Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model
Yoshiyama, Yasumasa, Higuchi, Makoto, Zhang, Bin, Huang, Shu-Ming, Iwata, Nobuhisa, Saido, Takaomi C., Maeda, Jun, Suhara, Tetsuya +2 more·2007·Neuron
Cited by (1,029)
Items 401–500 of 1,029
- Targeting histone K4 trimethylation for treatment of cognitive and synaptic deficits in mouse models of Alzheimer’s diseaseCao, Qing, Wang, Wei, Williams, Jamal B., Yang, Fengwei, Wang, Zi-Jun, Yan, Zhen · 2020 · Science Advances
- Distinct Signaling Pathways Regulate TREM2 Phagocytic and NFκB Antagonistic ActivitiesYao, Hailan, Coppola, Kyle, Schweig, Jonas Elias, Crawford, Fiona, Mullan, Michael, Paris, Daniel · 2019 · Frontiers in Cellular Neuroscience
- Synapse elimination during development and disease: immune molecules take centre stageDorothy P. Schafer, Beth Stevens · 2010 · Biochemical Society Transactions
- Tau biology, tauopathy, traumatic brain injury, and diagnostic challengesCastellani, Rudy J., Perry, George · 2019 · Journal of Alzheimer’s Disease
- TGF-β1 signalling in Alzheimer’s pathology and cytoskeletal reorganization: a specialized Tau perspectiveMahima Kapoor, Subashchandrabose Chinnathambi · 2023 · Journal of Neuroinflammation
- Tau filaments are tethered within brain extracellular vesicles in Alzheimer’s diseaseStephanie L. Fowler, Tiana S. Behr, Emir Turkes, Darragh Patrick O'Brien, Paula Maglio Cauhy, Isadora Rawlinson, Marisa J. Edmonds, Martha S. Foiani, Ari W. Schaler, Gerard Crowley et al. · 2024 · Nature Neuroscience
- Relationships between default-mode network connectivity, medial temporal lobe structure, and age-related memory deficitsAndrew M. Ward, Elizabeth C. Mormino, Willem Huijbers, Aaron P. Schultz, Trey Hedden, Reisa Anne Sperling · 2014 · Neurobiology of Aging
- Bioluminescence imaging of Aβ deposition in bigenic mouse models of Alzheimer's diseaseWatts, Joel C., Giles, Kurt, Grillo, Sunny K., Lemus, Azucena, DeArmond, Stephen J., Prusiner, Stanley B. · 2011 · Proceedings of the National Academy of Sciences
- Application of Iron Oxide Nanoparticles in the Diagnosis and Treatment of Neurodegenerative Diseases With Emphasis on Alzheimer’s DiseaseShen Luo, Chi Ma, Mingqin Zhu, Wei-Na Ju, Yang Yu, Xu Wang · 2020 · Frontiers in Cellular Neuroscience
- An Engulfment Assay: A Protocol to Assess Interactions Between CNS Phagocytes and NeuronsSchafer, Dorothy P., Lehrman, Emily K., Heller, Christopher T., Stevens, Beth · 2014 · Journal of Visualized Experiments
- Inflammation and Alzheimer’s Disease: Mechanisms and Therapeutic Implications by Natural ProductsMashoque Ahmad Rather, Andleeb Khan, Saeed Alshahrani, Hina Rashid, Marwa M. Qadri, Summya Rashid, Rana M. Alsaffar, Mohammad Amjad Kamal, Muneeb U. Rehman · 2021 · Mediators of Inflammation
- CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathyLjungberg, M. Cecilia, Ali, Yousuf O., Zhu, Jie, Wu, Chia-Shan, Oka, Kazuhiro, Zhai, R. Grace, Lu, Hui-Chen · 2012 · Human Molecular Genetics
