Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model

Yoshiyama, Yasumasa, Higuchi, Makoto, Zhang, Bin, Huang, Shu-Ming, Iwata, Nobuhisa, Saido, Takaomi C., Maeda, Jun, Suhara, Tetsuya, Trojanowski, John Q., Lee, Virginia M.-Y.·2007·Neuron
DOI 10.1016/j.neuron.2007.01.010

Cited by (1,030)

Items 1,001–1,030 of 1,030

  1. Early alterations of neurovascular unit in the retina in mouse models of tauopathy
    Fan Xia, Yonju Ha, Shuizhen Shi, Yi Li, Shengguo Li, Jonathan D. Luisi, Rakez Kayed, Massoud Motamedi, Hua Liu, Wenbo Zhang · 2021 · Acta Neuropathologica Communications
  2. Alzheimer's disease and synapse Loss: What can we learn from induced pluripotent stem Cells?
    Francisco Javier Rodríguez-Jiménez, Juan R. Ureña‐Peralta, Pavla Jendelová, Slaven Erceg · 2023 · Journal of Advanced Research
  3. Genetic Variation in N-Methyl-D-Aspartate Receptor Subunit NR3A but Not NR3B Influences Susceptibility to Alzheimer’s Disease
    Liu, Hsin-Ping, Lin, Wei-Yong, Liu, Shu-Hsiang, Wang, Wen-Fu, Tsai, Chon-Haw, Wu, Bor-Tsang, Wang, Chien-Kuo, Tsai, Fuu-Jen · 2009 · Dementia and Geriatric Cognitive Disorders
  4. Modulation of L-type calcium channels in Alzheimer’s disease: A potential therapeutic target
    Crossley, Chelsea A., Rajani, Vishaal, Yuan, Qi · 2023 · Computational and Structural Biotechnology Journal
  5. Diffusion tensor imaging reveals whole-brain microstructural changes in the P301L mouse model of tauopathy.
    Massalimova, Aidana, Ni, Ruiqing, Nitsch, Roger M., Reisert, Marco, von Elverfeldt, Dominik, Klohs, Jan · 2020 · Neurodegenerative Diseases
  6. APOE Christchurch enhances a disease-associated microglial response to plaque but suppresses response to tau pathology
    Tran, Kristine M., Kwang, Nellie E., Butler, Claire A., Gomez-Arboledas, Angela, Kawauchi, Shimako, Mar, Cassandra, Chao, Donna, Barahona, Rocio A., Da Cunha, Celia, Tsourmas, Kate I. et al. · 2025 · Molecular Neurodegeneration
  7. THY-Tau22 mouse model accumulates more tauopathy at late stage of the disease in response to microglia deactivation through TREM2 deficiency
    Vautheny, Audrey, Duwat, Charlotte, Aurégan, Gwennaëlle, Joséphine, Charlène, Hérard, Anne-Sophie, Jan, Caroline, Mitja, Julien, Gipchtein, Pauline, Gaillard, Marie-Claude, Buée, Luc et al. · 2021 · Neurobiology of Disease
  8. Tau Oligomers in Sera of Patients with Alzheimer’s Disease and Aged Controls
    Kolarova, Michala, Sengupta, Urmi, Bartos, Ales, Ricny, Jan, Kayed, Rakez · 2017 · Journal of Alzheimer’s Disease
  9. Dendritic Spine Remodeling and Synaptic Tau Levels in PS19 Tauopathy Mice
    Walker, Courtney K., Greathouse, Kelsey M., Boros, Benjamin D., Poovey, Emily H., Clearman, Kelsey R., Ramdas, Raksha, Muhammad, Hamad M., Herskowitz, Jeremy H. · 2021 · Neuroscience
  10. Senescence in aging and disorders of the central nervous system
    Swenson, Barbara L., Meyer, Charlton F., Bussian, Tyler J., Baker, Darren J. · 2019 · Translational Medicine of Aging
  11. APOE3 - R136S mutation confers resilience against tau pathology via cGAS-STING-IFN inhibition
    Naguib, Sarah, Lopez-Lee, Chloe, Torres, Eileen Ruth, Lee, Se-In, Zhu, Jingjie, Zhu, Daphne, Ye, Pearly, Norman, Kendra, Zhao, Mingrui, Wong, Man Ying et al. · 2024
  12. Combinatorial model of amyloid β and tau reveals synergy between amyloid deposits and tangle formation
    Koller, Emily J., Ibanez, Kristen R., Vo, Quan, McFarland, Karen N., Gonzalez De La Cruz, Elsa, Zobel, Lillian, Williams, Tristan, Xu, Guilian, Ryu, Daniel, Patel, Preya et al. · 2022 · Neuropathology and Applied Neurobiology
  13. Postmortem Interval Leads to Loss of Disease-Specific Signatures in Brain Tissue
    Olney, Kimberly C., Gibson, Katelin A., Cadiz, Mika P., Rahimzadeh, Negin, Swarup, Vivek, Fryer, John D. · 2025 · eneuro
  14. Retromer dysfunction at the nexus of tauopathies
    Carosi, Julian M., Denton, Donna, Kumar, Sharad, Sargeant, Timothy J. · 2021 · Cell Death & Differentiation
  15. TREM2-Deficient Microglia Attenuate Tau Spreading In Vivo
    Lee-Gosselin, Audrey, Jury-Garfe, Nur, You, Yanwen, Dabin, Luke, Soni, Disha, Dutta, Sayan, Rochet, Jean-Christophe, Kim, Jungsu, Oblak, Adrian L., Lasagna-Reeves, Cristian A. · 2023 · Cells
  16. Increase in Tau Pathology in P290S Mapt Knock-In Mice Crossed with App NL-G-F Mice
    Huang, Melissa, Macdonald, Jennifer, Lavenir, Isabelle, Chen, Renren, Craxton, Molly, Slavik-Smith, Elizabeth, Davies, Stephen W., Goedert, Michel · 2022 · eneuro
  17. Characterization of a Mouse Model of Alzheimer’s Disease Expressing Aβ4-42 and Human Mutant Tau
    Zampar, Silvia, Wirths, Oliver · 2021 · International Journal of Molecular Sciences
  18. GSK3α: An Important Paralog in Neurodegenerative Disorders and Cancer
    Silva-García, Octavio, Cortés-Vieyra, Ricarda, Mendoza-Ambrosio, Francisco N., Ramírez-Galicia, Guillermo, Baizabal-Aguirre, Víctor M. · 2020 · Biomolecules
  19. β-amyloid accumulation enhances microtubule associated protein tau pathology in an APPNL-G-F/MAPTP301S mouse model of Alzheimer’s disease
    Jiang, Lulu, Roberts, Rebecca, Wong, Melissa, Zhang, Lushuang, Webber, Chelsea Joy, Libera, Jenna, Wang, Zihan, Kilci, Alper, Jenkins, Matthew, Ortiz, Alejandro Rondón et al. · 2024 · Frontiers in Neuroscience
  20. Perineuronal net deglycosylation associates with tauopathy‐induced gliosis and neurodegeneration
    Logsdon, Aric F., Foresi, Brian, Hu, Shannon J., Quah, Emily, Meuret, Cristiana J., Le, Jaden P., Hendrickson, Aarun S., Redford, Ingrid K., Kumar, Asmit, Phan, Bao Anh et al. · 2024 · Journal of Neurochemistry
  21. Synergistic toxicity in an in vivo model of neurodegeneration through the co-expression of human TDP-43M337V and tauT175D protein
    Moszczynski, Alexander J., Harvey, Madeline, Fulcher, Niveen, de Oliveira, Cleusa, McCunn, Patrick, Donison, Neil, Bartha, Robert, Schmid, Susanne, Strong, Michael J., Volkening, Kathryn · 2019 · Acta Neuropathologica Communications
  22. Inpp5d haplodeficiency alleviates tau pathology in the PS19 mouse model of Tauopathy
    Soni, Disha M., Lin, Peter Bor‐Chian, Lee‐Gosselin, Audrey, Lloyd, Christopher D., Mason, Emily, Ingraham, Cynthia M., Perkins, Abigail, Moutinho, Miguel, Lamb, Bruce T., Chu, Shaoyou et al. · 2024 · Alzheimer's & Dementia
  23. Parkin is dispensable for mitochondrial function, but its ubiquitin ligase activity is critical for macroautophagy and neurotransmitters: therapeutic potential beyond Parkinson's disease
    Moussa, Charbel E.-H. · 2015 · Neurodegenerative Diseases
  24. Common and divergent pathways in early stages of glutamate and tau-mediated toxicities in neurodegeneration
    Chongtham, Anjalika, Sharma, Abhijeet, Nath, Banshi, Murtha, Kaitlin, Gorbachev, Kirill, Ramakrishnan, Aarthi, Schmidt, Eric F., Shen, Li, Pereira, Ana C. · 2024 · Experimental Neurology
  25. Spontaneous pathology in PS19 tauopathy mice progresses via brain networks
    Ramirez, Denise M.O., Whitesell, Jennifer D., Bhagwat, Nikhil, Thomas, Talitha L., Ajay, Apoorva D., Nawaby, Ariana, Delatour, Benoît, Bay, Sylvie, LaFaye, Pierre, Harris, Julie A. et al. · 2025 · Neurobiology of Disease
  26. Network analysis identifies strain-dependent response to tau and tau seeding-associated genes
    Acri, Dominic J., You, Yanwen, Tate, Mason D., Karahan, Hande, Martinez, Pablo, McCord, Brianne, Sharify, A. Daniel, John, Sutha, Kim, Byungwook, Dabin, Luke C. et al. · 2023 · Journal of Experimental Medicine
  27. Tet2 and Jak2 clonal hematopoiesis do not modify murine tauopathy
    Gaebel, Lena, Gerhardt, Teresa, Khamhoung, Annie, Huynh, Pacific, Heiser, Merlin, Brisnovali, Niki F., Jacob, Walter, Yates, Abi G., Douglas, Aaron, Fidler, Trevor et al. · 2026 · Journal of Alzheimer’s Disease
  28. APOE4 reduces hippocampal expression of phosphoglycerate kinase 1 and sodium potassium pump to enhance seizure susceptibility in mice
    Singh, Tanveer, Bridgeman, Emma, Baker, Annie J., Noblet, Hayden A., Yang, Kang Yi, Kang, Sehong, Lim, Ki H., Lee, Sarah S., Amundsen, Nicolette M., Lee, Yongjae et al. · 2026 · Neurobiology of Disease
  29. SORLA up-regulation suppresses pathological effects in aged tauopathy mouse brain
    Huang, Huijie, Shi, Christina Huan, Yang, Wenqi, Piña-Crespo, Juan C., Bhatnagar, Jay, Curatolo, Julian, Murad, Rabi, Shah, Palak, Campos, Alex, Houser, Alexandra et al. · 2026 · Science Advances
  30. Unique transcriptomic alterations in 5XFAD;PS19 mouse model identify glial lipid dysregulation and coordinated microglial–oligodendrocyte responses
    Park, Jung Hyun, Kim, Byungwook, Al‐Amin, Md Mamun, Tate, Mason Douglas, Sharify, Ahmad Daniel, John, Sutha K., Karahan, Hande, Lu, Hui‐Chen, Dabin, Luke Child, Kim, Jungsu · 2026 · Alzheimer's & Dementia