The Effect of Acute Tryptophan Depletion on the Neural Correlates of Emotional Processing in Healthy Volunteers
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The processing of affective material is known to be modulated by serotonin (5-HT), but few studies have used neurophysiological measures to characterize the effect of changes in 5-HT on neural responses to emotional stimuli. We used functional magnetic resonance imaging to investigate the effect of acute tryptophan depletion, which reduces central 5-HT synthesis, on neural responses to emotionally valenced verbal stimuli. Though no participants experienced significant mood change, emotional information processing was substantially modified following 5-HT depletion. A behavioral bias toward positive stimuli was attenuated following depletion, which was accompanied by increased hemodynamic responses during the processing of emotional words in several subcortical structures. Inter-individual differences in tryptophan depletion-elicited anxiety correlated positively with the caudate bias toward negative stimuli. These data suggest that 5-HT may play an important role in mediating automatic negative attentional biases in major depression, as well as resilience against negative distracting stimuli in never-depressed individuals.
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ATD had no effect on selective recall of emotional words.
“Consistent with these generally negative findings, ATD had no effect in a similar task studying selective recall of emotional words (Roiser et al., 2008).”
From Affective Cognition and its Disruption in Mood Disorders (2011) · cites this paper as Roiser et al., 2008
Few changes were seen between happy and sad targets.
“Few changes were seen between happy and sad targets.”
From Affective Cognition and its Disruption in Mood Disorders (2011) · cites this paper as Roiser et al., 2008
In an affective Go/No-Go task, ATD resulted in altered responses in a variety of areas including enhanced activation of amygdala and hippocampus on the left and thalamus, anterior insula and parahippocampal gyrus on the right for emotional compared with neutral targets, whereas decreased activity was seen in the ACC.
“By contrast, in an elaborately analysed study using the affective Go/No-Go task, Roiser et al. (Roiser et al., 2008;Roiser et al., 2009) found that ATD resulted in altered responses in a variety of areas including enhanced activation of amygdala and hippocampus on the left and thalamus, anterior insula and parahippocampal gyrus on the right for emotional compared with neutral targets whereas”
From Affective Cognition and its Disruption in Mood Disorders (2011) · cites this paper as Roiser et al., 2008
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- Authors
- Roiser, J. P., Levy, J., Fromm, S. J., Wang, H., Hasler, G., Sahakian, B. J., & Drevets, W. C.
- Affiliations
- UCL Queen Square Institute of Neurology (GB)
- National Institutes of Health (US)
- University of Cambridge (GB)
- Corresponding author
- Roiser, Jonathan P
- Venue
- Neuropsychopharmacology
- Published
- 2007-09-19
- Volume
- 33
- Issue
- 8
- Pages
- 1992-2006
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC2645340
- OpenAlex
- W2052818558
- Cited by
- 80
- References
- 62
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 5 · 2017: 2 · 2016: 4 · 2015: 7 · 2014: 2 · 2013: 7 · 2012: 7
- FWCI
- 3.45
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- National Institutes of Health
- National Institute of Mental Health (Z01MH002817)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- tryptophan depletion, serotonin, emotional processing, emotional words, attentional bias, caudate nucleus, anxiety, individual differences, depression, resilience, hemodynamic response, subcortical structures
- MeSH terms
- Adolescent, Adult, Affect, Amino Acids, Blood Pressure, Brain, Cognition, Double-Blind Method, Emotions, Female, Heart Rate, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Psychiatric Status Rating Scales, Psychomotor Performance, Serotonin, Social Perception, Tryptophan, Prefrontal Cortex, Cross-Over Studies
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