The role of serotonin in the neurocircuitry of negative affective bias: serotonergic modulation of the dorsal medial prefrontal-amygdala aversive amplification circuit
Open accessAbstract
Serotonergic medications can mitigate the negative affective biases in disorders such as depression or anxiety, but the neural mechanism by which this occurs is largely unknown. In line with recent advances demonstrating that negative affective biases may be driven by specific medial prefrontal-amygdala circuitry, we asked whether serotonin manipulation can alter affective processing within a key dorsal medial prefrontal-amygdala circuit: the putative human homologue of the rodent prelimbic-amygdala circuit or 'aversive amplification' circuit. In a double-blind, placebo-controlled crossover pharmaco-fMRI design, subjects (N=19) performed a forced-choice face identification task with word distractors in an fMRI scanner over two separate sessions. On one session subjects received dietary depletion of the serotonin precursor tryptophan while on the other session they received a balanced placebo control diet. Results showed that dorsal medial prefrontal responding was elevated in response to fearful relative to happy faces under depletion but not placebo. This negative bias under depletion was accompanied by a corresponding increase in positive dorsal medial prefrontal-amygdala functional connectivity. We therefore conclude that serotonin depletion engages a prefrontal-amygdala circuit during the processing of fearful relative to happy face stimuli. This same 'aversive amplification' circuit is also engaged during anxiety induced by shock anticipation. As such, serotonergic projections may inhibit engagement of the 'aversive amplification' circuit and dysfunction in this projection may contribute to the negative affective bias in mood and anxiety disorders. These findings thus provide a promising explanation for the role of serotonin and serotonergic medications in the neurocircuitry of negative affective bias.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Lowering brain serotonin using acute tryptophan depletion leads to an increased negative affective bias as a result of a change in the connectivity between mPFC and amygdala, which has been associated with the risk of depression.
“Lowering brain serotonin using acute tryptophan depletion leads to an increased negative affective bias as a result of a change in the connectivity between mPFC and amygdala (Robinson et al., 2013), which has been associated with the risk of depression (Roiser et al., 2012).”
From Social functioning in major depressive disorder (2016) · cites this paper as Robinson et al., 2013
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Tzourio-Mazoyer, N., Landeau, B., Papathanassiou, D., Crivello, F., Etard, O., Delcroix, N., Mazoyer, B., & Joliot, M. (2002) · NeuroImage · doi:10.1006/nimg.2001.0978 · Cited by 16,319 · see citing works
Insel, T., Cuthbert, B., Garvey, M., Heinssen, R., Pine, D. S., Quinn, K., Sanislow, C., & Wang, P. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09091379 · Cited by 7,067 · see citing works
Self-citationFriston, K. J., Harrison, L., & Penny, W. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00202-7 · Cited by 4,583 · see citing works
Psychophysiological and Modulatory Interactions in Neuroimaging
Friston, K. J., Buechel, C., Fink, G. R., Morris, J., Rolls, E., & Dolan, R. J. (1997) · NeuroImage · doi:10.1006/nimg.1997.0291 · Cited by 3,097 · see citing works
Emotional processing in anterior cingulate and medial prefrontal cortex
Etkin, A., Egner, T., & Kalisch, R. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.11.004 · Cited by 3,059 · cited 2× · see citing works
“As such, we propose (in accordance with both rodent and human literature Etkin et al., 2011; Sierra-Mercado et al., 2011) that this reflects a top-down amplification mechanism, but future study with more complex techniques such as dynamic causal modeling (Friston et al., 2003) will be necessary to…”
BackgroundNeurocircuitry of Mood Disorders
Price, J. L., & Drevets, W. C. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.104 · Cited by 1,606 · see citing works
Recognizing emotion from facial expressions: psychological and neurological mechanisms
