Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model
Yoshiyama, Yasumasa, Higuchi, Makoto, Zhang, Bin, Huang, Shu-Ming, Iwata, Nobuhisa, Saido, Takaomi C., Maeda, Jun, Suhara, Tetsuya +2 more·2007·Neuron
Cited by (1,029)
Items 901–1,000 of 1,029
- Wolframin is a novel regulator of tau pathology and neurodegenerationShuo Chen, Diana M. Acosta, Liangping Li, Jiawen Liang, Yuzhou Chang, Cankun Wang, Julie Fitzgerald, Cody T. Morrison, Chris N. Goulbourne, Yoshi Nakano et al. · 2022 · Acta Neuropathologica
- Immunotherapeutic approaches for Alzheimer’s disease in transgenic mouse modelsThomas Wısnıewskı, Allal Boutajangout · 2009 · Brain Structure and Function
- The Effects of SIRT1 on Alzheimer's Disease ModelsGizem Dönmez · 2012 · International Journal of Alzheimer s Disease
- Lung endothelium, tau, and amyloids in health and diseaseRon Balczon, Mike T. Lin, Sarah B. Voth, Amy R. Nelson, Jonas C. Schupp, Brant M. Wagener, Jean‐François Pittet, Troy Stevens · 2023 · Physiological Reviews
- Moderate Environmental Enrichment Mitigates Tauopathy in a Neurofibrillary Tangle Mouse ModelInbal Lahiani-Cohen, Athanasios I. Lourbopoulos, Ester Haber, Lea Rozenstein‐Tsalkovich, Oded Abramsky, Nikolaos Grigoriadis, Hanna Rosenmann · 2011 · Journal of Neuropathology & Experimental Neurology
- Neurophysiological assessment of neural network plasticity and connectivity: Progress towards early functional biomarkers for disease interception therapies in Alzheimer’s diseaseCallum Walsh, Wilhelmus H. I. M. Drinkenburg, Abdallah Ahnaou · 2016 · Neuroscience & Biobehavioral Reviews
- Early intervention of tau pathology prevents behavioral changes in the rTg4510 mouse model of tauopathyXiaohai Wang, Karen D.B. Smith, Michelle S. Pearson, Anna C. Hughes, Mali L. Cosden, Jacob Marcus, J. Fred Hess, Mary J. Savage, Thomas W. Rosahl, Sean M. Smith et al. · 2018 · PLoS ONE
- Avenanthramide-C Restores Impaired Plasticity and Cognition in Alzheimer’s Disease Model MiceVijay Sankar Ramasamy, Manikandan Samidurai, Hyung Joon Park, Ming Wang, Ra Young Park, Seon Young Yu, Hee Kyung Kang, Semi Hong, Won‐Seok Choi, Yu‐Young Lee et al. · 2019 · Molecular Neurobiology
- Spleen tyrosine kinase (SYK) blocks autophagic Tau degradation in vitro and in vivoJonas Elias Schweig, Hailan Yao, Kyle Coppola, Chao Jin, Fiona Crawford, MICHAEL J. MULLAN, Daniel Paris · 2019 · Journal of Biological Chemistry
- β-Lactolin, a Whey-Derived Lacto-Tetrapeptide, Prevents Alzheimer’s Disease Pathologies and Cognitive DeclineYasuhisa Ano, Rena Ohya, Yuta Takaichi, Terukatsu Washinuma, Kazuyuki Uchida, Akihiko Takashima, Hiroyuki Nakayama · 2020 · Journal of Alzheimer s Disease
- Neuronal deficiency of p38α‐MAPK ameliorates symptoms and pathology of APP or Tau‐transgenic Alzheimer’s mouse modelsLaura Schnöder, Gilles Gasparoni, Karl J. V. Nordström, Andrea Schottek, Inge Tomic, Anne Christmann, Karl Herbert Schäfer, Michael Dieter Menger, Jörn Walter, Klaus C Fassbender et al. · 2020 · The FASEB Journal
- The potential role of glial cells in driving the prion-like transcellular propagation of tau in tauopathiesZein Amro, Andrea J. Yool, Lyndsey E. Collins‐Praino · 2021 · Brain Behavior & Immunity - Health
