The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Sucrose activates human taste pathways differently from artificial sweetener
Abstract
Animal models suggest that sucrose activates taste afferents differently than non-caloric sweeteners. Little information exists how artificial sweeteners engage central taste pathways in the human brain. We assessed sucrose and sucralose taste pleasantness across a concentration gradient in 12 healthy control women and applied 10% sucrose and matched sucralose during functional magnet resonance imaging. The results indicate that (1) both sucrose and sucralose activate functionally connected primary taste pathways; (2) taste pleasantness predicts left insula response; (3) sucrose elicits a stronger brain response in the anterior insula, frontal operculum, striatum and anterior cingulate, compared to sucralose; (4) only sucrose, but not sucralose, stimulation engages dopaminergic midbrain areas in relation to the behavioral pleasantness response. Thus, brain response distinguishes the caloric from the non-caloric sweetener, although the conscious mind could not. This could have important implications on how effective artificial sweeteners are in their ability to substitute sugar intake.
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In the citing paper
“Human imaging studies have shown that tasting palatable foods activated the insula and midbrain areas (143,144).”
From Obesity and addiction: Neurobiological overlaps (2013) · cites this paper as [144]
In the citing paper
“For example, when normal-weight women tasted a sweetener with calories (sucrose), both the insula and dopaminergic midbrain areas became activated, whereas tasting a calorie-free sweetener (sucralose) only activated the insula (144).”
From Obesity and addiction: Neurobiological overlaps (2013) · cites this paper as [144]
In the citing paper
“For example, when normal weight women tasted a sweetener with calories (sucrose), both the insula and DA midbrain areas became activated, whereas tasting a calorie-free sweetener (sucralose) only activated the insula (103).”
From The Addictive Dimensionality of Obesity (2013) · cites this paper as [103]
In the citing paper
“Indeed, in humans, tasting palatable foods activated the insula and midbrain areas (102,103).”
From The Addictive Dimensionality of Obesity (2013) · cites this paper as [103]
In the citing paper
“Human imaging studies have shown that tasting palatable foods activated the insula and midbrain areas (DelParigi et al 2005;Frank et al 2008).”
From Food and Drug Reward: Overlapping Circuits in Human Obesity and Addiction (2011) · cites this paper as Frank et al 2008
In the citing paper
“However, the DA signaling may also be necessary for sensing the calorie content of food.For example, when normal weight women tasted a sweetener with calories (sucrose), both the insula and dopaminergic midbrain areas became activated, whereas tasting a calorie-free sweetener (sucralose) only activated the insula (Frank et al 2008).”
From Food and Drug Reward: Overlapping Circuits in Human Obesity and Addiction (2011) · cites this paper as Frank et al 2008
Citations
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Cited by
Sorted by citations
How do you feel — now? The anterior insula and human awareness
(Bud) Craig, A. D. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2555 · Cited by 6,657
Obesity and addiction: Neurobiological overlaps
Volkow, N. D., Wang, G. ‐., Tomasi, D., & Baler, R. D. (2013) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.01031.x · Cited by 800
“Human imaging studies have shown that tasting palatable foods activated the insula and midbrain areas (143,144).”
BackgroundCraig, A. D. (. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0248-y · Cited by 600
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“This seems unlikely and it is notable that the only other non-nutritive sweetener, sucralose, that has been tested in this way showed patterns of activation that were distinct from those of a natural carbohydrate (Frank et al. 2008).”
BackgroundMethodResultFood and Drug Reward: Overlapping Circuits in Human Obesity and Addiction
Volkow, N. D., Wang, G. J., Fowler, J. S., Tomasi, D., & Baler, R. (2011) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2011_169 · Cited by 525
“Human imaging studies have shown that tasting palatable foods activated the insula and midbrain areas (DelParigi et al. 2005; Frank et al. 2008).”
Background
Metadata
- Authors
- Frank, G. K. W., Oberndorfer, T. A., Simmons, A. N., Paulus, M. P., Fudge, J. L., Yang, T. T., & Kaye, W. H.
- Affiliations
- Children's Hospital Colorado (US)
- University of California San Diego (US)
- University of Rochester Medicine (US)
- University of Pittsburgh (US)
- Corresponding author
- Kaye, Walter H.
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2008-02
- Volume
- 39
- Issue
- 4
- Pages
- 1559-1569
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2083215956
- Cited by
- 274
- References
- 59
- Citations by year
- 2026: 12 · 2025: 18 · 2024: 10 · 2023: 10 · 2022: 15 · 2021: 23 · 2020: 20 · 2019: 15 · 2018: 20 · 2017: 23 · 2016: 20 · 2015: 10 · 2014: 20 · 2013: 22 · 2012: 7
- FWCI
- 6.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (UL1TR000005)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- sucrose, sucralose, artificial sweeteners, taste pleasantness, anterior insula, frontal operculum, striatum, anterior cingulate cortex, dopaminergic midbrain, functional connectivity, sugar substitution
- MeSH terms
- Adult, Afferent Pathways, Brain, Cerebral Cortex, Dopamine, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Reward, Sucrose, Sweetening Agents, Taste, Taste Buds
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