- Molecular Chaperones: A Double-Edged Sword in Neurodegenerative DiseasesJessica Tittelmeier, Eliana Nachman, Carmen I. Nussbaum-Krammer · 2020 · Frontiers in Aging Neuroscience
- Characteristics of TBS-Extractable Hyperphosphorylated Tau Species: Aggregation Intermediates in rTg4510 Mouse BrainNaruhiko Sahara, Michael A. Deture, Yan Ren, Abdul-Shukkur Ebrahim, Dongcheul Kang, Joshua A. Knight, Christiane Volbracht, Jan T. Pedersen, Dennis W. Dickson, Shu-Hui C. Yen et al. · 2012 · Journal of Alzheimer s Disease
- Role of Microglial Cells in Alzheimer’s Disease Tau PropagationEna Španić, Lea Langer Horvat, Patrick R. Hof, Goran Šimić · 2019 · Frontiers in Aging Neuroscience
- TFEB–vacuolar ATPase signaling regulates lysosomal function and microglial activation in tauopathyBaiping Wang, Heidi Martini‐Stoica, Chuangye Qi, Tzu‐Chiao Lu, Shuo Wang, Wen Xiong, Yanyan Qi, Yin Xu, Marco Sardiello, Hongjie Li et al. · 2023 · Nature Neuroscience
- Anti-Inflammatory Impact of Minocycline in a Mouse Model of TauopathyGarwood, Claire J., Cooper, Jonathan D., Hanger, Diane P., Noble, Wendy · 2010 · Frontiers in Psychiatry
- Tau Accumulation, Altered Phosphorylation, and Missorting Promote Neurodegeneration in GlaucomaMarius Chiasseu, Jorge L. Cueva Vargas, Laurie Destroismaisons, Christine Vande Velde, Nicole M. Leclerc, Adriana Di Polo · 2016 · Journal of Neuroscience
- Alzheimer’s Disease: Etiology, Neuropathology and PathogenesisOlivia Sheppard, Michael P. Coleman · 2020 · Exon Publications eBooks
- Dendritic Spine Instability Leads to Progressive Neocortical Spine Loss in a Mouse Model of Huntington's DiseaseMurmu, R. P., Li, W., Holtmaat, A., Li, J.-Y. · 2013 · Journal of Neuroscience
- Neuroinflammation and J2 prostaglandins: linking impairment of the ubiquitin-proteasome pathway and mitochondria to neurodegenerationMaria E. Figueiredo‐Pereira, Patricia Rockwell, Thomas Schmidt‐Glenewinkel, Peter A. Serrano · 2015 · Frontiers in Molecular Neuroscience
- Tau physiology and pathomechanisms in frontotemporal lobar degenerationBodea, Liviu‐Gabriel, Eckert, Anne, Ittner, Lars Matthias, Piguet, Olivier, Götz, Jürgen · 2016 · Journal of Neurochemistry
- The Role of Protein Misfolding and Tau Oligomers (TauOs) in Alzheimer′s Disease (AD)Barbara Mroczko, Magdalena Groblewska, Ala Litman‐Zawadzka · 2019 · International Journal of Molecular Sciences
- CCL2 Overexpression in the Brain Promotes Glial Activation and Accelerates Tau Pathology in a Mouse Model of TauopathyAurélie Joly‐Amado, Jordan Hunter, Zainuddin Quadri, Frank Zamudio, Patricia Rocha-Rangel, Deanna Chan, Anisha Kesarwani, Kevin R. Nash, Daniel C. Lee, David Morgan et al. · 2020 · Frontiers in Immunology
- Interleukin-18 increases expression of kinases involved in tau phosphorylation in SH-SY5Y neuroblastoma cellsOjala, Johanna O., Sutinen, Elina M., Salminen, Antero, Pirttilä, Tuula · 2008 · Journal of Neuroimmunology
- Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy PathogenesisZhao, Yingjun, Tseng, I-Chu, Heyser, Charles J., Rockenstein, Edward, Mante, Michael, Adame, Anthony, Zheng, Qiuyang, Huang, Timothy, Wang, Xin, Arslan, Pharhad E. et al. · 2015 · Neuron
