Selective removal of cholinergic neurons in the basal forebrain alters cued target detection
Abstract
A spatial orienting task was used to assess attention in rats with selective cholinergic lesions of the basal forebrain. The task required each rat to press a lever in response to a visual target that could occur in one of two locations. A target could be preceded by a cue that either accurately predicted the location of the target (valid) or appeared in the location opposite the target (invalid). Target detection was facilitated by valid cues and degraded by invalid cues in control rats. Performance of rats with lesions was equivalent to that of control rats for valid cues, but reflected an increased cost of invalid cueing. These data support a modulatory role for the basal forebrain cholinergic system in visuospatial attention.
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The conceptualization of cholinergic transients in terms of mediating attentional orienting is consistent with the finding that cholinergic lesions or systemic or local cortical blockade of mAChRs impair attentional orienting.
“The conceptualization of cholinergic transients in terms of mediating attentional orienting is consistent with the finding that cholinergic lesions or systemic or local cortical blockade of mAChRs impair attentional orienting (Davidson & Marrocco, 2000; Davidson et al, 1999; Chiba et al, 1999; Phillips et al, 2000).”
From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Chiba et al, 1999
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- Authors
- Chiba, A. A., Bushnell, P. J., Oshiro, W. M., & Gallagher, M.
- Affiliations
- University of California San Diego (US)
- Environmental Protection Agency (US)
- Johns Hopkins University (US)
- Venue
- NeuroReport
- Published
- 1999-09
- Volume
- 10
- Issue
- 14
- Pages
- 3119-3123
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W1973235837
- Cited by
- 83
- References
- 14
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 1 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 4 · 2015: 3 · 2014: 2 · 2013: 3 · 2012: 3
- FWCI
- 3.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1k05mh001149-01a1)
- National Institute on Aging (P01AG009973, P0-AG09973)
- National Institute of Mental Health (F32-MH1099, KO5-MH01149)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Keywords
- cholinergic neurons, basal forebrain, cholinergic lesions, visuospatial attention, spatial orienting, cue validity, acetylcholine, attentional modulation
- MeSH terms
- Animals, Attention, Choline O-Acetyltransferase, Conditioning, Operant, Cues, Discrimination Learning, Immunohistochemistry, Male, Neurons, Orientation, Parasympathetic Nervous System, Space Perception, Task Performance and Analysis, Prosencephalon, Rats, Long-Evans, Rats
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