Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model

Yoshiyama, Yasumasa, Higuchi, Makoto, Zhang, Bin, Huang, Shu-Ming, Iwata, Nobuhisa, Saido, Takaomi C., Maeda, Jun, Suhara, Tetsuya +2 more·2007·Neuron

Cited by (1,029)

Items 901–1,000 of 1,029

  1. Wolframin is a novel regulator of tau pathology and neurodegeneration
    Shuo Chen, Diana M. Acosta, Liangping Li, Jiawen Liang, Yuzhou Chang, Cankun Wang, Julie Fitzgerald, Cody T. Morrison, Chris N. Goulbourne, Yoshi Nakano et al. · 2022 · Acta Neuropathologica
  2. Immunotherapeutic approaches for Alzheimer’s disease in transgenic mouse models
    Thomas Wısnıewskı, Allal Boutajangout · 2009 · Brain Structure and Function
  3. The Effects of SIRT1 on Alzheimer's Disease Models
    Gizem Dönmez · 2012 · International Journal of Alzheimer s Disease
  4. Lung endothelium, tau, and amyloids in health and disease
    Ron Balczon, Mike T. Lin, Sarah B. Voth, Amy R. Nelson, Jonas C. Schupp, Brant M. Wagener, Jean‐François Pittet, Troy Stevens · 2023 · Physiological Reviews
  5. Moderate Environmental Enrichment Mitigates Tauopathy in a Neurofibrillary Tangle Mouse Model
    Inbal Lahiani-Cohen, Athanasios I. Lourbopoulos, Ester Haber, Lea Rozenstein‐Tsalkovich, Oded Abramsky, Nikolaos Grigoriadis, Hanna Rosenmann · 2011 · Journal of Neuropathology & Experimental Neurology
  6. Neurophysiological assessment of neural network plasticity and connectivity: Progress towards early functional biomarkers for disease interception therapies in Alzheimer’s disease
    Callum Walsh, Wilhelmus H. I. M. Drinkenburg, Abdallah Ahnaou · 2016 · Neuroscience & Biobehavioral Reviews
  7. Early intervention of tau pathology prevents behavioral changes in the rTg4510 mouse model of tauopathy
    Xiaohai Wang, Karen D.B. Smith, Michelle S. Pearson, Anna C. Hughes, Mali L. Cosden, Jacob Marcus, J. Fred Hess, Mary J. Savage, Thomas W. Rosahl, Sean M. Smith et al. · 2018 · PLoS ONE
  8. Avenanthramide-C Restores Impaired Plasticity and Cognition in Alzheimer’s Disease Model Mice
    Vijay Sankar Ramasamy, Manikandan Samidurai, Hyung Joon Park, Ming Wang, Ra Young Park, Seon Young Yu, Hee Kyung Kang, Semi Hong, Won‐Seok Choi, Yu‐Young Lee et al. · 2019 · Molecular Neurobiology
  9. Spleen tyrosine kinase (SYK) blocks autophagic Tau degradation in vitro and in vivo
    Jonas Elias Schweig, Hailan Yao, Kyle Coppola, Chao Jin, Fiona Crawford, MICHAEL J. MULLAN, Daniel Paris · 2019 · Journal of Biological Chemistry
  10. β-Lactolin, a Whey-Derived Lacto-Tetrapeptide, Prevents Alzheimer’s Disease Pathologies and Cognitive Decline
    Yasuhisa Ano, Rena Ohya, Yuta Takaichi, Terukatsu Washinuma, Kazuyuki Uchida, Akihiko Takashima, Hiroyuki Nakayama · 2020 · Journal of Alzheimer s Disease
  11. Neuronal deficiency of p38α‐MAPK ameliorates symptoms and pathology of APP or Tau‐transgenic Alzheimer’s mouse models
    Laura Schnöder, Gilles Gasparoni, Karl J. V. Nordström, Andrea Schottek, Inge Tomic, Anne Christmann, Karl Herbert Schäfer, Michael Dieter Menger, Jörn Walter, Klaus C Fassbender et al. · 2020 · The FASEB Journal
  12. The potential role of glial cells in driving the prion-like transcellular propagation of tau in tauopathies