- Downregulating PTBP1 Fails to Convert Astrocytes into Hippocampal Neurons and to Alleviate Symptoms in Alzheimer's Mouse ModelsTiantian Guo, Xinjia Pan, Guangtong Jiang, Denghong Zhang, Jinghui Qi, Lin Shao, Zhanxiang Wang, Huaxi Xu, Yingjun Zhao · 2022 · Journal of Neuroscience
- Potential Immunotargets for Alzheimer's Disease Treatment StrategiesPatricia L. Fernández, Gabrielle B. Britton, K. S. Jagannatha Rao · 2012 · Journal of Alzheimer s Disease
- Altered brain arginine metabolism in a mouse model of tauopathyPranav Vemula, Jing Yu, Hu Zhang, Jerry B. Hunt, Leslie A. Sandusky‐Beltran, Daniel C. Lee, Ping Liu · 2019 · Amino Acids
- Association between single moderate to severe traumatic brain injury and long-term tauopathy in humans and preclinical animal models: a systematic narrative review of the literatureAriel P. Walker, Benjamin Albert Chapin, Jose Francisco Abisambra, Steven Trent DeKosky · 2022 · Acta Neuropathologica Communications
- Microtubule assembly by tau impairs endocytosis and neurotransmission via dynamin sequestration in Alzheimer’s disease synapse modelTetsuya Hori, Kohgaku Eguchi, Han-Ying Wang, Tomohiro Miyasaka, Laurent Guillaud, Zacharie Taoufiq, Satyajit Mahapatra, Hiroshi Yamada, Kohji Takei, Tomoyuki Takahashi · 2022 · eLife
- Cellular and molecular mechanisms of pathological tau phosphorylation in traumatic brain injury: implications for chronic traumatic encephalopathyNeil S. Donison, Jacqueline Palik, Kathryn Volkening, Michael Joseph Strong · 2025 · Molecular Neurodegeneration
- Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathologyDaniel Barnett, Till S. Zimmer, Caroline Booraem, Fernando Palaguachi, Samantha M. Meadows, Haopeng Xiao, Man Ying Wong, Wenjie Luo, Li Gan, Edward T. Chouchani et al. · 2025 · Nature Metabolism
- Evidence for accelerated tauopathy in the retina of transgenic P301S tau mice exposed to repetitive mild traumatic brain injuryLeyan Xu, Jiwon Ryu, Judy V. Nguyen, John D. Arena, Elizabeth Y Rha, Pamela Vranis, Devon Hitt, Nicholas Marsh‐Armstrong, Vassilis E. Koliatsos · 2015 · Experimental Neurology
- Alzheimer's Disease Selective Vulnerability and Modeling in Transgenic MiceJürgen Götz, Nicole Schönrock, Bryce Vissel, Lars Matthias Ittner · 2009 · Journal of Alzheimer s Disease
- Cell and Gene Therapy in Alzheimer's DiseaseMicaela Johanna Glat, Daniel Offen · 2013 · Stem Cells and Development
- Microglia in Alzheimer's Disease: A Role for Ion ChannelsLaura Thei, Jennifer L. Imm, Eleni Kaisis, Mark L. Dallas, Talitha L. Kerrigan · 2018 · Frontiers in Neuroscience
- The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic miceJing Di, Ibrar Ahmed Siddique, Zizheng Li, Ghattas J. Malki, Simon Hornung, Suman Dutta, Ian Hurst, Ella Ishaaya, Austin Wang, Sally Tu et al. · 2021 · Alzheimer s Research & Therapy
- In vivo coupling of dendritic complexity with presynaptic density in primary tauopathiesElijah Mak, Negin Holland, Peter Simon Jones, George Savulich, Audrey Low, Maura Malpetti, Sanne Simone Kaalund, Luca Passamonti, Timothy Rittman, Rafael Romero-García et al. · 2021 · Neurobiology of Aging
