071012 · Cited by 402 · see citing works

Targeting the Microglial NLRP3 Inflammasome and Its Role in Parkinson's Disease

Haque, M. E., Akther, M., Jakaria, M., Kim, I., Azam, S., & Choi, D. (2019) · Movement Disorders · doi:10.1002/mds.27874 · Cited by 248 · see citing works

The P2X7 Receptor

Sluyter, R. (2017) · Advances in Experimental Medicine and Biology · doi:10.1007/5584_2017_59 · Cited by 235 · see citing works

Microglia in Parkinson's disease

Ho, M. S. (2019) · Advances in Experimental Medicine and Biology · doi:10.1007/978-981-13-9913-8_13 · Cited by 227 · see citing works

P2X7 Interactions and Signaling – Making Head or Tail of It

Kopp, R., Krautloher, A., Ramírez-Fernández, A., & Nicke, A. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00183 · Cited by 217 · see citing works

Microglia Response During Parkinson’s Disease: Alpha-Synuclein Intervention

Ferreira, S. A., & Romero‐Ramos, M. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00247 · Cited by 220 · see citing works

The Pathogenesis of Parkinson's Disease: A Complex Interplay Between Astrocytes, Microglia, and T Lymphocytes?

Copas, A. N. M., McComish, S. F., Fletcher, J. M., & Caldwell, M. A. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.666737 · Cited by 175 · see citing works

NADPH oxidases in oxidant production by microglia: activating receptors, pharmacology and association with disease

Haslund‐Vinding, J., McBean, G., Jaquet, V, & Vilhardt, F. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13425 · Cited by 169 · see citing works

Innate immune activation in neurodegenerative diseases

Castro‐Gomez, S., & Heneka, M. T. (2024) · Immunity · doi:10.1016/j.immuni.2024.03.010 · Cited by 167 · see citing works

The P2X7 Receptor: Central Hub of Brain Diseases

Andrejew, R., Oliveira-Giacomelli, Á., Ribeiro, D. E., Glaser, T., Arnaud-Sampaio, V. F., Lameu, C., & Ulrich, H. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00124 · Cited by 162 · see citing works

NADPH oxidases in Parkinson’s disease: a systematic review

Bélarbi, K., Cuvelier, E., Destée, A., Gressier, B., & Chartier‐Harlin, M. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0225-5 · Cited by 158 · see citing works

Pathological α-synuclein exacerbates the progression of Parkinson’s disease through microglial activation

Zhang, Q.-S., Heng, Y., Yuan, Y.-H., & Chen, N.-H. (2017) · Toxicology Letters · doi:10.1016/j.toxlet.2016.11.002 · Cited by 156 · see citing works

Neuroinflammation represents a common theme amongst genetic and environmental risk factors for Alzheimer and Parkinson diseases

Boyd, R. J., Avramopoulos, D., Jantzie, L. L., & McCallion, A. S. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02584-x · Cited by 162 · see citing works

NADPH oxidase family proteins: signaling dynamics to disease management

Begum, R., Thota, S., Abdulkadir, A. S., Kaur, G., Bagam, P., & Batra, S. (2022) · Cellular and Molecular Immunology · doi:10.1038/s41423-022-00858-1 · Cited by 148 · see citing works

Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology

Ribeiro, D. E., Oliveira-Giacomelli, Á., Glaser, T., Arnaud-Sampaio, V. F., Andrejew, R., Dieckmann, L., Baranova, J., Lameu, C., Ratajczak, M. Z., & Ulrich, H. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-00965-3 · Cited by 145 · see citing works

Pharmacological Targeting of Microglial Activation: New Therapeutic Approach

Liu, C., Wang, X., Liu, C., & Zhang, H. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00514 · Cited by 141 · see citing works

DJ-1 Inhibits α-Synuclein Aggregation by Regulating Chaperone-Mediated Autophagy

Xu, C., Kang, W., Chen, Y., Jiang, T., Zhang, J., Zhang, L., Ding, J., Liu, J., & Chen, S. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00308 · Cited by 138 · see citing works

