Regional GABA Concentrations Modulate Inter-network Resting-state Functional Connectivity
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Coordinated activity within and differential activity between large-scale neuronal networks such as the default mode network (DMN) and the control network (CN) is a critical feature of brain organization. The CN usually exhibits activations in response to cognitive tasks while the DMN shows deactivations; in addition, activity between the two networks is anti-correlated at rest. To address this issue, we used functional MRI to measure whole-brain BOLD signal during resting-state and task-evoked conditions, and MR spectroscopy (MRS) to quantify GABA and glutamate concentrations, in nodes within the DMN and CN (MPFC and DLPFC, respectively) in 19 healthy individuals at 3 Tesla. We found that GABA concentrations in the MPFC were significantly associated with DMN deactivation during a working memory task and with anti-correlation between DMN and CN at rest and during task performance, while GABA concentrations in the DLPFC weakly modulated DMN-CN anti-correlation in the opposite direction. Highlighting specificity, glutamate played a less significant role related to brain activity. These findings indicate that GABA in the MPFC is potentially involved in orchestrating between-network brain activity at rest and during task performance.
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Higher resting state GABA levels in the DMN are associated with enhanced task-induced deactivation of this network.
“Higher resting state GABA levels in the DMN are associated with enhanced task-induced deactivation of this network [165–167]”
From Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer’s disease (2019) · cites this paper as [167]
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- Authors
- Chen, X., Fan, X., Hu, Y., Zuo, C., Whitfield-Gabrieli, S., Holt, D., Gong, Q., Yang, Y., Pizzagalli, D. A., Du, F., & Ongur, D.
- Affiliations
- Harvard University (US)
- National Institutes of Health (US)
- McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA
- West China Hospital of Sichuan University (CN)
- Psychotic Disorders Division, McLean Hospital, Harvard Medical School, Belmont, MA, USA
- Corresponding author
- Du, Fei
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-03-28
- Volume
- 29
- Issue
- 4
- Pages
- 1607-1618
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- PMC
- PMC6418388
- OpenAlex
- W2794927807
- Cited by
- 62
- References
- 93
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 16 · 2023: 10 · 2022: 5 · 2021: 7 · 2020: 7 · 2019: 3
- FWCI
- 2.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Cerebral Cortex (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Alliance for Research on Schizophrenia and Depression (MH114020, MH094594, MH104449)
- Intramural Research Program
- National Institute on Drug Abuse
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- GABA, glutamate, default mode network, control network, resting-state functional connectivity, medial prefrontal cortex, dorsolateral prefrontal cortex, working memory, brain deactivation, large-scale brain networks
- MeSH terms
- Adult, Brain, Brain Mapping, Female, gamma-Aminobutyric Acid, Humans, Magnetic Resonance Imaging, Male, Memory, Short-Term, Neural Pathways, Magnetic Resonance Spectroscopy, Glutamic Acid, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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