Calcium dynamics of spines depend on their dendritic location
Open accessAbstract
Dendritic spines are morphologically and functionally heterogeneous. To understand this diversity, we use two-photon imaging of layer 5 neocortical pyramidal cells and measure action potential-evoked [Ca(2+)]i transients in spines. Spine calcium kinetics are controlled by (i) the diameter of the parent dendrite, (ii) the length of the spine neck, and (iii) the strength of spine calcium pumps. These factors produce different calcium dynamics in spines from basal, proximal apical, and distal apical dendrites, differences that are more pronounced without exogenous buffers. In proximal and distal apical dendrites, different calcium dynamics correlate with different susceptibility to synaptic depression, and modifying calcium kinetics in spines changes the expression of long-term depression. Thus, the spine location apparently determines its calcium dynamics and synaptic plasticity. Our results highlight the precision in design of neocortical neurons.
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Dendritic diameter is thought to be an important contributor to signal integration and transduction in dendrites.
“dendritic diameter is thought to be an important contributor to signal integration and transduction in dendrites (Sorra and Harris, 2000;Holthoff et al., 2002)”
From Dendritic Spine Abnormalities in Amyloid Precursor Protein Transgenic Mice Demonstrated by Gene Transfer and Intravital Multiphoton Microscopy (2005) · cites this paper as Holthoff et al., 2002
Long and thin necks prevent the diffusion of calcium, whereas shorter and thicker necks allow for better diffusional coupling with the dendrite.
“Nevertheless, morphology does play a role, as long and thin necks prevent the diffusion of calcium, whereas shorter and thicker necks allow for better diffusional coupling with the dendrite (Majewska et al., 2000; Holthoff et al., 2002; Sabatini et al., 2002; Korkotian et al., 2004; Noguchi et al., 2005).”
From Barriers in the brain: resolving dendritic spine morphology and compartmentalization (2014) · cites this paper as Holthoff et al., 2002
Cites
Regulation of Synaptic Efficacy by Coincidence of Postsynaptic APs and EPSPs
Markram, H., Lübke, J., Frotscher, M., & Sakmann, B. (1997) · Science · doi:10.1126/science.275.5297.213 · Cited by 3,832 · see citing works
Berg, H. C. (1984) · Princeton University Press eBooks · doi:10.1515/9780691279886 · Cited by 2,400 · see citing works
The Ionic Channels in Excitable Membranes
Keynes, R. D. (1975) · Novartis Foundation symposium · doi:10.1002/9780470720134.ch11 · Cited by 1,671 · see citing works
Range of Messenger Action of Calcium Ion and Inositol 1,4,5-Trisphosphate
Allbritton, N. L., Meyer, T., & Stryer, L. (1992) · Science · doi:10.1126/science.1465619 · Cited by 1,156 · see citing works
Intracellular injections of EGTA block induction of hippocampal long-term potentiation
Lynch, G., Larson, J., Kelso, S., Barrionuevo, G., & Schottler, F. (1983) · Nature · doi:10.1038/305719a0 · Cited by 1,116 · see citing works
Harris, K., & Stevens, J. (1989) · The Journal of Neuroscience · doi:10.1523/jneurosci.09-08-02982.1989 · Cited by 1,073 · see citing works
Harris, K., & Kater, S. (1994) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.17.030194.002013 · Cited by 1,032 · see citing works
Dendritic spines as basic functional units of neuronal integration
Yuste, R., & Denk, W. (1995) · Nature · doi:10.1038/375682a0 · Cited by 950 · see citing works
Self-citationRapid Actin-Based Plasticity in Dendritic Spines
Fischer, M., Kaech, S., Knutti, D., & Matus, A. (1998) · Neuron · doi:10.1016/s0896-6273(00)80467-5 · Cited by 905 · see citing works
Postsynaptic Calcium Is Sufficient for Potentiation of Hippocampal Synaptic Transmission
Malenka, R. C., Kauer, J. A., Zucker, R. S., & Nicoll, R. A. (1988) · Science · doi:10.1126/science.2845577 · Cited by 829 · see citing works
Cell Type and Pathway Dependence of Synaptic AMPA Receptor Number and Variability in the Hippocampus
Nusser, Z., Lujan, R., Laube, G., Roberts, J. D. B., Molnar, E., & Somogyi, P. (1998) · Neuron · doi:10.1016/s0896-6273(00)80565-6 · Cited by 804 · see citing works
Experience-dependent plasticity of dendritic spines in the developing rat barrel cortex in vivo
Lendvai, B., Stern, E. A., Chen, B., & Svoboda, K. (2000) · Nature · doi:10.1038/35009107 · Cited by 802 · see citing works
Calcium gradients and buffers in bovine chromaffin cells.