- Microglial Activation in Alzheimers DiseaseJohannes C. M. Schlachetzki, Michael Hüll · 2009 · Current Alzheimer Research
- TIA1 regulates the generation and response to toxic tau oligomersLulu Jiang, Peter E.A. Ash, Brandon F. Maziuk, Heather I. Ballance, Samantha Boudeau, Ali Al Abdullatif, Marcello Orlando, Leonard Petrucelli, Tsuneya Ikezu, Benjamin L. Wolozin · 2018 · Acta Neuropathologica
- A dual-ligand fusion peptide improves the brain-neuron targeting of nanocarriers in Alzheimer's disease miceQian Guo, Shuting Xu, Peng Yang, Pengzhen Wang, Shuai Lü, Dongyu Sheng, Kang Qian, Jinxu Cao, Wei Lü, Qizhi Zhang · 2020 · Journal of Controlled Release
- An HDAC6-dependent surveillance mechanism suppresses tau-mediated neurodegeneration and cognitive declineTrzeciakiewicz, Hanna, Ajit, Deepa, Tseng, Jui-Heng, Chen, Youjun, Ajit, Aditi, Tabassum, Zarin, Lobrovich, Rebecca, Peterson, Claire, Riddick, Natallia V., Itano, Michelle S. et al. · 2020 · Nature Communications
- Alzheimer’s Disease: Mechanism and Approach to Cell TherapyTakashi Amemori, Pavla Jendelová, Jiří Růžička, Lucia Machová Urdzíková, Eva Syková · 2015 · International Journal of Molecular Sciences
- Long-term treadmill exercise attenuates tau pathology in P301S tau transgenic miceOdochi Ohia-Nwoko, Saghi Montazari, Yuen‐Sum Lau, Jason L. Eriksen · 2014 · Molecular Neurodegeneration
- Mechanistic involvement of the calpain‐calpastatin system in Alzheimer neuropathologyMakoto Higuchi, Nobuhisa Iwata, Yukio Matsuba, Jiro Takano, Takahiro Suemoto, Jun Maeda, Bin Ji, Maiko Ono, Matthias Staufenbiel, Tetsuya Suhara et al. · 2011 · The FASEB Journal
- Multicolor time-stamp reveals the dynamics and toxicity of amyloid depositionCarlo Condello, Aaron J. Schain, Jaime Grutzendler · 2011 · Scientific Reports
- Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathyYanamandra, Kiran, Patel, Tirth K., Jiang, Hong, Schindler, Suzanne, Ulrich, Jason D., Boxer, Adam L., Miller, Bruce L., Kerwin, Diana R., Gallardo, Gilbert, Stewart, Floy et al. · 2017 · Science Translational Medicine
- Hyperexcitability and epileptic seizures in a model of frontotemporal dementiaAna M. García-Cabrero, Rosa Guerrero, Beatriz G. Giráldez, Marı́a Llorens-Martı́n, Jesús Ávila, José María Serratosa, Marina P. Sánchez · 2013 · Neurobiology of Disease
- Chronic Sleep Disruption Advances the Temporal Progression of Tauopathy in P301S Mutant MiceYan Zhu, Guanxia Zhan, Polina Fenik, M Brandes, Patrick Bell, Noëlle François, Katherine Shulman, Sigrid Carlen Veasey · 2018 · Journal of Neuroscience
- Implications of microbe-derived ɣ-aminobutyric acid (GABA) in gut and brain barrier integrity and GABAergic signaling in Alzheimer’s diseaseKathryn A Conn, Emily M. Borsom, Emily K. Cope · 2024 · Gut Microbes
- Alpha7 nicotinic acetylcholine receptor: A link between inflammation and neurodegenerationConcepcion Conejero‐Goldberg, Peter Davies, Luis Ulloa · 2007 · Neuroscience & Biobehavioral Reviews