- Brain metabolism in tau and amyloid mouse models of Alzheimer's disease: An MRI studyZhiliang Wei, Jiadi Xu, Lin Chen, Lydiane Hirschler, Emmanuel Barbier, Tong Li, Philip C. Wong, Hanzhang Lu · 2021 · NMR in Biomedicine
- Gut commensal-derived butyrate reverses obesity-induced social deficits and anxiety-like behaviors via regulation of microglial homeostasisChengxing Duan, Ling Huang, Chi Zhang, Lu Zhang, Xiuwen Xia, Zhanqiong Zhong, Baojia Wang, Yili Wang, Maggie Pui Man Hoi, Weijun Ding et al. · 2021 · European Journal of Pharmacology
- FOXO and related transcription factors binding elements in the regulation of neurodegenerative disordersVaibhav Oli, Rohan V. Gupta, Pravir Kumar · 2021 · Journal of Chemical Neuroanatomy
- Enjoy Carefully: The Multifaceted Role of Vitamin E in Neuro-NutritionLiesa Regner-Nelke, Christopher Nelke, Christina B. Schroeter, Rainer Dziewas, Tobias Warnecke, Tobias Ruck, Sven Guenther Meuth · 2021 · International Journal of Molecular Sciences
- The penalty of stress ‐ Epichaperomes negatively reshaping the brain in neurodegenerative disordersStephen D. Ginsberg, Suhasini Joshi, Sahil Sharma, Gianny Guzman, Tai Wang, Ottavio Arancio, Gabriela Chiosis · 2021 · Journal of Neurochemistry
- The Expression and Localisation of G-Protein-Coupled Inwardly Rectifying Potassium (GIRK) Channels Is Differentially Altered in the Hippocampus of Two Mouse Models of Alzheimer’s DiseaseRocío Alfaro‐Ruiz, Alejandro Martín‐Belmonte, Carolina Aguado, Félix Hernández, Ana Esther Moreno‐Martínez, Jesús Ávila, Rafael Luján · 2021 · International Journal of Molecular Sciences
- Pathological tau signatures and nuclear alterations in neurons, astrocytes and microglia in Alzheimer's disease, progressive supranuclear palsy, and dementia with Lewy bodiesMauro Montalbano, Lajja Majmundar, Urmi Sengupta, Leiana Fung, Rakez Kayed · 2022 · Brain Pathology
- A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathyTony S. Eteläinen, M. Catarina Silva, Johanna K. Uhari-Väänänen, Francesca De Lorenzo, Maria Helena Jäntti, Hengjing Cui, Marta Chavero‐Pieres, Tommi P. Kilpeläinen, Christina Mechtler, Reinis Svarcbahs et al. · 2023 · Science Translational Medicine
- Biochemical Isolation of Insoluble Tau in Transgenic Mouse Models of TauopathiesCarl Julien, Alexis Bretteville, Emmanuel Planel · 2012 · Methods in molecular biology
- Increased hippocampal CA1 density of serotonergic terminals in a triple transgenic mouse model of Alzheimer's disease: an ultrastructural studyHarun Najib Noristani, Roger S. Meadows, Markel Olabarria, Alexei Verkhratsky, J J Rodríguez · 2011 · Cell Death and Disease
- Ameliorative Effects of Antioxidants on the Hippocampal Accumulation of Pathologic Tau in a Rat Model of Blast‐Induced Traumatic Brain InjuryXiaoping Du, Matthew West, Weihua Cheng, Donald L. Ewert, Wěi Li, Debra Saunders, Rheal A. Towner, Robert A. Floyd, Richard D. Kopke · 2015 · Oxidative Medicine and Cellular Longevity
- RT-QuIC detection of tauopathies using full-length tau substratesTennant, Joanne M., Henderson, Davin M., Wisniewski, Thomas M., Hoover, Edward A. · 2020 · Prion
