Attention strongly increases oxygen metabolic response to stimulus in primary visual cortex
Open accessAbstract
Top-down attention enhances neural processing, but its effect on metabolic activity in primary visual cortex (V1) is unclear. Combined blood flow and oxygenation measurements provide the best tool for investigating modulations of oxidative metabolism. We measured the human V1 response to a peripheral low contrast stimulus using fMRI and found a larger fractional modulation of blood flow with attention compared to the blood oxygenation level dependent (BOLD) response, thus indicating a much larger modulation of oxygen metabolism than was previously thought. These findings point to different aspects of neural activity driving flow and metabolic changes to different degrees. We propose that V1 flow is driven strongly but not exclusively by the initial sensory-driven neural activity, which dominates the response in the unattended condition, while V1 oxygen metabolism is driven strongly by the overall neural activity, which is modulated by top-down signals related to attention.
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The metabolic response seems capable of differentiating neural states that are intrinsically distinct, although they induce the same BOLD response.
“In more general terms, the metabolic response seems capable of differentiating neural states that are intrinsically distinct, although they induce the same BOLD response (Moradi et al., 2012).”
From Perception is associated with the brain’s metabolic response to sensory stimulation (2022) · cites this paper as Moradi et al., 2012
The Discussion says BOLD magnitude cannot be read as a simple measure of neural activity, while combined blood-flow and BOLD measurements can separate changes in flow and oxygen metabolism. The Results show a much larger metabolic response with attention, supporting the idea that metabolism provides information BOLD alone does not. But the measured BOLD responses were different—not the same—in the attended and unattended conditions, so the paper does not demonstrate that specific scenario. (LLM, conf=0.85)
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- Authors
- Moradi, F., Buračas, G. T., & Buxton, R. B.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Moradi, Farshad
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 59
- Issue
- 1
- Pages
- 601-607
- ISSN
- 1053-8119 (ISSN-L)
- PMC
- PMC3195991
- OpenAlex
- W2033400934
- Cited by
- 42
- References
- 48
- Citations by year
- 2023: 2 · 2022: 2 · 2021: 1 · 2020: 1 · 2018: 1 · 2017: 4 · 2016: 3 · 2015: 6 · 2014: 9 · 2013: 6 · 2012: 5
- FWCI
- 3.41
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (T32-EB005970, -36722)
- UCSD Center for Functional MRI
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- top-down attention, primary visual cortex, oxygen metabolism, cerebral blood flow, BOLD signal, peripheral visual field
- MeSH terms
- Adult, Attention, Brain Mapping, Cerebrovascular Circulation, Female, Humans, Magnetic Resonance Imaging, Male, Oxygen, Spin Labels, Visual Cortex, Young Adult
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