- Reductions in Amyloid-β-Derived Neuroinflammation, with Minocycline, Restore Cognition but do not Significantly Affect Tau HyperphosphorylationAnna I. Parachikova, Vitaly Vasilevko, David H. Cribbs, Frank M. LaFerla, Kim N. Green · 2010 · Journal of Alzheimer s Disease
- FK506 reduces abnormal prion protein through the activation of autolysosomal degradation and prolongs survival in prion-infected miceTakehiro Nakagaki, Katsuya Satoh, Daisuke Ishibashi, Takayuki Fuse, Kazunori Sano, Yuji O. Kamatari, Kazuo Kuwata, Kazuto Shigematsu, Yoshifumi Iwamaru, Takato Takenouchi et al. · 2013 · Autophagy
- Specific Calpain Inhibition by Calpastatin Prevents Tauopathy and Neurodegeneration and Restores Normal Lifespan in Tau P301L MiceMala V. Rao, Mary Kate McBrayer, J. Campbell, Ashok Kumar, Ali Talib Hashim, Henry W. Sershen, Philip H. Stavrides, Masuo Ohno, Mike Hutton, Ralph A. Nixon · 2014 · Journal of Neuroscience
- Tau oligomerization: a role for tau aggregation intermediates linked to neurodegenerationSahara, N., Maeda, S., Takashima, A. · 2008 · Current Alzheimer Research
- Proteinopathy-induced neuronal senescence: a hypothesis for brain failure in Alzheimer’s and other neurodegenerative diseasesGolde, Todd E, Miller, Victor M · 2009 · Alzheimer's Research & Therapy
- Extracellular low‐n oligomers of tau cause selective synaptotoxicity without affecting cell viabilitySenthilvelrajan Kaniyappan, RamReddy Chandupatla, Eva‐Maria Mandelkow, Eckhard Mandelkow · 2017 · Alzheimer s & Dementia
- Hippocampal tauopathy in tau transgenic mice coincides with impaired hippocampus-dependent learning and memory, and attenuated late-phase long-term depression of synaptic transmissionAnn Van der Jeugd, Tariq Ahmed, Sylvie Burnouf, Karim Bélarbi, Malika Hamdame, Marie‐Eve Grosjean, Sandrine Humez, Detlef Balschun, David L Blum, Luc Buée et al. · 2010 · Neurobiology of Learning and Memory
- Human misfolded truncated tau protein promotes activation of microglia and leukocyte infiltration in the transgenic rat model of tauopathyNorbert Žilka, Zuzana Stožická, Andrej Kováč, Emil Pilipcinec, Ondrej Bugos, Michal Novák · 2009 · Journal of Neuroimmunology
- Mouse models of frontotemporal dementiaErik D. Roberson · 2012 · Annals of Neurology
- Early behavioural markers of disease in P301S tau transgenic miceMaría Luisa Scattoni, Laura Gasparini, Enrico Alleva, Michel Goedert, Gemma Calamandrei, Maria Grazia Spillantini · 2009 · Behavioural Brain Research
- Characterization of tau prion seeding activity and strains from formaldehyde-fixed tissueSarah K. Kaufman, Talitha L. Thomas, Kelly Del Tredici, Heiko Braak, Marc I. Diamond · 2017 · Acta Neuropathologica Communications
- Inflammation in transgenic mouse models of neurodegenerative disordersSchwab, Claudia, Klegeris, Andis, McGeer, Patrick. L. · 2010 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- MEF2 is a Key Regulator of Cognitive Potential and Confers Resilience to NeurodegenerationBarker, Scarlett J., Raju, Ravikiran M., Milman, Noah E.P., Wang, Jun, Davila-Velderrain, Jose, Gunter-Rahman, Fatima, Parro, Cameron C., Bozzelli, P. Lorenzo, Abdurrob, Fatema, Abdelaal, Karim et al. · 2021 · Science Translational Medicine
- Biologic TNF-α inhibitors reduce microgliosis, neuronal loss, and tau phosphorylation in a transgenic mouse model of tauopathyWeijun Ou, Joshua Yang, Juste Simanauskaite, Matthew K. Choi, Demi M. Castellanos, Rudy Chang, Jiahong Sun, Nataraj Jagadeesan, Karen D. Parfitt, David H. Cribbs et al. · 2021 · Journal of Neuroinflammation
- TRIM11 protects against tauopathies and is down-regulated in Alzheimer’s diseaseZ. Zhang, Dilshan S. Harischandra, Ruifang Wang, Shivani Ghaisas, Janet Yinqing Zhao, Thomas P. McMonagle, Guixin Zhu, Kenzo D. Lacuarta, Jianing Song, John Q. Trojanowski et al. · 2023 · Science
- A neurodegenerative cellular stress response linked to dark microglia and toxic lipid secretionAnna G. Flury, Leen Aljayousi, Hye-Jin Park, Mohammadparsa Khakpour, Jack Mechler, Siaresh Aziz, Jackson D. McGrath, Pragney Deme, Colby Sandberg, Fernando Gonzàlez Ibáñez et al. · 2024 · Neuron
- The Role of Tau in Neurodegenerative Diseases and Its Potential as a Therapeutic TargetMichael S. Wolfe · 2012 · Scientifica
- Triggering Receptor Expressed on Myeloid Cells 2 Deficiency Alters Acute Macrophage Distribution and Improves Recovery after Traumatic Brain InjuryMaha Saber, Olga N. Kokiko‐Cochran, Shweta S. Puntambekar, Justin Durla Lathia, Bruce T. Lamb · 2016 · Journal of Neurotrauma
- Sensitive Detection of Proteopathic Seeding Activity with FRET Flow CytometryJennifer L. Furman, Brandon B. Holmes, Marc I. Diamond · 2015 · Journal of Visualized Experiments
- Tau-mediated synaptic damage in Alzheimer’s diseaseSantosh Jadhav, Veronika Cubinkova, Ivana Zimova, Veronika Brezováková, Aladár Maďari, Viera Cigánková, Norbert Žilka · 2015 · Translational Neuroscience
- Characterization of tau oligomeric seeds in progressive supranuclear palsyJulia E. Gerson, Urmi Sengupta, Cristian A. Lasagna‐Reeves, Marcos Jair Guerrero‐Munoz, Juan Carlos Troncoso, Rakez Kayed · 2014 · Acta Neuropathologica Communications
- Potential benefits of mindfulness-based interventions in mild cognitive impairment and Alzheimer’s disease: an interdisciplinary perspective.Larouche, Eddy, Hudon, Carol, Goulet, Sonia · 2015 · Behavioural Brain Research
- Amyloid‐β impairs the phagocytosis of dystrophic synapses by astrocytes in Alzheimer's diseaseSanchez‐Mico, Maria V., Jimenez, Sebastian, Gomez‐Arboledas, Angela, Muñoz‐Castro, Clara, Romero‐Molina, Carmen, Navarro, Victoria, Sanchez‐Mejias, Elisabeth, Nuñez‐Diaz, Cristina, Sanchez‐Varo, Raquel, Galea, Elena et al. · 2021 · Glia
- Tau hyperphosphorylation induces oligomeric insulin accumulation and insulin resistance in neuronsPatricia Rodriguez‐Rodriguez, Anna Matton, Paula Merino‐Serrais, Cristina Parrado‐Fernández, Alberto Rábano, Bengt G. Winblad, Jesús Ávila, Isidró Ferrer, Ángel Cedazo-Mı́nguez · 2017 · Brain
- Detection of Alzheimer Disease (AD)-Specific Tau Pathology in AD and NonAD Tauopathies by Immunohistochemistry With Novel Conformation-Selective Tau AntibodiesGibbons, Garrett S, Banks, Rachel A, Kim, Bumjin, Changolkar, Lakshmi, Riddle, Dawn M, Leight, Susan N, Irwin, David J, Trojanowski, John Q, Lee, Virginia M Y · 2018 · Journal of Neuropathology & Experimental Neurology
- Small Molecule p75NTR Ligands Reduce Pathological Phosphorylation and Misfolding of Tau, Inflammatory Changes, Cholinergic Degeneration, and Cognitive Deficits in AβPPL/S Transgenic MiceThuy‐Vi V. Nguyen, Lin Shen, Lilith Vander Griend, Lisa N. Quach, Nadia P. Belichenko, Nay Lui Saw, Tao Yang, Mehrdad Shamloo, Tony Wyss‐Coray, Stephen M. Massa et al. · 2014 · Journal of Alzheimer s Disease
- A novel transgenic mouse expressing double mutant tau driven by its natural promoter exhibits tauopathy characteristicsHanna Rosenmann, Nikolaos Grigoriadis, Hila Eldar-Levy, Avi Avital, Lea Rozenstein‐Tsalkovich, Olga Touloumi, Leah Behar, Tamir Ben‐Hur, Yosefa Avraham, Eliot Berry et al. · 2008 · Experimental Neurology
- Targeting Neural Hyperactivity as a Treatment to Stem Progression of Late-Onset Alzheimer's DiseaseRebecca P. Haberman, Audrey Branch, Michela Gallagher · 2017 · Neurotherapeutics
- Heterogeneity in brain distribution of activated microglia and astrocytes in a rat ischemic model of Alzheimer’s disease after 2 years of survivalLidija Radenović, Marija Nenadić, Marzena Ułamek-Kozioł, Sławomir Januszewski, Stanisław Jerzy Czuczwar, Pavle R. Anđjus, Ryszard M. Pluta · 2020 · Aging
- The Emerging Role of Nutraceuticals and Phytochemicals in the Prevention and Treatment of Alzheimer’s DiseaseCamila Calfío, Andrea González, Sandeep Kumar Singh, Leonel E. Rojo, Ricardo Benjamin Maccioni · 2020 · Journal of Alzheimer s Disease
- Chronic exercise ameliorates the neuroinflammation in mice carrying NSE/htau23Yea‐Hyun Leem, Young-Ik Lee, Hee-Jeong Son, Sangho Lee · 2011 · Biochemical and Biophysical Research Communications
- Tau downregulates BDNF expression in animal and cellular models of Alzheimer's diseaseElyse Rosa, Sujeivan Mahendram, Yazi Diana Ke, Lars Matthias Ittner, Stephen D. Ginsberg, Margaret L. Fahnestock · 2016 · Neurobiology of Aging
- The Role of MAPT in Neurodegenerative Diseases: Genetics, Mechanisms and TherapyChengcheng Zhang, Ang Xing, Meng‐Shan Tan, Lan Tan, Jin‐Tai Yu · 2015 · Molecular Neurobiology
- p73 Regulates Neurodegeneration and Phospho-Tau Accumulation during Aging and Alzheimer's DiseaseMonica K. Wetzel, Sibel Naska, Christine L. Laliberté, Vladimir V. Rymar, Masashi Fujitani, Jeffrey Biernaskie, Christy J. Cole, Jason P. Lerch, Shoshana Spring, Szu‐Han Wang et al. · 2008 · Neuron
- Brain-Penetrant, Orally Bioavailable Microtubule-Stabilizing Small Molecules Are Potential Candidate Therapeutics for Alzheimer’s Disease and Related TauopathiesKevin Lou, Yuemang Yao, Adam T. Hoye, Michael J. James, Anne‐Sophie Cornec, Edward G. Hyde, Bryant C. Gay, Virginia M.‐Y. Lee, John Q. Trojanowski, Amos B. Smith et al. · 2014 · Journal of Medicinal Chemistry
- Infectious origin of Alzheimer’s disease: Amyloid beta as a component of brain antimicrobial immunityVojtechova, Iveta, Machacek, Tomas, Kristofikova, Zdenka, Stuchlik, Ales, Petrasek, Tomas · 2022 · PLOS Pathogens
- Phosphorylated Tau: Toxic, Protective, or None of the AboveRudy J. Castellani, Akihiko Nunomura, Hyoung‐gon Lee, George L. Perry, Mark A. Smith · 2008 · Journal of Alzheimer s Disease
- Evidence of Tau Hyperphosphorylation and Dystrophic Microglia in the Common MarmosetJuan D. Rodríguez-Callejas, Eberhard Fuchs, Claudia Perez‐Cruz · 2016 · Frontiers in Aging Neuroscience
- Loss of tau rescues inflammation-mediated neurodegenerationMaphis, Nicole, Xu, Guixiang, Kokiko-Cochran, Olga N., Cardona, Astrid E., Ransohoff, Richard M., Lamb, Bruce T., Bhaskar, Kiran · 2015 · Frontiers in Neuroscience
- Decreased lipidated ApoE‐receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomesGuo, Jing L., Braun, Dylan, Fitzgerald, Gabriel A., Hsieh, Yun-Ting, Rougé, Lionel, Litvinchuk, Alexandra, Steffek, Micah, Propson, Nicholas E., Heffner, Catherine M., Discenza, Claire et al. · 2025 · Cell
- Genome-wide RNAseq study of the molecular mechanisms underlying microglia activation in response to pathological tau perturbation in the rTg4510 tau transgenic animal modelWang, Hong, Li, Yupeng, Ryder, John W., Hole, Justin T., Ebert, Philip J., Airey, David C., Qian, Hui-Rong, Logsdon, Benjamin, Fisher, Alice, Ahmed, Zeshan et al. · 2018 · Molecular Neurodegeneration
- Apolipoprotein E4 Reduction with Antisense Oligonucleotides Decreases Neurodegeneration in a Tauopathy ModelLitvinchuk, Alexandra, Huynh, Tien‐Phat V., Shi, Yang, Jackson, Rosemary J., Finn, Mary B., Manis, Melissa, Francis, Caroline M., Tran, Ainsley C., Sullivan, Patrick M., Ulrich, Jason D. et al. · 2021 · Annals of Neurology
- An astrocyte BMAL1-BAG3 axis protects against alpha-synuclein and tau pathologyPatrick W. Sheehan, Collin J. Nadarajah, Michael F. Kanan, Jessica N. Patterson, Brenna C. Novotny, Jennifer H. Lawrence, Melvin W. King, Logan Brase, Casey E. Inman, Carla M. Yuede et al. · 2023 · Neuron
- Microglia display modest phagocytic capacity for extracellular tau oligomersMajerova, Petra, Zilkova, Monika, Kazmerova, Zuzana, Kovac, Andrej, Paholikova, Kristina, Kovacech, Branislav, Zilka, Norbert, Novak, Michal · 2014 · Journal of Neuroinflammation
- Repositioning Microtubule Stabilizing Drugs for Brain DisordersArtemis Varidaki, Ye Hong, Eleanor T. Coffey · 2018 · Frontiers in Cellular Neuroscience
- Social isolation induces neuroinflammation and microglia overactivation, while dihydromyricetin prevents and improves themAlzahra J. Al Omran, Amy S. Shao, Saki Watanabe, Zeyu Zhang, Jifeng Zhang, Xue Chen, Junji Watanabe, Daryl L. Davies, Xuesi M. Shao, Jing Liang · 2022 · Journal of Neuroinflammation
- Trimeric Tau Is Toxic to Human Neuronal Cells at Low Nanomolar ConcentrationsTian, Huilai, Davidowitz, Eliot, Lopez, Patricia, Emadi, Sharareh, Moe, James, Sierks, Michael · 2013 · International Journal of Cell Biology
- Stimulation of TLR4 Attenuates Alzheimer’s Disease–Related Symptoms and Pathology in Tau-Transgenic MiceQin, Yiren, Liu, Yang, Hao, Wenlin, Decker, Yann, Tomic, Inge, Menger, Michael D, Liu, Chunfeng, Fassbender, Klaus · 2016 · The Journal of Immunology
- Tau at the interface between neurodegeneration and neuroinflammationDidonna, Alessandro · 2020 · Genes & Immunity
- Fractalkine/CX3CR1 is involved in the cross-talk between neuron and glia in neurological diseases.Piao Luo, Shi-Feng Chu, Zhao Zhang, Cong-yuan Xia, Nai-Hong Chen · 2019 · Brain Research Bulletin
- Crosstalk between Oxidative Stress and TauopathyMd. Mamunul Haque, Dhiraj P. Murale, Yun Kyung Kim, Jun‐Seok Lee · 2019 · International Journal of Molecular Sciences
- Tau fibrils induce glial inflammation and neuropathology via TLR2 in Alzheimer’s disease–related mouse modelsDutta, Debashis, Jana, Malabendu, Paidi, Ramesh Kumar, Majumder, Moumita, Raha, Sumita, Dasarathy, Sridevi, Pahan, Kalipada · 2023 · Journal of Clinical Investigation
- Presence of Reactive Microglia and Neuroinflammatory Mediators in a Case of Frontotemporal Dementia with P301S MutationArianna Bellucci, Orso Bugiani, Bernardino Francesco Ghetti, Maria Grazia Spillantini · 2011 · Neurodegenerative Diseases
- LSD1 protects against hippocampal and cortical neurodegenerationMichael A. Christopher, Dexter A. Myrick, Benjamin G. Barwick, Amanda Engstrom, Kirsten A. Porter‐Stransky, Jeremy M. Boss, David Weinshenker, Allan I. Levey, David J. Katz · 2017 · Nature Communications
- Microglial REV-ERBα regulates inflammation and lipid droplet formation to drive tauopathy in male miceJiyeon Lee, Julie M. Dimitry, Jong Hee Song, Minsoo Son, Patrick W. Sheehan, Melvin W. King, G. Travis Tabor, Young Ah Goo, Mitchell A. Lazar, Leonard Petrucelli et al. · 2023 · Nature Communications
- Pathways to Parkinsonism Redux: convergent pathobiological mechanisms in genetics of Parkinson's diseaseKumaran, Ravindran, Cookson, Mark R. · 2015 · Human Molecular Genetics
- Promoting Autophagic Clearance: Viable Therapeutic Targets in Alzheimer's DiseaseLauren G. Friedman, Yasir H. Qureshi, Wai Haung Yu · 2014 · Neurotherapeutics
- A Clear and Present Danger: Endogenous Ligands of Toll-like ReceptorsJacob A. Sloane, Daina Blitz, Zachary R. Margolin, Timothy K. Vartanian · 2009 · NeuroMolecular Medicine
- Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathiesJens Wagner, Sybille Krauß, Song Shi, Sergey Ryazanov, Julia Steffen, Carolin Miklitz, Andrei Leonov, Alexander Kleinknecht, Bettina Göricke, Jochen Hans Weishaupt et al. · 2015 · Acta Neuropathologica
- Tau Aggregates: Toxic, Inert, or Protective Species?Alexis Bretteville, Emmanuel Planel · 2008 · Journal of Alzheimer s Disease
- Invited review: Animal models of tauopathies and their implications for research/translation into the clinicSimon Dujardin, Morvane Colin, Luc Buée · 2014 · Neuropathology and Applied Neurobiology