Cited by 279Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsMedical Imaging Techniques and Applications

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Categorical and correlational analyses of baseline fluorodeoxyglucose positron emission tomography images from the Alzheimer’s Disease Neuroimaging Initiative (ADNI)

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Langbaum, Jessica B.S., Chen, Kewei, Lee, Wendy, Reschke, Cole, Bandy, Dan, Fleisher, Adam S., Alexander, Gene E., Foster, Norman L., Weiner, Michael W., Koeppe, Robert A., Jagust, William J., Reiman, Eric M.·2009·NeuroImage

DOI 10.1016/j.neuroimage.2008.12.072PMC PMC2886795

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Abstract

In mostly small single-center studies, Alzheimer's disease (AD) is associated with characteristic and progressive reductions in fluorodeoxyglucose positron emission tomography (PET) measurements of the regional cerebral metabolic rate for glucose (CMRgl). The AD Neuroimaging Initiative (ADNI) is acquiring FDG PET, volumetric magnetic resonance imaging, and other biomarker measurements in a large longitudinal multi-center study of initially mildly affected probable AD (pAD) patients, amnestic mild cognitive impairment (aMCI) patients, who are at increased AD risk, and cognitively normal controls (NC), and we are responsible for analyzing the PET images using statistical parametric mapping (SPM). Here we compare baseline CMRgl measurements from 74 pAD patients and 142 aMCI patients to those from 82 NC, we correlate CMRgl with categorical and continuous measures of clinical disease severity, and we compare apolipoprotein E (APOE) varepsilon4 carriers to non-carriers in each of these subject groups. In comparison with NC, the pAD and aMCI groups each had significantly lower CMRgl bilaterally in posterior cingulate, precuneus, parietotemporal and frontal cortex. Similar reductions were observed when categories of disease severity or lower Mini-Mental State Exam (MMSE) scores were correlated with lower CMRgl. However, when analyses were restricted to the pAD patients, lower MMSE scores were significantly correlated with lower left frontal and temporal CMRgl. These findings from a large, multi-site study support previous single-site findings, supports the characteristic pattern of baseline CMRgl reductions in AD and aMCI patients, as well as preferential anterior CMRgl reductions after the onset of AD dementia.

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IC‐P1‐036: Categorical and correlational analyses of baseline fluorodeoxyglucose positron emission tomography images from the Alzheimer's disease neuroimaging initiative
Lee, W., Langbaum, J. B. S., Chen, K., Recshke, C., Bandy, D. J., Alexander, G. E., Foster, N. L., Weiner, M. W., Koeppe, R. A., Jagust, W., et al. (2008) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2008.05.047
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P2‐037: Categorical and correlational analyses of baseline fluorodeoxyglucose positron emission tomography images from the Alzheimer's disease neuroimaging initiative
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P‐024: The pattern and severity of FDG pet abnormalities in Alzheimer's disease and amnestic mild cognitive impairment: Preliminary findings from the Alzheimer's disease neuroimaging initiative
Chen, K., Reiman, E. M., Alexander, G. E., Smilovici, O., Lee, W., Reschke, C., Bandy, D., Foster, N., Weiner, M. W., Koeppe, R. A., et al. (2007) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2007.04.240 · Cited by 1
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Twelve-month metabolic declines in probable Alzheimer's disease and amnestic mild cognitive impairment assessed using an empirically pre-defined statistical region-of-interest: Findings from the Alzheimer's Disease Neuroimaging Initiative
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O1–04–05: Six‐month cerebral metabolic declines in Alzheimer's disease, amnestic mild cognitive impairment and elderly normal control groups: Preliminary findings from the Alzheimer's disease neuroimaging initiative
Chen, K., Reiman, E. M., Alexander, G. E., Lee, W., Reschke, C., Smilovici, O., Bandy, D., Weiner, M. W., Koeppe, R. A., & Jagust, W. J. (2007) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2007.04.081
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Authors: Langbaum, J. B. S., Chen, K., Lee, W., Reschke, C., Bandy, D., Fleisher, A. S., Alexander, G. E., Foster, N. L., Weiner, M. W., Koeppe, R. A., Jagust, W. J., & Reiman, E. M.
Affiliations: Banner Alzheimer’s Institute (US)
University of Arizona (US)
University of California San Diego (US)
University of Utah (US)
San Francisco VA Medical Center (US)
University of Michigan (US)
University of California, Berkeley (US)
Translational Genomics Research Institute (US)
Corresponding author: Reiman, Eric M.
ORCID: Langbaum, Jessica B.S.
Chen, Kewei
Lee, Wendy
Fleisher, Adam S.
Alexander, Gene E.
Foster, Norman L.
Weiner, Michael W.
Koeppe, Robert A.
Jagust, William J.
Reiman, Eric M.
Venue: NeuroImage
Publisher: Elsevier BV
Published: 2009-05
Volume: 45
Issue: 4
Pages: 1107-1116
ISSN: 1053-8119 (ISSN-L)
DOI: 10.1016/j.neuroimage.2008.12.072
PMC: PMC2886795
OpenAlex: W2016228161
Cited by: 279
References: 59
Citations by year: 2026: 5 · 2025: 8 · 2024: 10 · 2023: 6 · 2022: 8 · 2021: 9 · 2020: 8 · 2019: 11 · 2018: 26 · 2017: 14 · 2016: 21 · 2015: 15 · 2014: 22 · 2013: 26 · 2012: 24
FWCI: 18.55
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: NeuroImage (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (5u01ag024904-10)
National Institute on Aging (U01-AG-024904, P30AG019610, U19AG010483)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
Keywords: Alzheimer's disease, amnestic mild cognitive impairment, FDG-PET, regional cerebral glucose metabolism, posterior cingulate cortex, precuneus, frontal and temporal cortex, disease severity, Mini-Mental State Examination, APOE ε4, ADNI
MeSH terms: Aged, Alzheimer Disease, Cerebral Cortex, Cognition Disorders, Female, Humans, Male, Middle Aged, Reference Values, Sensitivity and Specificity, Statistics as Topic, Reproducibility of Results, Radiopharmaceuticals, Fluorodeoxyglucose F18, Positron-Emission Tomography

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Categorical and correlational analyses of baseline fluorodeoxyglucose positron emission tomography images from the Alzheimer’s Disease Neuroimaging Initiative (ADNI)

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