Neher, E., & Augustine, G. J. (1992) · The Journal of Physiology · doi:10.1113/jphysiol.1992.sp019127 · Cited by 753 · see citing works
The small pyramidal neuron of the rat cerebral cortex. The perikaryon, dendrites and spines
Peters, A., & Kaiserman‐Abramof, I. R. (1970) · American Journal of Anatomy · doi:10.1002/aja.1001270402 · Cited by 740 · see citing works
Ca2+ buffering and action potential-evoked Ca2+ signaling in dendrites of pyramidal neurons
Helmchen, F., Imoto, K., & Sakmann, B. (1996) · Biophysical Journal · doi:10.1016/s0006-3495(96)79653-4 · Cited by 559 · see citing works
Selective Induction of LTP and LTD by Postsynaptic [Ca<sup>2+</sup>]<sub>i</sub> Elevation
Yang, S.-N., Tang, Y.-G., & Zucker, R. S. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.81.2.781 · Cited by 534 · see citing works
Local calcium signalling by inositol-1,4,5-trisphosphate in Purkinje cell dendrites
Finch, E., & Augustine, G. J. (1998) · Nature · doi:10.1038/25541 · Cited by 512 · see citing works
Dendritic spines as individual neuronal compartments for synaptic Ca2+ responses
Müller, W. S., & Connor, J. A. (1991) · Nature · doi:10.1038/354073a0 · Cited by 479 · see citing works
Effects of rapid buffers on Ca2+ diffusion and Ca2+ oscillations
Wagner, J., & Keizer, J. (1994) · Biophysical Journal · doi:10.1016/s0006-3495(94)80500-4 · Cited by 479 · see citing works
Lisman, J. E. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.9.3055 · Cited by 475 · see citing works
Electron Microscopy of Synaptic Contacts on Dendrite Spines of the Cerebral Cortex
Gray, E. G. (1959) · Nature · doi:10.1038/1831592a0 · Cited by 443 · see citing works
Emptage, N. J., Bliss, T., & Fine, A. (1999) · Neuron · doi:10.1016/s0896-6273(00)80683-2 · Cited by 435 · see citing works
Developmental regulation of spine motility in the mammalian central nervous system
Dunaevsky, A., Tashiro, A., Majewska, A., Mason, C., & Yuste, R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13438 · Cited by 412 · see citing works
Self-citationA new class of synaptic response involving calcium release in dendritic spines
Takechi, H., Eilers, J., & Konnerth, A. (1998) · Nature · doi:10.1038/25547 · Cited by 404 · see citing works
Markram, H., Helm, P. J., & Sakmann, B. J. (1995) · The Journal of Physiology · doi:10.1113/jphysiol.1995.sp020708 · Cited by 387 · see citing works
Koch, C., & Zador, A. M. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-02-00413.1993 · Cited by 372 · see citing works
From form to function: calcium compartmentalization in dendritic spines
Yuste, R., Majewska, A. K., & Holthoff, K. (2000) · Nature Neuroscience · doi:10.1038/76609 · Cited by 370 · see citing works
Self-citationKoester, H. J., & Sakmann, B. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9596 · Cited by 338 · see citing works
Calcium dynamics associated with a single action potential in a CNS presynaptic terminal
Helmchen, F., Borst, J. G. G., & Sakmann, B. J. (1997) · Biophysical Journal · doi:10.1016/s0006-3495(97)78792-7 · Cited by 306 · see citing works
Miller, S. G., & Kennedy, M. B. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)39454-1 · Cited by 304 · see citing works