P2X7 Receptors Amplify CNS Damage in Neurodegenerative Diseases

Illés, P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21175996 · Cited by 141 · see citing works

Interaction of Oxidative Stress and Misfolded Proteins in the Mechanism of Neurodegeneration

Abramov, A. Y., Potapova, E., Владимирович, Д. В., & Dunaev, A. (2020) · Life · doi:10.3390/life10070101 · Cited by 125 · see citing works

New Perspectives on Roles of Alpha-Synuclein in Parkinson’s Disease

Zhang, G., Xia, Y. F., Wan, F. J., Ma, K., Guo, X., Kou, L., Yin, S., Han, C., Liu, L., Huang, J., et al. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00370 · Cited by 115 · see citing works

Role of α-synuclein in microglia: autophagy and phagocytosis balance neuroinflammation in Parkinson’s disease

Lv, Q.-K., Tao, K., Wang, X.-B., Yao, X., Pang, M., Liu, J., Wang, F., & Liu, C. (2023) · Inflammation Research · doi:10.1007/s00011-022-01676-x · Cited by 108 · see citing works

Neuroinflammation Mediated by NLRP3 Inflammasome After Intracerebral Hemorrhage and Potential Therapeutic Targets

Xiao, L., Zheng, H., Li, J., Wang, Q., & Sun, H. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02082-2 · Cited by 106 · see citing works

α-Synuclein pathology as a target in neurodegenerative diseases

Park, H.-J., Kam, T., Dawson, V. L., & Dawson, T. M. (2024) · Nature Reviews Neurology · doi:10.1038/s41582-024-01043-w · Cited by 112 · see citing works

The purinergic P2X7 receptor as a potential drug target to combat neuroinflammation in neurodegenerative diseases

Calzaferri, F., Ruiz‐Ruiz, C., de Diego, A. M. G., de Pascual, R., Méndez‐López, I., Cano‐Abad, M. F., Maneu, V., Rı́os, C. D. L., Gandı́a, L., & de Diego, A. M. G. (2020) · Medicinal Research Reviews · doi:10.1002/med.21710 · Cited by 98 · see citing works

18 F-JNJ-64413739, a Novel PET Ligand for the P2X7 Ion Channel: Radiation Dosimetry, Kinetic Modeling, Test-Retest Variability, and Occupancy of the P2X7 Antagonist JNJ-54175446

Koole, M. J. B., Schmidt, M. E., Hijzen, A., Ravenstijn, P. G. M., Vandermeulen, C., Weehaeghe, D. V., Serdons, K., Celen, S., Bormans, G. M., Ceusters, M., et al. (2018) · Journal of Nuclear Medicine · doi:10.2967/jnumed.118.216747 · Cited by 95 · see citing works

Angiotensin Type 1 Receptor Antagonists Protect Against Alpha-Synuclein-Induced Neuroinflammation and Dopaminergic Neuron Death

Rodriguez-Perez, A. I., Sucunza, D., Pedrosa, M. A., Garrido‐Gil, P., Kulisevsky, J., Lanciego, J. L., & Labandeira-García, J. L. (2018) · Neurotherapeutics · doi:10.1007/s13311-018-0646-z · Cited by 91 · see citing works

Pathogenesis of α-Synuclein in Parkinson’s Disease: From a Neuron-Glia Crosstalk Perspective

Yi, S., Wang, L., Wang, H., Ho, M. S.-C., & Zhang, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314753 · Cited by 90 · see citing works

Quercetin mitigates ethanol-induced hepatic steatosis in zebrafish via P2X7R-mediated PI3K/ Keap1/Nrf2 signaling pathway

Zhao, X., Gong, L., Wang, C., Liu, M., Hu, N., Dai, X., Peng, C. Y., & Li, Y. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.113569 · Cited by 81 · see citing works