    Zein Amro, Andrea J. Yool, Lyndsey E. Collins‐Praino · 2021 · Brain Behavior & Immunity - Health
  13. Downregulating PTBP1 Fails to Convert Astrocytes into Hippocampal Neurons and to Alleviate Symptoms in Alzheimer's Mouse Models
    Tiantian Guo, Xinjia Pan, Guangtong Jiang, Denghong Zhang, Jinghui Qi, Lin Shao, Zhanxiang Wang, Huaxi Xu, Yingjun Zhao · 2022 · Journal of Neuroscience
  14. Potential Immunotargets for Alzheimer's Disease Treatment Strategies
    Patricia L. Fernández, Gabrielle B. Britton, K. S. Jagannatha Rao · 2012 · Journal of Alzheimer s Disease
  15. Altered brain arginine metabolism in a mouse model of tauopathy
    Pranav Vemula, Jing Yu, Hu Zhang, Jerry B. Hunt, Leslie A. Sandusky‐Beltran, Daniel C. Lee, Ping Liu · 2019 · Amino Acids
  16. Association between single moderate to severe traumatic brain injury and long-term tauopathy in humans and preclinical animal models: a systematic narrative review of the literature
    Ariel P. Walker, Benjamin Albert Chapin, Jose Francisco Abisambra, Steven Trent DeKosky · 2022 · Acta Neuropathologica Communications
  17. Microtubule assembly by tau impairs endocytosis and neurotransmission via dynamin sequestration in Alzheimer’s disease synapse model
    Tetsuya Hori, Kohgaku Eguchi, Han-Ying Wang, Tomohiro Miyasaka, Laurent Guillaud, Zacharie Taoufiq, Satyajit Mahapatra, Hiroshi Yamada, Kohji Takei, Tomoyuki Takahashi · 2022 · eLife
  18. Cellular and molecular mechanisms of pathological tau phosphorylation in traumatic brain injury: implications for chronic traumatic encephalopathy
    Neil S. Donison, Jacqueline Palik, Kathryn Volkening, Michael Joseph Strong · 2025 · Molecular Neurodegeneration
  19. Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology
    Daniel Barnett, Till S. Zimmer, Caroline Booraem, Fernando Palaguachi, Samantha M. Meadows, Haopeng Xiao, Man Ying Wong, Wenjie Luo, Li Gan, Edward T. Chouchani et al. · 2025 · Nature Metabolism
  20. Evidence for accelerated tauopathy in the retina of transgenic P301S tau mice exposed to repetitive mild traumatic brain injury
    Leyan Xu, Jiwon Ryu, Judy V. Nguyen, John D. Arena, Elizabeth Y Rha, Pamela Vranis, Devon Hitt, Nicholas Marsh‐Armstrong, Vassilis E. Koliatsos · 2015 · Experimental Neurology
  21. Alzheimer's Disease Selective Vulnerability and Modeling in Transgenic Mice
    Jürgen Götz, Nicole Schönrock, Bryce Vissel, Lars Matthias Ittner · 2009 · Journal of Alzheimer s Disease
  22. Cell and Gene Therapy in Alzheimer's Disease
    Micaela Johanna Glat, Daniel Offen · 2013 · Stem Cells and Development
  23. Microglia in Alzheimer's Disease: A Role for Ion Channels
    Laura Thei, Jennifer L. Imm, Eleni Kaisis, Mark L. Dallas, Talitha L. Kerrigan · 2018 · Frontiers in Neuroscience
  24. The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic mice
    Jing Di, Ibrar Ahmed Siddique, Zizheng Li, Ghattas J. Malki, Simon Hornung, Suman Dutta, Ian Hurst, Ella Ishaaya, Austin Wang, Sally Tu et al. · 2021 · Alzheimer s Research & Therapy
  25. In vivo coupling of dendritic complexity with presynaptic density in primary tauopathies
    Elijah Mak, Negin Holland, Peter Simon Jones, George Savulich, Audrey Low, Maura Malpetti, Sanne Simone Kaalund, Luca Passamonti, Timothy Rittman, Rafael Romero-García et al. · 2021 · Neurobiology of Aging
