Cortical chemoarchitecture shapes macroscale effective functional connectivity patterns in macaque cerebral cortex
Open accessAbstract
The mammalian cortex is a complex system of—at the microscale level—interconnected neurons and—at the macroscale level—interconnected areas, forming the infrastructure for local and global neural processing and information integration. While the effects of regional chemoarchitecture on local cortical activity are well known, the effect of local neurotransmitter receptor organization on the emergence of large scale region‐to‐region functional interactions remains poorly understood. Here, we examined reports of effective functional connectivity—as measured by the action of strychnine administration acting on the chemical balance of cortical areas—in relation to underlying regional variation in microscale neurotransmitter receptor density levels in the macaque cortex. Linking cortical variation in microscale receptor density levels to collated information on macroscale functional connectivity of the macaque cortex, we show macroscale patterns of effective corticocortical functional interactions—and in particular, the strength of connectivity of efferent macroscale pathways—to be related to the ratio of excitatory and inhibitory neurotransmitter receptor densities of cortical areas. Our findings provide evidence for the microscale chemoarchitecture of cortical areas to have a direct stimulating influence on the emergence of macroscale functional connectivity patterns in the mammalian brain. Hum Brain Mapp 37:1856–1865, 2016. © 2016 Wiley Periodicals, Inc.
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- Authors
- Turk, E., Scholtens, L. H., & van den Heuvel, M. P.
- Affiliations
- University Medical Center Utrecht (NL)
- Brain Center Rudolf Magnus, Department of Psychiatry University Medical Center Utrecht Utrecht The Netherlands
- Venue
- Human Brain Mapping
- Publisher
- Wiley
- Published
- 2016-03-11
- Volume
- 37
- Issue
- 5
- Pages
- 1856-1865
- ISSN
- 1065-9471 (ISSN-L)
- 1097-0193
- PMC
- PMC6867501
- OpenAlex
- W2293076938
- Cited by
- 27
- References
- 54
- Citations by year
- 2025: 5 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 6 · 2017: 2 · 2016: 4
- FWCI
- 0.46
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Human Brain Mapping (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion, other-oa)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- Utrecht University Repository (Utrecht University) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- neurotransmitter receptor density, strychnine, corticocortical connections, efferent pathways, information integration
- MeSH terms
- Animals, Brain Mapping, Cerebral Cortex, Macaca, Models, Neurological, Nerve Net, Neural Pathways, Strychnine, Receptors, Neurotransmitter, Glycine Agents
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