Upregulation of α-synuclein following immune activation: Possible trigger of Parkinson's disease

Kasen, A., Houck, C., Burmeister, A. R., Sha, Q., Brundin, L., & Brundin, P. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105654 · Cited by 78 · see citing works

CXCL12 is involved in α-synuclein-triggered neuroinflammation of Parkinson’s disease

Li, Y., Niu, M., Zhao, A., Kang, W., Chen, Z., Luo, N., Zhou, L., Zhu, X., Lu, L., & Liu, J. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1646-6 · Cited by 76 · see citing works

Neuronal P2X7 receptor-induced reactive oxygen species production contributes to nociceptive behavior in mice

Muñoz, F. M., Gao, R. Y., Tian, Y., Henstenburg, B. A., Barrett, J. E., & Hu, H. (2017) · Scientific Reports · doi:10.1038/s41598-017-03813-7 · Cited by 76 · see citing works

Neuroprotection of Rotenone-Induced Parkinsonism by Ursolic Acid in PD Mouse Model

Zahra, W., Nand, S., Birla, H., Singh, S. S., Rathore, A. S., Dilnashin, H., Singh, R., Keswani, C., Singh, R. K., & Singh, S. P. (2020) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527319666200812224457 · Cited by 74 · see citing works

Neuroinflammation and Glial Phenotypic Changes in Alpha-Synucleinopathies

Refolo, V., & Stefanova, N. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00263 · Cited by 71 · see citing works

The Interplay between α-Synuclein and Microglia in α-Synucleinopathies

Deyell, J., Sriparna, M., Ying, M., & Mao, X. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032477 · Cited by 71 · see citing works

Role of P2X7 Receptors in Immune Responses During Neurodegeneration

Oliveira-Giacomelli, Á., Petiz, L. L., Andrejew, R., Turrini, N., Silva, J. B., Sack, U., & Ulrich, H. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.662935 · Cited by 68 · see citing works

Central nervous system diseases related to pathological microglial phagocytosis

Wang, K., Li, J., Zhang, Y., Huang, Y., Chen, D., Shi, Z., Smith, A. D., Li, W., & Gao, Y. (2021) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13619 · Cited by 66 · see citing works

P2X7 Receptors in Neurodegeneration: Potential Therapeutic Applications From Basic to Clinical Approaches

Territo, P. R., & Zarrinmayeh, H. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.617036 · Cited by 68 · see citing works

Mitochondrial Damage-Associated Molecular Patterns Content in Extracellular Vesicles Promotes Early Inflammation in Neurodegenerative Disorders

Lopes, C., Mota, S., Deus, C., Tavares, H., & Beatriz, M. (2022) · Cells · doi:10.3390/cells11152364 · Cited by 71 · see citing works

Superoxide Radical Dismutation as New Therapeutic Strategy in Parkinson’s Disease

Lazzari, F. D., Bubacco, L., Whitworth, A. J., & Bisaglia, M. (2018) · Aging and Disease · doi:10.14336/ad.2017.1018 · Cited by 66 · see citing works

Rifampicin and Its Derivative Rifampicin Quinone Reduce Microglial Inflammatory Responses and Neurodegeneration Induced In Vitro by α-Synuclein Fibrillary Aggregates

Acuña, L., Hamadat, S., Corbalán, N. S., González-Lizárraga, F., dos-Santos-Pereira, M., Rocca, J., Sepúlveda Díaz, J., Del-Bel, E., Papy-García, D., Chehín, R. N., et al. (2019) · Cells · doi:10.3390/cells8080776 · Cited by 62 · see citing works

P2X7 receptor-pannexin 1 interaction mediates extracellular alpha-synuclein-induced ATP release in neuroblastoma SH-SY5Y cells

Wilkaniec, A., Gąssowska, M., Czapski, G. A., Cieślik, M., Sulkowski, G., & Adamczyk, A. (2017) · Purinergic Signalling · doi:10.1007/s11302-017-9567-2 · Cited by 61 · see citing works