  26. Brain metabolism in tau and amyloid mouse models of Alzheimer's disease: An MRI study
    Zhiliang Wei, Jiadi Xu, Lin Chen, Lydiane Hirschler, Emmanuel Barbier, Tong Li, Philip C. Wong, Hanzhang Lu · 2021 · NMR in Biomedicine
  27. Gut commensal-derived butyrate reverses obesity-induced social deficits and anxiety-like behaviors via regulation of microglial homeostasis
    Chengxing Duan, Ling Huang, Chi Zhang, Lu Zhang, Xiuwen Xia, Zhanqiong Zhong, Baojia Wang, Yili Wang, Maggie Pui Man Hoi, Weijun Ding et al. · 2021 · European Journal of Pharmacology
  28. FOXO and related transcription factors binding elements in the regulation of neurodegenerative disorders
    Vaibhav Oli, Rohan V. Gupta, Pravir Kumar · 2021 · Journal of Chemical Neuroanatomy
  29. Enjoy Carefully: The Multifaceted Role of Vitamin E in Neuro-Nutrition
    Liesa Regner-Nelke, Christopher Nelke, Christina B. Schroeter, Rainer Dziewas, Tobias Warnecke, Tobias Ruck, Sven Guenther Meuth · 2021 · International Journal of Molecular Sciences
  30. The penalty of stress ‐ Epichaperomes negatively reshaping the brain in neurodegenerative disorders
    Stephen D. Ginsberg, Suhasini Joshi, Sahil Sharma, Gianny Guzman, Tai Wang, Ottavio Arancio, Gabriela Chiosis · 2021 · Journal of Neurochemistry
  31. The Expression and Localisation of G-Protein-Coupled Inwardly Rectifying Potassium (GIRK) Channels Is Differentially Altered in the Hippocampus of Two Mouse Models of Alzheimer’s Disease
    Rocío Alfaro‐Ruiz, Alejandro Martín‐Belmonte, Carolina Aguado, Félix Hernández, Ana Esther Moreno‐Martínez, Jesús Ávila, Rafael Luján · 2021 · International Journal of Molecular Sciences
  32. Pathological tau signatures and nuclear alterations in neurons, astrocytes and microglia in Alzheimer's disease, progressive supranuclear palsy, and dementia with Lewy bodies
    Mauro Montalbano, Lajja Majmundar, Urmi Sengupta, Leiana Fung, Rakez Kayed · 2022 · Brain Pathology
  33. A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy
    Tony S. Eteläinen, M. Catarina Silva, Johanna K. Uhari-Väänänen, Francesca De Lorenzo, Maria Helena Jäntti, Hengjing Cui, Marta Chavero‐Pieres, Tommi P. Kilpeläinen, Christina Mechtler, Reinis Svarcbahs et al. · 2023 · Science Translational Medicine
  34. Biochemical Isolation of Insoluble Tau in Transgenic Mouse Models of Tauopathies
    Carl Julien, Alexis Bretteville, Emmanuel Planel · 2012 · Methods in molecular biology
  35. Increased hippocampal CA1 density of serotonergic terminals in a triple transgenic mouse model of Alzheimer's disease: an ultrastructural study
    Harun Najib Noristani, Roger S. Meadows, Markel Olabarria, Alexei Verkhratsky, J J Rodríguez · 2011 · Cell Death and Disease
  36. Ameliorative Effects of Antioxidants on the Hippocampal Accumulation of Pathologic Tau in a Rat Model of Blast‐Induced Traumatic Brain Injury
    Xiaoping Du, Matthew West, Weihua Cheng, Donald L. Ewert, Wěi Li, Debra Saunders, Rheal A. Towner, Robert A. Floyd, Richard D. Kopke · 2015 · Oxidative Medicine and Cellular Longevity
  37. RT-QuIC detection of tauopathies using full-length tau substrates