Adolphs, R. (2002) · Behavioral and Cognitive Neuroscience Reviews · doi:10.1177/1534582302001001003 · Cited by 1,432 · see citing works
Etkin, A., Egner, T., Peraza, D. M., Kandel, E. R., & Hirsch, J. (2006) · Neuron · doi:10.1016/j.neuron.2006.07.029 · Cited by 1,360 · see citing works
Sierra-Mercado, D., Padilla-Coreano, N., & Quirk, G. J. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.184 · Cited by 1,190 · see citing works
Neurocognitive mechanisms of anxiety: An integrative account
Bishop, S. J. (2007) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2007.05.008 · Cited by 976 · see citing works
Shin, L. M., Wright, C. I., Cannistraro, P. A., Wedig, M. M., McMullin, K., Martis, B., Macklin, M. L., Lasko, N. B., Cavanagh, S. R., Krangel, T. S., et al. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.3.273 · Cited by 960 · see citing works
Amat, J., Baratta, M. V., Paul, E., Bland, S. T., Watkins, L. R., & Maier, S. F. (2005) · Nature Neuroscience · doi:10.1038/nn1399 · Cited by 931 · see citing works
Siegle, G. J., Thompson, W., Carter, C. S., Steinhauer, S. R., & Thase, M. E. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.048 · Cited by 857 · see citing works
Neural circuits underlying the pathophysiology of mood disorders
Price, J. L., & Drevets, W. C. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.12.011 · Cited by 788 · see citing works
Prefrontal involvement in the regulation of emotion: convergence of rat and human studies
Quirk, G. J., & Beer, J. S. (2006) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2006.07.004 · Cited by 701 · see citing works
Serotoninergic regulation of emotional and behavioural control processes
Cools, R., Roberts, A. C., & Robbins, T. W. (2008) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2007.10.011 · Cited by 656 · see citing works
Fear extinction in rats: Implications for human brain imaging and anxiety disorders
Milad, M. R., Rauch, S. L., Pitman, R. K., & Quirk, G. J. (2006) · Biological Psychology · doi:10.1016/j.biopsycho.2006.01.008 · Cited by 597 · see citing works
Reward and Punishment Processing in Depression
Eshel, N., & Roiser, J. P. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.01.027 · Cited by 575 · see citing works
Etkin, A., Prater, K. E., Hoeft, F., Menon, V., & Schatzberg, A. F. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.09070931 · Cited by 550 · see citing works
Harmer, C. J., Goodwin, G. M., & Cowen, P. J. (2009) · British Journal of Psychiatry · doi:10.1192/bjp.bp.108.051193 · Cited by 542 · see citing works
A Role for the Human Dorsal Anterior Cingulate Cortex in Fear Expression
Milad, M. R., Quirk, G. J., Pitman, R. K., Orr, S. P., Fischl, B., & Rauch, S. L. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.04.032 · Cited by 485 · see citing works
The Study of Fear Extinction: Implications for Anxiety Disorders
Graham, B. M., & Milad, M. R. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11040557 · Cited by 387 · see citing works
Serotonin in Affective Control
Dayan, P., & Huys, Q. J. M. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135607 · Cited by 381 · see citing works
Affective Cognition and its Disruption in Mood Disorders
Elliott, R., Zahn, R., Deakin, J. F. W., & Anderson, I. M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.77 · Cited by 330 · see citing works
Etkin, A., & Schatzberg, A. F. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.10091290 · Cited by 311 · see citing works
Blair, K., Shaywitz, J., Smith, B. W., Rhodes, R., Geraci, M., Jones, M., McCaffrey, D., Vythilingam, M., Finger, E., Mondillo, K., et al. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.07071060 · Cited by 282 · see citing works
Self-citationCrockett, M. J., Clark, L., & Robbins, T. W. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.2513-09.2009 · Cited by 271 · see citing works
Serotonin, inhibition, and negative mood
Dayan, P., & Huys, Q. J. M. (2008) · PLoS Computational Biology · doi:10.1371/journal.pcbi.0040004 · Cited by 263 · see citing works
Puig, M. V. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh104 · Cited by 232 · see citing works
Serotonin and emotional processing: does it help explain antidepressant drug action?