Myeloid‐specific dopamine D2 receptor signalling controls inflammation in acute pancreatitis via inhibiting M1 macrophage

Han, X., Ni, J., Wu, Z., Wu, J., Li, B., Ye, X., Dai, J., Chen, C., Xue, J., Wan, R., et al. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15026 · Cited by 61 · see citing works

TSPO imaging in parkinsonian disorders

Gerhard, A. (2016) · Clinical and Translational Imaging · doi:10.1007/s40336-016-0171-1 · Cited by 60 · see citing works

Microglial glutamate release evoked by α‐synuclein aggregates is prevented by dopamine

Pereira, M. D. S., Acuña, L., Hamadat, S., Rocca, J., González‐Lizárraga, F., Chehín, R. N., Sepulveda-Diaz, J. E., Bel, E. A. D., Raisman‐Vozari, R., & Michel, P. P. (2018) · Glia · doi:10.1002/glia.23472 · Cited by 59 · see citing works

α-Synuclein amplifies cytoplasmic peroxide flux and oxidative stress provoked by mitochondrial inhibitors in CNS dopaminergic neurons in vivo

Laar, V. S. V., Chen, J., Zharikov, A., Bai, Q., Maio, R. D., Dukes, A. A., Hastings, T. G., Watkins, S. C., Greenamyre, J. T., Croix, C. M. S., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101695 · Cited by 56 · see citing works

Proteostasis of α-Synuclein and Its Role in the Pathogenesis of Parkinson’s Disease

Han, D., Zheng, W., Wang, X., & Chen, Z. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00045 · Cited by 53 · see citing works

Neurons and Glia Interplay in α-Synucleinopathies

Mavroeidi, P., & Xilouri, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094994 · Cited by 52 · see citing works

P2X7 Receptor is Involved in Mitochondrial Dysfunction Induced by Extracellular Alpha Synuclein in Neuroblastoma SH-SY5Y Cells

Wilkaniec, A., Cieślik, M., Murawska, E., Babiec, L., Gąssowska-Dobrowolska, M., Pałasz, E., Jęśko, H. M., & Adamczyk, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113959 · Cited by 50 · see citing works

Purinergic Receptors in Neurological Diseases With Motor Symptoms: Targets for Therapy

Oliveira-Giacomelli, Á., Naaldijk, Y., Sardá-Arroyo, L., Gonçalves, M. C. B., Corrêa-Velloso, J., Pillat, M. M., de Souza, H. D. N., & Ulrich, H. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00325 · Cited by 50 · see citing works

The Impact of Purinergic System Enzymes on Noncommunicable, Neurological, and Degenerative Diseases

Bagatini, M. D., dos Santos, A. A., Cardoso, A. M., Mânica, A., Reschke, C. R., & Carvalho, F. B. (2018) · Journal of Immunology Research · doi:10.1155/2018/4892473 · Cited by 49 · see citing works

Reactive oxygen species play a role in P2X7 receptor-mediated IL-6 production in spinal astrocytes

Muñoz, F. M., Patel, P. A., Gao, X., Mei, Y., Xia, J., Gilels, S., & Hu, H. (2020) · Purinergic Signalling · doi:10.1007/s11302-020-09691-5 · Cited by 49 · see citing works

Glial Purinergic Signaling in Neurodegeneration

Pietrowski, M. J., Gabr, A. A., Kozlov, S. O., Blum, D. L., Halle, A., & Carvalho, K. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.654850 · Cited by 47 · see citing works

Purinergic signaling: A gatekeeper of blood-brain barrier permeation

Wang, Y., Zhu, Y., Wang, J., Dong, L., Liu, S., Li, S., & Wu, Q. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1112758 · Cited by 47 · see citing works

Altered Expression Patterns of Inflammation-Associated and Trophic Molecules in Substantia Nigra and Striatum Brain Samples from Parkinson's Disease, Incidental Lewy Body Disease and Normal Control Cases