Yuste, R., Gutnick, M. J., Saar, D., Delaney, K. R., & Tank, D. W. (1994) · Neuron · doi:10.1016/0896-6273(94)90457-x · Cited by 294 · see citing works
Self-citationYuste, R., Majewska, A. K., Cash, S. S., & Denk, W. T. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-06-01976.1999 · Cited by 288 · see citing works
Self-citationEstructura de los centros nerviosos de las Aves
Ramon, Y., & Cajal, S. (1888) · Cited by 275 · see citing works
NMDA Receptor-Mediated Subthreshold Ca2+Signals in Spines of Hippocampal Neurons
Kovalchuk, Y., Eilers, J., Lisman, J. E., & Konnerth, A. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-05-01791.2000 · Cited by 270 · see citing works
Analysis of calcium channels in single spines using optical fluctuation analysis
Sabatini, B. L., & Svoboda, K. (2000) · Nature · doi:10.1038/35046076 · Cited by 269 · see citing works
Morphological variations in the dendritic spines of the neocortex
Jones, E. G., & Powell, T. P. S. (1969) · Journal of Cell Science · doi:10.1242/jcs.5.2.509 · Cited by 261 · see citing works
Lisman, J. E., & Goldring, M. A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5320 · Cited by 257 · see citing works
Majewska, A., Brown, E., Ross, J., & Yuste, R. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-05-01722.2000 · Cited by 248 · see citing works
Self-citationThe dendritic spine: a multifunctional integrative unit
Shepherd, G. M. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.75.6.2197 · Cited by 221 · see citing works
Quantitative fine-structural analysis of olfactory cortical synapses
Schikorski, T., & Stevens, C. F. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.4107 · Cited by 204 · see citing works
Regulation of Spine Calcium Dynamics by Rapid Spine Motility
Majewska, A. K., Tashiro, A., & Yuste, R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-22-08262.2000 · Cited by 201 · see citing works
Self-citationA quantitative analysis of presynaptic calcium dynamics that contribute to short-term enhancement
Tank, D. W., Regehr, W. G., & Delaney, K. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-12-07940.1995 · Cited by 197 · see citing works
A custom-made two-photon microscope and deconvolution system
Majewska, A. K., Yiu, G. C., & Yuste, R. (2000) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s004240000435 · Cited by 165 · see citing works
Self-citationSupralinear Ca2+ Signaling by Cooperative and Mobile Ca2+ Buffering in Purkinje Neurons
Maeda, H., Ellis‐Davies, G. C. R., Ito, K., Miyashita, Y., & Kasai, H. (1999) · Neuron · doi:10.1016/s0896-6273(00)81045-4 · Cited by 126 · see citing works
Wickens, J. R. (1988) · Progress in Neurobiology · doi:10.1016/0301-0082(88)90013-5 · Cited by 112 · see citing works
Fast confocal imaging of calcium released from stores in dendritic spines
Korkotian, E., & Segal, M. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00219.x · Cited by 97 · see citing works
Conchello, J.-A. (1998) · Journal of the Optical Society of America A · doi:10.1364/josaa.15.002609 · Cited by 93 · see citing works
Murthy, V. N., Sejnowski, T. J., & Stevens, C. F. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.2.901 · Cited by 70 · see citing works
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1 of the 49 references couldn’t be matched to a known paper.
