Dynamics of male sexual arousal: distinct components of brain activation revealed by fMRI
Abstract
The peripheral mechanisms of male sexual arousal are well known. Recently, neuroimaging techniques, such as PET or fMRI, allowed the investigation of the subjacent cerebral mechanisms. In ten healthy subjects, we have simultaneously recorded fMRI images of brain activation elicited by viewing erotic scenes, and the time course of penile tumescence by means of a custom-built MRI-compatible pneumatic cuff. We have compared activation elicited by video clips with a long duration, that led to sexual arousal and penile erection, and activation elicited by briefly presented still images, that did induce sexual arousal without erection. This comparison and the use of the time course of penile tumescence in video clips allowed to perform a time resolved data analysis and to correlate different patterns of brain activation with different phases of sexual response. The activation maps highlighted a complex neural circuit involved in sexual arousal. Of this circuit, only a few areas (anterior cingulate, insula, amygdala, hypothalamus, and secondary somatosensory cortices) were specifically correlated with penile erection. Finally, these areas showed distinct dynamic relationships with the time course of sexual response. These differences might correspond to different roles in the development and appraisal of the sexual response. These findings shed light on the psychophysiology of male sexuality and open new perspectives for the diagnosis, therapy, and possible rehabilitation of sexual…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Both men and women experiencing visually-induced sexual arousal show increased activity in the amygdala, hippocampus, mPFC, NAc, OFC, ACC, and IC.
“Both men and women experiencing visually-induced sexual arousal show increased activity in the amygdala, hippocampus, mPFC, NAc, OFC, ACC, and IC [129,130,131,132].”
From The Neurobiology of Love and Pair Bonding from Human and Animal Perspectives (2023) · cites this paper as [131]
Cites
Co-Planar Stereotaxic Atlas of the Human Brain
Talairach, J., & Tournoux, P. (1988) · Medical Entomology and Zoology · Cited by 11,798 · see citing works
Statistical parametric maps in functional imaging: A general linear approach
Friston, K. J., Holmes, A. P., Worsley, K. J., Poline, J. ‐., Frith, C. D., & Frackowiak, R. S. J. (1994) · Human Brain Mapping · doi:10.1002/hbm.460020402 · Cited by 9,688 · see citing works
Co-planar stereotaxic atlas of the human brain
Laitinen, L. (1989) · Clinical Neurology and Neurosurgery · doi:10.1016/0303-8467(89)90128-5 · Cited by 7,565 · see citing works
Rosen, R. C., Riley, A., Wagner, G., Osterloh, I. H., Kirkpatrick, J., & Mishra, A. (1997) · Urology · doi:10.1016/s0090-4295(97)00238-0 · Cited by 5,849 · see citing works
Movement‐Related effects in fMRI time‐series
Friston, K. J., Williams, S., Howard, R., Frackowiak, R. S. J., & Turner, R. (1996) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910350312 · Cited by 3,774 · see citing works
Contributions of anterior cingulate cortex to behaviour
Devinsky, O., Morrell, M. J., & Vogt, B. A. (1995) · Brain · doi:10.1093/brain/118.1.279 · Cited by 3,377 · see citing works
Temporal Autocorrelation in Univariate Linear Modeling of FMRI Data
Woolrich, M. W., Ripley, B. D., Brady, M., & Smith, S. M. (2001) · NeuroImage · doi:10.1006/nimg.2001.0931 · Cited by 2,859 · see citing works
Linear Systems Analysis of Functional Magnetic Resonance Imaging in Human V1
Boynton, G., Engel, S., Glover, G., & Heeger, D. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-13-04207.1996 · Cited by 2,522 · see citing works
Neural correlates of conscious self-regulation of emotion
Beauregard, M., Lévesque, J., & Bourgouin, P. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-j0001.2001 · Cited by 1,033 · see citing works
Integration of Auditory and Visual Information about Objects in Superior Temporal Sulcus
Beauchamp, M. S., Lee, K. E., Argall, B., & Martin, A. D. (2004) · Neuron · doi:10.1016/s0896-6273(04)00070-4 · Cited by 765 · see citing works
Statistical methods of estimation and inference for functional MR image analysis