Walker, D. G., Lue, L., Serrano, G. E., Adler, C. H., Caviness, J. N., Sue, L. I., & Beach, T. G. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00507 · Cited by 44 · see citing works

Taurine protects dopaminergic neurons in paraquat-induced Parkinson’s disease mouse model through PI3K/Akt signaling pathways

Wang, K., Zhang, B., Tian, T., Zhang, B., Shi, G., Zhang, C., Li, G., & Huang, M. (2021) · Amino Acids · doi:10.1007/s00726-021-03104-6 · Cited by 43 · see citing works

P2X7 Receptor and Purinergic Signaling: Orchestrating Mitochondrial Dysfunction in Neurodegenerative Diseases

Zelentsova, A. S., Deykin, A. V., Soldatov, V. O., Ulezko, A. A., Borisova, A. Y., Belyaeva, V. S., Skorkina, M. Y., & Angelova, P. R. (2022) · eNeuro · doi:10.1523/eneuro.0092-22.2022 · Cited by 39 · see citing works

Role and therapeutic targets of P2X7 receptors in neurodegenerative diseases

Zheng, H., Liu, Q., Zhou, S., Luo, H., & Zhang, W. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1345625 · Cited by 40 · see citing works

Immunoregulation of microglial polarization: an unrecognized physiological function of α-synuclein

Li, N., Stewart, T., Sheng, L., Shi, M. Y., Cilento, E. M., Wu, Y., Hong, J.-S., & Zhang, J. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01940-z · Cited by 38 · see citing works

Targeting Microglial and Neuronal Toll-like Receptor 2 in Synucleinopathies

Kwon, S., Iba, M., Masliah, E., & Kim, C. (2019) · Experimental Neurobiology · doi:10.5607/en.2019.28.5.547 · Cited by 35 · see citing works

Parkinson Disease: Translating Insights from Molecular Mechanisms to Neuroprotection

Pirooznia, S. K., Rosenthal, L. S., Dawson, V. L., & Dawson, T. M. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000189 · Cited by 36 · see citing works

Purinergic Signalling in Parkinson’s Disease: A Multi-target System to Combat Neurodegeneration

Tóth, A., Antal, Z., Bereczki, D., & Sperlágh, B. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02798-1 · Cited by 34 · see citing works

Unlocking the therapeutic potential of P2X7 receptor: a comprehensive review of its role in neurodegenerative disorders

Liu, X., Li, Y., Huang, L., Kuang, Y., Wu, X., Ma, X., Zhao, B., & Lan, J. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1450704 · Cited by 33 · see citing works

Purinergic Receptors in Basal Ganglia Diseases: Shared Molecular Mechanisms between Huntington’s and Parkinson’s Disease

Glaser, T., Andrejew, R., Oliveira‐Giacomelli, Á., Ribeiro, D. E., Marques, L. B., Ye, Q., Ren, W., Semyanov, A. V., Illés, P., Tang, Y., et al. (2020) · Neuroscience Bulletin · doi:10.1007/s12264-020-00582-8 · Cited by 33 · see citing works

Cathepsin L-containing exosomes from α-synuclein-activated microglia induce neurotoxicity through the P2X7 receptor

Jiang, T., Xu, C., Gao, S., Zhang, J., Zheng, J., Wu, X., Lu, Q., Cao, L., Yang, D., Xu, J., et al. (2022) · npj Parkinson s Disease · doi:10.1038/s41531-022-00394-9 · Cited by 32 · see citing works

The role of P2X7R in neuroinflammation and implications in Alzheimer's disease

Chen, Y.-H., Lin, R.-R., & Tao, Q. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119187 · Cited by 30 · see citing works

Modulation of Microglial Function by ATP-Gated P2X7 Receptors: Studies in Rat, Mice and Human

Tewari, M., Michalski, S. A., & Egan, T. M. (2024) · Cells · doi:10.3390/cells13020161 · Cited by 33 · see citing works