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Dendritic Excitability and Synaptic Plasticity
Sjöström, P. J., Rancz, E. A., Roth, A., & Häusser, M. (2008) · Physiological Reviews · doi:10.1152/physrev.00016.2007 · Cited by 721 · see citing works
Rodriguez, A., Ehlenberger, D. B., Dickstein, D. L., Hof, P. R., & Wearne, S. L. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001997 · Cited by 563 · see citing works
Spires, T. L., Meyer-Luehmann, M., Stern, E. A., McLean, P. J., Skoch, J., Nguyen, P. T., Bacskai, B. J., & Hyman, B. T. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1879-05.2005 · Cited by 550 · see citing works
“Insofar as dendritic diameter is thought to be an important contributor to signal integration and transduction in dendrites (Sorra and Harris, 2000; Holthoff et al., 2002), dendritic tortuosity is thought to alter temporal integration of convergent afferents (Knowles et al., 1999), and dendritic…”
BackgroundSpine-Neck Geometry Determines NMDA Receptor-Dependent Ca2+ Signaling in Dendrites
Noguchi, J., Matsuzaki, M., Ellis-Davies, G. C. R., & Kasai, H. (2005) · Neuron · doi:10.1016/j.neuron.2005.03.015 · Cited by 419 · see citing works
Bonhoeffer, T., & Yuste, R. (2002) · Neuron · doi:10.1016/s0896-6273(02)00906-6 · Cited by 337 · see citing works
Self-citationDendritic spines and distributed circuits
Yuste, R. (2011) · Neuron · doi:10.1016/j.neuron.2011.07.024 · Cited by 298 · see citing works
Self-citationAnomalous Diffusion in Purkinje Cell Dendrites Caused by Spines
Santamaria, F., Wils, S., De Schutter, E., & Augustine, G. J. (2006) · Neuron · doi:10.1016/j.neuron.2006.10.025 · Cited by 279 · see citing works
Optical induction of synaptic plasticity using a light-sensitive channel
Zhang, Y., & Oertner, T. G. (2006) · Nature Methods · doi:10.1038/nmeth988 · Cited by 238 · see citing works
Dendritic spine geometry: functional implication and regulation
Hayashi, Y., & Majewska, A. K. (2005) · Neuron · doi:10.1016/j.neuron.2005.05.006 · Cited by 237 · see citing works
Chronic cellular imaging of mouse visual cortex during operant behavior and passive viewing
Andermann, M. L. (2010) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2010.00003 · Cited by 217 · see citing works
Spike timing, calcium signals and synaptic plasticity
Sjöström, P. (2002) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(02)00325-2 · Cited by 231 · see citing works
Calcium Time Course as a Signal for Spike-Timing–Dependent Plasticity
Rubin, J. E., Gerkin, R. C., Bi, G., & Chow, C. C. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00803.2004 · Cited by 184 · see citing works
Imaging membrane potential in dendritic spines
Nuriya, M., Jiang, J., Nemet, B. A., Eisenthal, K. B., & Yuste, R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510092103 · Cited by 182 · see citing works
Self-citationElectrical compartmentalization in dendritic spines
Yuste, R. (2013) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062111-150455 · Cited by 180 · see citing works
Self-citationSchmidt, H., Stiefel, K. M., Račay, P., Schwaller, B., & Eilers, J. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.035824 · Cited by 168 · see citing works
Calcium regulation of actin dynamics in dendritic spines
Oertner, T. G., & Matus, A. I. (2005) · Cell Calcium · doi:10.1016/j.ceca.2005.01.016 · Cited by 159 · see citing works
Dendritic Spine Heterogeneity Determines Afferent-Specific Hebbian Plasticity in the Amygdala
Humeau, Y., Herry, C., Kemp, N., Shaban, H., Fourcaudot, E., Bissière, S., & Lüthi, A. (2005) · Neuron · doi:10.1016/j.neuron.2004.12.019 · Cited by 148 · see citing works
Dendritic spines linearize the summation of excitatory potentials
Araya, R., Eisenthal, K. B., & Yuste, R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609225103 · Cited by 141 · see citing works
Self-citationDensity and morphology of dendritic spines in mouse neocortex.
