Étude des liens entre sommeil et mémoire épisodique chez le sujet jeune et âgé, et dans la maladie d’Alzheimer
Abstract
Introduction A large body of evidence indicates that sleep favors memory consolidation.State of the art This process would occur, mainly during slow-wave sleep, by means of a dialogue between the hippocampus and neocortical areas. Low levels of acetylcholine and cortisol are also needed to favor the transfer of memory traces toward the neocortex, where they will be stored for the long-term.Perspectives The aim of this article is, first, to give an overview of studies conducted in young healthy subjects and underpinning the hypothesis that sleep is involved in memory consolidation. Then, we will investigate the potential links between changes in sleep architecture and episodic memory impairment in both aging and Alzheimer's disease. Finally, we will see how these results can affect clinical practice.Conclusion Sleep-dependent memory consolidation is impaired both in aging and Alzheimer's disease. These findings suggest the importance of taking into account sleep when assessing memory function in patients.
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SD may exacerbate cognitive deficits in AD through impairment of sleep-dependent memory consolidation.
“SD may exacerbate cognitive deficits in AD through impairment of sleep-dependent memory consolidation [565, 566].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [565]
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- Authors
- Rauchs, G., Harand, C., Bertran, F., Desgranges, B., & Eustache, F.
- Affiliations
- Inserm (FR)
- Corresponding author
- Rauchs, G.
- Venue
- Revue Neurologique
- Publisher
- Elsevier BV
- Published
- 2010-11
- Volume
- 166
- Issue
- 11
- Pages
- 873-881
- ISSN
- 0035-3787 (ISSN-L)
- OpenAlex
- W1997275886
- Cited by
- 19
- References
- 56
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 1 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 0.07
- Type
- journal article
- Language
- fr
- Open access
- closed
- Locations
- Revue Neurologique (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- sleep, episodic memory, memory consolidation, Alzheimer's disease, aging, slow-wave sleep, acetylcholine, cortisol, sleep architecture, memory impairment
- MeSH terms
- Adult, Aged, Aging, Alzheimer Disease, Hippocampus, Humans, Memory Disorders, Mental Recall, Sleep, Sleep Wake Disorders, Neocortex
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