- Dysfunctional microglia and tau pathology in Alzheimer’s diseaseGunel Ayyubova · 2022 · Reviews in the Neurosciences
- Targeting Astrocyte Signaling Alleviates Cerebrovascular and Synaptic Function Deficits in a Diet-Based Mouse Model of Small Cerebral Vessel DiseasePradoldej M Sompol, Jenna L. Gollihue, Blaine E. Weiss, Ruei‐Lung Lin, Sami L. Case, Susan D. Kraner, Erica M. Weekman, John C. Gant, Colin B. Rogers, Dana M. Niedowicz et al. · 2023 · Journal of Neuroscience
- The E3 Ubiquitin Ligase, CHIP/STUB1, Inhibits Aggregation of Phosphorylated Proteoforms of Microtubule-associated Protein Tau (MAPT)Cory M. Nadel, Aye C. Thwin, Matthew Callahan, Kanghyun Lee, Emily J. Connelly, Charles S. Craik, Daniel R. Southworth, Jason E. Gestwicki · 2023 · Journal of Molecular Biology
- Lamivudine (3TC), a Nucleoside Reverse Transcriptase Inhibitor, Prevents the Neuropathological Alterations Present in Mutant Tau Transgenic MiceVallés-Saiz, Laura, Ávila, Jesús, Hernández, Félix · 2023 · International Journal of Molecular Sciences
- Senolytic therapy preserves blood-brain barrier integrity and promotes microglia homeostasis in a tauopathy modelMinmin Yao, Zhiliang Wei, Jonathan Scharff Nielsen, Yuxiao Ouyang, Aaron Kakazu, Haitong Wang, Lida Du, Ruoxuan Li, Tiffany Chu, Susanna Scafidi et al. · 2024 · Neurobiology of Disease
- Biomarkers of synaptic degeneration in Alzheimer’s diseaseQian Cheng, Yiou Fan, Pengfei Zhang, Huan Liu, Jialin Han, Qian Yu, Xueying Wang, Shuang Wu, Zhiming Lu · 2024 · Ageing Research Reviews
- Fractalkine Mediates Communication between Pathogenic Proteins and Microglia: Implications of Anti-Inflammatory Treatments in Different Stages of Neurodegenerative DiseasesNicole M. Desforges, Michaeline L. Hebron, Norah Khaled Algarzae, Irina Lonskaya, Charbel Moussa · 2012 · International Journal of Alzheimer s Disease
- Assessment of neuroinflammation in a mouse model of obesity and β-amyloidosis using PETAnna M. Barron, Masaki Tokunaga, Ming‐Rong Zhang, Bin Ji, Tetsuya Suhara, Makoto Higuchi · 2016 · Journal of Neuroinflammation
- Ellagic acid ameliorates learning and memory impairment in APP/PS1 transgenic mice via inhibition of β‑amyloid production and tau hyperphosphorylationLili Zhong, Hong Liu, Weijia Zhang, Xu Liu, Bo Jiang, Hongxin Fei, Zhongren Sun · 2018 · Experimental and Therapeutic Medicine
- Amyloidosis is associated with thicker myelin and increased oligodendrogenesis in the adult mouse brainSolène Ferreira, Kimberley A. Pitman, Shiwei Wang, Benjamin S. Summers, Nicole Bye, Kaylene M. Young, Carlie Laura Cullen · 2020 · Journal of Neuroscience Research
- NLRP1 Inflammasome Activation in the Hippocampal Formation in Alzheimer’s Disease: Correlation with Neuropathological Changes and Unbiasedly Estimated Neuronal LossEna Španić, Lea Langer Horvat, Katarina Ilić, Patrick R. Hof, Goran Šimić · 2022 · Cells
- Characterizing microglial senescence: Tau as a key playerDeniz Karabag, Hannah Scheiblich, Angelika Griep, Francesco Santarelli, Stephanie Schwartz, Michael Thomas Heneka, Christina Ising · 2023 · Journal of Neurochemistry