    Tennant, Joanne M., Henderson, Davin M., Wisniewski, Thomas M., Hoover, Edward A. · 2020 · Prion
  38. Dysfunctional microglia and tau pathology in Alzheimer’s disease
    Gunel Ayyubova · 2022 · Reviews in the Neurosciences
  39. Targeting Astrocyte Signaling Alleviates Cerebrovascular and Synaptic Function Deficits in a Diet-Based Mouse Model of Small Cerebral Vessel Disease
    Pradoldej M Sompol, Jenna L. Gollihue, Blaine E. Weiss, Ruei‐Lung Lin, Sami L. Case, Susan D. Kraner, Erica M. Weekman, John C. Gant, Colin B. Rogers, Dana M. Niedowicz et al. · 2023 · Journal of Neuroscience
  40. The E3 Ubiquitin Ligase, CHIP/STUB1, Inhibits Aggregation of Phosphorylated Proteoforms of Microtubule-associated Protein Tau (MAPT)
    Cory M. Nadel, Aye C. Thwin, Matthew Callahan, Kanghyun Lee, Emily J. Connelly, Charles S. Craik, Daniel R. Southworth, Jason E. Gestwicki · 2023 · Journal of Molecular Biology
  41. Lamivudine (3TC), a Nucleoside Reverse Transcriptase Inhibitor, Prevents the Neuropathological Alterations Present in Mutant Tau Transgenic Mice
    Vallés-Saiz, Laura, Ávila, Jesús, Hernández, Félix · 2023 · International Journal of Molecular Sciences
  42. Senolytic therapy preserves blood-brain barrier integrity and promotes microglia homeostasis in a tauopathy model
    Minmin Yao, Zhiliang Wei, Jonathan Scharff Nielsen, Yuxiao Ouyang, Aaron Kakazu, Haitong Wang, Lida Du, Ruoxuan Li, Tiffany Chu, Susanna Scafidi et al. · 2024 · Neurobiology of Disease
  43. Biomarkers of synaptic degeneration in Alzheimer’s disease
    Qian Cheng, Yiou Fan, Pengfei Zhang, Huan Liu, Jialin Han, Qian Yu, Xueying Wang, Shuang Wu, Zhiming Lu · 2024 · Ageing Research Reviews
  44. Fractalkine Mediates Communication between Pathogenic Proteins and Microglia: Implications of Anti-Inflammatory Treatments in Different Stages of Neurodegenerative Diseases
    Nicole M. Desforges, Michaeline L. Hebron, Norah Khaled Algarzae, Irina Lonskaya, Charbel Moussa · 2012 · International Journal of Alzheimer s Disease
  45. Assessment of neuroinflammation in a mouse model of obesity and β-amyloidosis using PET
    Anna M. Barron, Masaki Tokunaga, Ming‐Rong Zhang, Bin Ji, Tetsuya Suhara, Makoto Higuchi · 2016 · Journal of Neuroinflammation
  46. Ellagic acid ameliorates learning and memory impairment in APP/PS1 transgenic mice via inhibition of β‑amyloid production and tau hyperphosphorylation
    Lili Zhong, Hong Liu, Weijia Zhang, Xu Liu, Bo Jiang, Hongxin Fei, Zhongren Sun · 2018 · Experimental and Therapeutic Medicine
  47. Amyloidosis is associated with thicker myelin and increased oligodendrogenesis in the adult mouse brain
    Solène Ferreira, Kimberley A. Pitman, Shiwei Wang, Benjamin S. Summers, Nicole Bye, Kaylene M. Young, Carlie Laura Cullen · 2020 · Journal of Neuroscience Research
  48. NLRP1 Inflammasome Activation in the Hippocampal Formation in Alzheimer’s Disease: Correlation with Neuropathological Changes and Unbiasedly Estimated Neuronal Loss
    Ena Španić, Lea Langer Horvat, Katarina Ilić, Patrick R. Hof, Goran Šimić · 2022 · Cells
  49. Characterizing microglial senescence: Tau as a key player
    Deniz Karabag, Hannah Scheiblich, Angelika Griep, Francesco Santarelli, Stephanie Schwartz, Michael Thomas Heneka, Christina Ising · 2023 · Journal of Neurochemistry