P2X7 receptor/NLRP3 inflammasome complex and α‐synuclein in peripheral blood mononuclear cells: a prospective study in neo‐diagnosed, treatment‐naïve Parkinson’s disease

Solini, A., Rossi, C., Santini, E., Giuntini, M., Raggi, F., Parolini, F., Biancalana, E., Prete, E. D., Bonuccelli, U., & Ceravolo, R. (2021) · European Journal of Neurology · doi:10.1111/ene.14918 · Cited by 29 · see citing works

Structure-Activity Relationships and Therapeutic Potential of Purinergic P2X7 Receptor Antagonists

Idrissi, I. G. E., Podlewska, S., Abate, C., Bojarski, A. J., Lacivita, E., & Leopoldo, M. (2023) · Current Medicinal Chemistry · doi:10.2174/0929867330666230403094538 · Cited by 27 · see citing works

LRRK2 Inhibition Mitigates the Neuroinflammation Caused by TLR2-Specific α-Synuclein and Alleviates Neuroinflammation-Derived Dopaminergic Neuronal Loss

Ho, D. H., Nam, D., Seo, M. K., Park, S., Seol, W., & Son, I. (2022) · Cells · doi:10.3390/cells11050861 · Cited by 27 · see citing works

Platelets and the Role of P2X Receptors in Nociception, Pain, Neuronal Toxicity and Thromboinflammation

Rawish, E., & Langer, H. F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126585 · Cited by 26 · see citing works

NADPH Oxidases in Neurodegenerative Disorders: Mechanisms and Therapeutic Opportunities

Fiadeiro, M. B., Diogo, J. C., Silva, A., Kim, Y., & Cristóvão, A. C. (2024) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0002 · Cited by 24 · see citing works

Mechanistic Insight from Preclinical Models of Parkinson’s Disease Could Help Redirect Clinical Trial Efforts in GDNF Therapy

Delgado-Minjares, K. M., Martínez‐Fong, D., Martínez-Dávila, I. A., Bañuelos, C., Gutiérrez-Castillo, M. E., Blanco-Álvarez, V. M., Cárdenas‐Aguayo, M. D. C., Luna‐Muñoz, J., Pacheco‐Herrero, M., & Soto-Rojas, L. O. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111702 · Cited by 20 · see citing works

Modulation of the neuronal network activity by P2X receptors and their involvement in neurological disorders

Sáez-Orellana, F., Godoy, P. A., Silva-Grecchi, T., Barra, K., & Fuentealba, J. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.06.009 · Cited by 20 · see citing works

Spinal P2X7R contributes to streptozotocin-induced mechanical allodynia in mice

Ni, C.-M., Sun, H.-P., Xu, X., Ling, B., Jin, H., Zhang, Y., Zhao, Z., Cao, H., & Xu, L. (2020) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1900456 · Cited by 20 · see citing works

Purinergic-associated immune responses in neurodegenerative diseases

Carracedo, S., Launay, A., Déchelle-Marquet, P.-A., Faivre, É., Blum, D. L., Delarasse, C., & Boué‐Grabot, É. (2024) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2024.102693 · Cited by 19 · see citing works

LPS-Induced Systemic Neonatal Inflammation: Blockage of P2X7R by BBG Decreases Mortality on Rat Pups and Oxidative Stress in Hippocampus of Adult Rats

da Silva, C. S., Calió, M. L., Mosini, A. C., Pires, J. M., Rêgo, D. B., Mello, L. E., & Leslie, A. T. F. S. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00240 · Cited by 19 · see citing works

Deferiprone and efonidipine mitigated iron-overload induced neurotoxicity in wild-type and thalassemic mice

Sripetchwandee, J., Khamseekaew, J., Svasti, S., Srichairatanakool, S., Fucharoen, S., Chattipakorn, N., & Chattipakorn, S. C. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116878 · Cited by 18 · see citing works