Harmer, C. J. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.06.036 · Cited by 219 · see citing works
Evers, E. A. T., Cools, R., Clark, L., van der Veen, F. M., Jolles, J., Sahakian, B. J., & Robbins, T. W. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300663 · Cited by 208 · see citing works
Reproducibility of fMRI Results across Four Institutions Using a Spatial Working Memory Task
Casey, B. J., Cohen, J., O'Craven, K., Davidson, R. J., Irwin, W., Nelson, C. A., Noll, D. C., Hu, X. P., Lowe, M. J., Rosen, B. R., et al. (1998) · NeuroImage · doi:10.1006/nimg.1998.0360 · Cited by 203 · see citing works
Robinson, O. J., Charney, D. R., Overstreet, C. M., Vytal, K. E., & Grillon, C. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.11.096 · Cited by 196 · see citing works
Self-citationPotentiated amygdala response to repeated emotional pictures in borderline personality disorder
Hazlett, E. A., Zhang, J., New, A. S., Zelmanova, Y., Goldstein, K. E., Haznedar, M. M., Meyerson, D., Goodman, M., Siever, L. J., & Chu, K.-W. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.03.027 · Cited by 186 · see citing works
Cools, R., Robinson, O. J., & Sahakian, B. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301598 · Cited by 172 · see citing works
Self-citationShin, L. M., Bush, G., Milad, M. R., Lasko, N. B., Brohawn, K. H., Hughes, K. C., Macklin, M. L., Gold, A. L., Karpf, R. D., Orr, S. P., et al. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.09121812 · Cited by 170 · see citing works
Hayward, G., Goodwin, G. M., Cowen, P. J., & Harmer, C. J. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.016 · Cited by 162 · see citing works
Cools, R., Calder, A. J., Lawrence, A. D., Clark, L., Bullmore, E., & Robbins, T. W. (2005) · Psychopharmacology · doi:10.1007/s00213-005-2215-5 · Cited by 161 · see citing works
Passamonti, L., Crockett, M. J., Apergis-Schoute, A. M., Clark, L., Rowe, J. B., Calder, A. J., & Robbins, T. W. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.07.033 · Cited by 137 · see citing works
Efficacy markers in depression
Harmer, C. J., Cowen, P. J., & Goodwin, G. M. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881110367722 · Cited by 122 · see citing works
van der Veen, F. M., Evers, E. A. T., Deutz, N. E. P., & Schmitt, J. A. J. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301212 · Cited by 118 · see citing works
Robinson, O. J., Letkiewicz, A. M., Overstreet, C. M., Monique Ernst, D., & Grillon, C. (2011) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-011-0030-5 · Cited by 113 · see citing works
Self-citationSSRI administration reduces resting state functional connectivity in dorso-medial prefrontal cortex
McCabe, C., Mishor, Z., Filippini, N., Cowen, P. J., Taylor, M. J., & Harmer, C. J. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.138 · Cited by 104 · see citing works
Linnman, C., Zeidan, M. A., Furtak, S. C., Pitman, R. K., Quirk, G. J., & Milad, M. R. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.10121780 · Cited by 101 · see citing works
Evidence for cortical inhibitory and excitatory dysfunction in obsessive compulsive disorder
Richter, M. A., de Jesus, D. R., Hoppenbrouwers, S., Daigle, M., Deluce, J., Ravindran, L. N., Fitzgerald, P. B., & Daskalakis, Z. J. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.300 · Cited by 100 · see citing works
Roiser, J. P., Levy, J., Fromm, S. J., Wang, H., Hasler, G., Sahakian, B. J., & Drevets, W. C. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301581 · Cited by 80 · see citing works
Tryptophan depletion disinhibits punishment but not reward prediction: implications for resilience
Robinson, O. J., Cools, R., & Sahakian, B. J. (2012) · Psychopharmacology · doi:10.1007/s00213-011-2410-5 · Cited by 73 · see citing works
Self-citationConverging evidence for central 5-HT effects in acute tryptophan depletion
Crockett, M. J., Clark, L., Roiser, J. P., Robinson, O. J., Cools, R., Chase, H. W., den Ouden, H. E. M., Apergis-Schoute, A. M., Campbell-Meiklejohn, D. K., Seymour, B., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.106 · Cited by 71 · see citing works
Self-citationJarcho, J. M., Fox, N. A., Pine, D. S., Etkin, A., Leibenluft, E., Shechner, T., & Monique Ernst, D. (2012) · Biological Psychology · doi:10.1016/j.biopsycho.2012.09.008 · Cited by 68 · see citing works
Self-citationMultisite fMRI reproducibility of a motor task using identical MR systems
Costafreda, S. G., Brammer, M. J., Vêncio, R. Z. N., Mourao, M. L. S., Portela, L. A. P., de Castro, C. C., Giampietro, V., & Amaro, E. (2007) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.21118 · Cited by 56 · see citing works
Attentional bias in untreated panic disorder
Reinecke, A., Cooper, M., Favaron, E., Massey-Chase, R. A., & Harmer, C. J. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2010.07.020 · Cited by 53 · see citing works
Converging evidence for central 5-HT effects in acute tryptophan depletion?