- Aggregation, Transmission, and Toxicity of the Microtubule-Associated Protein Tau: A Complex ComprehensionJiaxin Hu, Wenchi Sha, Shuangshuang Yuan, Jiarui Wu, Yunpeng Huang · 2023 · International Journal of Molecular Sciences
- Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in an Alzheimer’s disease mouse modelCarolyn Tallon, Benjamin J. Bell, Medhinee M. Malvankar, Pragney Deme, Carlos J. Nogueras‐Ortiz, Erden Eren, Ajit G. Thomas, Kristen R. Hollinger, Arindom Pal, Maja Mustapić et al. · 2023 · Translational Neurodegeneration
- Distinct tau filament folds in human MAPT mutants P301L and P301TManuel Schweighauser, Yang Shi, Alexey G. Murzin, Holly J. Garringer, Rubén Vidal, Jill R. Murrell, María Elena Erro, Harro Seelaar, Isidró Ferrer, John Cornelis Van Swieten et al. · 2025 · Nature Structural & Molecular Biology
- Microglia changes associated to Alzheimer’s disease pathology in aged chimpanzeesM. Edler, C. Sherwood, R. Meindl, Emily L. Munger, William D. Hopkins, J. Ely, J. Erwin, Daniel P Perl, E. Mufson, Patrick R. Hof et al. · 2018 · The Journal of comparative neurology
- Adeno‐associated virus‐based Alzheimer's disease mouse models and potential new therapeutic avenuesLars Matthias Ittner, Matthias Klugmann, Yazi Diana Ke · 2019 · British Journal of Pharmacology
- IL-6 and IL-1β upregulation and tau protein phosphorylation in response to chronic alcohol exposure in the mouse hippocampusCihao Jiang, Yi Zhang, Xiaolu Tang, Chenchen Jing, Shasha Qiu, Baolin Li, Yanning Li · 2021 · Neuroreport
- Tau Seeding Mouse Models with Patient Brain-Derived AggregatesAiko Robert, Michael Schöll, Thomas Vogels · 2021 · International Journal of Molecular Sciences
- Extracellular tau stimulates phagocytosis of living neurons by activated microglia via Toll-like 4 receptor–NLRP3 inflammasome–caspase-1 signalling axisKatryna Pampuščenko, Ramunė Morkūnienė, Lukas Krasauskas, Vytautas Smirnovas, Guy Charles Brown, Vilmantė Borutaitė · 2023 · Scientific Reports
- Senescent Microglia Represent a Subset of Disease-Associated Microglia in P301S MicePei Ying Ng, Cheng Zhang, Hu Li, Darren J. Baker · 2023 · Journal of Alzheimer s Disease
- The direct role of 5-lipoxygenase on tau pathology, synaptic integrity and cognition in a mouse model of tauopathyAlana N. Vagnozzi, Phillip F. Giannopoulos, Domenico Praticò · 2017 · Translational Psychiatry
- A synapsin Ⅰ cleavage fragment contributes to synaptic dysfunction in Alzheimer's diseaseLanxia Meng, Li Bo Zou, Min Xiong, Jiehui Chen, Xingyu Zhang, Ting Yu, Yiming Li, Congcong Liu, Guiqin Chen, Zhihao Wang et al. · 2022 · Aging Cell
- Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathyA. Harrison Brody, Sarah Helena Nies, Fulin Guan, Levi M. Smith, Bandhan Mukherjee, Santiago A. Salazar, Suho Lee, Tu Kiet T. Lam, Stephen M. Strittmatter · 2022 · Molecular Neurodegeneration
- Truncation of tau at E391 Promotes Early Pathologic Changes in Transgenic MicePamela J. McMillan, Brian C. Kraemer, Linda Robinson, James B. Leverenz, Murray A. Raskind, Gerard D. Schellenberg · 2011 · Journal of Neuropathology & Experimental Neurology
