Cited by 338Sexual function and dysfunction studiesTreatment of Major DepressionSexuality, Behavior, and Technology

Sexual Dysfunction, Depression, and the Impact of Antidepressants

Kennedy, Sidney H., Rizvi, Sakina·2009·Journal of Clinical Psychopharmacology

Abstract

Sexual dysfunction is a common symptom of depression. Although decreased libido is most often reported, difficulties with arousal, resulting in vaginal dryness in women and erectile dysfunction in men, and absent or delayed orgasm are also prevalent. Sexual dysfunction is also a frequent adverse effect of treatment with most antidepressants and is one of the predominant reasons for premature drug discontinuation. Selective serotonin reuptake inhibitors are the most widely prescribed antidepressants and have significant effects on arousal and orgasm compared with antidepressants that target norepinephrine, dopamine, and melatonin systems. The availability of an antidepressant that does not cause or exacerbate sexual dysfunction represents an advance in pharmacotherapy for mood disorders and should reduce treatment noncompliance and decrease the need for switching antidepressants or adding antidotes. The purpose of this review was to provide an update on the prevalence, psychobiology, and relative adverse effect burden of sexual dysfunction associated with different antidepressants.

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Registry

Crossref · 10.1097/jcp.0b013e31819c76e9

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114 of 114 references verified0 citation errors · 0 not checkable

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Authors
Kennedy, S. H., & Rizvi, S.
Affiliations
University Health Network (CA)
Corresponding author
  • Kennedy, Sidney H.
  • Rizvi, Sakina
Venue
Journal of Clinical Psychopharmacology
Published
2009-04
Volume
29
Issue
2
Pages
157-164
ISSN
0271-0749 (ISSN-L)
OpenAlex
W2158447906
Cited by
338
References
114
Citations by year
2026: 10 · 2025: 14 · 2024: 17 · 2023: 21 · 2022: 18 · 2021: 24 · 2020: 12 · 2019: 13 · 2018: 22 · 2017: 23 · 2016: 24 · 2015: 17 · 2014: 19 · 2013: 31 · 2012: 21
FWCI
3.03
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Clinical Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Social Sciences › Psychology › Clinical Psychology › Sexuality, Behavior, and Technology
Keywords
sexual dysfunction, depression, antidepressants, selective serotonin reuptake inhibitors, erectile dysfunction, female sexual dysfunction, orgasm, sexual desire, adverse drug reactions, treatment discontinuation, treatment non-adherence, norepinephrine, dopamine, melatonin
MeSH terms
Antidepressive Agents, Major Depressive Disorder, Female, Humans, Erectile Dysfunction, Libido, Male, Orgasm, Selective Serotonin Reuptake Inhibitors, Sexual Dysfunctions, Psychological, Medication Adherence

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