Minocycline Inhibition of Microglial Rescues Nigrostriatal Dopaminergic Neurodegeneration Caused by Mutant Alpha-Synuclein Overexpression

Wang, Y., Wang, Q., Yu, R., Zhang, Q., Zhang, Z., Li, H., Ren, C., Yang, R., & Niu, H. (2020) · Aging · doi:10.18632/aging.103440 · Cited by 17 · see citing works

The impacts of obesity in rheumatoid arthritis and insights into therapeutic purinergic modulation

Braga, G. D. C., Simões, J. L. B., dos Santos, Y. J. T., Filho, J. C. M., & Bagatini, M. D. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112357 · Cited by 14 · see citing works

Revisiting the Immune Balance Theory: A Neurological Insight Into the Epidemic of COVID-19 and Its Alike

Wu, J., & Tang, Y. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.566680 · Cited by 14 · see citing works

Dysregulation of Immune Mediators and Synaptic Plasticity in Central Nervous System Disorders

Imbriani, P., D’Ambra, C., Mori, R. D., Ionta, M., Renna, A., & Bonsi, P. (2026) · Cells · doi:10.3390/cells15020201 · Cited by 15 · see citing works

What Can Inflammation Tell Us about Therapeutic Strategies for Parkinson’s Disease?

Xue, J., Tao, K., Wang, W., & Wang, X. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031641 · Cited by 14 · see citing works

Inhibition of P2X7R alleviates neuroinflammation and brain edema after traumatic brain injury by suppressing the NF-κB/NLRP3 inflammasome pathway

Tao, B., Pei, J., Li, H., Yang, G., Shi, X., Zhang, Z., Wang, H., Zhou, Z., Liu, Y., & Zhang, J. (2024) · Journal of Neurorestoratology · doi:10.1016/j.jnrt.2024.100106 · Cited by 14 · see citing works

Nucleotides regulate the common molecular mechanisms that underlie neurodegenerative diseases; Therapeutic implications

Sebastián‐Serrano, Á., de Diego-García, L., Lauro, C. D., Bianchi, C., & Dı́az-Hernández, M. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.01.031 · Cited by 13 · see citing works

Minimally invasive quantification of cerebral P2X7R occupancy using dynamic [18F]JNJ-64413739 PET and MRA-driven image derived input function

Mertens, N., Schmidt, M. E., Hijzen, A., Weehaeghe, D. V., Ravenstijn, P. G. M., Depré, M., Hoon, J. N. J. M. D., Laere, K. V., & Koole, M. J. B. (2021) · Scientific Reports · doi:10.1038/s41598-021-95715-y · Cited by 12 · see citing works

Brain-derived extracellular vesicles: A promising avenue for Parkinson’s disease pathogenesis, diagnosis, and treatment

Zhang, S., Li, J., Hu, X., Liu, H., Yu, Q., Kuang, G., Liu, L., Yu, D., Lin, Z., & Xiong, N. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-01262 · Cited by 11 · see citing works

Triggering of Major Brain Disorders by Protons and ATP: The Role of ASICs and P2X Receptors

Cherninskyi, A., Storozhuk, M., Maximyuk, O. P., Kulyk, V. B., & Krishtal, O. (2022) · Neuroscience Bulletin · doi:10.1007/s12264-022-00986-8 · Cited by 11 · see citing works

New insights into pathogenisis and therapies of P2X7R in Parkinson’s disease

Wei, S., Song, X., Mou, Y., Yang, T., Wang, H., Wang, H., Ren, C., & Song, X. (2025) · npj Parkinson s Disease · doi:10.1038/s41531-025-00980-7 · Cited by 8 · see citing works

Role of the P2 × 7 receptor in neurodegenerative diseases and its pharmacological properties

Hu, Z., Luo, Y., Zhu, J., Jiang, D., Luo, Z., Wu, L., Jin, L., Peng, S., & Hu, J. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01161-w · Cited by 8 · see citing works

