Cited by 211Functional Brain Connectivity StudiesAdvanced MRI Techniques and ApplicationsAdvanced Neuroimaging Techniques and Applications

The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.

Posteromedial cortex glutamate and GABA predict intrinsic functional connectivity of the default mode network

Open access

Kapogiannis, Dimitrios, Reiter, David A., Willette, Auriel A., Mattson, Mark P.·2013·NeuroImage

DOI 10.1016/j.neuroimage.2012.09.029PMC PMC3801193

Open this paper in CoChat — free account

Abstract

The balance between excitatory glutamatergic projection neurons and inhibitory GABAergic interneurons determines the function of cortical microcircuits. How these neurotransmitters relate to the functional status of an entire macro-scale network remains unknown. The posteromedial cortex (PMC) is the default mode network (DMN) node with the greatest functional connectivity; therefore, we hypothesized that PMC glutamate and GABA predict intrinsic functional connectivity (iFC) across the entire DMN. In 20 healthy men, we combined J-resolved magnetic resonance spectroscopy to measure glutamate and GABA in the PMC and resting fMRI followed by group Independent Components Analysis to extract the entire DMN. We showed that, controlling for age and partial GM volume in the MRS voxel, PMC glutamate and GABA explained about half of the variance of DMN iFC (represented by the network's beta coefficient for rest). Glutamate correlated positively and GABA correlated negatively with DMN iFC; in an alternative statistical model which included the glutamate/GABA ratio, the ratio correlated positively with DMN iFC. Age had no independent association with DMN iFC. No other network was associated with PMC glutamate or GABA. We conclude that regional neurotransmitter concentrations in a network node strongly predict network but not global brain iFC.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.neuroimage.2012.09.029

Cites

67 of 67 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Complex brain networks: graph theoretical analysis of structural and functional systems
Bullmore, E., & Sporns, O. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2575 · Cited by 11,820
The Brain's Default Network: Anatomy, Function, and Relevance to Disease
Buckner, R. L., Andrews‐Hanna, J. R., & Schacter, D. L. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1440.011 · Cited by 9,761
A fast diffeomorphic image registration algorithm
Ashburner, J. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.07.007 · Cited by 8,122
A theory of cortical responses.
Friston, K. (2005) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2005.1622 · Cited by 4,578
Mapping the structural core of human cerebral cortex
Hagmann, P., Cammoun, L., Gigandet, X., Meuli, R., Honey, C. J., Wedeen, V. J., & Sporns, O. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060159 · Cited by 4,173
Estimation of metabolite concentrations from localized in vivo proton NMR spectra
Provencher, S. W. (1993) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910300604 · Cited by 3,659
What we can do and what we cannot do with fMRI
Logothetis, N. K. (2008) · Nature · doi:10.1038/nature06976 · Cited by 3,612
Cortical Hubs Revealed by Intrinsic Functional Connectivity: Mapping, Assessment of Stability, and Relation to Alzheimer's Disease
Buckner, R. L., Sepulcre, J., Talukdar, T., Krienen, F. M., Liu, H., Hedden, T., Andrews-Hanna, J. R., Sperling, R. A., & Johnson, K. A. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5062-08.2009 · Cited by 2,862
Region of interest analysis using an SPM toolbox
Brett, M. (2002) · NeuroImage · Cited by 2,273
Resting-State Functional Connectivity Reflects Structural Connectivity in the Default Mode Network
Greicius, M. D., Supekar, K., Menon, V., & Dougherty, R. F. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhn059 · Cited by 2,175