- Chronic consumption of Annona muricata juice triggers and aggravates cerebral tau phosphorylation in wild‐type and MAPT transgenic miceRobert Rottscholl, Marlen Haegele, B. Jainsch, Hong Wei Xu, Gesine Respondek, Matthias Höllerhage, Thomas W. Rösler, Emilie Bony, Jessica Le Ven, Vincent Guérineau et al. · 2016 · Journal of Neurochemistry
- Mouse models of frontotemporal dementia: A comparison of phenotypes with clinical symptomatologyRebekah M. Ahmed, Muireann Irish, Janet van Eersel, Arne Ittner, Yazi Diana Ke, Alexander M. Volkerling, Julia van der Hoven, Kimi Tanaka, Tim Karl, Michael Kassiou et al. · 2017 · Neuroscience & Biobehavioral Reviews
- Synaptic changes in psychiatric and neurological disorders: State-of-the art of in vivo imagingHowes, Oliver, Marcinkowska, Julia, Turkheimer, Federico E., Carr, Richard · 2025 · Neuropsychopharmacology
- The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathwayNaguib, Sarah, Lopez-Lee, Chloe, Torres, Eileen Ruth, Lee, Se-In, Zhu, Jingjie, Zhu, Daphne, Ye, Pearly, Norman, Kendra, Zhao, Mingrui, Wong, Man Ying et al. · 2025 · Immunity
- Single-domain antibody–based noninvasive in vivo imaging of α-synuclein or tau pathologyYixiang Jiang, Yan Lin, Senthilkumar Krishnaswamy, Ruimin Pan, Qian Wu, Leslie A. Sandusky‐Beltran, Mengyu Liu, Min‐Hao Kuo, Xiang‐Peng Kong, Erin E. Congdon et al. · 2023 · Science Advances
- Late-stage Anle138b treatment ameliorates tau pathology and metabolic decline in a mouse model of human Alzheimer’s disease tauMatthias Brendel, Maximilian Deußing, Tanja Blume, Lena Kaiser, Federico Probst, Felix Overhoff, Finn Peters, Barbara von Ungern‐Sternberg, Sergey Ryazanov, Andrei Leonov et al. · 2019 · Alzheimer s Research & Therapy
- Alzheimer’s disease: phenotypic approaches using disease models and the targeting of tau proteinElisabetta Lauretti, Domenico Praticò · 2020 · Expert Opinion on Therapeutic Targets
- Dual Neutral Sphingomyelinase-2/Acetylcholinesterase Inhibitors for the Treatment of Alzheimer’s DiseaseTina V. Bilousova, Bryan J. Simmons, Rachel R. Knapp, Chris Jean Elias, Jesus J. Campagna, Mikhail Melnik, Sujyoti Chandra, Samantha Focht, Chunni Zhu, Kanagasabai Vadivel et al. · 2020 · ACS Chemical Biology
- Longitudinal TSPO expression in tau transgenic P301S mice predicts increased tau accumulation and deteriorated spatial learningEckenweber, Florian, Medina-Luque, Jose, Blume, Tanja, Sacher, Christian, Biechele, Gloria, Wind, Karin, Deussing, Maximilian, Briel, Nils, Lindner, Simon, Boening, Guido et al. · 2020 · Journal of Neuroinflammation
- Partial Inhibition of Mitochondrial Complex I Reduces Tau Pathology and Improves Energy Homeostasis and Synaptic Function in 3xTg-AD MiceAndrea Stojakovic, Su-Youne Chang, Jarred J. Nesbitt, Nicholas P. Pichurin, Mark Ostroot, Tomonori Aikawa, Takahisa Kanekiyo, Eugenia V. Trushina · 2020 · Journal of Alzheimer s Disease
- Loss of presenilin function enhances tau phosphorylation and aggregation in miceCarlos M. Soto-Faguás, Paula Sanchez-Molina, Carlos A. Saura · 2021 · Acta Neuropathologica Communications
