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Investigating white matter development in infancy and early childhood using myelin water faction and relaxation time mapping
Open accessAbstract
The elaboration of the myelinated white matter is essential for normal neurodevelopment, establishing and mediating rapid communication pathways throughout the brain. These pathways facilitate the synchronized communication required for higher order behavioral and cognitive functioning. Altered neural messaging (or 'disconnectivity') arising from abnormal white matter and myelin development may underlie a number of neurodevelopmental psychiatric disorders. Despite the vital role myelin plays, few imaging studies have specifically examined its maturation throughout early infancy and childhood. Thus, direct investigations of the relationship(s) between evolving behavioral and cognitive functions and the myelination of the supporting neural systems have been sparse. Further, without knowledge of the 'normative' developmental time-course, identification of early abnormalities associated with developmental disorders remains challenging. In this work, we examined the use of longitudinal (T(1)) and transverse (T(2)) relaxation time mapping, and myelin water fraction (MWF) imaging to investigate white matter and myelin development in 153 healthy male and female children, 3 months through 60 months in age. Optimized age-specific acquisition protocols were developed using the DESPOT and mcDESPOT imaging techniques; and mean T(1), T(2) and MWF trajectories were determined for frontal, temporal, occipital, parietal and cerebellar white matter, and genu, body and splenium of the corpus callosum. MWF results provided a spatio-temporal pattern in-line with prior histological studies of myelination. Comparison of T(1), T(2) and MWF measurements demonstrates dissimilar sensitivity to tissue changes associated with neurodevelopment, with each providing differential but complementary information.
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“Males also show increased global gyrification at 2 years of age compared with females (adjusting for total brain volume)”
From Imaging structural and functional brain development in early childhood (2018) · cites this paper as [127]
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“local or regional gyrification index is similar between males and females at each age127.”
From Imaging structural and functional brain development in early childhood (2018) · cites this paper as [127]
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“but not at 0 or 1 year of age”
From Imaging structural and functional brain development in early childhood (2018) · cites this paper as [127]
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“this strategy of template creation mirrors our prior work that has been shown to successfully create structural and quantitative MRI templates of the pediatric brain (Deoni et al., 2012, Dean et al., 2014).”
From Quantifying cortical development in typically developing toddlers and young children, 1–6 years of age (2017) · cites this paper as Deoni et al., 2012
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Imaging structural and functional brain development in early childhood
Gilmore, J. H., Knickmeyer, R. C., & Gao, W. (2018) · Nature Reviews Neuroscience · doi:10.1038/nrn.2018.1 · Cited by 1,013
Dubois, J., Dehaene-Lambertz, G., Kulikova, S., Poupon, C., Hüppi, P. S., & Hertz-Pannier, L. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2013.12.044 · Cited by 851
Biological embedding of childhood adversity: from physiological mechanisms to clinical implications
Berens, A. E., Jensen, S. K. G., & Nelson, C. A. (2017) · BMC Medicine · doi:10.1186/s12916-017-0895-4 · Cited by 657
“Dramatic growth in gray and white matter occurs in the first 2 years of life, when the brain attains 80–90% of its adult volume before continuing to grow at an attenuated rate [22, 23].”
BackgroundAn open resource for transdiagnostic research in pediatric mental health and learning disorders
Alexander, L. M., Escalera, J., Ai, L., Andreotti, C., Febre, K., Mangone, A., Potler, N. V., Langer, N., Alexander, A., Kovacs, M., et al. (2017) · Scientific Data · doi:10.1038/sdata.2017.181 · Cited by 681
The development of brain white matter microstructure
Lebel, C., & Deoni, S. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2017.12.097 · Cited by 602
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Metadata
- Authors
- Deoni, S. C. L., Dean, D. C., O'Muircheartaigh, J., Dirks, H., & Jerskey, B. A.
- Affiliations
- Brown University (US)
- Corresponding author
- Deoni, Sean C.L.
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2012-11
- Volume
- 63
- Issue
- 3
- Pages
- 1038-1053
- ISSN
- 1053-8119 (ISSN-L)
- PMC
- PMC3711836
- OpenAlex
- W2131940336
- Cited by
- 390
- References
- 86
- Citations by year
- 2026: 18 · 2025: 28 · 2024: 25 · 2023: 32 · 2022: 27 · 2021: 36 · 2020: 64 · 2019: 32 · 2018: 27 · 2017: 27 · 2016: 25 · 2015: 21 · 2014: 14 · 2013: 12 · 2012: 2
- FWCI
- 11.84
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- NeuroImage (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- National Institutes of Mental Health (R01 MH087510)
- Sir Henry Wellcome Postdoctoral Fellowship (No 096195)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Physical Sciences › Chemistry › Spectroscopy › NMR spectroscopy and applications
- Keywords
- white matter development, myelination, myelin water fraction, T1 relaxation time, T2 relaxation time, corpus callosum, brain development, infancy, early childhood, despots, cerebellum
- MeSH terms
- Brain, Brain Mapping, Child, Preschool, Female, Humans, Infant, Male, Myelin Sheath, Neurogenesis
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