Show all 67 references

Sorted by citations

Glutamate and Gamma-Aminobutyric Acid Systems in the Pathophysiology of Major Depression and Antidepressant Response to Ketamine
Lener, M. S., Niciu, M. J., Ballard, E. D., Park, M., Park, L. T., Nugent, A. C., & Zarate, C. A. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.05.005 · Cited by 468
Brain default-mode network dysfunction in addiction
Zhang, R., & Volkow, N. D. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.06.036 · Cited by 386
Somatostatin-Positive Gamma-Aminobutyric Acid Interneuron Deficits in Depression: Cortical Microcircuit and Therapeutic Perspectives
Fee, C., Banasr, M., & Sibille, E. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.05.024 · Cited by 329
Ketamine has distinct electrophysiological and behavioral effects in depressed and healthy subjects
Nugent, A. C., Ballard, E. D., Gould, T. D., Park, L. T., Moaddel, R., Brutsche, N. E., & Zarate, C. A. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0028-2 · Cited by 250
Modulation of GABA and resting state functional connectivity by transcranial direct current stimulation
Bachtiar, V., Near, J., Johansen‐Berg, H., & Stagg, C. J. (2015) · eLife · doi:10.7554/elife.08789 · Cited by 261
Multivariate analysis reveals genetic associations of the resting default mode network in psychotic bipolar disorder and schizophrenia
Meda, S. A., Ruaño, G., Windemuth, A., O’Neil, K., Berwise, C., Dunn, S. M., Boccaccio, L. E., Narayanan, B., Kocherla, M., Sprooten, E., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1313093111 · Cited by 242
Associations of regional GABA and glutamate with intrinsic and extrinsic neural activity in humans—A review of multimodal imaging studies
Duncan, N. W., Wiebking, C., & Northoff, G. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.07.016 · Cited by 230
Insulin Resistance as a Link between Amyloid-Beta and Tau Pathologies in Alzheimer’s Disease
Mullins, R. J., Diehl, T. C., Chia, C. W., & Kapogiannis, D. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00118 · Cited by 227
Self-citation
Local GABA concentration is related to network-level resting functional connectivity
Stagg, C. J., Bachtiar, V., Amadi, U., Gudberg, C., Ilie, A. S., Sampaio‐Baptista, C., O’Shea, J., Woolrich, M. W., Smith, S. M., Filippini, N., et al. (2014) · eLife · doi:10.7554/elife.01465 · Cited by 222
EEG hyper-connectivity in high-risk infants is associated with later autism
The BASIS Team, Orekhova, E. V., Elsabbagh, M., Jones, E. J., Dawson, G., Charman, T., & Johnson, M. H. (2014) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-6-40 · Cited by 210
Functional Connectivity Is Associated With Altered Brain Chemistry in Women With Endometriosis-Associated Chronic Pelvic Pain
As-Sanie, S., Kim, J., Schmidt-Wilcke, T., Sundgren, P. C., Clauw, D. J., Napadow, V., & Harris, R. E. (2016) · The Journal of Pain · doi:10.1016/j.jpain.2015.09.008 · Cited by 199
GABAergic dysfunction, neural network hyperactivity and memory impairments in human aging and Alzheimer’s disease
Jiménez-Baladó, J., & Eich, T. S. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.01.005 · Cited by 194
Big GABA: Edited MR spectroscopy at 24 research sites
Mikkelsen, M. E., Barker, P. B., Bhattacharyya, P. K., Brix, M. K., Buur, P. F., Cecil, K. M., Chan, K. L., Chen, D. Y. T., Craven, A. R., Cuypers, K., et al. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.07.021 · Cited by 184
Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer’s disease
Najm, R., Jones, E. A., & Huang, Y. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0324-6 · Cited by 183
Resting-State Glutamate and GABA Concentrations Predict Task-Induced Deactivation in the Default Mode Network
Hu, Y., Chen, X., Gu, H., & Yang, Y. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1973-13.2013 · Cited by 167
Neuroimaging of Parkinson's disease: Expanding views
Weingarten, C. P., Sundman, M. H., Hickey, P., & Chen, N. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.09.007 · Cited by 164
Neural Noise Hypothesis of Developmental Dyslexia
Hancock, R., Pugh, K. R., & Hoeft, F. (2017) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2017.03.008 · Cited by 176
Sensorimotor network segregation declines with age and is linked to GABA and to sensorimotor performance
Cassady, K. E., Gagnon, H. C., Lalwani, P., Simmonite, M., Foerster, B. R., Park, D. C., Peltier, S., Petrou, M., Taylor, S. F., Weissman, D. H., et al. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.11.008 · Cited by 156
Why are cortical GABA neurons relevant to internal focus in depression? A cross-level model linking cellular, biochemical and neural network findings