Bullmore, E. T., Brammer, M. J., Williams, S., Rabe‐Hesketh, S., Janot, N., David, A. S., Mellers, J. D. C., Howard, R. J., & Sham, P. C. (1996) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910350219 · Cited by 683 · see citing works
Men and women differ in amygdala response to visual sexual stimuli
Hamann, S., Herman, R. A., Nolan, C. L., & Wallen, K. (2004) · Nature Neuroscience · doi:10.1038/nn1208 · Cited by 603 · see citing works
Areas of brain activation in males and females during viewing of erotic film excerpts
Karama, S., Lecours, A. R., Leroux, J., Bourgouin, P., Beaudoin, G., Joubert, S., & Beauregard, M. (2002) · Human Brain Mapping · doi:10.1002/hbm.10014 · Cited by 522 · see citing works
Brain processing of visual sexual stimuli in human males
Redout�, J., Stol�ru, S., Gr�goire, M.-C., Costes, N., Cinotti, L., Lavenne, F., Bars, D. L., Forest, M. G., & Pujol, J. F. (2000) · Human Brain Mapping · doi:10.1002/1097-0193(200011)11:3 · Cited by 517 · see citing works
Artifacts due to stimulus correlated motion in functional imaging of the brain
Hajnal, J. V., Myers, R., Oatridge, A., Schwieso, J. E., YOUNG, I. R., & Bydder, G. M. (1994) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910310307 · Cited by 486 · see citing works
Lane, R. D., Chua, P. M.-L., & Dolan, R. J. (1999) · Neuropsychologia · doi:10.1016/s0028-3932(99)00017-2 · Cited by 479 · see citing works
Brain activation and sexual arousal in healthy, heterosexual males
Arnow, B. A., Desmond, J. E., Banner, L. L., Glover, G. H., Solomon, A., Polan, M. L., Lue, T. F., & Atlas, S. W. (2002) · Brain · doi:10.1093/brain/awf108 · Cited by 425 · see citing works
Brain Activation during Human Male Ejaculation
Holstege, G., Georgiadis, J. R., Paans, A. M. J., Meiners, L. C., van der Graaf, F. H. C. E., & Reinders, A. A. T. S. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-27-09185.2003 · Cited by 424 · see citing works
Neuroanatomical Correlates of Visually Evoked Sexual Arousal in Human Males
Stoléru, S., Grégoire, M., Gérard, D., Decety, J., Lafarge, E., Cinotti, L., Lavenne, F., Bars, D. L., Vernet-Maury, E., Rada, H., et al. (1999) · Archives of Sexual Behavior · doi:10.1023/a:1018733420467 · Cited by 418 · see citing works
Erectile Physiological and Pathophysiological Pathways Involved in Erectile Dysfunction
Andersson, K. (2003) · The Journal of Urology · doi:10.1097/01.ju.0000075362.08363.a4 · Cited by 233 · see citing works
Giuliano, F., & Rampin, O. (2004) · Physiology and Behavior · doi:10.1016/j.physbeh.2004.08.014 · Cited by 226 · see citing works
Mouras, H., Stoléru, S., Bittoun, J., Glutron, D., Pélégrini‐Issac, M., Paradis, A., & Burnod, Y. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00408-7 · Cited by 204 · see citing works
Park, K., Seo, J., Kang, H., Ryu, S., Kim, H., & Jeong, G. (2001) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3900649 · Cited by 162 · see citing works
Bocher, M., Chisin, R., Parag, Y., Freedman, N., Weil, Y. M., Lester, H., Mishani, E., & Bonne, O. B. (2001) · NeuroImage · doi:10.1006/nimg.2001.0794 · Cited by 148 · see citing works
Brain processing of visual sexual stimuli in treated and untreated hypogonadal patients
Redouté, J., Stoléru, S., Pugeat, M., Costes, N., Lavenne, F., Le Bars, D., Dechaud, H., Cinotti, L., & Pujol, J.-F. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2004.12.003 · Cited by 126 · see citing works
Simonsen, U., García‐Sacristán, A., & Prieto, D. (2002) · Journal of Vascular Research · doi:10.1159/000065541 · Cited by 120 · see citing works
Park, K., Kang, H. K., Seo, J. J., Kim, H. J., Ryu, S. B., & Jeong, G. (2001) · Urology · doi:10.1016/s0090-4295(01)00992-x · Cited by 104 · see citing works
Sexual dysfunction in partial epilepsy
Morrell, M. J., Sperling, M. R., Stecker, M. M., & Dichter, M. A. (1994) · Neurology · doi:10.1212/wnl.44.2.243 · Cited by 102 · see citing works
Time course of the subjective emotional response to aversive pictures: relevance to fMRI studies
Garrett, A. S., & Maddock, R. J. (2001) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(01)00110-x · Cited by 76 · see citing works
Montorsi, F. (2003) · European Urology · doi:10.1016/s0302-2838(03)00053-8 · Cited by 66 · see citing works
