Cited by 62Functional Brain Connectivity StudiesAdvanced MRI Techniques and ApplicationsNeural dynamics and brain function

Regional GABA Concentrations Modulate Inter-network Resting-state Functional Connectivity

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Chen, Xi, Fan, Xiaoying, Hu, Yuzheng, Zuo, Chun, Whitfield-Gabrieli, Susan, Holt, Daphne, Gong, Qiyong, Yang, Yihong +3 more·2019·Cerebral Cortex

Abstract

Coordinated activity within and differential activity between large-scale neuronal networks such as the default mode network (DMN) and the control network (CN) is a critical feature of brain organization. The CN usually exhibits activations in response to cognitive tasks while the DMN shows deactivations; in addition, activity between the two networks is anti-correlated at rest. To address this issue, we used functional MRI to measure whole-brain BOLD signal during resting-state and task-evoked conditions, and MR spectroscopy (MRS) to quantify GABA and glutamate concentrations, in nodes within the DMN and CN (MPFC and DLPFC, respectively) in 19 healthy individuals at 3 Tesla. We found that GABA concentrations in the MPFC were significantly associated with DMN deactivation during a working memory task and with anti-correlation between DMN and CN at rest and during task performance, while GABA concentrations in the DLPFC weakly modulated DMN-CN anti-correlation in the opposite direction. Highlighting specificity, glutamate played a less significant role related to brain activity. These findings indicate that GABA in the MPFC is potentially involved in orchestrating between-network brain activity at rest and during task performance.

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Authors
Chen, X., Fan, X., Hu, Y., Zuo, C., Whitfield-Gabrieli, S., Holt, D., Gong, Q., Yang, Y., Pizzagalli, D. A., Du, F., & Ongur, D.
Affiliations
  • Harvard University (US)
  • National Institutes of Health (US)
  • McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA
  • West China Hospital of Sichuan University (CN)
  • Psychotic Disorders Division, McLean Hospital, Harvard Medical School, Belmont, MA, USA
Corresponding author
Du, Fei
Venue
Cerebral Cortex
Published
2018-03-28
Volume
29
Issue
4
Pages
1607-1618
ISSN
  • 1047-3211 (ISSN-L)
  • 1460-2199
OpenAlex
W2794927807
Cited by
62
References
93
Citations by year
2026: 6 · 2025: 8 · 2024: 16 · 2023: 10 · 2022: 5 · 2021: 7 · 2020: 7 · 2019: 3
FWCI
2.53
Type
journal article
Language
en
Open access
Locations
  • Cerebral Cortex (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Alliance for Research on Schizophrenia and Depression (MH114020, MH094594, MH104449)
  • Intramural Research Program
  • National Institute on Drug Abuse
  • National Institutes of Health
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
GABA, glutamate, default mode network, control network, resting-state functional connectivity, medial prefrontal cortex, dorsolateral prefrontal cortex, working memory, brain deactivation, large-scale brain networks
MeSH terms
Adult, Brain, Brain Mapping, Female, gamma-Aminobutyric Acid, Humans, Magnetic Resonance Imaging, Male, Memory, Short-Term, Neural Pathways, Magnetic Resonance Spectroscopy, Glutamic Acid, Young Adult

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