  50. Aggregation, Transmission, and Toxicity of the Microtubule-Associated Protein Tau: A Complex Comprehension
    Jiaxin Hu, Wenchi Sha, Shuangshuang Yuan, Jiarui Wu, Yunpeng Huang · 2023 · International Journal of Molecular Sciences
  51. Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in an Alzheimer’s disease mouse model
    Carolyn Tallon, Benjamin J. Bell, Medhinee M. Malvankar, Pragney Deme, Carlos J. Nogueras‐Ortiz, Erden Eren, Ajit G. Thomas, Kristen R. Hollinger, Arindom Pal, Maja Mustapić et al. · 2023 · Translational Neurodegeneration
  52. Distinct tau filament folds in human MAPT mutants P301L and P301T
    Manuel Schweighauser, Yang Shi, Alexey G. Murzin, Holly J. Garringer, Rubén Vidal, Jill R. Murrell, María Elena Erro, Harro Seelaar, Isidró Ferrer, John Cornelis Van Swieten et al. · 2025 · Nature Structural & Molecular Biology
  53. Microglia changes associated to Alzheimer’s disease pathology in aged chimpanzees
    M. Edler, C. Sherwood, R. Meindl, Emily L. Munger, William D. Hopkins, J. Ely, J. Erwin, Daniel P Perl, E. Mufson, Patrick R. Hof et al. · 2018 · The Journal of comparative neurology
  54. Adeno‐associated virus‐based Alzheimer's disease mouse models and potential new therapeutic avenues
    Lars Matthias Ittner, Matthias Klugmann, Yazi Diana Ke · 2019 · British Journal of Pharmacology
  55. IL-6 and IL-1β upregulation and tau protein phosphorylation in response to chronic alcohol exposure in the mouse hippocampus
    Cihao Jiang, Yi Zhang, Xiaolu Tang, Chenchen Jing, Shasha Qiu, Baolin Li, Yanning Li · 2021 · Neuroreport
  56. Tau Seeding Mouse Models with Patient Brain-Derived Aggregates
    Aiko Robert, Michael Schöll, Thomas Vogels · 2021 · International Journal of Molecular Sciences
  57. Extracellular tau stimulates phagocytosis of living neurons by activated microglia via Toll-like 4 receptor–NLRP3 inflammasome–caspase-1 signalling axis
    Katryna Pampuščenko, Ramunė Morkūnienė, Lukas Krasauskas, Vytautas Smirnovas, Guy Charles Brown, Vilmantė Borutaitė · 2023 · Scientific Reports
  58. Senescent Microglia Represent a Subset of Disease-Associated Microglia in P301S Mice
    Pei Ying Ng, Cheng Zhang, Hu Li, Darren J. Baker · 2023 · Journal of Alzheimer s Disease
  59. The direct role of 5-lipoxygenase on tau pathology, synaptic integrity and cognition in a mouse model of tauopathy
    Alana N. Vagnozzi, Phillip F. Giannopoulos, Domenico Praticò · 2017 · Translational Psychiatry
  60. A synapsin Ⅰ cleavage fragment contributes to synaptic dysfunction in Alzheimer's disease
    Lanxia Meng, Li Bo Zou, Min Xiong, Jiehui Chen, Xingyu Zhang, Ting Yu, Yiming Li, Congcong Liu, Guiqin Chen, Zhihao Wang et al. · 2022 · Aging Cell
  61. Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy
    A. Harrison Brody, Sarah Helena Nies, Fulin Guan, Levi M. Smith, Bandhan Mukherjee, Santiago A. Salazar, Suho Lee, Tu Kiet T. Lam, Stephen M. Strittmatter · 2022 · Molecular Neurodegeneration
  62. Truncation of tau at E391 Promotes Early Pathologic Changes in Transgenic Mice
    Pamela J. McMillan, Brian C. Kraemer, Linda Robinson, James B. Leverenz, Murray A. Raskind, Gerard D. Schellenberg · 2011 · Journal of Neuropathology & Experimental Neurology