Northoff, G., & Sibille, E. L. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.68 · Cited by 148
tDCS-Induced Modulation of GABA Levels and Resting-State Functional Connectivity in Older Adults
Antonenko, D., Schubert, F., Bohm, F., Ittermann, B., Aydın, S., Hayek, D., Grittner, U., & Flöel, A. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.0079-17.2017 · Cited by 151
Changing Brain Networks Through Non-invasive Neuromodulation
To, W. T., De Ridder, D., Hart Jr., J., & Vanneste, S. (2018) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2018.00128 · Cited by 135
“…are increased by tDCS (Clark et al., 2011) and that there is a strong relationship between Glx and functional connectivity (Horn et al., 2010; Kapogiannis et al., 2013), Frontiers in Human Neuroscience | www.frontiersin.org 5 April 2018 | Volume 12 | Article 128 studies have been…”
Background
Baseline effects of transcranial direct current stimulation on glutamatergic neurotransmission and large-scale network connectivity
Hunter, M. A., Coffman, B. A., Gasparovic, C., Calhoun, V. D., Trumbo, M., & Clark, V. P. (2014) · Brain Research · doi:10.1016/j.brainres.2014.09.066 · Cited by 140
The Influence of the Amplitude of Low-Frequency Fluctuations on Resting-State Functional Connectivity
Di, X., Kim, E. H., Huang, C., Tsai, S., Lin, C., & Biswal, B. B. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00118 · Cited by 119
Changes in functional connectivity and GABA levels with long-term motor learning
Sampaio‐Baptista, C., Filippini, N., Stagg, C. J., Near, J., Scholz, J., & Johansen‐Berg, H. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.11.032 · Cited by 119
Magnetic resonance spectroscopy reveals abnormalities of glucose metabolism in the Alzheimer's brain
Mullins, R. J., Reiter, D. A., & Kapogiannis, D. (2018) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.530 · Cited by 98
Self-citation
Resting-state functional connectivity, cortical GABA, and neuroactive steroids in peripartum and peripartum depressed women: a functional magnetic resonance imaging and spectroscopy study.
Deligiannidis, K. M., Fales, C. L., Kroll-Desrosiers, A. R., Shaffer, S. A., Villamarin, V., Tan, Y., Hall, J. E., Frederick, B. B., Sikoglu, E. M., Edden, R. A., et al. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-018-0242-2 · Cited by 92
What has functional connectivity and chemical neuroimaging in fibromyalgia taught us about the mechanisms and management of `centralized' pain?
Napadow, V., & Harris, R. E. (2014) · Arthritis Research & Therapy · doi:10.1186/s13075-014-0425-0 · Cited by 92
Multiscale Neuroscience of Psychiatric Disorders
van den Heuvel, M. P., Scholtens, L. H., & Kahn, R. S. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.05.015 · Cited by 79
The role of inhibition in human motor cortical plasticity
Bachtiar, V., & Stagg, C. J. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.07.059 · Cited by 79
Regional balance between glutamate+glutamine and GABA+ in the resting human brain
Steel, A., Mikkelsen, M. E., Edden, R. A. E., & Robertson, C. E. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.117112 · Cited by 70
Regional GABA Concentrations Modulate Inter-network Resting-state Functional Connectivity
Chen, X., Fan, X., Hu, Y., Zuo, C., Whitfield-Gabrieli, S., Holt, D., Gong, Q., Yang, Y., Pizzagalli, D. A., Du, F., et al. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhy059 · Cited by 62
GABA, Resting-State Connectivity and the Developing Brain
Kwon, S. H., Scheinost, D., Lacadie, C., Benjamin, J. R., Myers, E. H., Qiu, M., Schneider, K. C., Rothman, D. L., Constable, R. T., & Ment, L. R. (2014) · Neonatology · doi:10.1159/000362433 · Cited by 62
Learning to optimize perceptual decisions through suppressive interactions in the human brain
Frangou, P., Emir, U. E., Karlaftis, V. M., Nettekoven, C., Hinson, E. L., Larcombe, S. J., Bridge, H., Stagg, C. J., & Kourtzi, Z. (2019) · Nature Communications · doi:10.1038/s41467-019-08313-y · Cited by 63
Impact of glutamate levels on neuronal response and cognitive abilities in schizophrenia
Falkenberg, L. E., Westerhausen, R., Craven, A. R., Johnsen, E., Kroken, R. A., L⊘berg, E.-M., Specht, K., & Hugdahl, K. (2014) · NeuroImage Clinical · doi:10.1016/j.nicl.2014.03.014 · Cited by 59
Cortical functional hyperconnectivity in a mouse model of depression and selective network effects of ketamine
McGirr, A., LeDue, J. M., Chan, A. W., Xie, Y., & Murphy, T. H. (2017) · Brain · doi:10.1093/brain/awx142 · Cited by 60
Regional excitation-inhibition balance predicts default-mode network deactivation via functional connectivity
