Cited by 167Functional Brain Connectivity StudiesAdvanced MRI Techniques and ApplicationsMind wandering and attention

Resting-State Glutamate and GABA Concentrations Predict Task-Induced Deactivation in the Default Mode Network

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Hu, Yuzheng, Chen, Xi, Gu, Hong, Yang, Yihong·2013·The Journal of Neuroscience

Abstract

Deactivation of the human brain's default mode network (DMN) is regarded as suppression of endogenous activity to support exogenous task-related processes. This phenomenon has important functional relevance and insufficient DMN deactivation has been implicated in several neuropsychiatric disorders. However, the neurochemical mechanism of the DMN′s deactivation remains largely unknown. In the present study, we test the hypothesis that the major excitatory and inhibitory neurotransmitters, glutamate and GABA, respectively, are associated with DMN deactivation. We used magnetic resonance spectroscopy to measure neurotransmitter concentrations in the posterior cingulate cortex/precuneus (PCC/PCu), a key component of the DMN, and functional magnetic resonance imaging to evaluate DMN deactivation induced by an n-back working memory task. Our results demonstrate significant associations of glutamate and GABA with DMN deactivation. Specifically, high regional GABA concentration in the PCC/PCu area is associated with enhanced deactivation induced by the task in the same region, whereas high glutamate concentration is associated with reduced deactivation. Furthermore, the association between GABA and DMN deactivation increases with the cognitive loads. These neurochemical characteristics of DMN deactivation may provide novel insights toward better understanding of the DMN′s functions under normal physiological conditions and dysfunctions in neuropsychiatric disorders.

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Crossref · 10.1523/jneurosci.1973-13.2013

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  • Alteration of glutamate/GABA equilibrium has been related to a diminished capability to focus on demanding tasks and to result in DA dysregulation, causing inhibition of defective pyramidal neurons and a decrease shift in excitation towards tasks regulated in the PFC.

    “Alteration of glutamate/GABA equilibrium has been related to a diminished capability to focus on demanding tasks [98] and to result in DA dysregulation, causing inhibition of defective pyramidal neurons and a decrease shift in excitation towards tasks regulated in the PFC [99, 100].”

    From Molecular Characterisation of the Mechanism of Action of Stimulant Drugs Lisdexamfetamine and Methylphenidate on ADHD Neurobiology: A Review (2022) · cites this paper as [98]

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  • Higher resting state GABA levels in the DMN are associated with enhanced task-induced deactivation of this network.

    “Higher resting state GABA levels in the DMN are associated with enhanced task-induced deactivation of this network [165–167]”

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Authors
Hu, Y., Chen, X., Gu, H., & Yang, Y.
Affiliations
National Institutes of Health (US)
Venue
The Journal of Neuroscience
Published
2013-11-20
Volume
33
Issue
47
Pages
18566-18573
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
OpenAlex
W2039065383
Cited by
167
References
62
Citations by year
2026: 7 · 2025: 14 · 2024: 9 · 2023: 15 · 2022: 13 · 2021: 17 · 2020: 18 · 2019: 18 · 2018: 13 · 2017: 13 · 2016: 12 · 2015: 14 · 2014: 3 · 2013: 1
FWCI
5.48
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Siemens Medical Solutions USA
  • National Institutes of Health
  • National Institute on Drug Abuse
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Mind wandering and attention
Keywords
default mode network, glutamate, GABA, posterior cingulate cortex, precuneus, cognitive load, excitatory and inhibitory neurotransmitters, neuropsychiatric disorders
MeSH terms
Adult, Analysis of Variance, Brain, Brain Mapping, Female, gamma-Aminobutyric Acid, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Memory, Short-Term, Models, Neurological, Neural Pathways, Magnetic Resonance Spectroscopy, Oxygen, Predictive Value of Tests, Rest, Glutamic Acid

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