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Cited by 190

The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.

Functional connectivity and alterations in baseline brain state in humans

Open access
Martuzzi, Roberto, Ramani, Ramachandran, Qiu, Maolin, Rajeevan, Nallakkandi, Constable, R. Todd·2010·NeuroImage

Abstract

This work examines the influence of changes in baseline activity on the intrinsic functional connectivity fMRI (fc-fMRI) in humans. Baseline brain activity was altered by inducing anesthesia (sevoflurane end-tidal concentration 1%) in human volunteers and fc-fMRI maps between the pre-anesthetized and anesthetized conditions were compared across different brain networks. We particularly focused on low-level sensory areas (primary somatosensory, visual, auditory cortices), the thalamus, and pain (insula), memory (hippocampus) circuits, and the default mode network (DMN), the latter three to examine higher order brain regions. The results indicate that, while fc-fMRI patterns did not significantly differ (p<0.005; 20-voxel cluster threshold) in sensory cortex and in the DMN between the pre- and anesthetized conditions, fc-fMRI in high-order cognitive regions (i.e. memory and pain circuits) was significantly altered by anesthesia. These findings provide further evidence that fc-fMRI reflects intrinsic brain properties, while also demonstrating that 0.5 MAC sevoflurane anesthesia preferentially modulates higher-order connections.

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Crossref · 10.1016/j.neuroimage.2009.07.028

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Metadata

Authors
Martuzzi, R., Ramani, R., Qiu, M., Rajeevan, N., & Constable, R. T.
Venue
NeuroImage
Publisher
Elsevier BV
Published
2010-01
Volume
49
Issue
1
Pages
823-834
ISSN
1053-8119 (ISSN-L)
OpenAlex
W2137001923
Cited by
190
References
16
FWCI
8.22
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Functional connectivity and alterations in baseline brain state in humans. https://app.cochat.ai/papers/10.1016/j.neuroimage.2009.07.028
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Martuzzi, R., Ramani, R., Qiu, M., Rajeevan, N., & Constable, R. T. (2010). Functional connectivity and alterations in baseline brain state in humans. NeuroImage. https://doi.org/10.1016/j.neuroimage.2009.07.028

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.