Gu, H., Hu, Y., Chen, X., Yong He, A., & Yang, Y. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.10.055 · Cited by 59
Subcortical Glutamate Mediates the Reduction of Short-Range Functional Connectivity with Age in a Developmental Cohort
Ghisleni, C., Bollmann, S., Poil, S., Brandeis, D., Martin, E., Michels, L., Tuura, R., & Klaver, P. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4375-14.2015 · Cited by 56
Upregulation of cortical GABAA receptor concentration in fibromyalgia
Pomares, F. B., Roy, S., Funck, T., Feier, N. A., Thiel, A., Fitzcharles, M., & Schweinhardt, P. (2019) · Pain · doi:10.1097/j.pain.0000000000001707 · Cited by 55
The impact of a lack of mathematical education on brain development and future attainment
Zacharopoulos, G., Sella, F., & Kadosh, R. C. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2013155118 · Cited by 68
Anterior Cingulate Glutamate and GABA Associations on Functional Connectivity in Schizophrenia
Shukla, D. K., Wijtenburg, S. A., Chen, H., Chiappelli, J., Kochunov, P., Hong, L. E., & Rowland, L. M. (2018) · Schizophrenia Bulletin · doi:10.1093/schbul/sby075 · Cited by 52
Hyper-connectivity of the thalamus during early stages following mild traumatic brain injury
Sours, C., George, E. O., Zhuo, J., Roys, S., & Gullapalli, R. P. (2015) · Brain Imaging and Behavior · doi:10.1007/s11682-015-9424-2 · Cited by 52
Hippocampal‐parietal dysconnectivity and glutamate abnormalities in unmedicated patients with schizophrenia
Kraguljac, N. V., White, D. M., Hadley, J. A., Reid, M. A., & Lahti, A. C. (2014) · Hippocampus · doi:10.1002/hipo.22332 · Cited by 54
Functional Connectivity of Insula, Basal Ganglia, and Prefrontal Executive Control Networks during Hypoglycemia in Type 1 Diabetes
Bolo, N. R., Musen, G., Simonson, D. C., Nickerson, L. D. H., Flores, V. L., Siracusa, T., Hager, B. M., Lyoo, I. K., Renshaw, P. F., & Jacobson, A. M. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0319-15.2015 · Cited by 53
Neurochemical Modulation in Posteromedial Default-mode Network Cortex Induced by Transcranial Magnetic Stimulation
Vidal-Piñeiro, D., Martín-Trias, P., Falcón, C., Bargalló, N., Clemente, I. C., Valls-Solé, J., Junqué, C., Pascual-Leone, A., & Bartrés-Faz, D. (2015) · Brain Stimulation · doi:10.1016/j.brs.2015.04.005 · Cited by 49
Prognostic classification of mild cognitive impairment and Alzheimer׳s disease: MRI independent component analysis
Willette, A. A., Calhoun, V. D., Egan, J. M., & Kapogiannis, D. (2014) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2014.08.005 · Cited by 52
Self-citation
Neuroimaging markers of glutamatergic and GABAergic systems in drug addiction: Relationships to resting-state functional connectivity
Moeller, S. J., London, E. D., & Northoff, G. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.11.010 · Cited by 50
Cingulate GABA levels inversely correlate with the intensity of ongoing chronic knee osteoarthritis pain
Reckziegel, D., Raschke, F., Cottam, W. J., & Auer, D. P. (2016) · Molecular Pain · doi:10.1177/1744806916650690 · Cited by 51
Neural correlate of resting-state functional connectivity under α2 adrenergic receptor agonist, medetomidine
Nasrallah, F. A., Lew, S. K., Low, A. S.-M., & Chuang, K. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.08.004 · Cited by 45
Multiscale dynamic mean field (MDMF) model relates resting-state brain dynamics with local cortical excitatory–inhibitory neurotransmitter homeostasis
Naskar, A., Vattikonda, A. N., Deco, G., Roy, D., & Banerjee, A. (2021) · Network Neuroscience · doi:10.1162/netn_a_00197 · Cited by 42
Increase in glutamate/glutamine concentration in the medial prefrontal cortex during mental imagery: A combined functional mrs and fMRI study: Glx Increases During Mental Imagery
Huang, Z., Davis Iv, H. H., Yue, Q., Wiebking, C., Duncan, N. W., Zhang, J., Wagner, N.-F., Wolff, A., & Northoff, G. (2015) · Human Brain Mapping · doi:10.1002/hbm.22841 · Cited by 43
A Glutamate Transporter EAAT1 Gene Variant Influences Amygdala Functional Connectivity in Bipolar Disorder
Poletti, S., Riberto, M., Vai, B., Ghiglino, D., Lorenzi, C., Vitali, A., Brioschi, S., Locatelli, C., Serretti, A., Colombo, C., et al. (2018) · Journal of Molecular Neuroscience · doi:10.1007/s12031-018-1138-7 · Cited by 43
Non-Invasive Brain Stimulation in Dementia: A Complex Network Story
Pini, L., Manenti, R., Cotelli, M., Pizzini, F. B., Frisoni, G. B., & Pievani, M. (2018) · Neurodegenerative Diseases · doi:10.1159/000495945 · Cited by 41
Anterior cingulate GABA and glutamate concentrations are associated with resting-state network connectivity