Ballesteros-Yáñez, I., Benavides-Piccione, R., Elston, G. N., Yuste, R., & DeFelipe, J. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.11.038 · Cited by 143 · see citing works
Self-citationNew developments in multiphoton microscopy
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A Morphological Correlate of Synaptic Scaling in Visual Cortex
Wallace, W., & Bear, M. F. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1110-04.2004 · Cited by 139 · see citing works
Mechanisms Underlying the Rules for Associative Plasticity at Adult Human Neocortical Synapses
Verhoog, M. B., Goriounova, N. A., Obermayer, J., Stroeder, J., Hjorth, J. J. J., Testa-Silva, G., Baayen, J. C., de Kock, C. P. J., Meredith, R. M., & Mansvelder, H. D. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3158-13.2013 · Cited by 127 · see citing works
Maiti, P., Manna, J., Ilavazhagan, G., Rossignol, J., & Dunbar, G. L. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.09.020 · Cited by 118 · see citing works
Tan, A. M., Stamboulian, S., Chang, Y.-W., Zhao, P., Hains, A. B., Waxman, S. G., & Hains, B. C. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3142-08.2008 · Cited by 122 · see citing works
Convergent CaMK and RacGEF signals control dendritic structure and function
Penzes, P., Cahill, M. E., Jones, K. A., & Srivastava, D. P. (2008) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.07.002 · Cited by 118 · see citing works
Jackson, M. B., & Redman, S. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-05-01612.2003 · Cited by 116 · see citing works
Abel, H. J., Lee, J. C. F., Callaway, J. C., & Foehring, R. C. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00583.2003 · Cited by 110 · see citing works
Luebke, J. I., Weaver, C. M., Rocher, A. B., Rodriguez, A., Crimins, J. L., Dickstein, D. L., Wearne, S. L., & Hof, P. R. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0244-2 · Cited by 113 · see citing works
Three functional facets of calbindin D-28k
Schmidt, H. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00025 · Cited by 107 · see citing works
Low-Threshold Ca 2+ Current Amplifies Distal Dendritic Signaling in Thalamic Reticular Neurons
Crandall, S. R., Govindaiah, G., & Cox, C. L. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3636-10.2010 · Cited by 103 · see citing works
On the electrical function of dendritic spines
Tsay, D., & Yuste, R. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.11.008 · Cited by 103 · see citing works
Self-citationFactors critical for the plasticity of dendritic spines and memory storage
Matsuzaki, M. (2006) · Neuroscience Research · doi:10.1016/j.neures.2006.09.017 · Cited by 99 · see citing works
Facilitation of L-Type Ca2+Channels in Dendritic Spines by Activation of β2Adrenergic Receptors
Hoogland, T. M., & Saggau, P. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1677-04.2004 · Cited by 102 · see citing works
Calmodulin Activation by Calcium Transients in the Postsynaptic Density of Dendritic Spines
Keller, D. X., Franks, K. M., Bartol, T. M., & B, T. J. S. A. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002045 · Cited by 94 · see citing works
Spinal cord injury, dendritic spine remodeling, and spinal memory mechanisms
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Tan, A. M., Chang, Y.-W., Zhao, P., Hains, B. C., & Waxman, S. G. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.08.028 · Cited by 82 · see citing works
Neural anatomy and optical microscopy (NAOMi) simulation for evaluating calcium imaging methods
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Ca2+Dynamics along Identified Synaptic Terminals inDrosophilaLarvae
Lnenicka, G. A., Grizzaffi, J., Lee, B., & Rumpal, N. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2665-06.2006 · Cited by 73 · see citing works
Rózsa, B. J., Zelles, T., Vizi, E. S., & Lendvai, B. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3906-03.2004 · Cited by 72 · see citing works
Dendritic signalling and homeostatic adaptation
Yu, L. M. Y., & Goda, Y. (2009) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.07.002 · Cited by 70 · see citing works
Gao, W., & Zheng, Z. (2004) · The Journal of Comparative Neurology · doi:10.1002/cne.20224 · Cited by 70 · see citing works
Distinct synaptic plasticity rules operate across dendritic compartments in vivo during learning
Wright, W. J., Hedrick, N. G., & Komiyama, T. (2025) · Science · doi:10.1126/science.ads4706 · Cited by 69 · see citing works
Konur, S., & Yuste, R. (2004) · Journal of Neurobiology · doi:10.1002/neu.10306 · Cited by 65 · see citing works
Self-citationChristie, J. M., & Westbrook, G. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00997.2002 · Cited by 65 · see citing works
Application of multiline two-photon microscopy to functional in vivo imaging
Kurtz, R., Fricke, M., Kalb, J., Tinnefeld, P., & Sauer, M. (2006) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2005.12.003 · Cited by 63 · see citing works
Barriers in the brain: resolving dendritic spine morphology and compartmentalization
Adrian, M., Kusters, R., Wierenga, C. J., Storm, C., Hoogenraad, C. C., & Kapitein, L. C. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00142 · Cited by 62 · see citing works
“…morphology does play a role, as long and thin necks prevent the diffusion of calcium, whereas shorter and thicker necks allow for better diffusional coupling with the dendrite (Majewska et al., 2000; Holthoff et al., 2002; Sabatini et al., 2002; Korkotian et al., 2004; Noguchi et al., 2005).”