Self-citationMontorsi, F., Perani, D., Anchisi, D., Salonia, A., Scifo, P., Rigiroli, P., Zanoni, M. L., Heaton, J., Rigatti, P., & Fazio, F. (2003) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3900999 · Cited by 54 · see citing works
Self-citationHagemann, J. (2003) · European Urology · doi:10.1016/s0302-2838(03)00002-2 · Cited by 53 · see citing works
Male sexual arousal elicited by film and fantasy matched in content
Koukounas, E., & Over, R. (1997) · Australian Journal of Psychology · doi:10.1080/00049539708259843 · Cited by 27 · see citing works
Cognitive behavioral assessment
(1996) · PsycEXTRA Dataset · doi:10.1037/e525652004-001 · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Sescousse, G., Caldú, X., Segura, B., & Dreher, J.-C. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.02.002 · Cited by 782 · see citing works
Somatosensation in social perception
Keysers, C., Kaas, J. H., & Gazzola, V. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2833 · Cited by 787 · see citing works
Voon, V., Mole, T. B., Banca, P., Porter, L., Morris, L., Mitchell, S., Lapa, T. R., Karr, J., Harrison, N. A., Potenza, M. N., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102419 · Cited by 462 · see citing works
The Impact of Internet Pornography on Adolescents: A Review of the Research
Owens, E. W., Behun, R. J., Manning, J. C., & Reid, R. C. (2012) · Sexual Addiction & Compulsivity The Journal of Treatment and Prevention · doi:10.1080/10720162.2012.660431 · Cited by 445 · see citing works
Neural Substrate of the Late Positive Potential in Emotional Processing
Liu, Y., Huang, H., Deweese, M. M., Keil, A., & Ding, M. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.3109-12.2012 · Cited by 415 · see citing works
The human sexual response cycle: Brain imaging evidence linking sex to other pleasures
Georgiadis, J. R., & Kringelbach, M. L. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.05.004 · Cited by 399 · see citing works
Mechanisms of Penile Erection and Basis for Pharmacological Treatment of Erectile Dysfunction
Andersson, K. (2011) · Pharmacological Reviews · doi:10.1124/pr.111.004515 · Cited by 399 · see citing works
Stoléru, S., Fonteille, V., Cornélis, C., Joyal, C. C., & Moulier, V. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.03.006 · Cited by 357 · see citing works
Sexual function in men and women with neurological disorders
Rees, P. M., Fowler, C. J., & Maas, C. P. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60238-4 · Cited by 342 · see citing works
Sexual Dysfunction, Depression, and the Impact of Antidepressants
Kennedy, S. H., & Rizvi, S. (2009) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31819c76e9 · Cited by 338 · see citing works
Immunohistochemical localization of oxytocin receptors in human brain
Boccia, M. L., Petrusz, P., Suzuki, K., Marson, L., & Pedersen, C. A. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.08.048 · Cited by 276 · see citing works
From Agents to Objects: Sexist Attitudes and Neural Responses to Sexualized Targets
Cikara, M., Eberhardt, J. L., & Fiske, S. T. (2010) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2010.21497 · Cited by 253 · see citing works
The neural correlates of subjective pleasantness
Kühn, S., & Gallinat, J. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.02.065 · Cited by 232 · see citing works
Pleasure Rather Than Salience Activates Human Nucleus Accumbens and Medial Prefrontal Cortex
Sabatinelli, D., Bradley, M. M., Lang, P. J., Costa, V. D., & Versace, F. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00230.2007 · Cited by 225 · see citing works
Walter, M., Bermpohl, F., Mouras, H., Schiltz, K., Tempelmann, C., Rotte, M., Heinze, H. J., Bogerts, B., & Northoff, G. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.01.040 · Cited by 210 · see citing works
Regional cerebral blood flow changes associated with clitorally induced orgasm in healthy women
Georgiadis, J. R., Kortekaas, R., Kuipers, R., Nieuwenburg, A., Pruim, J., Reinders, A. A. T. S., & Holstege, G. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05206.x · Cited by 205 · see citing works
Neuroanatomy and function of human sexual behavior: A neglected or unknown issue?
