Segregation of cognitive and emotional function in the prefrontal cortex: a stereotactic meta-analysis
Abstract
Imaging studies of major depressive disorder and schizophrenia strongly implicate the prefrontal cortex. Interpretation of such studies is hindered by the limited knowledge of normal functional segregation. Different anatomical regions may be functionally specialised. Elucidating such specialisation may assist design and interpretation of patient studies. In this meta-analysis, 330 emotion induction and cognitive task studies of normal subjects published over the past decade reporting prefrontal activation have been examined. It was hypothesised that emotion induction would result in inferior medial activation and cognitive tasks dorsolateral activation. A significant difference in the pattern of reported activations was found in keeping with this hypothesis. Estimates of most likely reported activation loci for emotion induction and cognitive task studies have been made. In Montreal Neurological Institute (MNI) stereotactic space, these comprise of +/-5, 46, 18 and +/-5, 28, 31 for the medial prefrontal cortex, and +/-42, 28, -16 and +/-54, 28, 18 for the lateral prefrontal cortex, respectively. Additionally, estimates of the boundaries between emotional and cognitive-processing regions have been made. We restricted the effects of various potential sources of bias on the above estimates by attempting to include all relevant studies and independent selection by both authors of at most two activation loci from each study according to prespecified criteria. Such estimates of mo…
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Lesions placed a little behind the genu should affect medial prefrontal, anterior cingulate, and amygdala interactions thought to be involved in emotion and cognitive processing.
“This placement is interesting as it should affect medial prefrontal, anterior cingulate, and amygdala interactions thought to be involved in emotion and cognitive processing (Heilbronner and Haber, 2014; Steele and Lawrie, 2004).”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Steele and Lawrie, 2004
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- Authors
- Steele, J. D., & Lawrie, S. M.
- Affiliations
- Royal Edinburgh Hospital (GB)
- Corresponding author
- Steele, J.D
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2004-03
- Volume
- 21
- Issue
- 3
- Pages
- 868-875
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W1975970315
- Cited by
- 185
- References
- 5
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 3 · 2022: 8 · 2021: 4 · 2020: 4 · 2019: 5 · 2018: 7 · 2017: 1 · 2016: 9 · 2015: 12 · 2014: 13 · 2013: 11 · 2012: 17
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Discovery Research Portal (University of Dundee) (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- prefrontal cortex, functional segregation, emotion induction, cognitive tasks, medial prefrontal cortex, dorsolateral prefrontal cortex, major depressive disorder, schizophrenia, neuroimaging interpretation, stereotactic coordinates
- MeSH terms
- Brain Mapping, Cerebrovascular Circulation, Cognition, Emotions, Humans, Image Processing, Computer-Assisted, Stereotaxic Techniques, Prefrontal Cortex
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