Reconciling the Role of Serotonin in Behavioral Inhibition and Aversion: Acute Tryptophan Depletion Abolishes Punishment-Induced Inhibition in Humans
Open accessAbstract
The neuromodulator serotonin has been implicated in a large number of affective and executive functions, but its precise contribution to motivation remains unclear. One influential hypothesis has implicated serotonin in aversive processing; another has proposed a more general role for serotonin in behavioral inhibition. Because behavioral inhibition is a prepotent reaction to aversive outcomes, it has been a challenge to reconcile these two accounts. Here, we show that serotonin is critical for punishment-induced inhibition but not overall motor response inhibition or reporting aversive outcomes. We used acute tryptophan depletion to temporarily lower brain serotonin in healthy human volunteers as they completed a novel task designed to obtain separate measures of motor response inhibition, punishment-induced inhibition, and sensitivity to aversive outcomes. After a placebo treatment, participants were slower to respond under punishment conditions compared with reward conditions. Tryptophan depletion abolished this punishment-induced inhibition without affecting overall motor response inhibition or the ability to adjust response bias in line with punishment contingencies. The magnitude of reduction in punishment-induced inhibition depended on the degree to which tryptophan depletion reduced plasma tryptophan levels. These findings extend and clarify previous research on the role of serotonin in aversive processing and behavioral inhibition and fit with current theorizing on the involvement of serotonin in predicting aversive outcomes.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The four experimental feedback blocks were given in counterbalanced order.
“Participants performed a go/no-go task and completed four experimental feedback blocks in counterbalanced order (Crockett et al. 2009).”
From Punishment promotes response control deficits in obsessive-compulsive disorder: evidence from a motivational go/no-go task (2013) · cites this paper as Crockett et al. 2009
An earlier study with a comparable task reported slower responding under punishment than under reward, and this difference disappeared after acute tryptophan depletion.
“A previous study using a similar task found slowing in the punished relative to rewarded conditions and this was abolished under acute tryptophan depletion (Crockett et al. 2009).”
From Punishment promotes response control deficits in obsessive-compulsive disorder: evidence from a motivational go/no-go task (2013) · cites this paper as Crockett et al. 2009
Serotonin contributes to behavioural suppression under punishment conditions.
“These are precisely the conditions where serotonin plays a role in behavioural suppression (Cools et al. 2008; Crockett et al. 2009)”
From Punishment promotes response control deficits in obsessive-compulsive disorder: evidence from a motivational go/no-go task (2013) · cites this paper as Crockett et al. 2009
Acute tryptophan depletion removed punishment-induced inhibition in the same task.
“tryptophan depletion eliminated punishment-induced inhibition in the same task (Crockett et al. 2009).”
From Punishment promotes response control deficits in obsessive-compulsive disorder: evidence from a motivational go/no-go task (2013) · cites this paper as Crockett et al. 2009
Commission errors in this study were much lower than those reported in the earlier study.
“In the present study commission errors were considerably lower than in the previous study”
From Punishment promotes response control deficits in obsessive-compulsive disorder: evidence from a motivational go/no-go task (2013) · cites this paper as Crockett et al. 2009
The Results section ('Lowering serotonin does not affect motor response inhibition'; page unavailable) reports commission-error findings for the cited study, but does not compare its error rates with those of the citing paper’s present study. Searches for lower commission-error rates and a previous-study comparison found no passage establishing the claimed difference. (LLM, conf=0.70)
Experimental — accuracy not yet measured
Serotonin affects learning from punishment, reward and resilience.
“Robinson et al. (2012), Cools et al. (2008) and Crockett et al. (2009) have all emphasised the effects of serotonin on learning from punishment, but also its impact on reward and resilience.”
From The role of habit in compulsivity (2016) · cites this paper as Crockett et al. (2009)
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The NimStim set of facial expressions: Judgments from untrained research participants.