Calabrò, R. S., Cacciola, A., Bruschetta, D., Milardi, D., Quattrini, F., Sciarrone, F., Rosa, G. L., Bramanti, P., & Anastasi, G. (2019) · Brain and Behavior · doi:10.1002/brb3.1389 · Cited by 208 · see citing works
A functional endophenotype for sexual orientation in humans
Ponseti, J., Bosinski, H. A. G., Wolff, S., Peller, M., Jansen, O., Mehdorn, H. M., Büchel, C., & Siebner, H. R. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.08.002 · Cited by 197 · see citing works
Cerebral white matter deficiencies in pedophilic men
Cantor, J. M., Kabani, N. J., Christensen, B. K., Zipursky, R. B., Barbaree, H. E., DICKEY, R. W., Klassen, P. E., Mikulis, D. J., Kuban, M. E., Blak, T., et al. (2007) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2007.10.013 · Cited by 190 · see citing works
The Common Neural Bases Between Sexual Desire and Love: A Multilevel Kernel Density fMRI Analysis
Cacioppo, S., Bianchi‐Demicheli, F., Frum, C., Pfaus, J. G., & Lewis, J. W. (2012) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2012.02651.x · Cited by 176 · see citing works
van de Riet, W. A. C., Grèzes, J., & de Gelder, B. (2009) · Social Neuroscience · doi:10.1080/17470910701865367 · Cited by 159 · see citing works
Decoding human brain activity during real-world experiences
Spiers, H. J., & Maguire, E. A. (2007) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2007.06.002 · Cited by 155 · see citing works
Viewing sexual stimuli associated with greater sexual responsiveness, not erectile dysfunction
Prause, N., & Pfaus, J. (2015) · Sexual Medicine · doi:10.1002/sm2.58 · Cited by 150 · see citing works
Is Love Passion an Addictive Disorder?
Reynaud, M., Karila, L., Blecha, L., & Benyamina, A. (2010) · The American Journal of Drug and Alcohol Abuse · doi:10.3109/00952990.2010.495183 · Cited by 141 · see citing works
Neurological control of human sexual behaviour: insights from lesion studies
Baird, A. D., Wilson, S. J., Bladin, P. F., Saling, M. M., & Reutens, D. C. (2007) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2006.107193 · Cited by 140 · see citing works
Neuroanatomical correlates of penile erection evoked by photographic stimuli in human males
Moulier, V., Mouras, H., Pélégrini‐Issac, M., Glutron, D., Rouxel, R., Grandjean, B., Bittoun, J., & Stoléru, S. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.06.037 · Cited by 138 · see citing works
Walter, M., Witzel, J. G., Wiebking, C., Gubka, U., Rotte, M., Schiltz, K., Bermpohl, F., Tempelmann, C., Bogerts, B., Heinze, H. J., et al. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.10.018 · Cited by 138 · see citing works
Georgiadis, J. R., Reinders, A. A. T. S., Paans, A. M. J., Renken, R. J., & Kortekaas, R. (2009) · Human Brain Mapping · doi:10.1002/hbm.20733 · Cited by 134 · see citing works
Physiology of women's sexual function: basic knowledge and new findings.
Salonia, A., Giraldi, A., Chivers, M. L., Georgiadis, J. R., Levin, R., Maravilla, K. R., & McCarthy, M. M. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01810.x · Cited by 132 · see citing works
Self-citationNeural correlates of sexual arousal in homosexual and heterosexual men.
