Neural basis of global resting-state fMRI activity
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Functional MRI (fMRI) has uncovered widespread hemodynamic fluctuations in the brain during rest. Recent electroencephalographic work in humans and microelectrode recordings in anesthetized monkeys have shown this activity to be correlated with slow changes in neural activity. Here we report that the spontaneous fluctuations in the local field potential (LFP) measured from a single cortical site in monkeys at rest exhibit widespread, positive correlations with fMRI signals over nearly the entire cerebral cortex. This correlation was especially consistent in a band of upper gamma-range frequencies (40–80 Hz), for which the hemodynamic signal lagged the neural signal by 6–8 s. A strong, positive correlation was also observed in a band of lower frequencies (2–15 Hz), albeit with a lag closer to zero. The global pattern of correlation with spontaneous fMRI fluctuations was similar whether the LFP signal was measured in occipital, parietal, or frontal electrodes. This coupling was, however, dependent on the monkey's behavioral state, being stronger and anticipatory when the animals’ eyes were closed. These results indicate that the often discarded global component of fMRI fluctuations measured during the resting state is tightly coupled with underlying neural activity.
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Such improvements likely reflect the reduction in shared variance amongst regions due to noise and a true global signal.
“Such improvements, also consistent with other reports (Fox et al., 2009, Keller et al., 2013), likely reflect the reduction in shared variance amongst regions due to noise and a true global signal (Scholvinck et al., 2010) – an important consideration for the current report.”
From Characterizing heterogeneity in children with and without ADHD based on reward system connectivity (2015) · cites this paper as Scholvinck et al., 2010
Without sensory input, spontaneous BOLD fluctuations still correlate with underlying synaptic activity measured by LFP, ECoG, and EEG.
“In the absence of any sensory input, spontaneous BOLD fluctuations are still correlated with underlying synaptic activity observed with LFP (136, 137), ECoG (138), and EEG (139, 140).”
From Electrophysiological source imaging: A noninvasive window to brain dynamics (2018) · cites this paper as [137]
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- Authors
- Schölvinck, M. L., Maier, A., Ye, F. Q., Duyn, J. H., & Leopold, D. A.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Leopold, David A.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2010-05-03
- Volume
- 107
- Issue
- 22
- Pages
- 10238-10243
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2890438
- OpenAlex
- W1987777969
- Cited by
- 939
- References
- 58
- Citations by year
- 2026: 28 · 2025: 43 · 2024: 57 · 2023: 43 · 2022: 56 · 2021: 68 · 2020: 65 · 2019: 62 · 2018: 77 · 2017: 70 · 2016: 71 · 2015: 76 · 2014: 61 · 2013: 73 · 2012: 45
- FWCI
- 30.84
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Trust
- National Institute of Mental Health
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- resting-state fMRI, local field potentials, hemodynamic fluctuations, neuronal activity, global signal, gamma oscillations, cortical synchronization, behavioral state, eyes closed, monkey cortex
- MeSH terms
- Animals, Cerebral Cortex, Female, Humans, Macaca mulatta, Magnetic Resonance Imaging, Rest, Signal Processing, Computer-Assisted, Echo-Planar Imaging, Electrophysiological Phenomena
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