Badoual, M., Zou, Q., Davison, A. P., Rudolph, M., Bal, T., Frégnac, Y., & Alain Destexhe, A. (2006) · International Journal of Neural Systems · doi:10.1142/s0129065706000524 · Cited by 60 · see citing works
Cornelisse, L. N., van Elburg, R. A. J., Meredith, R. M., Yuste, R., & Mansvelder, H. D. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001073 · Cited by 57 · see citing works
Self-citationA unified computational model for cortical post-synaptic plasticity
Mäki‐Marttunen, T., Iannella, N. L., Edwards, A. G., Einevoll, G. T., & Blackwell, K. T. (2020) · eLife · doi:10.7554/elife.55714 · Cited by 55 · see citing works
Schmidt, H., & Eilers, J. (2009) · Journal of Computational Neuroscience · doi:10.1007/s10827-009-0139-5 · Cited by 53 · see citing works
Hernjak, N., Slepchenko, B. M., Fernald, K., Fink, C. C., Fortin, D. A., Moraru, I. I., Watras, J. M., & Loew, L. M. (2005) · Biophysical Journal · doi:10.1529/biophysj.105.065771 · Cited by 52 · see citing works
Postsynaptic Signal Transduction Models for Long-Term Potentiation and Depression
Manninen, T., Hituri, K., Kotaleski, J. H., Blackwell, K. T., & Linne, M. (2010) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2010.00152 · Cited by 50 · see citing works
Spine motility: a means towards an end?
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Sekerková, G., Loomis, P. A., Changyaleket, B., Zheng, L., Eytan, R. I., Chen, B., Mugnaini, E., & Bartles, J. R. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-04-01310.2003 · Cited by 48 · see citing works
Dynamic Multiphoton Imaging: A Live View from Cells to Systems
Stutzmann, G. E., & Parker, I. (2005) · Physiology · doi:10.1152/physiol.00028.2004 · Cited by 47 · see citing works
Spino‐dendritic cross‐talk in rodent Purkinje neurons mediated by endogenous Ca2+‐binding proteins
Schmidt, H., Kunerth, S., Wilms, C. D., Strotmann, R., & Eilers, J. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.127860 · Cited by 47 · see citing works
Rusakov, D. A., Saitow, F., Lehre, K. P., & Konishi, S. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0338-05.2005 · Cited by 47 · see citing works
Dendritic spine dysgenesis in superficial dorsal horn sensory neurons after spinal cord injury
Cao, X., Pappalardo, L. W., Waxman, S. G., & Tan, A. M. (2017) · Molecular Pain · doi:10.1177/1744806916688016 · Cited by 42 · see citing works
Calcium dynamics at developing synapses: mechanisms and functions
Michaelsen, K., & Löhmann, C. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07341.x · Cited by 39 · see citing works
Neural coding: computational and biophysical perspectives
Kreiman, G. (2004) · Physics of Life Reviews · doi:10.1016/j.plrev.2004.06.001 · Cited by 37 · see citing works
Role of Dendritic Spines in Action Potential Backpropagation: A Numerical Simulation Study
Tsay, D., & Yuste, R. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00781.2001 · Cited by 37 · see citing works
Self-citationAnwar, H., Roome, C. J., Nedelescu, H., Chen, W., Kühn, B., & Schutter, E. D. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00168 · Cited by 34 · see citing works
Local signaling with molecular diffusion as a decoder of Ca2+ signals in synaptic plasticity
Naoki, H., Sakumura, Y., & Ishii, S. (2005) · Molecular Systems Biology · doi:10.1038/msb4100035 · Cited by 32 · see citing works
Molecular Regulation of Dendritic Spine Shape and Function
Sala, C. (2002) · Neurosignals · doi:10.1159/000065433 · Cited by 32 · see citing works
Multiphoton microscopy: An introduction to gastroenterologists
Cho, H. J. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i40.4456 · Cited by 28 · see citing works
Schmidt, H., Stiefel, K. M., Račay, P., Schwaller, B., & Eilers, J. (2003) · The Journal of Physiology · doi:10.1111/j.1469-7793.2003.00013.x · Cited by 27 · see citing works