Safron, A., Barch, B., Bailey, J. M., Gitelman, D. R., Parrish, T. B., & Reber, P. J. (2007) · Behavioral Neuroscience · doi:10.1037/0735-7044.121.2.237 · Cited by 123 · see citing works
Kisspeptin modulates sexual and emotional brain processing in humans
Comninos, A. N., Wall, M. B., Demetriou, L., Shah, A., Clarke, S. A., Narayanaswamy, S., Nesbitt, A., Izzi‐Engbeaya, C. N., Prague, J., Abbara, A., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci89519 · Cited by 121 · see citing works
Gola, M. K., Draps, M., Marchewka, A., & Sescousse, G. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00402 · Cited by 120 · see citing works
Caria, A., Venuti, P., & de Falco, S. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr084 · Cited by 118 · see citing works
Neural Substrates of Sexual Desire in Individuals with Problematic Hypersexual Behavior
Seok, J.-W., & Sohn, J.-H. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00321 · Cited by 118 · see citing works
Functional brain correlates of heterosexual paedophilia
Schiffer, B., Paul, T., Gizewski, E. R., Forsting, M., Leygraf, N., Schedlowski, M., & Krüger, T. H. C. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.02.008 · Cited by 115 · see citing works
Distinct brain systems underlie the processing of valence and arousal of affective pictures
Nielen, M. M. A., Heslenfeld, D. J., Heinen, K., Van Strien, J. W., Witter, M. P., Jonker, C., & Veltman, D. J. (2009) · Brain and Cognition · doi:10.1016/j.bandc.2009.05.007 · Cited by 114 · see citing works
Human brain activation during sexual stimulation of the penis
Georgiadis, J. R., & Holstege, G. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20735 · Cited by 110 · see citing works
Chen, P.-H. A., Jolly, E., Cheong, J. H., & Chang, L. J. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.116851 · Cited by 106 · see citing works
A Quantitative Meta-Analysis on Cue-Induced Male Sexual Arousal
Kühn, S., & Gallinat, J. (2011) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2011.02322.x · Cited by 102 · see citing works
The role of oxytocin in mating and pregnancy
Borrow, A. P., & Cameron, N. M. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.11.001 · Cited by 101 · see citing works
Mouras, H., Stoléru, S., Moulier, V., Pélégrini‐Issac, M., Rouxel, R., Grandjean, B., Glutron, D., & Bittoun, J. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.05.051 · Cited by 97 · see citing works
Poeppl, T. B., Langguth, B., Laird, A. R., & Eickhoff, S. B. (2013) · Human Brain Mapping · doi:10.1002/hbm.22262 · Cited by 96 · see citing works
Brain response to visual sexual stimuli in homosexual pedophiles
Schiffer, B., Krueger, T. H. C., Paul, T., de Greiff, A., Forsting, M., Leygraf, N., Schedlowski, M., & Gizewski, E. R. (2008) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0804 · Cited by 92 · see citing works
Hypersexual behavior in frontotemporal dementia: a comparison with early-onset Alzheimer’s disease
Mendez, M. F., & Shapira, J. S. (2013) · Archives of Sexual Behavior · doi:10.1007/s10508-012-0042-4 · Cited by 86 · see citing works
Abler, B., Seeringer, A., Hartmann, A., Grön, G., Metzger, C. D., Walter, M., & Stingl, J. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.66 · Cited by 83 · see citing works
Georgiadis, J. R., Farrell, M. J., Boessen, R., Denton, D. A., Gavrilescu, M., Kortekaas, R., Renken, R. J., Hoogduin, J. M., & Egan, G. F. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.12.034 · Cited by 80 · see citing works
Neural correlates of erotic stimulation under different levels of female sexual hormones
Abler, B., Kumpfmüller, D., Grön, G., Walter, M., Stingl, J., & Seeringer, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054447 · Cited by 75 · see citing works
Abnormal amygdala activation profile in pedophilia
Sartorius, A., Ruf, M., Kief, C., Demirakça, T., Bailer, J., Ende, G., Henn, F. A., Meyer‐Lindenberg, A., & Dreßing, H. R. (2008) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-008-0782-2 · Cited by 73 · see citing works
Gender Commonalities and Differences in the Neural Processing of Visual Sexual Stimuli
Wehrum‐Osinsky, S., Klucken, T., Kagerer, S., Walter, B., Hermann, A., Vaitl, D., & Stark, R. M. (2013) · The Journal of Sexual Medicine · doi:10.1111/jsm.12096 · Cited by 69 · see citing works
The neural basis of sex differences in sexual behavior: A quantitative meta-analysis
Poeppl, T. B., Langguth, B., Rupprecht, R., Safron, A., Bzdok, D., Laird, A. R., & Eickhoff, S. B. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.10.001 · Cited by 69 · see citing works
High resolution fMRI of subcortical regions during visual erotic stimulation at 7 T
Walter, M., Stadler, J., Tempelmann, C., Speck, O., & Northoff, G. (2008) · Magnetic Resonance Materials in Physics Biology and Medicine · doi:10.1007/s10334-007-0103-1 · Cited by 68 · see citing works
Characteristics of Men Who Report Persistent Sexual Symptoms After Finasteride Use for Hair Loss
Basaria, S. S., Jasuja, R., Huang, G. T.-W., Wharton, W., Pan, H., Pencina, K. M., Li, Z., Travison, T. G., Bhawan, J., Gonthier, R., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-2726 · Cited by 68 · see citing works
Poeppl, T. B., Nitschke, J., Dombert, B., Santtila, P. O., Greenlee, M. W., Osterheider, M., & Mokros, A. (2011) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2011.02248.x · Cited by 66 · see citing works
Pedophilic behavior from brain disease.
