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Cited by 165Neuroscience and Neuropharmacology ResearchNeuroscience and Music PerceptionHearing, Cochlea, Tinnitus, Genetics

Differential modulation of auditory thalamocortical and intracortical synaptic transmission by cholinergic agonist

Hsieh, Candace Y, Cruikshank, Scott J, Metherate, Raju·2000·Brain Research
DOI 10.1016/s0006-8993(00)02766-9
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Abstract

To investigate synaptic mechanisms underlying information processing in auditory cortex, we examined cholinergic modulation of synaptic transmission in a novel slice preparation containing thalamocortical and intracortical inputs to mouse auditory cortex. Extracellular and intracellular recordings were made in cortical layer IV while alternately stimulating thalamocortical afferents (via medial geniculate or downstream subcortical stimulation) and intracortical afferents. Either subcortical or intracortical stimulation elicited a fast, 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX)-sensitive, monosynaptic EPSP followed by long-duration, polysynaptic activity. The cholinergic agonist carbachol suppressed each of the synaptic potentials to different degrees. At low concentrations (5 microM) carbachol strongly reduced (>60%) the polysynaptic slow potentials for both pathways but did not affect the monosynaptic fast potentials. At higher doses (10-50 microM), carbachol also reduced the fast potentials, but reduced the intracortically-elicited fast potential significantly more than the thalamocortically-elicited fast potential, which at times was actually enhanced. Atropine (0.5 microM) blocked the effects of carbachol, indicating muscarinic receptor involvement. We conclude that muscarinic modulation can strongly suppress intracortical synaptic activity while exerting less suppression, or actually enhancing, thalamocortical inputs. Such differential actions imply that auditory information processing may favor sensory information relayed through the thalamus over ongoing cortical activity during periods of increased acetylcholine (ACh) release.

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  • Muscarinic acetylcholine receptors located on pyramidal cell axon terminals suppress cortico-cortical transmission.

    “In contrast, mAChRs located on pyramidal cell axon terminals suppress cortico-cortical transmission (Gil et al., 1997; Hsieh et al., 2000; Kimura and Baughman, 1997; Oldford and Castro-Alamancos, 2003).”

    From Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior (2012) · cites this paper as Hsieh et al., 2000

  • Stimulation of nAChRs enhances glutamatergic transmission at thalamocortical synapses, thereby enhancing thalamic activation of subsets of cortical neurons.

    “Previous studies have shown that stimulation of nAChRs enhances the glutamatergic transmission at thalamocortical synapses (Gil et al., 1997; Gioanni et al., 1999; Hsieh et al., 2000), thereby enhancing the thalamic activation of subsets of cortical neurons.”

    From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Hsieh et al., 2000

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Authors
Hsieh, C. Y., Cruikshank, S. J., & Metherate, R.
Affiliations
University of California, Irvine (US)
Corresponding author
Metherate, Raju
ORCID
Venue
Brain Research
Publisher
Elsevier BV
Published
2000-10
Volume
880
Issue
1-2
Pages
51-64
ISSN
0006-8993 (ISSN-L)
DOI
10.1016/s0006-8993(00)02766-9
OpenAlex
W2079075815
Cited by
165
References
77
Citations by year
2026: 1 · 2025: 4 · 2024: 2 · 2023: 5 · 2022: 5 · 2021: 6 · 2020: 7 · 2019: 12 · 2018: 12 · 2017: 4 · 2016: 6 · 2015: 8 · 2014: 4 · 2013: 7 · 2012: 10
FWCI
1.68
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Mental Health (MH 14599, T32MH014599)
  • National Institute on Deafness and Other Communication Disorders (DC 02967)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
  • Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
Keywords
cholinergic modulation, muscarinic receptors, auditory cortex, thalamocortical synapses, synaptic transmission, carbachol, atropine, medial geniculate body, monosynaptic EPSPs, acetylcholine, auditory processing
MeSH terms
Animals, Atropine, Auditory Cortex, Carbachol, Electric Stimulation, Evoked Potentials, Mice, Inbred Strains, Synaptic Transmission, Thalamus, 2-Amino-5-phosphonovalerate, Receptors, AMPA, Kainic Acid Receptors, Receptors, Kainic Acid, Patch-Clamp Techniques, Cholinergic Agonists, 6-Cyano-7-nitroquinoxaline-2,3-dione, Excitatory Postsynaptic Potentials, Mice, In Vitro Techniques

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