Dendritic spine morphology regulates calcium-dependent synaptic weight change
Bell, M. K., Holst, M., Lee, C. T., & Rangamani, P. (2022) · The Journal of General Physiology · doi:10.1085/jgp.202112980 · Cited by 24 · see citing works
Role of presenilin1 in structural plasticity of cortical dendritic spines in vivo
Jung, C. K. E., Fuhrmann, M., Honarnejad, K., Leuven, F. V., & Herms, J. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07503.x · Cited by 19 · see citing works
Otsu, Y., & Murphy, T. H. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2060-04.2004 · Cited by 21 · see citing works
Spinal cord motor neuron plasticity accompanies second‐degree burn injury and chronic pain
Patwa, S., Benson, C. A., Dyer, L., Olson, K., Bangalore, L., Hill, M., Waxman, S. G., & Tan, A. M. (2019) · Physiological Reports · doi:10.14814/phy2.14288 · Cited by 20 · see citing works
Integration of multiscale dendritic spine structure and function data into systems biology models
Mancuso, J. J., Cheng, J., Yin, Z., Gilliam, J. C., Xia, X., Li, X., & Wong, S. T. C. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00130 · Cited by 18 · see citing works
Raising the speed limit – fast Ca2+ handling in dendritic spines
Helmchen, F. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02232-4 · Cited by 18 · see citing works
Saftenku, E. É. (2011) · The Cerebellum · doi:10.1007/s12311-011-0263-4 · Cited by 17 · see citing works
Verhoog, M. B., & Mansvelder, H. D. (2011) · Neural Plasticity · doi:10.1155/2011/870763 · Cited by 16 · see citing works
Separate Ca2+Sources Are Buffered by Distinct Ca2+Handling Systems inAplysiaNeuroendocrine Cells
Groten, C. J., Rebane, J. T., Blohm, G., & Magoski, N. S. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.6384-11.2013 · Cited by 16 · see citing works
Can the human brain do quantum computing?
da Rocha, A. F., Massad, E., & Coutinho, F. A. B. (2004) · Medical Hypotheses · doi:10.1016/j.mehy.2004.03.044 · Cited by 16 · see citing works
Perceptual Information Integration: Hypothetical Role of Astrocytes
Pereira, A. (2011) · Cognitive Computation · doi:10.1007/s12559-011-9120-5 · Cited by 16 · see citing works
Gilbert, M. T., & Soderstrom, K. (2011) · Brain Research · doi:10.1016/j.brainres.2011.06.019 · Cited by 13 · see citing works
Biophysical Modeling of Synaptic Plasticity
Lee, C. T., Bell, M. K., Bonilla-Quintana, M., & Rangamani, P. (2024) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-072123-124954 · Cited by 12 · see citing works
Dendritic spine heterogeneity and calcium dynamics in basolateral amygdala principal neurons
Power, J., & Sah, P. (2014) · Journal of Neurophysiology · doi:10.1152/jn.00770.2013 · Cited by 11 · see citing works
Calcium dynamics in dendritic spines: A link to structural plasticity
Dur-e-Ahmad, M., Imran, M., & Gul, A. (2011) · Mathematical Biosciences · doi:10.1016/j.mbs.2011.01.002 · Cited by 10 · see citing works
Saftenku, E. É. (2008) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2008.12.002 · Cited by 10 · see citing works
Saftenku, E. É., & Friel, D. D. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-2888-2_26 · Cited by 9 · see citing works
A model of activity-dependent changes in dendritic spine density and spine structure
Crook, S. M., Dur-e-Ahmad, M., & Baer, S. M. (2007) · Mathematical Biosciences & Engineering · doi:10.3934/mbe.2007.4.617 · Cited by 9 · see citing works
Konsolaki, E., & Skaliora, I. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhu019 · Cited by 9 · see citing works
Principles for Dendritic Spine Size and Density in Human and Mouse Cortical Pyramidal Neurons
Benavides‐Piccione, R., Fernaud-Espinosa, I., Kastanauskaite, A., & DeFelipe, J. (2025) · The Journal of Comparative Neurology · doi:10.1002/cne.70060 · Cited by 9 · see citing works