Plasse, G. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.44 · Cited by 52 · see citing works
Modulation of neural response to happy and sad faces by acute tryptophan depletion
Fusar-Poli, P., Allen, P., Lee, F., Surguladze, S., Tunstall, N., Fu, C. H. Y., Brammer, M. J., Cleare, A. J., & McGuire, P. K. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0757-4 · Cited by 43 · see citing works
Self-citationRobinson, O. J., Overstreet, C., Allen, P. S., Pine, D. S., & Grillon, C. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.43 · Cited by 35 · see citing works
Self-citationBetween- and within-scanner variability in the CaliBrain study n-back cognitive task
Gradin, V. B., Gountouna, V., Waiter, G. D., Ahearn, T. S., Brennan, D., Condon, B. R., Marshall, I., McGonigle, D. J., Murray, A. D., Whalley, H. C., et al. (2010) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2010.08.010 · Cited by 27 · see citing works
Daly, E., Deeley, Q., Hallahan, B. P., Craig, M., Brammer, M. J., Lamar, M., Cleare, A. J., Giampietro, V., Ecker, C., Page, L., et al. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1850-7 · Cited by 26 · see citing works
Boost resilience to tackle mental illness
Robinson, O. J. (2011) · Nature · doi:10.1038/478459b · Cited by 5 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- First MB Spitzer RL Gibbon M Williams JBW Structured Clinical Interview for DSM-IV-TR Axis I Disorders—Patient edition (SCID-I/P, 11/2002 Revision) 2002 New York New York State Psychiatric Institute
Cited by
Sorted by citations
Social functioning in major depressive disorder
Kupferberg, A., Bicks, L., & Hasler, G. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.07.002 · Cited by 663 · see citing works
Social brain, social dysfunction and social withdrawal
Porcelli, S., van der Wee, N. J. A., van der Werff, S. J., Aghajani, M., Glennon, J. C., van Heukelum, S., Mogavero, F., Lobo, A., Olivera, F. J. N., Lobo, E., et al. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.012 · Cited by 397 · see citing works
Phillips, M. L., Chase, H. W., Sheline, Y. I., Etkin, A., Almeida, J. R. C., Deckersbach, T., & Trivedi, M. H. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.14010076 · Cited by 267 · see citing works
Robinson, O. J., Krimsky, M., Lieberman, L., Allen, P. S., Vytal, K. E., & Grillon, C. (2014) · The Lancet Psychiatry · doi:10.1016/s2215-0366(14)70305-0 · Cited by 155 · see citing works
Self-citationUlrich, M., Keller, J., & Grön, G. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsv133 · Cited by 117 · see citing works
Acute effects of LSD on amygdala activity during processing of fearful stimuli in healthy subjects
Müller, F., Lenz, C., Dolder, P. C., Harder, S., Schmid, Y., Lang, U. E., Liechti, M. E., & Borgwardt, S. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.54 · Cited by 128 · see citing works
Kraehenmann, R., Schmidt, A., Friston, K., Preller, K. H., Seifritz, E., & Vollenweider, F. X. (2016) · NeuroImage: Clinical · doi:10.1016/j.nicl.2015.08.009 · Cited by 104 · see citing works
Tryptophan supplementation and serotonin function: genetic variations in behavioural effects
Gibson, E. L. (2018) · Proceedings of The Nutrition Society · doi:10.1017/s0029665117004451 · Cited by 99 · see citing works
Neural Mechanisms and Psychology of Psychedelic Ego Dissolution
Stoliker, D., Egan, G. F., Friston, K. J., & Razi, A. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.121.000508 · Cited by 89 · see citing works
Challis, C., & Berton, O. (2015) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00007 · Cited by 81 · see citing works
Vytal, K. E., Overstreet, C. M., Charney, D. R., Robinson, O. J., & Grillon, C. (2014) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.130145 · Cited by 82 · see citing works
Self-citationFaulkner, P., & Deakin, J. F. W. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.07.024 · Cited by 73 · see citing works