Microglial and neuronal fates following inhibition of CSF-1R in synucleinopathy mouse model

Iba, M., Lee, Y., Horan-Portelance, L., Chang, K., Szabo, M. P., Rissman, R. A., You, S., Masliah, E., & Kim, C. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.09.016 · Cited by 8 · see citing works

Caloric Restriction Mimetics as Priming Agents of Mesenchymal Stem Cells Secretome to Enhance Regenerative Responses to Parkinson’s Disease

Carneiro-Pereira, B., Ferreira-Antunes, F., Campos, J., Salgado, A. J., & Sampaio‐Marques, B. (2025) · Molecules · doi:10.3390/molecules30112260 · Cited by 6 · see citing works

Targeting NOX inhibitors in neurodegeneration: a therapeutic perspective

Kaur, S., Verma, R., Sharma, V., & Singh, T. G. (2025) · Metabolic Brain Disease · doi:10.1007/s11011-025-01644-4 · Cited by 6 · see citing works

Targeting the P2X7 receptor signaling pathway: Unlocking therapeutic strategies for autism spectrum disorder

Ahire, C. G., & Kaur, G. (2025) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2025.101037 · Cited by 6 · see citing works

P2X7R activation promotes ferroptosis in dopaminergic neurons via NF-κB signaling pathway in vitro and in vivo models of MPP+/MPTP-induced Parkinson’s disease

Si, Y., Yan, S., Li, X., Ding, W., Zhang, X., Jia, K., Yao, L., Yang, F., & Shi, W. (2025) · Brain Research · doi:10.1016/j.brainres.2025.149824 · Cited by 6 · see citing works

Direct inhibition of microglial activation by a μ receptor selective agonist alleviates inflammatory-induced pain hypersensitivity

Wang, J., Ru, Q.-M., Ru, Q.-M., Wang, C., Li, K., Wang, C., Li, N., Zhao, J., Wood, J. N., Liu, X., et al. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.176182 · Cited by 6 · see citing works

Aggregated α‐synuclein activates microglia: a process leading to disease progression in Parkinson's disease

Zhang, W., Wang, T., Pei, Z., Miller, D. S., Wu, X., Block, M. L., Wilson, B., Zhang, W., Zhou, Y., Hong, J.-S., et al. (2005) · The FASEB Journal · doi:10.1096/fj.04-2751com · Cited by 1,265 · see citing works

Microglial PHOX and Mac‐1 are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant alpha‐synuclein

Zhang, W., Dallas, S., Zhang, D., Guo, J., Pang, H., Wilson, B. C., Miller, D. S., Chen, B., Zhang, W., McGeer, P. L., et al. (2007) · Glia · doi:10.1002/glia.20532 · Cited by 161 · see citing works

Alpha-Synuclein Proteins Promote Pro-Inflammatory Cascades in Microglia: Stronger Effects of the A53T Mutant

Hoenen, C., Gustin, A., Birck, C., Kirchmeyer, M., Beaume, N., Felten, P., Grandbarbe, L., Heuschling, P., & Heurtaux, T. (2016) · PLOS ONE · doi:10.1371/journal.pone.0162717 · Cited by 159 · see citing works

Integrin CD11b mediates α-synuclein-induced activation of NADPH oxidase through a Rho-dependent pathway

Hou, L., Bao, X., Zang, C., Yang, H., Sun, F., Che, Y., Wu, X., Li, S., Zhang, D., & Wang, Q. (2018) · Redox Biology · doi:10.1016/j.redox.2017.11.010 · Cited by 98 · see citing works

P2X7 Receptor is Involved in Mitochondrial Dysfunction Induced by Extracellular Alpha Synuclein in Neuroblastoma SH-SY5Y Cells

Wilkaniec, A., Cieślik, M., Murawska, E., Babiec, L., Gąssowska-Dobrowolska, M., Pałasz, E., Jęśko, H. M., & Adamczyk, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113959 · Cited by 50 · see citing works