Schmidt, H., Arendt, O., & Eilers, J. (2011) · The Cerebellum · doi:10.1007/s12311-010-0246-x · Cited by 8 · see citing works
Multiphoton fluorescence recovery after photobleaching in bounded systems
Sullivan, K. D., & Brown, E. B. (2011) · Physical Review E · doi:10.1103/physreve.83.051916 · Cited by 8 · see citing works
Kurtz, R. (2004) · Journal of Neurophysiology · doi:10.1152/jn.01058.2003 · Cited by 8 · see citing works
Warling, A., Uchida, R., Shin, H., Dodelson, C., Garcia, M. E., Shea‐Shumsky, N. B., Svirsky, S. E., Pothast, M. J., Kelley, H., Schumann, C. M., et al. (2020) · The Journal of Comparative Neurology · doi:10.1002/cne.25022 · Cited by 6 · see citing works
Krieger, P., de Kock, C. P. J., & Frick, A. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00194 · Cited by 7 · see citing works
Classical-quantum interfaces in living neural tissue supporting conscious functions
(2020) · Advances in Quantum Chemistry · doi:10.1016/bs.aiq.2020.08.002 · Cited by 6 · see citing works
Krieger, P. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06977.x · Cited by 6 · see citing works
Priel, A., Dai, X., Chen, X., Scarinci, N., Cantero, M. D. R., & Cantiello, H. F. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.769725 · Cited by 6 · see citing works
All-optical mapping of Ca2+ transport and homeostasis in dendrites
Hayward, R. F., & Cohen, A. E. (2024) · Cell Calcium · doi:10.1016/j.ceca.2024.102983 · Cited by 5 · see citing works
Distribution of spine classes shows intra-neuronal dendritic heterogeneity in mouse cortex
Theobald, C. C., Lotfinia, A., Knobloch, J. A., Medlej, Y., Stevens, D. R., & Lauterbach, M. A. (2024) · Neurophotonics · doi:10.1117/1.nph.12.1.015001 · Cited by 4 · see citing works
Spatial profile of back-propagating action potential-evoked Ca2+ transients in basal dendrites
Cho, K., Kim, M.-J., Yoon, S. H., Hahn, S. J., Jo, Y., Kim, M.-S., & Rhie, D. (2006) · Neuroreport · doi:10.1097/01.wnr.0000198949.85197.ac · Cited by 4 · see citing works
A model of activity-dependent changes in dendritic spine density and spine structure
Dur-e-Ahmad, M., Crook, S. M., & Baer, S. (2007) · BMC Neuroscience · doi:10.1186/1471-2202-8-s2-p91 · Cited by 4 · see citing works
STED microscopy reveals dendrite-specificity of spines in turtle cortex
Knobloch, J. A., Laurent, G., & Lauterbach, M. A. (2023) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2023.102541 · Cited by 2 · see citing works
Monitoring Intracellular Ca2+ in Brain Slices with Fluorescent Indicators
Mulligan, S. J., & MacVicar, B. A. (2007) · Springer eBooks · doi:10.1007/0-387-27526-6_2 · Cited by 2 · see citing works
- Authors
- Holthoff, K., Tsay, D., & Yuste, R.
- Affiliations
- Columbia University (US)
- Corresponding author
- Holthoff, Knut
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2002-01
- Volume
- 33
- Issue
- 3
- Pages
- 425-437
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1979356066
- Cited by
- 117
- References
- 49
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 1 · 2017: 2 · 2015: 2 · 2014: 5 · 2013: 4 · 2012: 2
- FWCI
- 4.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Eye Institute (EY-11787, R01EY013237, EY 13237, R01EY011787)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Keywords
- dendritic spines, calcium dynamics, calcium transients, calcium pump, synaptic depression, long-term depression, synaptic plasticity, layer 5 pyramidal neurons, neocortex, calcium buffering
- MeSH terms
- Animals, Calcium, Dendrites, Fluorescent Dyes, Mathematics, Models, Biological, Models, Neurological, Neuronal Plasticity, Statistics as Topic, Visual Cortex, Pyramidal Cells, Patch-Clamp Techniques, Microscopy, Confocal, Mice, In Vitro Techniques
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