Bernik, M., Sampaio, T. P. D. A., & Gandarela, L. M. (2013) · Current Pain and Headache Reports · doi:10.1007/s11916-013-0358-3 · Cited by 69 · see citing works
Modeling anxiety in healthy humans: a key intermediate bridge between basic and clinical sciences
Grillon, C., Robinson, O. J., Cornwell, B., & Ernst, M. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0445-1 · Cited by 65 · see citing works
Self-citationCheng, Y., Xu, J., Arnone, D., Nie, B., Yu, H., Jiang, H., Bai, Y., Luo, C., Campbell, R. A. A., Shan, B., et al. (2016) · Psychological Medicine · doi:10.1017/s0033291716002440 · Cited by 51 · see citing works
Molecular and neurocircuitry mechanisms of social avoidance
Gellner, A., Voelter, J., Schmidt, U., Beins, E. C., Stein, V., Philipsen, A., & Hurlemann, R. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03649-x · Cited by 51 · see citing works
Stoliker, D., Novelli, L., Vollenweider, F. X., Egan, G. F., Preller, K. H., & Razi, A. (2024) · Biological Psychiatry · doi:10.1016/j.biopsych.2024.01.002 · Cited by 44 · see citing works
Carlisi, C. O., & Robinson, O. J. (2018) · Brain and Neuroscience Advances · doi:10.1177/2398212818774223 · Cited by 42 · see citing works
Self-citationMiskowiak, K. W., Glerup, L., Vestbo, C., Harmer, C. J., Reinecke, A., Macoveanu, J., Siebner, H. R., Kessing, L. V., & Vinberg, M. (2014) · Psychological Medicine · doi:10.1017/s0033291714002542 · Cited by 39 · see citing works
Familial Retinal Arteriolar Tortuosity with Acute Hippocampal Infarction
Kim, T. H., Lee, S., & Lim, S. J. (2017) · Case Reports in Ophthalmology · doi:10.1159/000456069 · Cited by 37 · see citing works
Integrating sleep, neuroimaging, and computational approaches for precision psychiatry
Goldstein‐Piekarski, A. N., Holt-Gosselin, B., O’Hora, K., & Williams, L. M. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0483-8 · Cited by 38 · see citing works
Raab, K., Kirsch, P., & Mier, D. U. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.08.031 · Cited by 35 · see citing works
Cholinergic Modulation of Disorder-Relevant Neural Circuits in Generalized Anxiety Disorder
Wise, T., Patrick, F., Meyer, N., Mazibuko, N., Oates, A. E., van der Bijl, A. H. M., Danjou, P., O'Connor, S. M., Doolin, E. E., Wooldridge, C., et al. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.12.013 · Cited by 31 · see citing works
Aberrant Dynamic Connectivity for Fear Processing in Anorexia Nervosa and Body Dysmorphic Disorder
Rangaprakash, D., Bohon, C., Lawrence, K. E., Moody, T. D., Morfini, F., Khalsa, S. S., Strober, M. A., & Feusner, J. D. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00273 · Cited by 30 · see citing works
Anxiety-potentiated amygdala–medial frontal coupling and attentional control
Robinson, O., Krimsky, M., Lieberman, L., Vytal, K., Ernst, M., & Grillon, C. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.105 · Cited by 26 · see citing works
Self-citationGonzález‐Escamilla, G., Chirumamilla, V. C., Meyer, B., Bonertz, T., von Grotthus, S., Vogt, J., Stroh, A., Horstmann, J.-P., Tüscher, O., Kalisch, R., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-32781-9 · Cited by 22 · see citing works
Serotonin in panic and anxiety disorders
Zangrossi, H., Del‐Ben, C. M., Graeff, F. G., & Guimarães, F. S. (2020) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-444-64125-0.00036-0 · Cited by 21 · see citing works
Bär, K., Köhler, S., de la Cruz, F., Schumann, A., Zepf, F. D., & Wagner, G. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.116362 · Cited by 19 · see citing works
Amino acid challenge and depletion techniques in human functional neuroimaging studies: an overview
Biskup, C. S., Gaber, T. J., Helmbold, K., Bubenzer‐Busch, S., & Zepf, F. D. (2015) · Amino Acids · doi:10.1007/s00726-015-1919-z · Cited by 18 · see citing works
van Dalfsen, J. H., & Markus, C. R. (2019) · Journal of Psychopharmacology · doi:10.1177/0269881119855978 · Cited by 18 · see citing works