Levar, N., van Doesum, T., Denys, D. A. J. P., & van Wingen, G. A. (2019) · Scientific Reports · doi:10.1038/s41598-018-38078-1 · Cited by 41
Preliminary differences in resting state MEG functional connectivity pre- and post-ketamine in major depressive disorder
Nugent, A. C., Robinson, S. E., Coppola, R., & Zarate, C. A. (2016) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2016.06.006 · Cited by 42
GABA and glutamate levels correlate with MTR and clinical disability: Insights from multiple sclerosis
Nantes, J. C., Proulx, S., zhong, J., Holmes, S. A., Narayanan, S., Brown, R. A., Hoge, R. D., & Koski, L. M. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.01.033 · Cited by 43
Default Mode Network Maturation and Environmental Adversities During Childhood
Rebello, K., Moura, L. M., Pinaya, W. H. L., Rohde, L. A., & Sato, J. R. (2018) · Chronic Stress · doi:10.1177/2470547018808295 · Cited by 46
Multimodal analysis of cortical chemoarchitecture and macroscale fMRI resting‐state functional connectivity
van den Heuvel, M. P., Scholtens, L. H., Turk, E., Mantini, D., Vanduffel, W., & Barrett, L. F. (2016) · Human Brain Mapping · doi:10.1002/hbm.23229 · Cited by 40
Altered hippocampal GABA and glutamate levels and uncoupling from functional connectivity in multiple sclerosis
Gao, F., Yin, X., Edden, R. A. E., Evans, A. C., Xu, J., Cao, G., Li, H., Li, M., Zhao, B., Wang, J., et al. (2018) · Hippocampus · doi:10.1002/hipo.23001 · Cited by 42
Resting state functional connectivity of the hippocampus along the anterior–posterior axis and its association with glutamatergic metabolism
Wagner, G., Gussew, A., Köhler, S., de la Cruz, F., Smesny, S., Reichenbach, J. R., & Bär, K. (2016) · Cortex · doi:10.1016/j.cortex.2016.03.022 · Cited by 40
Empagliflozin Induced Ketosis, Upregulated IGF-1/Insulin Receptors and the Canonical Insulin Signaling Pathway in Neurons, and Decreased the Excitatory Neurotransmitter Glutamate in the Brain of Non-Diabetics
Avgerinos, K. I., Mullins, R. J., Vreones, M. P., Mustapić, M., Chen, Q., Melvin, D. L., Kapogiannis, D., & Egan, J. M. (2022) · Cells · doi:10.3390/cells11213372 · Cited by 41
Self-citation
GABA concentrations in the anterior temporal lobe predict human semantic processing
Jung, J., Williams, S. R., Nezhad, F. S., & Ralph, M. A. L. (2017) · Scientific Reports · doi:10.1038/s41598-017-15981-7 · Cited by 45
Interrelation of resting state functional connectivity, striatal GABA levels, and cognitive control processes
Haag, L. M., Quetscher, C., Dharmadhikari, S., Dydak, U., Schmidt‐Wilcke, T., & Beste, C. (2015) · Human Brain Mapping · doi:10.1002/hbm.22920 · Cited by 37
Resting state functional connectivity in the default mode network: Relationships between cannabis use, gender, and cognition in adolescents and young adults
Ritchay, M. M., Huggins, A. A., Wallace, A. L., Larson, C. L., & Lisdahl, K. M. (2021) · NeuroImage Clinical · doi:10.1016/j.nicl.2021.102664 · Cited by 36
GABA content within medial prefrontal cortex predicts the variability of fronto-limbic effective connectivity
Pizzi, S. D., Chiacchiaretta, P., Mantini, D., Bubbico, G., Edden, R. A. E., ONOFRJ, M. C., Ferretti, A., & Bonanni, L. (2017) · Brain Structure and Function · doi:10.1007/s00429-017-1399-x · Cited by 37
Functional disruption in prefrontal-striatal network in obsessive-compulsive disorder
Sha, Z., Versace, A., Edmiston, E. K., Fournier, J. C. J., Graur, S., Greenberg, T., Santos, J. P. L., Chase, H. W., Stiffler, R. S., Bonar, L. K., et al. (2020) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2020.111081 · Cited by 41
Modulation of striatal functional connectivity differences in adults with and without autism spectrum disorder in a single-dose randomized trial of cannabidivarin
Pretzsch, C. M., Floris, D. L., Voinescu, B., Elsahib, M., Méndez, M. A., Wichers, R., Ajram, L. A., Ivin, G., Heasman, M., Pretzsch, E., et al. (2021) · Molecular Autism · doi:10.1186/s13229-021-00454-6 · Cited by 35
On the relationship between GABA+ and glutamate across the brain
Rideaux, R., Ehrhardt, S. E., Wards, Y., Filmer, H. L., Jin, J., Deelchand, D. K., Marjańska, M., Mattingley, J. B., & Dux, P. E. (2022) · NeuroImage · doi:10.1016/j.neuroimage.2022.119273 · Cited by 38
Human brain functional MRS reveals interplay of metabolites implicated in neurotransmission and neuroenergetics
Koush, Y., Rothman, D. L., Behar, K. L., de Graaf, R. A., & Hyder, F. (2022) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x221076570 · Cited by 36
Intelligence and Brain Efficiency: Investigating the Association between Working Memory Performance, Glutamate, and GABA
