The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Signaling Mechanisms Underlying Slit2-Induced Collapse of Xenopus Retinal Growth Cones
Open accessAbstract
Summary Slits mediate multiple axon guidance decisions, but the mechanisms underlying the responses of growth cones to these cues remain poorly defined. We show here that collapse induced by Slit2-conditioned medium (Slit2-CM) in Xenopus retinal growth cones requires local protein synthesis (PS) and endocytosis. Slit2-CM elicits rapid activation of translation regulators and MAP kinases in growth cones, and inhibition of MAPKs or disruption of heparan sulfate blocks Slit2-CM-induced PS and repulsion. Interestingly, Slit2-CM causes a fast PS-dependent decrease in cytoskeletal F-actin concomitant with a PS-dependent increase in the actin-depolymerizing protein cofilin. Our findings reveal an unexpected link between Slit2 and cofilin in growth cones and suggest that local translation of actin regulatory proteins contributes to repulsion.
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Cites
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Cited by
Mechanosensing is critical for axon growth in the developing brain
Koser, D. E., Thompson, A. J., Foster, S. K., Dwivedy, A., Pillai, E. K., Sheridan, G. K., Svoboda, H., Viana, M., Costa, L. D. F., Guck, J., et al. (2016) · Nature Neuroscience · doi:10.1038/nn.4394 · Cited by 649
Self-citationThe Growth Cone Cytoskeleton in Axon Outgrowth and Guidance
Dent, E. W., Gupton, S. L., & Gertler, F. B. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001800 · Cited by 649
The Central Dogma Decentralized: New Perspectives on RNA Function and Local Translation in Neurons
Holt, C. E., & Schuman, E. M. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.036 · Cited by 525
Self-citationExtracellular Matrix: Functions in the Nervous System
Barros, C. S., Franco, S. J., & Muller, U. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005108 · Cited by 506
Asymmetrical β-actin mRNA translation in growth cones mediates attractive turning to netrin-1
Leung, K.-M., van Horck, F. P., Lin, A. C., Allison, R., Standart, N., & Holt, C. E. (2006) · Nature Neuroscience · doi:10.1038/nn1775 · Cited by 478
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Metadata
- Authors
- Piper, M., Anderson, R., Dwivedy, A., Weinl, C., van Horck, F., Leung, K. M., Cogill, E., & Holt, C.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2006-01
- Volume
- 49
- Issue
- 2
- Pages
- 215-228
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2047112279
- Cited by
- 272
- References
- 65
- FWCI
- 7.75
- Type
- journal article
- Language
- en
- Open access
- bronze
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