Mendez, M., & Shapira, J. (2011) · Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.02172.x · Cited by 69 · see citing works
Association between brain structure and phenotypic characteristics in pedophilia
Poeppl, T. B., Nitschke, J., Santtila, P. O., Schecklmann, M., Langguth, B., Greenlee, M. W., Osterheider, M., & Mokros, A. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.01.003 · Cited by 66 · see citing works
Brain Activity Unique to Orgasm in Women: An fMRI Analysis
Wise, N. J., Frangos, E., & Komisaruk, B. R. (2017) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2017.08.014 · Cited by 66 · see citing works
Neural correlates of sexual arousal in heterosexual and homosexual women and men.
Sylva, D., Safron, A., Rosenthal, A. M., Reber, P. J., Parrish, T., & Bailey, J. M. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2013.08.003 · Cited by 67 · see citing works
Maravilla, K. R., & Yang, C. C. (2008) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2008.00839.x · Cited by 65 · see citing works
Lombardi, G., Nelli, F., Celso, M. F., Mencarini, M., & POPOLO, G. D. (2012) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2011.02615.x · Cited by 65 · see citing works
Another major function of the anterior cingulate cortex: The representation of requirements
Weston, C. S. E. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.04.014 · Cited by 64 · see citing works
Neural Bases of Hypoactive Sexual Desire Disorder in Women: An Event-Related fMRI Study
Bianchi-Demicheli, F., Cojan, Y., Waber, L., Recordon, N., Vuilleumier, P. O., & Ortigue, S. (2011) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2011.02376.x · Cited by 62 · see citing works
Decision neuroscience: neuroeconomics
Smith, D. V., & Huettel, S. A. (2010) · Wiley Interdisciplinary Reviews Cognitive Science · doi:10.1002/wcs.73 · Cited by 62 · see citing works
Cera, N., Pierro, E. D. D., Ferretti, A., Tartaro, A., Romani, G. L., & Perrucci, M. G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105336 · Cited by 60 · see citing works
Self-citationThe Neurobiology of Love and Pair Bonding from Human and Animal Perspectives
Blumenthal, S. A., & Young, L. J. (2023) · Biology · doi:10.3390/biology12060844 · Cited by 59 · see citing works
Brain activation evoked by erotic films varies with different menstrual phases: An fMRI study
Zhu, X., Wang, X., Parkinson, C. M., Cai, C., Gao, S., & Hu, P. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.09.027 · Cited by 58 · see citing works
Miyagawa, Y., Tsujimura, A., Fujita, K., Matsuoka, Y., Takahashi, T., Takao, T., Takada, S., Matsumiya, K., Osaki, Y., Takasawa, M., et al. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.03.055 · Cited by 59 · see citing works
Fauth‐Bühler, M., Vollstädt‐Klein, S., Klemen, J., & Smolka, M. N. (2008) · Behavioral and Brain Functions · doi:10.1186/1744-9081-4-30 · Cited by 57 · see citing works
Neural Correlates of Sexual Orientation in Heterosexual, Bisexual, and Homosexual Men
Safron, A., Sylva, D., Klimaj, V., Rosenthal, A. M., Li, M., Walter, M., & Bailey, J. M. (2017) · Scientific Reports · doi:10.1038/srep41314 · Cited by 57 · see citing works
Sexuality in patients with Parkinson's disease, Alzheimer's disease, and other dementias
Bronner, G., Aharon‐Peretz, J., & Hassin‐Baer, S. (2015) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63247-0.00017-1 · Cited by 55 · see citing works