Rádosi, A., Pászthy, B., Sebők-Welker, T., Zubovics, E. A., Réthelyi, J., Ulbert, I., & Bunford, N. (2020) · Addictive Behaviors · doi:10.1016/j.addbeh.2020.106719 · Cited by 17 · see citing works
Reinecke, A., & Harmer, C. J. (2015) · Psychopathology Review · doi:10.5127/pr.035113 · Cited by 13 · see citing works
Windle, M. T., Kogan, S. M., Lee, S., Chen, Y., Lei, K. M., Brody, G. H., Beach, S. R. H., & Yu, T. (2015) · Development and Psychopathology · doi:10.1017/s095457941500053x · Cited by 14 · see citing works
Prouty, E. W., Chandler, D. J., Gao, W., & Waterhouse, B. D. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14355 · Cited by 12 · see citing works
Wang, L., Zhou, S.-Z., Xue, Y., Li, Q., Cao, M., & Gu, C.-H. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20043338 · Cited by 12 · see citing works
Moeller, S. J., Parvaz, M. A., Shumay, E., Wu, S., Beebe-Wang, N., Konova, A. B., Misyrlis, M., Nelly Alia-klein, A., & Goldstein, R. Z. (2014) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2014.04.019 · Cited by 11 · see citing works
The Neural Mechanism of Negative Bias
Yongze, Z. H. U., Weibin, M. A. O., & Wang, R. (2014) · Advances in Psychological Science · doi:10.3724/sp.j.1042.2014.01393 · Cited by 12 · see citing works
Brain serotonin transporter is associated with cognitive‐affective biases in healthy individuals
Armand, S., Ozenne, B., Svart, N., Frøkjær, V. G., Knudsen, G. M., Fisher, P. M., & Stenbæk, D. S. (2022) · Human Brain Mapping · doi:10.1002/hbm.25946 · Cited by 9 · see citing works
Deza-Araujo, Y. I., Baez-Lugo, S., Vuilleumier, P. O., Chocat, A., Chételat, G., Poisnel, G., & Klimecki, O. (2021) · Biological Psychology · doi:10.1016/j.biopsycho.2021.108051 · Cited by 9 · see citing works
Management of Anxiety in Parkinson's Disease
Berry, A. J., Costello, H., Jesús, S., Price, G. W., & Jha, A. (2025) · Movement Disorders Clinical Practice · doi:10.1002/mdc3.70144 · Cited by 8 · see citing works
Malamud, J., Lewis, G., Moutoussis, M., Duffy, L., Bone, J. K., Srinivasan, R., Lewis, G., & Huys, Q. J. M. (2024) · Psychological Medicine · doi:10.1017/s0033291724000837 · Cited by 7 · see citing works
Sharp, P. B., & Telzer, E. H. (2017) · NeuroImage Clinical · doi:10.1016/j.nicl.2017.09.012 · Cited by 8 · see citing works
Armand, S., Larsen, K., Madsen, M. K., Ozenne, B., Preller, K. H., Knudsen, G. M., Stenbæk, D. S., & Fisher, P. M. (2023) · Neuroscience Applied · doi:10.1016/j.nsa.2023.103934 · Cited by 7 · see citing works
Resolving ambiguity: Negative interpretation biases
Yoon, K. L., Shaffer, V. N., & Benedict, A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-816660-4.00006-4 · Cited by 6 · see citing works
The Role of Serotonin in Aversive Inhibition: Behavioural, Cognitive and Neural Perspectives
Robinson, O. J., & Roiser, J. P. (2015) · Psychopathology Review · doi:10.5127/pr.034013 · Cited by 6 · see citing works
Self-citationNeuroimaging Connectivity Analyses and Their Application in Psychiatric Research
Smallwood, R. F., Hutson, R., & Robin, D. A. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-386456-7.05217-5 · Cited by 5 · see citing works
Kim, S. N., Choi, J., Park, M., Yoo, S. Y., Choi, A., Koo, J. W., & Kang, U. G. (2025) · Frontiers in Public Health · doi:10.3389/fpubh.2024.1494313 · Cited by 5 · see citing works
Task MRI-Based Functional Brain Network of Major Depression
Lai, C. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-981-33-6044-0_2 · Cited by 5 · see citing works
Lukow, P. B., Lowther, M., Pike, A. C., Yamamori, Y., Chavanne, A. V., Gormley, S., Aylward, J., McCloud, T., Goble, T., Rodriguez-Sanchez, J., et al. (2024) · Journal of Psychopharmacology · doi:10.1177/02698811241286773 · Cited by 3 · see citing works
“Moreover, acute depletion of the serotonin precursor tryptophan was found to increase anxiety-related amygdala-prefrontal connectivity (Robinson et al., 2013).”