  63. Chronic consumption of Annona muricata juice triggers and aggravates cerebral tau phosphorylation in wild‐type and MAPT transgenic mice
    Robert Rottscholl, Marlen Haegele, B. Jainsch, Hong Wei Xu, Gesine Respondek, Matthias Höllerhage, Thomas W. Rösler, Emilie Bony, Jessica Le Ven, Vincent Guérineau et al. · 2016 · Journal of Neurochemistry
  64. Mouse models of frontotemporal dementia: A comparison of phenotypes with clinical symptomatology
    Rebekah M. Ahmed, Muireann Irish, Janet van Eersel, Arne Ittner, Yazi Diana Ke, Alexander M. Volkerling, Julia van der Hoven, Kimi Tanaka, Tim Karl, Michael Kassiou et al. · 2017 · Neuroscience & Biobehavioral Reviews
  65. Synaptic changes in psychiatric and neurological disorders: State-of-the art of in vivo imaging
    Howes, Oliver, Marcinkowska, Julia, Turkheimer, Federico E., Carr, Richard · 2025 · Neuropsychopharmacology
  66. The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway
    Naguib, Sarah, Lopez-Lee, Chloe, Torres, Eileen Ruth, Lee, Se-In, Zhu, Jingjie, Zhu, Daphne, Ye, Pearly, Norman, Kendra, Zhao, Mingrui, Wong, Man Ying et al. · 2025 · Immunity
  67. Single-domain antibody–based noninvasive in vivo imaging of α-synuclein or tau pathology
    Yixiang Jiang, Yan Lin, Senthilkumar Krishnaswamy, Ruimin Pan, Qian Wu, Leslie A. Sandusky‐Beltran, Mengyu Liu, Min‐Hao Kuo, Xiang‐Peng Kong, Erin E. Congdon et al. · 2023 · Science Advances
  68. Late-stage Anle138b treatment ameliorates tau pathology and metabolic decline in a mouse model of human Alzheimer’s disease tau
    Matthias Brendel, Maximilian Deußing, Tanja Blume, Lena Kaiser, Federico Probst, Felix Overhoff, Finn Peters, Barbara von Ungern‐Sternberg, Sergey Ryazanov, Andrei Leonov et al. · 2019 · Alzheimer s Research & Therapy
  69. Alzheimer’s disease: phenotypic approaches using disease models and the targeting of tau protein
    Elisabetta Lauretti, Domenico Praticò · 2020 · Expert Opinion on Therapeutic Targets
  70. Dual Neutral Sphingomyelinase-2/Acetylcholinesterase Inhibitors for the Treatment of Alzheimer’s Disease
    Tina V. Bilousova, Bryan J. Simmons, Rachel R. Knapp, Chris Jean Elias, Jesus J. Campagna, Mikhail Melnik, Sujyoti Chandra, Samantha Focht, Chunni Zhu, Kanagasabai Vadivel et al. · 2020 · ACS Chemical Biology
  71. Longitudinal TSPO expression in tau transgenic P301S mice predicts increased tau accumulation and deteriorated spatial learning
    Eckenweber, Florian, Medina-Luque, Jose, Blume, Tanja, Sacher, Christian, Biechele, Gloria, Wind, Karin, Deussing, Maximilian, Briel, Nils, Lindner, Simon, Boening, Guido et al. · 2020 · Journal of Neuroinflammation
  72. Partial Inhibition of Mitochondrial Complex I Reduces Tau Pathology and Improves Energy Homeostasis and Synaptic Function in 3xTg-AD Mice
    Andrea Stojakovic, Su-Youne Chang, Jarred J. Nesbitt, Nicholas P. Pichurin, Mark Ostroot, Tomonori Aikawa, Takahisa Kanekiyo, Eugenia V. Trushina · 2020 · Journal of Alzheimer s Disease
  73. Loss of presenilin function enhances tau phosphorylation and aggregation in mice
    Carlos M. Soto-Faguás, Paula Sanchez-Molina, Carlos A. Saura · 2021 · Acta Neuropathologica Communications