Marsman, A., Mandl, R. C. W., Klomp, D. W. J., Cahn, W., Kahn, R. S., Luijten, P. R., & Pol, H. E. H. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00154 · Cited by 38
Inhibitory dysfunction and social processing difficulties in autism: A comprehensive narrative review
Parrella, N.-F., Hill, A. T., Dipnall, L. M., Loke, Y. J., Enticott, P. G., & Ford, T. C. (2023) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2023.11.014 · Cited by 33
Cortical iron disrupts functional connectivity networks supporting working memory performance in older adults
Zachariou, V., Bauer, C. E., Seago, E. R., Raslau, F. D., Powell, D. K., & Gold, B. T. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.117309 · Cited by 33
Atypical functional connectivity in resting-state networks of individuals with 22q11.2 deletion syndrome: associations with neurocognitive and psychiatric functioning
Mattiaccio, L. M., Coman, I. L., Schreiner, M. J., Antshel, K. M., Fremont, W. P., Bearden, C. E., & Kates, W. R. (2016) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-016-9135-z · Cited by 32
Investigating the Role of Glutamate and GABA in the Modulation of Transthalamic Activity: A Combined fMRI-fMRS Study
Just, N., & Sonnay, S. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00030 · Cited by 30
Measurement of GABA using J‐difference edited 1H‐MRS following modulation of synaptic GABA concentration with tiagabine
Myers, J. F., Evans, J., Kalk, N. J., Edden, R. A. E., & Lingford-Hughes, A. R. (2014) · Synapse · doi:10.1002/syn.21747 · Cited by 30
Multimodal Fingerprints of Resting State Networks as assessed by Simultaneous Trimodal MR-PET-EEG Imaging
Shah, N. J., Arrubla, J., Rajkumar, R., Farrher, E., Mauler, J., Kops, E. R., Tellmann, L., Scheins, J. J., Boers, F., Dammers, J., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-05484-w · Cited by 30
Intrinsic Connectivity Networks of Glutamate-Mediated Antidepressant Response: A Neuroimaging Review
Demchenko, I., Tassone, V. K., Kennedy, S. H., Dunlop, K., & Bhat, V. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.864902 · Cited by 29
“1H-MRS studies have demonstrated an association between altered metrics corresponding to glutamate levels and functional changes in the nodes of the DMN (108, 109, 112, 117), AN (118–123), RN (124, 125), CEN (126, 127), SN (98, 110, 116, 128), SMN (129), and CAN (130).”
Background
Predicting learning and achievement using GABA and glutamate concentrations in human development
Zacharopoulos, G., Sella, F., Kadosh, K. C., Hartwright, C. E., Emir, U. E., & Kadosh, R. C. (2021) · PLoS Biology · doi:10.1371/journal.pbio.3001325 · Cited by 31
Salience network glutamate and brain connectivity in medication-naïve first episode patients – A multimodal magnetic resonance spectroscopy and resting state functional connectivity MRI study
Maximo, J. O., Briend, F., Armstrong, W. P., Kraguljac, N. V., & Lahti, A. C. (2021) · NeuroImage Clinical · doi:10.1016/j.nicl.2021.102845 · Cited by 29
Modulatory Interactions of Resting-State Brain Functional Connectivity
Di, X., & Biswal, B. B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071163 · Cited by 29
P osterior dopamine D2/3 receptors and brain network functional connectivity
Nagano‐Saito, A., Lissemore, J. I., Gravel, P., Leyton, M., Carbonell, F., & Benkelfat, C. (2017) · Synapse · doi:10.1002/syn.21993 · Cited by 29
Cortical chemoarchitecture shapes macroscale effective functional connectivity patterns in macaque cerebral cortex
Turk, E., Scholtens, L. H., & van den Heuvel, M. P. (2016) · Human Brain Mapping · doi:10.1002/hbm.23141 · Cited by 27
Precision of metabolite‐selective MRS measurements of glutamate, GABA and glutathione: A review of human brain studies
Kanagasabai, K., Palaniyappan, L. K., & Théberge, J. (2023) · NMR in Biomedicine · doi:10.1002/nbm.5071 · Cited by 27
How Energy Supports Our Brain to Yield Consciousness: Insights From Neuroimaging Based on the Neuroenergetics Hypothesis
Chen, Y., & Zhang, J. (2021) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2021.648860 · Cited by 39
GABA Concentration in Posterior Cingulate Cortex Predicts Putamen Response during Resting State fMRI
Arrubla, J., Tse, D. H. Y., Amkreutz, C., Neuner, I., & Shah, N. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106609 · Cited by 27
Assessment of intra- and inter-regional interrelations between GABA+, Glx and BOLD during pain perception in the human brain – A combined 1H fMRS and fMRI study
Cleve, M., Gussew, A., Wagner, G., Bär, K., & Reichenbach, J. R. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.09.037 · Cited by 27