- Presynaptic membrane protein dysfunction occurs prior to neurodegeneration and predicts faster cognitive declineGuoyu Lan, Anqi Li, Zhen Liu, Shaohua Ma, Tengfei Guo, Alzheimer’s Disease Neuroimaging Initiative · 2022 · Alzheimer s & Dementia
- Gene Therapy Models of Alzheimer’s Disease and Other DementiasBenjamin Combs, Andrew Kneynsberg, Nicholas M. Kanaan · 2015 · Methods in molecular biology
- Oxidative Stress and Alzheimer’s DiseaseSandeep Kumar Singh, Rudy J. Castellani, George L. Perry · 2016 · Oxidative stress in applied basic research and clinical practice
- Bioassays and Inactivation of PrionsKurt Giles, Amanda L. Woerman, David B. Berry, Stanley B. Prusiner · 2017 · Cold Spring Harbor Perspectives in Biology
- A new perspective on Alzheimer’s disease: m6A modificationLei Xia, Fan Zhang, Yulu Li, Yuemi Mo, Lingqiu Zhang, Qianhua Li, Minghuang Luo, Xiaotao Hou, Zhengcai Du, Jiagang Deng et al. · 2023 · Frontiers in Genetics
- Reduced progranulin increases tau and α-synuclein inclusions and alters mouse tauopathy phenotypes via glucocerebrosidaseHideyuki Takahashi, Sanaea Z. Bhagwagar, Sarah Helena Nies, Hongping Ye, Xianlin Han, Marius Chiasseu, Guilin Wang, Ian R. Mackenzie, Stephen M. Strittmatter · 2024 · Nature Communications
- Autophagy and Cellular Senescence in Alzheimer's Disease: Key Drivers of NeurodegenerationMd Sadique Hussain, Neetu Agrawal, Baby Ilma, M. M. Rekha, Priya Priyadarshini Nayak, Mandeep Kaur, Anil Khachi, Kavita Goyal, Arcot Rekha, Saurabh Gupta et al. · 2025 · CNS Neuroscience & Therapeutics
- Molecular imaging of dementiaTakaaki Mori, Jun Maeda, Hitoshi Shimada, Makoto Higuchi, Hitoshi Shinotoh, Shuichi Ueno, Tetsuya Suhara · 2012 · Psychogeriatrics
- Persistence of intact retinal ganglion cell terminals after axonal transport loss in the DBA/2J mouse model of glaucomaMatthew A. Smith, Christina Z. Xia, Samuel D. Crish, Kelly M. Fening, Denise M. Inman, Brett R. Schofield, Samuel D. Crish · 2016 · The Journal of Comparative Neurology
- Fundamental role of pan-inflammation and oxidative-nitrosative pathways in neuropathogenesis of Alzheimer's disease in focal cerebral ischemic rats.Mak Adam Daulatzai · 2016 · Europe PMC (PubMed Central)
- A unique tau conformation generated by an acetylation-mimic substitution modulates P301S-dependent tau pathology and hyperphosphorylationDeepa Ajit, Hanna Trzeciakiewicz, Jui‐Heng Tseng, Connor M. Wander, Youjun Chen, Aditi Ajit, Diamond P. King, Todd J. Cohen · 2019 · Journal of Biological Chemistry
- A synthetic heparinoid blocks Tau aggregate cell uptake and amplificationBarbara Elena Stopschinski, Talitha L. Thomas, Sourena Nadji, Eric Darvish, Linfeng Fan, Brandon B. Holmes, Anuja R. Modi, Jordan G. Finnell, Omar M. Kashmer, Sandi Jo Estill et al. · 2020 · Journal of Biological Chemistry
- An Overview of Astrocyte Responses in Genetically Induced Alzheimer’s Disease Mouse ModelsFokion Spanos, Shane Antony Liddelow · 2020 · Cells
- Epigenetic treatment of behavioral and physiological deficits in a tauopathy mouse modelWei Wang, Qing Cao, Tao Tan, Fengwei Yang, Jamal B. Williams, Zhen Yan · 2021 · Aging Cell