  74. Presynaptic membrane protein dysfunction occurs prior to neurodegeneration and predicts faster cognitive decline
    Guoyu Lan, Anqi Li, Zhen Liu, Shaohua Ma, Tengfei Guo, Alzheimer’s Disease Neuroimaging Initiative · 2022 · Alzheimer s & Dementia
  75. Gene Therapy Models of Alzheimer’s Disease and Other Dementias
    Benjamin Combs, Andrew Kneynsberg, Nicholas M. Kanaan · 2015 · Methods in molecular biology
  76. Oxidative Stress and Alzheimer’s Disease
    Sandeep Kumar Singh, Rudy J. Castellani, George L. Perry · 2016 · Oxidative stress in applied basic research and clinical practice
  77. Bioassays and Inactivation of Prions
    Kurt Giles, Amanda L. Woerman, David B. Berry, Stanley B. Prusiner · 2017 · Cold Spring Harbor Perspectives in Biology
  78. A new perspective on Alzheimer’s disease: m6A modification
    Lei Xia, Fan Zhang, Yulu Li, Yuemi Mo, Lingqiu Zhang, Qianhua Li, Minghuang Luo, Xiaotao Hou, Zhengcai Du, Jiagang Deng et al. · 2023 · Frontiers in Genetics
  79. Reduced progranulin increases tau and α-synuclein inclusions and alters mouse tauopathy phenotypes via glucocerebrosidase
    Hideyuki Takahashi, Sanaea Z. Bhagwagar, Sarah Helena Nies, Hongping Ye, Xianlin Han, Marius Chiasseu, Guilin Wang, Ian R. Mackenzie, Stephen M. Strittmatter · 2024 · Nature Communications
  80. Autophagy and Cellular Senescence in Alzheimer's Disease: Key Drivers of Neurodegeneration
    Md Sadique Hussain, Neetu Agrawal, Baby Ilma, M. M. Rekha, Priya Priyadarshini Nayak, Mandeep Kaur, Anil Khachi, Kavita Goyal, Arcot Rekha, Saurabh Gupta et al. · 2025 · CNS Neuroscience & Therapeutics
  81. Molecular imaging of dementia
    Takaaki Mori, Jun Maeda, Hitoshi Shimada, Makoto Higuchi, Hitoshi Shinotoh, Shuichi Ueno, Tetsuya Suhara · 2012 · Psychogeriatrics
  82. Persistence of intact retinal ganglion cell terminals after axonal transport loss in the DBA/2J mouse model of glaucoma
    Matthew A. Smith, Christina Z. Xia, Samuel D. Crish, Kelly M. Fening, Denise M. Inman, Brett R. Schofield, Samuel D. Crish · 2016 · The Journal of Comparative Neurology
  83. Fundamental role of pan-inflammation and oxidative-nitrosative pathways in neuropathogenesis of Alzheimer's disease in focal cerebral ischemic rats.
    Mak Adam Daulatzai · 2016 · Europe PMC (PubMed Central)
  84. A unique tau conformation generated by an acetylation-mimic substitution modulates P301S-dependent tau pathology and hyperphosphorylation
    Deepa Ajit, Hanna Trzeciakiewicz, Jui‐Heng Tseng, Connor M. Wander, Youjun Chen, Aditi Ajit, Diamond P. King, Todd J. Cohen · 2019 · Journal of Biological Chemistry
  85. A synthetic heparinoid blocks Tau aggregate cell uptake and amplification
    Barbara Elena Stopschinski, Talitha L. Thomas, Sourena Nadji, Eric Darvish, Linfeng Fan, Brandon B. Holmes, Anuja R. Modi, Jordan G. Finnell, Omar M. Kashmer, Sandi Jo Estill et al. · 2020 · Journal of Biological Chemistry
  86. An Overview of Astrocyte Responses in Genetically Induced Alzheimer’s Disease Mouse Models
    Fokion Spanos, Shane Antony Liddelow · 2020 · Cells
  87. Epigenetic treatment of behavioral and physiological deficits in a tauopathy mouse model
    Wei Wang, Qing Cao, Tao Tan, Fengwei Yang, Jamal B. Williams, Zhen Yan · 2021 · Aging Cell
