Acetylcholine contributes through muscarinic receptors to attentional modulation in V1
Open accessAbstract
Attention exerts a strong influence over neuronal processing in cortical areas. It selectively increases firing rates and affects tuning properties, including changing receptive field locations and sizes. Although these effects are well studied, their cellular mechanisms are poorly understood. To study the cellular mechanisms, we combined iontophoretic pharmacological analysis of cholinergic receptors with single cell recordings in V1 while rhesus macaque monkeys (Macaca mulatta) performed a task that demanded top-down spatial attention. Attending to the receptive field of the V1 neuron under study caused an increase in firing rates. Here we show that this attentional modulation was enhanced by low doses of acetylcholine. Furthermore, applying the muscarinic antagonist scopolamine reduced attentional modulation, whereas the nicotinic antagonist mecamylamine had no systematic effect. These results demonstrate that muscarinic cholinergic mechanisms play a central part in mediating the effects of attention in V1.
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In primates, locally applied ACh enhances the attentional modulation of neuronal activity in the primary visual cortex.
“In primates, locally applied ACh enhances the attentional modulation of neuronal activity in the primary visual cortex, while the muscarinic antagonist scopolamine reduces the effects of attention (Herrero et al., 2008).”
From Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior (2012) · cites this paper as Herrero et al., 2008
In primates, the muscarinic antagonist scopolamine reduces the effects of attention.
“while the muscarinic antagonist scopolamine reduces the effects of attention (Herrero et al., 2008).”
From Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior (2012) · cites this paper as Herrero et al., 2008
In the primary visual cortex, blockade of muscarinic but not nicotinic AChRs impairs the attentional modulation of V1 neurons.
“Herrero et al. demonstrated that in the primary visual cortex, blockade of muscarinic but not nicotinic AChRs impaired the attentional modulation of V1 neurons (Herrero et al, 2008; see also Deco and Thiele, 2009).”
From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Herrero et al, 2008
Activation of muscarinic ACh receptors, but not nicotinic ACh receptors, may in part mediate attentional modulation of neural response gain in non-human-primate cortex.
“Other work in non-human-primate cortex suggests that activation of muscarinic ACh receptors (mAChRs), but not nAChRs, may in part mediate the attentional modulation of neural response gain174.”
From Mechanisms underlying gain modulation in the cortex (2020) · cites this paper as [174]
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- Authors
- Herrero, J. L., Roberts, M. J., Delicato, L. S., Gieselmann, M. A., Dayan, P., & Thiele, A.
- Affiliations
- Newcastle University (GB)
- Gatsby Computational Neuroscience Unit (GB)
- Corresponding author
- Thiele, A.
- Venue
- Nature
- Published
- 2008-07-16
- Volume
- 454
- Issue
- 7208
- Pages
- 1110-1114
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC2666819
- OpenAlex
- W2162056177
- Cited by
- 459
- References
- 30
- Citations by year
- 2026: 14 · 2025: 23 · 2024: 26 · 2023: 20 · 2022: 18 · 2021: 34 · 2020: 24 · 2019: 20 · 2018: 30 · 2017: 34 · 2016: 20 · 2015: 28 · 2014: 29 · 2013: 33 · 2012: 30
- FWCI
- 12.92
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Sunderland Repository (University of Sunderland) (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- Wellcome Trust (070380)
- Biotechnology and Biological Sciences Research Council (BB/F021399/1, BBS/B/09325)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Keywords
- acetylcholine, muscarinic receptors, nicotinic acetylcholine receptors, primary visual cortex, attentional modulation, cholinergic modulation, scopolamine, mecamylamine, rhesus monkeys, neuronal firing rate
- MeSH terms
- Acetylcholine, Animals, Attention, Macaca mulatta, Magnetic Resonance Imaging, Male, Mecamylamine, Receptors, Cholinergic, Receptors, Muscarinic, Scopolamine, Cholinergic Antagonists, Muscarinic Antagonists, Nicotinic Antagonists
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