The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Dissociation of cortical regions modulated by both working memory load and sleep deprivation and by sleep deprivation alone
Open accessAbstract
Working memory is an important mental capacity that is compromised following sleep deprivation (SD). To understand how working memory load interacts with state to influence brain activation in load-sensitive regions, and the extent to which SD-related changes are common across different loads, we used fMRI to study twelve healthy subjects following 24 h of SD using a verbal n-back task with three load levels. Performance decline was observed by way of reduced accuracy and slower response times following SD. The left prefrontal region and thalamus showed load dependent activity modulation that interacted with state. The right parietal and anterior medial frontal regions showed load dependent changes in activity as well as an effect of state. The anterior cingulate and occipital regions showed activation that displayed state effects that were independent of working memory load. These findings represent a step toward identifying how different brain regions exhibit varying vulnerability to the deleterious effects of SD on working memory.
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“Additional work has suggested that various brain regions are differentially activated following sleep deprivation depending upon the complexity of the working memory task (Choo et al. 2005).”
From Sleep Problems Across Development: A Pathway to Adolescent Risk Taking Through Working Memory (2015) · cites this paper as Choo et al. 2005
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“Existing studies of WM during SD show that in some instances, decrements in performance may be correlated with reduced frontal activation (Drummond et al., 1999; Thomas et al., 2000) whereas in other instances performance is somewhat indifferent to changes in frontal activation (Habeck et al.”
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Neurocognitive consequences of sleep deprivation
Goel, N., Rao, H., Durmer, J., & Dinges, D. (2009) · Seminars in Neurology · doi:10.1055/s-0029-1237117 · Cited by 2,154
The sleep-deprived human brain
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Sleep and emotion regulation: An organizing, integrative review
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The neurocognitive consequences of sleep restriction: A meta-analytic review
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Metadata
- Authors
- Choo, W.-C., Lee, W.-W., Venkatraman, V., Sheu, F.-S., & Chee, M. W. L.
- Affiliations
- SingHealth (SG)
- National University of Singapore (SG)
- Corresponding author
- Chee, Michael W.L.
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2005-04
- Volume
- 25
- Issue
- 2
- Pages
- 579-587
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2089696953
- Cited by
- 203
- References
- 30
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 9 · 2023: 12 · 2022: 7 · 2021: 16 · 2020: 11 · 2019: 11 · 2018: 11 · 2017: 8 · 2016: 8 · 2015: 9 · 2014: 11 · 2013: 15 · 2012: 15
- FWCI
- 13.01
- Type
- journal article
- Language
- en
- Open access
- green
- autopapers.ssrn.com
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion)
- SSRN Electronic Journal (submittedVersion)
- Funders
- National Medical Research Council
- Biomedical Research Council
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- sleep deprivation, working memory load, prefrontal cortex, thalamus, parietal cortex, anterior cingulate cortex, occipital cortex, brain activation, state effects
- MeSH terms
- Adult, Cerebral Cortex, Female, Humans, Male, Memory, Sleep Deprivation
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