Neural Correlates of Sexual Orientation in Heterosexual, Bisexual, and Homosexual Women
Safron, A., Klimaj, V., Sylva, D., Rosenthal, A. M., Li, M., Walter, M., & Bailey, J. M. (2018) · Scientific Reports · doi:10.1038/s41598-017-18372-0 · Cited by 54 · see citing works
Antidepressant-related sexual dysfunction — Perspectives from neuroimaging
Graf, H., Walter, M., Metzger, C. D., & Abler, B. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.12.003 · Cited by 53 · see citing works
Qamar, M. A., Sauerbier, A., Politis, M., Carr, H. J., Loehrer, P. A., & Chaudhuri, К. R. (2017) · npj Parkinson s Disease · doi:10.1038/s41531-016-0006-9 · Cited by 53 · see citing works
Tart‐Zelvin, A., & Xu, X. (2016) · Journal of Positive Sexuality · doi:10.51681/1.222 · Cited by 51 · see citing works
Macrostructural Alterations of Subcortical Grey Matter in Psychogenic Erectile Dysfunction
Cera, N., Pizzi, S. D., Pierro, E. D. D., Gambi, F., Tartaro, A., Vicentini, C., Galatioto, G. P., Romani, G. L., & Ferretti, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039118 · Cited by 50 · see citing works
Self-citationAssessment of Sexual Orientation Using the Hemodynamic Brain Response to Visual Sexual Stimuli
Ponseti, J., Granert, O., Jansen, O., Wolff, S., Mehdorn, H. M., Bosinski, H. A. G., & Siebner, H. R. (2009) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2009.01233.x · Cited by 49 · see citing works
Borg, C., de Jong, P. J., & Georgiadis, J. R. (2012) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nss117 · Cited by 46 · see citing works
Neural Activation Toward Erotic Stimuli in Homosexual and Heterosexual Males
Kagerer, S., Klucken, T. M., Wehrum, S., Zimmermann, M., Schienle, A., Walter, B., Vaitl, D., & Stark, R. (2011) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2011.02449.x · Cited by 46 · see citing works
Brunetti, M., Babiloni, C., Ferretti, A., Gratta, C. D., Merla, A., Belardinelli, M. O., & Romani, G. L. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06241.x · Cited by 45 · see citing works
Self-citationZhang, S., Wang, W., Zhornitsky, S., & Li, C.-S. R. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00344 · Cited by 40 · see citing works
Woodard, T. L., Nowak, N. T., Balon, R., Tancer, M. E., & Diamond, M. P. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.05.041 · Cited by 41 · see citing works
Reports of intimate touch: Erogenous zones and somatosensory cortical organization
Turnbull, O. H., Lovett, V. E., Chaldecott, J., & Lucas, M. (2013) · Cortex · doi:10.1016/j.cortex.2013.07.010 · Cited by 42 · see citing works
Basal ganglia lateralization in different types of reward
Arsalidou, M., Vijayarajah, S., & Sharaev, M. (2020) · Brain Imaging and Behavior · doi:10.1007/s11682-019-00215-3 · Cited by 42 · see citing works
Kisspeptin enhances brain responses to olfactory and visual cues of attraction in men
Yang, L. Y., Demetriou, L., Wall, M. B., Mills, E., Zargaran, D., Sykes, M. C., Prague, J., Abbara, A., Owen, B. M., Bassett, P., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.133633 · Cited by 40 · see citing works
Walter, M., Matthiae, C., Wiebking, C., Rotte, M., Tempelmann, C., Bogerts, B., Heinze, H., & Northoff, G. (2007) · Human Brain Mapping · doi:10.1002/hbm.20506 · Cited by 39 · see citing works
Does dorsolateral prefrontal cortex (DLPFC) activation return to baseline when sexual stimuli cease?