Tottenham, N., Tanaka, J. W., Leon, A. C., McCarry, T., Nurse, M., Hare, T. A., Marcus, D. J., Westerlund, A., Casey, B., & Nelson, C. (2009) · Psychiatry Research · doi:10.1016/j.psychres.2008.05.006 · Cited by 3,454 · see citing works
Inhibition and the right inferior frontal cortex
Aron, A. R., Robbins, T. W., & Poldrack, R. A. (2004) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2004.02.010 · Cited by 3,197 · see citing works
Self-citationDifferences between males and females in rates of serotonin synthesis in human brain
Nishizawa, S., Benkelfat, C., Young, S. N., Leyton, M., Mzengeza, S., de Montigny, C., Blier, P., & Dikšić, M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5308 · Cited by 901 · see citing works
Opponent interactions between serotonin and dopamine
Daw, N. D., Kakade, S., & Dayan, P. (2002) · Neural Networks · doi:10.1016/s0893-6080(02)00052-7 · Cited by 844 · see citing works
Tryptophan depletion causes a rapid lowering of mood in normal males
Young, S. N., Smith, S. E., Pihl, R. O., & Ervin, F. R. (1985) · Psychopharmacology · doi:10.1007/bf00431803 · Cited by 715 · see citing works
Different types of fear-conditioned behaviour mediated by separate nuclei within amygdala
Killcross, S., Robbins, T., & Everitt, B. (1997) · Nature · doi:10.1038/41097 · Cited by 697 · see citing works
Self-citationSerotoninergic regulation of emotional and behavioural control processes
Cools, R., Roberts, A. C., & Robbins, T. W. (2008) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2007.10.011 · Cited by 656 · see citing works
Self-citationNeurochemical Modulation of Response Inhibition and Probabilistic Learning in Humans
Chamberlain, S. R., Müller, U., Blackwell, A. D., Clark, L., Robbins, T. W., & Sahakian, B. J. (2006) · Science · doi:10.1126/science.1121218 · Cited by 573 · see citing works
Self-citationEagle, D. M., Bari, A., & Robbins, T. W. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1127-6 · Cited by 548 · see citing works
Self-citationSerotonin in Affective Control
Dayan, P., & Huys, Q. J. M. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135607 · Cited by 381 · see citing works
Tryptophan Depletion During Continuous CSF Sampling in Healthy Human Subjects
Carpenter, L. L. (1998) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00198-x · Cited by 298 · see citing works
Rogers, R. D., Blackshaw, A. J., Middleton, H. C., Matthews, K., Hawtin, K., Crowley, C., Hopwood, A., Wallace, C., Deakin, J. F. W., Sahakian, B. J., et al. (1999) · Psychopharmacology · doi:10.1007/pl00005494 · Cited by 289 · see citing works
Self-citationBiggio, G., Fadda, F., Fanni, P., Tagliamonte, A., & Gessa, G. L. (1974) · Life Sciences · doi:10.1016/0024-3205(74)90440-8 · Cited by 265 · see citing works
The effects of tryptophan depletion on cognitive and affective processing in healthy volunteers
Murphy, F., Smith, K., Cowen, P., Robbins, T., & Sahakian, B. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1128-9 · Cited by 255 · see citing works
Self-citationA single dose of citalopram increases fear recognition in healthy subjects
Browning, M., Reid, C., Cowen, P. J., Goodwin, G. M., & Harmer, C. J. (2007) · Journal of Psychopharmacology · doi:10.1177/0269881106074062 · Cited by 245 · see citing works
5-Hydroxytryptamine and punishment
Tye, N. C., Everitt, B. J., & Iversen, S. D. (1977) · Nature · doi:10.1038/268741a0 · Cited by 232 · see citing works
On serotonin and experimental anxiety
Graeff, F. G. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1112-4 · Cited by 219 · see citing works
Bari, A., Eagle, D. M., Mar, A. C., Robinson, E. S. J., & Robbins, T. W. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1537-0 · Cited by 194 · see citing works
Self-citationGessa, G. L., Biggio, G., Fadda, F., Corsini, G. U., & Tagliamonte, A. (1974) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1974.tb04308.x · Cited by 191 · see citing works
Ávila, C. (2001) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.80.2.311 · Cited by 183 · see citing works
TRYPTAMINERGIC MECHANISMS IN PUNISHED AND NONPUNISHED BEHAVIOR
Graeff, F. G., & Schoenfeld, R. I. (1970) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)28566-4 · Cited by 181 · see citing works
Clark, L., Roiser, J. P., Cools, R., Rubinsztein, D. C., Sahakian, B. J., & Robbins, T. W. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0104-6 · Cited by 175 · see citing works
Self-citationCools, R., Robinson, O. J., & Sahakian, B. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301598 · Cited by 172 · see citing works
Rubia, K., Lee, F., Cleare, A. J., Tunstall, N., Fu, C. H. Y., Brammer, M., & McGuire, P. (2005) · Psychopharmacology · doi:10.1007/s00213-004-2116-z · Cited by 171 · see citing works
Moja, E. A., Cipolla, P., Castoldi, D., & Tofanetti, O. (1989) · Life Sciences · doi:10.1016/0024-3205(89)90497-9 · Cited by 156 · see citing works
Eagle, D. M., Lehmann, O., Theobald, D. E. H., Peña, Y., Zakaria, R., Ghosh, R., Dalley, J. W., & Robbins, T. W. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.202 · Cited by 155 · see citing works
Self-citationHarrison, A. A., Everitt, B. J., & Robbins, T. W. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(98)00117-x · Cited by 152 · see citing works
Self-citationLeMarquand, D. G., Benkelfat, C., Pihl, R. O., Palmour, R. M., & Young, S. N. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.11.1771 · Cited by 150 · see citing works
Cools, R., Blackwell, A. D., Clark, L., Menzies, L. A., Cox, S. M. L., & Robbins, T. W. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300704 · Cited by 145 · see citing works
Self-citationEvidence of -noradrenergic reward receptors and serotonergic punishment receptors in the rat brain.
Cd, W., Bd, B., & Stein, L. (1973) · PubMed · Cited by 142 · see citing works
The effects of benzodiazepines and serotonergic manipulations on punished responding
Tye, N. C. (1979) · Neuropharmacology · doi:10.1016/0028-3908(79)90036-4 · Cited by 136 · see citing works
Tryptophan Depletion, Executive Functions, and Disinhibition in Aggressive, Adolescent Males
LeMarquand, D. G., Pihl, R. O., Young, S. N., Tremblay, R. E., Séguin, J. R., Palmour, R. M., & Benkelfat, C. (1998) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00029-3 · Cited by 110 · see citing works
Thiébot, M.-H., Hamon, M., & Soubrié, P. (1982) · Neuroscience · doi:10.1016/0306-4522(82)90139-7 · Cited by 96 · see citing works
Stancampiano, R., Melis, F., Sarais, L., Cocco, S., Cugusi, C., & Fadda, F. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.272.3.r991 · Cited by 86 · see citing works
Mood congruent memory bias induced by tryptophan depletion
KLAASSEN, T., RIEDEL, W. J., DEUTZ, N. E. P., & VAN PRAAG, H. M. (2002) · Psychological Medicine · doi:10.1017/s003329170100438x · Cited by 85 · see citing works
Evers, E. A. T., van der Veen, F. M., van Deursen, J. A., Schmitt, J. A. J., Deutz, N. E. P., & Jolles, J. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0411-6 · Cited by 80 · see citing works
Inescapable shock activates serotonergic neurons in all raphe nuclei of rat
Takase, L. F., Nogueira, M. I., Baratta, M. V., Bland, S. T., Watkins, L. R., Maier, S. F., Fornal, C. A., & Jacobs, B. L. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.12.020 · Cited by 77 · see citing works
Evers, E. A. T., van der Veen, F. M., Jolles, J., Deutz, N. E. P., & Schmitt, J. A. J. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.03.026 · Cited by 71 · see citing works
Stevens, D. A., Fechter, L. D., & Resnick, O. (1969) · Life Sciences · doi:10.1016/0024-3205(69)90062-9 · Cited by 70 · see citing works
A physiological method to selectively decrease brain serotonin release
Fadda, F., Cocco, S., & Stancampiano, R. (2000) · Brain Research Protocols · doi:10.1016/s1385-299x(00)00016-7 · Cited by 64 · see citing works
Dekeyne, A., Brocco, M., Adhumeau-Auclair, A., Gobert, A., & Millan, M. J. (2000) · Psychopharmacology · doi:10.1007/s002130000449 · Cited by 62 · see citing works
Cervo, L., Mocaër, E., Bertaglia, A., & SAMANIN, R. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(99)00189-6 · Cited by 45 · see citing works
van der Stelt, H. M., Broersen, L. M., Olivier, B., & Westenberg, H. G. M. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1632-6 · Cited by 44 · see citing works
Effect of acute tryptophan depletion on noradrenaline and dopamine in the rat brain
Ardis, T., Cahir, M., Elliott, J., Bell, R., Reynolds, G. P., & Cooper, S. J. (2008) · Journal of Psychopharmacology · doi:10.1177/0269881108089597 · Cited by 41 · see citing works
Plasse, G., Meerkerk, D. T. J., Lieben, C. K. J., Blokland, A., & Feenstra, M. G. P. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0908-7 · Cited by 31 · see citing works
Fadda, F., Cocco, S., Rossetti, Z. L., et al. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00140-0 · Cited by 20 · see citing works
Delayed Effects of Nicotine on Timing Behavior in the Rat
Geller, I., DeMarco, A., & Seifter, J. (1960) · Science · doi:10.1126/science.131.3402.735 · Cited by 10 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- Cochran WG Cox GM Experimental designs 1957 Wiley New York, N.Y.
- Gray JA McNaughton N The neuropsychology of anxiety 2000 Oxford University Press Oxford, England
- Rubia K Lee F Cleare AJ Tunstall N Fu CH Brammer M McGuire P Tryptophan depletion reduces right inferior prefrontal activation during response inhibition in fast, event-related fMRI Psychopharmacology (Berl) 2005b 179 791 803 15887056
Cited by
Sorted by citations
Serotonin and brain function: a tale of two receptors
Carhart-Harris, R., & Nutt, D. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117725915 · Cited by 739 · see citing works
Gillan, C. M., Papmeyer, M., Morein-Zamir, S., Sahakian, B. J., Fineberg, N. A., Robbins, T. W., & de Wit, S. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.10071062 · Cited by 609 · see citing works
Self-citationSerotonin selectively influences moral judgment and behavior through effects on harm aversion
Crockett, M. J., Clark, L., Hauser, M. D., & Robbins, T. W. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009396107 · Cited by 526 · see citing works
Self-citationDopamine, serotonin and impulsivity
Dalley, J. W., & Roiser, J. P. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.03.065 · Cited by 501 · see citing works
Logue, S. F., & Gould, T. J. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.08.007 · Cited by 477 · see citing works
Serotonin and dopamine: unifying affective, activational, and decision functions.
Cools, R., Nakamura, K., & Daw, N. D. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.121 · Cited by 464 · see citing works
Dorsal raphe neurons signal reward through 5-HT and glutamate
Liu, Z., Zhou, J., Li, Y., Hu, F., Lu, Y., Ma, M., Feng, Q., Zhang, J.-E., Wang, D., Zeng, J., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.010 · Cited by 469 · see citing works
Opponency revisited: competition and cooperation between dopamine and serotonin
Boureau, Y.-L., & Dayan, P. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.151 · Cited by 456 · see citing works
Huys, Q. J. M., Eshel, N., O'Nions, E., Sheridan, L., Dayan, P., & Roiser, J. P. (2012) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002410 · Cited by 439 · see citing works
Serotonergic neurons signal reward and punishment on multiple timescales
Cohen, J. Y., Amoroso, M. W., & Uchida, N. (2015) · eLife · doi:10.7554/elife.06346 · Cited by 388 · see citing works
Neuroinflammation as a risk factor for attention deficit hyperactivity disorder
Dunn, G. A., Nigg, J. T., & Sullivan, E. L. (2019) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2019.05.005 · Cited by 299 · see citing works
The role of habit in compulsivity
Gillan, C. M., Robbins, T. W., Sahakian, B. J., van den Heuvel, O. A., & van Wingen, G. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.12.033 · Cited by 292 · see citing works
Self-citationAction versus valence in decision making
Guitart-Masip, M., Duzel, E., Dolan, R., & Dayan, P. (2014) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2014.01.003 · Cited by 270 · see citing works
Serotonin Selectively Modulates Reward Value in Human Decision-Making
Seymour, B., Daw, N. D., Roiser, J. P., Dayan, P., & Dolan, R. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.0053-12.2012 · Cited by 252 · see citing works
Depression: a decision-theoretic analysis
Huys, Q. J. M., Daw, N. D., & Dayan, P. (2015) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071714-033928 · Cited by 221 · see citing works
Guitart-Masip, M., Fuentemilla, L., Bach, D. R., Huys, Q. J. M., Dayan, P., Dolan, R. J., & Duzel, E. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.6376-10.2011 · Cited by 216 · see citing works
Twenty-Five Lessons from Computational Neuromodulation
Dayan, P. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.027 · Cited by 190 · see citing works
The role of serotonin in the regulation of patience and impulsivity
Miyazaki, K., Miyazaki, K. W., & Doya, K. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8232-6 · Cited by 162 · see citing works
Serotonin and decision making processes
Homberg, J. R. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.06.001 · Cited by 167 · see citing works
Crockett, M. J., Clark, L., Lieberman, M. D., Tabibnia, G., & Robbins, T. W. (2010) · Emotion · doi:10.1037/a0019861 · Cited by 159 · see citing works
Self-citationModeling Avoidance in Mood and Anxiety Disorders Using Reinforcement Learning
Mkrtchian, A., Aylward, J., Dayan, P., Roiser, J. P., & Robinson, O. J. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.01.017 · Cited by 151 · see citing works
Serotonin Modulates Striatal Responses to Fairness and Retaliation in Humans
Crockett, M. J., Apergis-Schoute, A., Herrmann, B., Lieberman, M. D., Müller, U., Robbins, T. W., & Clark, L. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.2761-12.2013 · Cited by 134 · see citing works
Self-citationThe neural underpinnings of cognitive flexibility and their disruption in psychotic illness
Waltz, J. A. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2016.06.005 · Cited by 122 · see citing works
Worbe, Y., Savulich, G., Voon, V., Fernandez-Egea, E., & Robbins, T. W. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.351 · Cited by 125 · see citing works
Self-citationIigaya, K., Fonseca, M. S., Murakami, M., Mainen, Z. F., & Dayan, P. (2018) · Nature Communications · doi:10.1038/s41467-018-04840-2 · Cited by 120 · see citing works
Skandali, N., Rowe, J. B., Voon, V., Deakin, J. B., Cardinal, R. N., Cormack, F., Passamonti, L., Bevan-Jones, W. R., Regenthal, R., Chamberlain, S. R., et al. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0229-z · Cited by 89 · see citing works
Self-citationRygula, R., Clarke, H. F., Cardinal, R. N., Cockcroft, G. J., Xia, J., Dalley, J. W., Robbins, T. W., & Roberts, A. C. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhu102 · Cited by 85 · see citing works
Self-citationHerzallah, M. M., Moustafa, A. A., Natsheh, J. Y., Abdellatif, S. M., Taha, M. B., Tayem, Y. I., Sehwail, M. A., Amleh, I., Petrides, G., Myers, C. E., et al. (2013) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2013.00067 · Cited by 77 · see citing works
Tryptophan depletion disinhibits punishment but not reward prediction: implications for resilience
Robinson, O. J., Cools, R., & Sahakian, B. J. (2012) · Psychopharmacology · doi:10.1007/s00213-011-2410-5 · Cited by 73 · see citing works
Robinson, O. J., Overstreet, C., Allen, P. S., Letkiewicz, A., Vytal, K., Pine, D. S., & Grillon, C. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.03.075 · Cited by 64 · see citing works
Palminteri, S., Clair, A.-H., Mallet, L., & Pessiglione, M. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.12.028 · Cited by 60 · see citing works
Serotonin Decreases the Gain of Visual Responses in Awake Macaque V1
Seillier, L., Lorenz, C., Kawaguchi, K., Ott, T., Nieder, A., Pourriahi, P., & Nienborg, H. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.1339-17.2017 · Cited by 57 · see citing works
Sex-dependent effects on tasks assessing reinforcement learning and interference inhibition
Evans, K. L., & Hampson, E. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.01044 · Cited by 52 · see citing works
Morein-Zamir, S., Papmeyer, M., Gillan, C. M., Crockett, M. J., Fineberg, N. A., Sahakian, B. J., & Robbins, T. W. (2013) · Psychological Medicine · doi:10.1017/s0033291712001018 · Cited by 43 · see citing works
Self-citationRobinson, O. J., Overstreet, C., Allen, P. S., Pine, D. S., & Grillon, C. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.43 · Cited by 35 · see citing works
Serotonin depletion impairs both Pavlovian and instrumental reversal learning in healthy humans
Kanen, J. W., Apergis-Schoute, A. M., Yellowlees, R., Arntz, F. E., van der Flier, F. E., Price, A., Cardinal, R. N., Christmas, D. M., Clark, L., Sahakian, B. J., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01240-9 · Cited by 34 · see citing works
Self-citationNota, J. A., Schubert, J. R., & Coles, M. E. (2016) · Journal of Behavior Therapy and Experimental Psychiatry · doi:10.1016/j.jbtep.2015.04.011 · Cited by 35 · see citing works
Fischer, A. G., Endrass, T., Reuter, M., Kubisch, C., & Ullsperger, M. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.5124-14.2015 · Cited by 29 · see citing works
A Role for Serotonin in Modulating Opposing Drive and Brake Circuits of Impulsivity
Desrochers, S. S., Spring, M. G., & Nautiyal, K. M. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.791749 · Cited by 29 · see citing works
Reitz, A. K., & Staudinger, U. M. (2017) · Personality Development Across the Lifespan · doi:10.1016/b978-0-12-804674-6.00014-4 · Cited by 17 · see citing works
- Authors
- Crockett, M. J., Clark, L., & Robbins, T. W.
- Affiliations
- University of Cambridge (GB)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2009-09-23
- Volume
- 29
- Issue
- 38
- Pages
- 11993-11999
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2775933
- OpenAlex
- W1989848448
- Cited by
- 271
- References
- 47
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 6 · 2023: 15 · 2022: 11 · 2021: 13 · 2020: 13 · 2019: 9 · 2018: 16 · 2017: 26 · 2016: 16 · 2015: 34 · 2014: 18 · 2013: 28 · 2012: 27
- FWCI
- 7.09
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Trust (076244/Z/04/Z, 076274/Z/04/Z)
- University of Cambridge
- Cambridge Trust
- Gates Cambridge Trust
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- serotonin, tryptophan depletion, behavioral inhibition, motor inhibition, response bias, motivation, aversive outcomes
- MeSH terms
- Adult, Analysis of Variance, Brain, Double-Blind Method, Female, Humans, Impulsive Behavior, Male, Motor Activity, Neuropsychological Tests, Psychomotor Performance, Punishment, Reaction Time, Serotonin, Task Performance and Analysis, Tryptophan
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