Cognitive function: holarchy or holacracy?
Bîrle, C., Slăvoacă, D., Balea, M., Popa, L. L., Mureșanu, I. A., Ștefănescu, E., Văcăraș, V., Dina, C., Strilciuc, Ș., Popescu, B. O., et al. (2020) · Neurological Sciences · doi:10.1007/s10072-020-04737-3 · Cited by 36
Dynamic Recovery: GABA Agonism Restores Neural Variability in Older, Poorer Performing Adults
Lalwani, P., Garrett, D. D., & Polk, T. A. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.0335-21.2021 · Cited by 22
Lower functional connectivity of default mode network in cognitively normal young adults with mutation of APP, presenilins and APOE ε4
Su, Y. Y., Zhang, X. D., Schoepf, U. J., Varga‐Szemes, Á., Stubenrauch, A. C., Liang, X., Zheng, L. J., Zheng, G., Kong, X., Xu, Q., et al. (2016) · Brain Imaging and Behavior · doi:10.1007/s11682-016-9556-z · Cited by 25
The pollutome-connectome axis: a putative mechanism to explain pollution effects on neurodegeneration
Pini, L., Salvalaggio, A., Wennberg, A. M. V., Dimakou, A., Matteoli, M., & Corbetta, M. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101867 · Cited by 26
Low episodic memory performance in cognitively normal elderly subjects is associated with increased posterior cingulate gray matter N-acetylaspartate: a 1H MRSI study at 7 Tesla
Schreiner, S. J., Kirchner, T., Wyss, M., Bergen, J. M. G. V., Quevenco, F. C., Steininger, S. C., Griffith, E. Y., Meier, I. B., Michels, L., Gietl, A. F., et al. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.08.022 · Cited by 25
GABAergic effect on resting-state functional connectivity: Dynamics under pharmacological antagonism
Nasrallah, F. A., Singh, K. K. D. O. R., Yeow, L. Y., & Chuang, K. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.01.040 · Cited by 27
High γ‐Aminobutyric Acid Content Within the Medial Prefrontal Cortex Is a Functional Signature of Somatic Symptoms Disorder in Patients With Parkinson's Disease
Pizzi, S. D., Franciotti, R., Ferretti, A., Edden, R. A. E., Zöllner, H. J., Esposito, R., Bubbico, G., Aiello, C., Calvanese, F., Sensi, S. L., et al. (2020) · Movement Disorders · doi:10.1002/mds.28221 · Cited by 22
No balance between glutamate+glutamine and GABA+ in visual or motor cortices of the human brain: A magnetic resonance spectroscopy study
Rideaux, R. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.118191 · Cited by 26
Reductions in rostral anterior cingulate GABA are associated with stress circuitry in females with major depression: a multimodal imaging investigation
Ironside, M., Moser, A. D., Holsen, L. M., Zuo, C. S., Du, F., Perlo, S., Richards, C. E., Duda, J. M., Chen, X., Nickerson, L. D. H., et al. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01127-x · Cited by 23
Large-scale momentary brain co-activation patterns are associated with hyperalgesia and mediate focal neurochemistry and cross-network functional connectivity in fibromyalgia
Mawla, I., Huang, Z., Kaplan, C. M., Ichesco, E., Waller, N., Larkin, T. E., Zöllner, H. J., Edden, R. A. E., Harte, S. E., Clauw, D. J., et al. (2023) · Pain · doi:10.1097/j.pain.0000000000002973 · Cited by 27
Plasticity–stability dynamics during post-training processing of learning
Yamada, T., Watanabe, T., & Sasaki, Y. (2023) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2023.09.002 · Cited by 23
Early metabolic development of posteromedial cortex and thalamus in humans analyzed via in vivo quantitative magnetic resonance spectroscopy
Degnan, A. J., Ceschin, R. C., Lee, V., Schmithorst, V. J., Blüml, S., & Panigrahy, A. (2014) · The Journal of Comparative Neurology · doi:10.1002/cne.23634 · Cited by 22
GAD65 Promoter Polymorphism rs2236418 Modulates Harm Avoidance in Women via Inhibition/Excitation Balance in the Rostral ACC
Čolić, L., Li, M., Demenescu, L. R., Li, S., Müller, I., Richter, A., Behnisch, G., Seidenbecher, C. I., Speck, O., Schott, B. H., et al. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.1985-17.2018 · Cited by 22
GABAA receptors in visual and auditory cortex and neural activity changes during basic visual stimulation
Qin, P., Duncan, N. W., Wiebking, C., Gravel, P., Lyttelton, O. C., Hayes, D. J., Verhaeghe, J. A. J., Kostikov, A. P., Schirrmacher, R., Reader, A. J., et al. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00337 · Cited by 22
Richness in Functional Connectivity Depends on the Neuronal Integrity within the Posterior Cingulate Cortex
Lord, A., Li, M., Demenescu, L. R., van der Meer, J. N., Borchardt, V., Krause, A. L., Heinze, H., Breakspear, M. J., & Walter, M. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00184 · Cited by 23