Leon-Carrion, J., Martín-Rodríguez, J. F., Damas-López, J., Pourrezai, K., Izzetoglu, K., Barroso y Martin, J. M., & Dominguez-Morales, M. R. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.01.058 · Cited by 46 · see citing works
Real-time functional magnetic imaging—brain–computer interface and virtual reality
Renaud, P., Joyal, C. C., Stoléru, S., Goyette, M., Weiskopf, N., & Birbaumer, N. (2011) · Progress in brain research · doi:10.1016/b978-0-444-53355-5.00014-2 · Cited by 38 · see citing works
Amygdala responses to valence and its interaction by arousal revealed by MEG
Styliadis, C., Ioannides, A. A., Bamidis, P. D., & Papadelis, C. L. (2013) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2013.05.006 · Cited by 38 · see citing works
The Biological Treatment of Paraphilic Disorders: an Updated Review
Holoyda, B. J., & Kellaher, D. C. (2016) · Current Psychiatry Reports · doi:10.1007/s11920-015-0649-y · Cited by 38 · see citing works
Meseguer, V., Romero, M. J., Barrós‐Loscertales, A., Belloch, V., Bosch‐Morell, F., Romero, J., & Ávila, C. (2007) · PubMed · Cited by 36 · see citing works
Epidemiology and pathophysiology of male sexual dysfunction
Kaminetsky, J. C. (2008) · International Journal of Impotence Research · doi:10.1038/ijir.2008.16 · Cited by 39 · see citing works
Lesion mapping of stroke-related erectile dysfunction
Winder, K., Seifert, F. C., Köhrmann, M., Crodel, C. C., Kloska, S. P., Dörfler, A., Hösl, K. M., Schwab, S., & Hilz, M. J. (2017) · Brain · doi:10.1093/brain/awx080 · Cited by 39 · see citing works
Cera, N., Pierro, E. D. D., Sepede, G., Gambi, F., Perrucci, M. G., Merla, A., Tartaro, A., Gratta, C. D., Galatioto, G. P., Vicentini, C., et al. (2012) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2012.02719.x · Cited by 38 · see citing works
Self-citationMohandass, A., Krishnan, V., Gribkova, E., Asuthkar, S., Baskaran, P., Nersesyan, Y., Hussain, Z., Wise, L. M., George, R. E., Stokes, N. L., et al. (2020) · The FASEB Journal · doi:10.1096/fj.202000794r · Cited by 37 · see citing works
Neuroimaging and Sexual Behavior: Identification of Regional and Functional Differences
Cheng, J., Secondary, J., Burke, W. H., Fedoroff, J. P., & Dwyer, R. G. (2015) · Current Psychiatry Reports · doi:10.1007/s11920-015-0593-x · Cited by 37 · see citing works
The cortical sensory representation of genitalia in women and men: a systematic review
Cazala, F., Vienney, N., & Stoléru, S. (2015) · Socioaffective Neuroscience & Psychology · doi:10.3402/snp.v5.26428 · Cited by 38 · see citing works
Wang, Y., Dong, M., Guan, M., Wu, J., He, Z., Zou, Z., Chen, X., Shi, D., Liang, J., & Zhang, X. (2017) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2017.00221 · Cited by 36 · see citing works
Hietanen, J. K., Kirjavainen, I., & Nummenmaa, L. (2014) · Biological Psychology · doi:10.1016/j.biopsycho.2014.09.003 · Cited by 34 · see citing works
At the Second Glance: Stability of Neural Responses Toward Visual Sexual Stimuli
Wehrum‐Osinsky, S., Klucken, T., Kagerer, S., Walter, B., Hermann, A., & Stark, R. M. (2014) · The Journal of Sexual Medicine · doi:10.1111/jsm.12653 · Cited by 32 · see citing works
Zhao, L., Guan, M., Zhang, X., Karama, S., Khundrakpam, B. S., Wang, M., Dong, M., Qin, W., Tian, J., Evans, A. C., et al. (2015) · Human Brain Mapping · doi:10.1002/hbm.22925 · Cited by 33 · see citing works
Contextual modulation of pain in masochists
Kamping, S., Andoh, J., Bomba, I. C., Diers, M., Diesch, E., & Flor, H. (2015) · Pain · doi:10.1097/j.pain.0000000000000390 · Cited by 34 · see citing works
- Authors
- Ferretti, A., Caulo, M., Del Gratta, C., Di Matteo, R., Merla, A., Montorsi, F., Pizzella, V., Pompa, P., Rigatti, P., Rossini, P. M., Salonia, A., Tartaro, A., & Romani, G. L.
- Affiliations
- University of Chieti-Pescara (IT)
- Vita-Salute San Raffaele University (IT)
- Ospedale SS. Annunziata (IT)
- Università Campus Bio-Medico (IT)
- Corresponding author
- Ferretti, Antonio
- ORCID
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2005-07
- Volume
- 26
- Issue
- 4
- Pages
- 1086-1096
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2021586194
- Cited by
- 288
- References
- 35
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 5 · 2023: 12 · 2022: 11 · 2021: 11 · 2020: 11 · 2019: 11 · 2018: 16 · 2017: 24 · 2016: 17 · 2015: 18 · 2014: 10 · 2013: 22 · 2012: 21
- FWCI
- 7.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Social Sciences › Psychology › Clinical Psychology › Sexuality, Behavior, and Technology
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- male sexual arousal, penile tumescence, brain activation, anterior cingulate cortex, insula, amygdala, hypothalamus, secondary somatosensory cortex, sexual dysfunction
- MeSH terms
- Adult, Brain, Brain Mapping, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Male, Nerve Net, Oxygen, Penile Erection, Photic Stimulation, Sexual Behavior
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