- Broad activation of the Parkin pathway induces synaptic mitochondrial deficits in early tauopathyYu Young Jeong, Sinsuk Han, Nuo Jia, Mingyang Zhang, Preethi Sheshadri, Prasad Tammineni, Jasmine Cheung, Marialaina Nissenbaum, Sindhuja S. Baskar, Kelvin Y. Kwan et al. · 2022 · UCL Discovery (University College London)
- Brain cellular senescence in mouse models of Alzheimer’s diseaseAngela O. Dorigatti, Ruben Riordan, Zhen Yu, Grace Ross, Rong Wang, Nadjalisse C. Reynolds-Lallement, Kathy Ruth Magnusson, Verónica Galván, Viviana Pérez · 2022 · GeroScience
- Disruption of tubulin-alpha4a polyglutamylation prevents aggregation of hyper-phosphorylated tau and microglia activation in miceTorben Johann Hausrat, Philipp Christoph Janiesch, Petra Breiden, David Lutz, Sabine Hoffmeister‐Ullerich, Irm Hermans‐Borgmeyer, Antonio Virgilio Failla, Matthias Kneussel · 2022 · Nature Communications
- The Role of Traditional Chinese Medicine Natural Products in β-Amyloid Deposition and Tau Protein Hyperphosphorylation in Alzheimer’s DiseaseHuiying Yan, Li-Na Feng, Ming-Quan Li · 2023 · Drug Design, Development and Therapy
- Recent advances in using Drosophila to model neurodegenerative diseasesBingwei Lu · 2009 · APOPTOSIS
- Transcellular Spreading of Tau in TauopathiesKoen C. Demaegd, Joost W. H. Schymkowitz, Frédéric Rousseau · 2018 · ChemBioChem
- Chaperone-like Antibodies Targeting Misfolded Tau Protein: New Vistas in the Immunotherapy of Neurodegenerative FoldopathiesNorbert Žilka, Eva Kontseková, Michal Novák · 2008 · Journal of Alzheimer s Disease
- Imatinib methanesulfonate reduces hyperphosphorylation of tau following repeated peripheral exposure to lipopolysaccharideGardner, L.E., White, J.D., Eimerbrink, M.J., Boehm, G.W., Chumley, M.J. · 2016 · Neuroscience
- Upregulated astrocyte HDAC7 induces Alzheimer-like tau pathologies via deacetylating transcription factor-EB and inhibiting lysosome biogenesisJinwang Ye, Suyue Zhong, Huali Wan, Xing Guo, Xuanbao Yao, Qiong Liu, Liming Chen, Jian‐Zhi Wang, Shifeng Xiao · 2025 · Molecular Neurodegeneration
- 3D Visualization of the Temporal and Spatial Spread of Tau Pathology Reveals Extensive Sites of Tau Accumulation Associated with Neuronal Loss and Recognition Memory Deficit in Aged Tau Transgenic MiceHongjun Fu, S. Abid Hussaini, Susanne Wegmann, Caterina P. Profaci, Jacob D. Daniels, Mathieu Herman, Sheina Emrani, Helen Y. Figueroa, Bradley T. Hyman, Peter Davies et al. · 2016 · PLoS ONE
- Dynamics of the Complement, Cytokine, and Chemokine Systems in the Regulation of Synaptic Function and Dysfunction Relevant to Alzheimer’s DiseaseShanya Jiang, Kiran Bhaskar · 2017 · Journal of Alzheimer s Disease
- Entanglement of CCR5 and Alzheimer’s DiseaseTianwen Li, Jianhong Zhu · 2019 · Frontiers in Aging Neuroscience
- Relationship between tau, neuroinflammation and atrophy in Alzheimer's disease: The NIMROD studyLi Su, Ajenthan Surendranathan, Yujing Huang, William Richard Bevan-Jones, Luca Passamonti, Yong T. Hong, Robert J. Arnold, Patricia Vázquez Rodríguez, Yi Wang, Elijah Mak et al. · 2020 · Information Fusion