  88. Broad activation of the Parkin pathway induces synaptic mitochondrial deficits in early tauopathy
    Yu Young Jeong, Sinsuk Han, Nuo Jia, Mingyang Zhang, Preethi Sheshadri, Prasad Tammineni, Jasmine Cheung, Marialaina Nissenbaum, Sindhuja S. Baskar, Kelvin Y. Kwan et al. · 2022 · UCL Discovery (University College London)
  89. Brain cellular senescence in mouse models of Alzheimer’s disease
    Angela O. Dorigatti, Ruben Riordan, Zhen Yu, Grace Ross, Rong Wang, Nadjalisse C. Reynolds-Lallement, Kathy Ruth Magnusson, Verónica Galván, Viviana Pérez · 2022 · GeroScience
  90. Disruption of tubulin-alpha4a polyglutamylation prevents aggregation of hyper-phosphorylated tau and microglia activation in mice
    Torben Johann Hausrat, Philipp Christoph Janiesch, Petra Breiden, David Lutz, Sabine Hoffmeister‐Ullerich, Irm Hermans‐Borgmeyer, Antonio Virgilio Failla, Matthias Kneussel · 2022 · Nature Communications
  91. The Role of Traditional Chinese Medicine Natural Products in β-Amyloid Deposition and Tau Protein Hyperphosphorylation in Alzheimer’s Disease
    Huiying Yan, Li-Na Feng, Ming-Quan Li · 2023 · Drug Design, Development and Therapy
  92. Recent advances in using Drosophila to model neurodegenerative diseases
    Bingwei Lu · 2009 · APOPTOSIS
  93. Transcellular Spreading of Tau in Tauopathies
    Koen C. Demaegd, Joost W. H. Schymkowitz, Frédéric Rousseau · 2018 · ChemBioChem
  94. Chaperone-like Antibodies Targeting Misfolded Tau Protein: New Vistas in the Immunotherapy of Neurodegenerative Foldopathies
    Norbert Žilka, Eva Kontseková, Michal Novák · 2008 · Journal of Alzheimer s Disease
  95. Imatinib methanesulfonate reduces hyperphosphorylation of tau following repeated peripheral exposure to lipopolysaccharide
    Gardner, L.E., White, J.D., Eimerbrink, M.J., Boehm, G.W., Chumley, M.J. · 2016 · Neuroscience
  96. Upregulated astrocyte HDAC7 induces Alzheimer-like tau pathologies via deacetylating transcription factor-EB and inhibiting lysosome biogenesis
    Jinwang Ye, Suyue Zhong, Huali Wan, Xing Guo, Xuanbao Yao, Qiong Liu, Liming Chen, Jian‐Zhi Wang, Shifeng Xiao · 2025 · Molecular Neurodegeneration
  97. 3D Visualization of the Temporal and Spatial Spread of Tau Pathology Reveals Extensive Sites of Tau Accumulation Associated with Neuronal Loss and Recognition Memory Deficit in Aged Tau Transgenic Mice
    Hongjun Fu, S. Abid Hussaini, Susanne Wegmann, Caterina P. Profaci, Jacob D. Daniels, Mathieu Herman, Sheina Emrani, Helen Y. Figueroa, Bradley T. Hyman, Peter Davies et al. · 2016 · PLoS ONE
  98. Dynamics of the Complement, Cytokine, and Chemokine Systems in the Regulation of Synaptic Function and Dysfunction Relevant to Alzheimer’s Disease
    Shanya Jiang, Kiran Bhaskar · 2017 · Journal of Alzheimer s Disease
  99. Entanglement of CCR5 and Alzheimer’s Disease
    Tianwen Li, Jianhong Zhu · 2019 · Frontiers in Aging Neuroscience
  100. Relationship between tau, neuroinflammation and atrophy in Alzheimer's disease: The NIMROD study
    Li Su, Ajenthan Surendranathan, Yujing Huang, William Richard Bevan-Jones, Luca Passamonti, Yong T. Hong, Robert J. Arnold, Patricia Vázquez Rodríguez, Yi Wang, Elijah Mak et al. · 2020 · Information Fusion