Cited by 162Neural and Behavioral Psychology StudiesTreatment of Major DepressionNeurotransmitter Receptor Influence on Behavior

Neural response to pleasant stimuli in anhedonia: an fMRI study

Mitterschiffthaler, Martina T., Kumari, Veena, Malhi, Gin S., Brown, Richard G., Giampietro, Vincent P., Brammer, Michael J., Suckling, John, Poon, Lucia +3 more·2003·NeuroReport

Abstract

The aim of this study was to investigate the neural correlates of affect processing in depressed anhedonic patients and healthy controls. Whole brain functional magnetic resonance imaging scans were obtained from seven females with a diagnosis of chronic unipolar major depression and high levels of anhedonia, and seven healthy females, while they were presented with positive valence and neutral images. Patients, compared to controls, showed decreased activation in medial frontal cortex, and increased activation in inferior frontal cortex, anterior cingulate, thalamus, putamen and insula. Reduced activation in medial frontal cortex may underlie abnormal positive affect processing in patients. Increases in neural activation in putamen and thalamus, previously found in transient sadness, and anterior cingulate could point to an involvement of these structures in anhedonia.

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Crossref · 10.1097/00001756-200302100-00003

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27 of 27 references verified0 citation errors · 0 not checkable

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  • Functional neuroimaging studies in MDD consistently indicate hypoactivation in reward-processing regions, including the dorsal and ventral striatum, medial prefrontal cortex, pregenual and subgenual anterior cingulate, and medial frontal gyrus.

    “Functional neuroimaging studies in MDD have consistently indicated hypoactivation in reward-processing regions, including the dorsal and ventral striatum [210-214] and a host of other reward structures, including the medial prefrontal cortex [215,216], the pregenual and subgenual anterior cingulate, and the medial frontal gyrus [217,218].”

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Authors
Mitterschiffthaler, M. T., Kumari, V., Malhi, G. S., Brown, R. G., Giampietro, V. P., Brammer, M. J., Suckling, J., Poon, L., Simmons, A., Andrew, C., & Sharma, T.
Affiliations
King's College London (GB)
Venue
NeuroReport
Published
2003-02
Volume
14
Issue
2
Pages
177-182
ISSN
0959-4965 (ISSN-L)
OpenAlex
W2081122328
Cited by
162
References
27
Citations by year
2026: 3 · 2025: 7 · 2024: 7 · 2023: 2 · 2022: 2 · 2021: 6 · 2020: 8 · 2019: 7 · 2018: 6 · 2017: 5 · 2016: 7 · 2015: 11 · 2014: 11 · 2013: 8 · 2012: 12
FWCI
3.10
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroreport (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
anhedonia, major depressive disorder, emotional processing, medial frontal cortex, inferior frontal cortex, anterior cingulate cortex, thalamus, putamen, insula, neural correlates
MeSH terms
Adult, Analysis of Variance, Brain, Major Depressive Disorder, Emotions, Female, Humans, Magnetic Resonance Imaging, Middle Aged, Photic Stimulation, Sensory Thresholds

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