Dendritic spine geometry: functional implication and regulation
Open accessAbstract
Dendritic spines are tiny protrusions on dendritic shafts where most excitatory synapses are located. Recent advances in imaging technologies have given us great insight into the function of spines as biochemical compartments. Here we review recent evidence suggesting that the geometry of dendritic spines controls postsynaptic calcium signaling and is bidirectionally regulated during synaptic plasticity.
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Spine morphology is highly dynamic and inextricably linked to synaptic activity and strength.
“Spine morphology is highly dynamic and inextricably linked to synaptic activity and strength (Yuste and Bonhoeffer, 2001, Matsuzaki et al., 2004, Hayashi and Majewska, 2005, Bertling et al., 2016, Bertling and Hotulainen, 2017, Efimova et al., 2017, Pfeiffer et al., 2018).”
From Dendritic Spine Remodeling and Synaptic Tau Levels in PS19 Tauopathy Mice (2021) · cites this paper as Hayashi and Majewska, 2005
The sections on rapid structural plasticity and functional significance describe continual changes in spine morphology, activity-dependent changes in geometry, and a positive correlation between spine expansion and enhanced synaptic transmission. But the paper also says direct evidence connecting structural and functional plasticity is limited and that whether structural plasticity is necessary for functional plasticity remains an open question. “Inextricably linked” overstates that evidence. (LLM, conf=0.83)
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Cites
Structural basis of long-term potentiation in single dendritic spines
Matsuzaki, M., Honkura, N., Ellis-Davies, G. C. R., & Kasai, H. (2004) · Nature · doi:10.1038/nature02617 · Cited by 2,500 · see citing works
Matsuzaki, M., Ellis-Davies, G. C. R., Nemoto, T., Miyashita, Y., Iino, M., & Kasai, H. (2001) · Nature Neuroscience · doi:10.1038/nn736 · Cited by 1,563 · cited 1× · see citing works
“…to stimulate single, identified dendritic spines, Noguchi et al. confirm and extend previous findings showing that both AMPA *Correspondence: yhayashi@mit.edu; majewska@mit.edu (IAMPA) and NMDA (INMDA) currents scale linearly with spine head size (Matsuzaki et al., 2001; Noguchi et al., 2005).”
ResultLong-term dendritic spine stability in the adult cortex
Grutzendler, J., Kasthuri, N., & Gan, W.-B. (2002) · Nature · doi:10.1038/nature01276 · Cited by 1,198 · see citing works
Shrinkage of dendritic spines associated with long-term depression of hippocampal synapses
Zhou, Q., Homma, K. J., & Poo, M.-M. (2004) · Neuron · doi:10.1016/j.neuron.2004.11.011 · Cited by 1,025 · see citing works
Dendritic Spine Dynamics Are Regulated by Monocular Deprivation and Extracellular Matrix Degradation
Oray, S., Majewska, A., & Sur, M. (2004) · Neuron · doi:10.1016/j.neuron.2004.12.001 · Cited by 296 · see citing works
Self-citationLang, C., Barco, A., Zablow, L., Kandel, E. R., Siegelbaum, S. A., & Zakharenko, S. S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407581101 · Cited by 245 · see citing works
Calcium dynamics of spines depend on their dendritic location
Holthoff, K., Tsay, D., & Yuste, R. (2002) · Neuron · doi:10.1016/s0896-6273(02)00576-7 · Cited by 117 · see citing works
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Multi-electrode array technologies for neuroscience and cardiology
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The Postsynaptic Architecture of Excitatory Synapses: A More Quantitative View
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The Subspine Organization of Actin Fibers Regulates the Structure and Plasticity of Dendritic Spines
Honkura, N., Matsuzaki, M., Noguchi, J., Ellis-Davies, G. C. R., & Kasai, H. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.013 · Cited by 490 · see citing works
Structural plasticity of dendritic spines
Bosch, M., & Hayashi, Y. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.09.002 · Cited by 415 · see citing works
Self-citationThe postsynaptic density proteins Homer and Shank form a polymeric network structure
Hayashi, M. K., Tang, C., Verpelli, C., Narayanan, R., Stearns, M. H., Xu, R.-M., Li, H., Sala, C., & Hayashi, Y. (2009) · Cell · doi:10.1016/j.cell.2009.01.050 · Cited by 356 · see citing works
Self-citationStructural and synaptic plasticity in stress-related disorders
Christoffel, D. J., Golden, S. A., & Russo, S. J. (2011) · Reviews in the Neurosciences · doi:10.1515/rns.2011.044 · Cited by 334 · see citing works
Okamoto, K.-I., Narayanan, R., Lee, S. H., Murata, K., & Hayashi, Y. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701656104 · Cited by 328 · see citing works
Self-citationSpine Expansion and Stabilization Associated with Long-Term Potentiation
Yang, Y., Wang, X.-B., Frerking, M., & Zhou, Q. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3998-07.2008 · Cited by 222 · see citing works
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Dendritic Spines: Mediators of Cognitive Resilience in Aging and Alzheimer’s Disease
Walker, C. K., & Herskowitz, J. H. (2021) · The Neuroscientist · doi:10.1177/1073858420945964 · Cited by 86 · see citing works
A cellular mechanism for dendritic spine loss in the pilocarpine model of status epilepticus
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Dendritic Spine Remodeling and Synaptic Tau Levels in PS19 Tauopathy Mice
Walker, C. K., Greathouse, K. M., Boros, B. D., Poovey, E. H., Clearman, K. R., Ramdas, R., Muhammad, H. M., & Herskowitz, J. H. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2020.12.006 · Cited by 27 · see citing works
Cellular components of the human medial amygdaloid nucleus
Dall'Oglio, A., Xavier, L. L., Hilbig, A., Ferme, D., Moreira, J. E., Achaval, M., & Rasia‐Filho, A. A. (2013) · Journal of Comparative Neurology · doi:10.1002/cne.23192 · Cited by 24 · see citing works
“This field would benefit from further investigation of the identification and quantification of spine subtypes and whether they are formed and shaped by network activity (Kasai et al., 2003; Hayashi and Majewska, 2005; Bourne and Harris, 2007; Arellano et al., 2007; Segal, 2010).”
Background
- Authors
- Hayashi, Y., & Majewska, A. K.
- Affiliations
- Massachusetts Institute of Technology (US)
- Corresponding author
- Hayashi, Yasunori
- Majewska, Ania K.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2005-05
- Volume
- 46
- Issue
- 4
- Pages
- 529-532
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2063683201
- Cited by
- 237
- References
- 7
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 16 · 2023: 9 · 2022: 17 · 2021: 9 · 2020: 12 · 2019: 8 · 2018: 8 · 2017: 4 · 2016: 5 · 2015: 9 · 2014: 12 · 2013: 9 · 2012: 10
- FWCI
- 5.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2999 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- dendritic spines, spine geometry, synaptic plasticity, excitatory synapses
- MeSH terms
- Animals, Calcium, Models, Neurological, Neuronal Plasticity, Signal Transduction, Receptors, Glutamate, Dendritic Spines
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