Authors: Kapogiannis, D., Reiter, D. A., Willette, A. A., & Mattson, M. P.
Affiliations: National Institute on Aging (US)
Corresponding author: Kapogiannis, Dimitrios
ORCID: Kapogiannis, Dimitrios
Reiter, David A.
Willette, Auriel A.
Mattson, Mark P.
Venue: NeuroImage
Publisher: Elsevier BV
Published: 2013-01
Volume: 64
Pages: 112-119
ISSN: 1053-8119 (ISSN-L)
DOI: 10.1016/j.neuroimage.2012.09.029
PMC: PMC3801193
OpenAlex: W1971032414
Cited by: 211
References: 67
Citations by year: 2026: 11 · 2025: 14 · 2024: 12 · 2023: 15 · 2022: 15 · 2021: 23 · 2020: 19 · 2019: 17 · 2018: 18 · 2017: 19 · 2016: 14 · 2015: 11 · 2014: 18 · 2013: 4
FWCI: 5.57
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: NeuroImage (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging
National Institutes of Health
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Keywords: posteromedial cortex, default mode network, intrinsic functional connectivity, glutamate, GABA, glutamate/GABA ratio, neurotransmitter concentrations, cortical microcircuits, excitation-inhibition balance, resting-state functional connectivity, age effects
MeSH terms: Brain Mapping, Cerebral Cortex, gamma-Aminobutyric Acid, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Net, Neural Pathways, Magnetic Resonance Spectroscopy, Tissue Distribution, Neurotransmitter Agents, Glutamic Acid, Connectome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Posteromedial cortex glutamate and GABA predict intrinsic functional connectivity of the default mode network

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks