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Cited by 128Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and Outcomes

Response inhibition and its relation to multidimensional impulsivity

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Wilbertz, Tilmann, Deserno, Lorenz, Horstmann, Annette, Neumann, Jane, Villringer, Arno, Heinze, Hans-Jochen, Boehler, Carsten N., Schlagenhauf, Florian·2014·NeuroImage
DOI 10.1016/j.neuroimage.2014.09.021
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Abstract

Impulsivity is a multidimensional construct that has been suggested as a vulnerability factor for several psychiatric disorders, especially addiction disorders. Poor response inhibition may constitute one facet of impulsivity. Trait impulsivity can be assessed by self-report questionnaires such as the widely used Barratt Impulsiveness Scale (BIS-11). However, regarding the multidimensionality of impulsivity different concepts have been proposed, in particular the UPPS self-report questionnaire ('Urgency', 'Lack of Premeditation', 'Lack of Perseverance', 'Sensation Seeking') that is based on a factor analytic approach. The question as to which aspects of trait impulsivity map on individual differences of the behavioral and neural correlates of response inhibition so far remains unclear. In the present study, we investigated 52 healthy individuals that scored either very high or low on the BIS-11 and underwent a reward-modulated Stop-signal task during fMRI. Neither behavioral nor neural differences were observed with respect to high- and low-BIS groups. In contrast, UPPS subdomain Urgency best explained inter-individual variability in SSRT scores and was further negatively correlated to right IFG/aI activation in 'Stop>Go' trials - a key region for response inhibition. Successful response inhibition in rewarded compared to nonrewarded stop trials yielded ventral striatal (VS) activation which might represent a feedback signal. Interestingly, only participants with low Urgency scores were able to use this VS feedback signal for better response inhibition. Our findings indicate that the relationship of impulsivity and response inhibition has to be treated carefully. We propose Urgency as an important subdomain that might be linked to response inhibition as well as to the use of reward-based neural signals. Based on the present results, further studies examining the influence of impulsivity on psychiatric disorders should take into account Urgency as an important modulator of behavioral adaptation.

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  53. Erklärung über die eigenständige Abfassung der Arbeit Hiermit erkläre ich, dass ich die vorliegende Arbeit selbstständig und ohne unzulässige Hilfe oder Benutzung anderer als der angegebenen Hilfsmittel angefertigt habe. Ich versichere, dass Dritte von mir weder unmittelbar noch mittelbar eine Vergütung oder geldwerte Leistungen für Arbeiten erhalten haben, die im Zusammenhang mit dem Inhalt der vorgelegten Dissertation stehen, und dass die vorgelegte Arbeit weder im Inland noch im Ausland in gleicher oder ähnlicher Form einer anderen Prüfungsbehörde zum Zweck einer Promotion oder eines anderen Prüfungsverfahrens vorgelegt wurde. Alles aus anderen Quellen und von anderen Personen übernommene Material, das in der Arbeit verwendet wurde oder auf das direkt Bezug genommen wird, wurde als solches kenntlich gemacht. Insbesondere wurden alle Personen genannt, die direkt an der Entstehung der vorliegenden Arbeit beteiligt waren. Die aktuellen gesetzlichen Vorgaben in Bezug auf die Zulassung der klinischen Studien, die Bestimmungen des Tierschutzgesetzes, die Bestimmungen des Gentechnikgesetzes und die allgemeinen Datenschutzbestimmungen wurden eingehalten. Ich versichere, dass ich die Regelungen der Satzung der Universität Leipzig zur Sicherung guter wissenschaftlicher Praxis kenne und eingehalten habe. .................................................... .................................................... Datum Unterschrift
  54. Publikationen und Poster Sjoerds, Z., Deserno, L., Reiter, A. M. F., Radenbach, C., Wilbertz, T., Golz, L., Heinze, H.-J., Schlagenhauf, F. (2017). S. 14.03 Goal-directed and habit-based decision making: computational modelling in alcohol dependence and related disorders. European Neuropsychopharmacology, 25, S132. doi:10.1016/S0924-977X(15)30074-2 · DOI

Authors
Wilbertz, T., Deserno, L., Horstmann, A., Neumann, J., Villringer, A., Heinze, H.-J., Boehler, C. N., & Schlagenhauf, F.
Affiliations
  • Max Planck Institute for Human Cognitive and Brain Sciences (DE)
  • University Hospital Leipzig (DE)
  • Humboldt-Universität zu Berlin (DE)
  • Ghent University (BE)
Corresponding author
Wilbertz, Tilmann
ORCID
Venue
NeuroImage
Publisher
Elsevier BV
Published
2014-12
Volume
103
Pages
241-248
ISSN
1053-8119 (ISSN-L)
DOI
10.1016/j.neuroimage.2014.09.021
OpenAlex
W1989476056
Cited by
128
References
54
Citations by year
2026: 8 · 2025: 6 · 2024: 13 · 2023: 8 · 2022: 7 · 2021: 5 · 2020: 15 · 2019: 14 · 2018: 14 · 2017: 15 · 2016: 14 · 2015: 9
FWCI
7.05
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • NeuroImage (publishedVersion)
  • PubMed (publishedVersion)
  • Ghent University Academic Bibliography (Ghent University) (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
  • Qucosa (Saxon State and University Library Dresden) (submittedVersion, other-oa)
Funders
  • German Research Foundation (DFG SCHL 1968/2-1, SCHL 1969/1-1, SCHL 1968/2-1)
  • German Federal Ministry of Education and Research (FKZ:01EO1001)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords
response inhibition, trait impulsivity, Barratt Impulsiveness Scale, ventral striatum, feedback signals, anterior insula, individual differences, addiction vulnerability
MeSH terms
Adult, Brain, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Impulsive Behavior, Inhibition, Psychological, Magnetic Resonance Imaging, Male, Reward

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