BackgroundSelf-citationLiu, C., Li, K., Fu, M., Zhang, Y., Sindermann, C., Montag, C., Zheng, X., Zhang, H., Yao, S., Wang, Z., et al. (2023) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2023.08.484 · Cited by 3 · see citing works
Smith, A. L. W., Hamilton, S., Murphy, S. E., Cowen, P. J., & Harmer, C. J. (2025) · Psychopharmacology · doi:10.1007/s00213-025-06770-6 · Cited by 2 · see citing works
Jiang, W., Zhang, Y., Dong, X., & Hou, K. (2025) · Medicine · doi:10.1097/md.0000000000042295 · Cited by 1 · see citing works
Snyder, A. D., Zuniga, E. A., Ma, L., Steinberg, J. L., Woisard, K., Narayana, P. A., Lane, S. D., Schmitz, J. M., & Moeller, F. G. (2020) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2020.111127 · Cited by 1 · see citing works
Абрамец, И. И., Кузнецов, Ю. В., Евдокимов, Д. В., & Зайка, Т. О. (2019) · Университетская клиника · doi:10.26435/uc.v0i2(31).303 · Cited by 1 · see citing works
Drabek, M. M., Cottam, W. J., Iwabuchi, S. J., Tadjibaev, A., Mohammadi‐Nejad, A., & Auer, D. P. (2022) · medRxiv · doi:10.1101/2022.03.01.22271607 · Cited by 1 · see citing works
Mecca, F. F. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.17.2019.tde-27052020-074722
Neurobiologia del cervello sociale nei disturbi d'ansia e dell'umore - Mini-review
Porcelli, S. (2023) · QUADERNI DI PSICOTERAPIA COGNITIVA · doi:10.3280/qpc51-2022oa15181
Liu, C., Li, K., Fu, M., Zhang, Y., Sindermann, C., Montag, C., Zheng, X., Zhang, H., Shuxia, Y., Wang, Z., et al. (2023) · medRxiv · doi:10.1101/2023.03.18.23287402
Malamud, J., Lewis, G., Moutoussis, M., Duffy, L., Bone, J. K., Srinivasan, R., Lewis, G., & Huys, Q. J. M. (2023) · doi:10.31234/osf.io/y4uxq
Salloum, F., Farran, M. T., Shaib, H. A., Jurjus, A. R., Sleiman, R., & Khalil, M. I. M. (2024) · Behavioural Neurology · doi:10.1155/2024/4504858
Kim, G. S., Tirumalaraju, V., & Selvaraj, S. (2025) · Cambridge University Press eBooks · doi:10.1017/9781009334730.021
Lukow, P. B., Lowther, M., Pike, A. C., Yamamori, Y., Chavanne, A. V., Gormley, S., Aylward, J., Vera, C. E., McCloud, T. L., Goble, T., et al. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120682
Self-citationMolecular, Structural, and Functional Neuroimaging in Major Depression
Lai, C. (2026) · Advances in experimental medicine and biology · doi:10.1007/978-981-95-6872-7_19
- Authors
- Robinson, O. J., Overstreet, C., Allen, P. S., Letkiewicz, A., Vytal, K., Pine, D. S., & Grillon, C.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Robinson, Oliver J.
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 78
- Pages
- 217-223
- ISSN
- 1053-8119 (ISSN-L)
- PMC
- PMC3677215
- OpenAlex
- W1976863244
- Cited by
- 64
- References
- 57
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 4 · 2023: 6 · 2022: 3 · 2021: 2 · 2020: 6 · 2019: 7 · 2018: 5 · 2017: 4 · 2016: 4 · 2015: 8 · 2014: 7 · 2013: 1
- FWCI
- 3.27
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Intramural Research Program of the National Institutes of Mental Health
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- serotonin, dorsomedial prefrontal cortex, amygdala, tryptophan depletion, anxiety, depression, serotonergic medications
- MeSH terms
- Adult, Affect, Affective Symptoms, Amygdala, Anxiety, Depression, Double-Blind Method, Emotions, Female, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Male, Neural Pathways, Serotonin, Tryptophan, Bias, Serotonin Receptor Agonists, Prefrontal Cortex, Cross-Over Studies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
