Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model

Yoshiyama, Yasumasa, Higuchi, Makoto, Zhang, Bin, Huang, Shu-Ming, Iwata, Nobuhisa, Saido, Takaomi C., Maeda, Jun, Suhara, Tetsuya +2 more·2007·Neuron

Cited by (1,029)

Items 601–700 of 1,029

  1. The Role of P2X7 Receptor in Alzheimer’s Disease
    Linda Francistiová, Carolina Bianchi, Caterina Di Lauro, Álvaro Sebastián‐Serrano, Laura de Diego-García, Julianna Kobolák, András Dinnyés, Miguel Dı́az-Hernández · 2020 · Frontiers in Molecular Neuroscience
  2. Regulation of the neurodegenerative process associated to Parkinson's disease by CD4+ T-cells
    González, Hugo, Contreras, Francisco, Pacheco, Rodrigo · 2015 · Journal of Neuroimmune Pharmacology
  3. Tau-tubulin kinase
    Seiko Ikezu, Tsuneya Ikezu · 2014 · Frontiers in Molecular Neuroscience
  4. Rapamycin Ester Analog CCI-779/Temsirolimus Alleviates Tau Pathology and Improves Motor Deficit in Mutant Tau Transgenic Mice
    Christelle Frédérick, Kunié Ando, Karelle Leroy, Céline Héraud, Valérie Suain, Luc Buée, Jean‐Pierre Brion · 2015 · Journal of Alzheimer s Disease
  5. Chronic traumatic encephalopathy-integration of canonical traumatic brain injury secondary injury mechanisms with tau pathology
    Jacqueline Renee Kulbe, Edward D. Hall · 2017 · Progress in Neurobiology
  6. Branched-Chain Amino Acids Are Linked with Alzheimer’s Disease-Related Pathology and Cognitive Deficits
    Siddik, Md Abu Bakkar, Mullins, Caitlyn A., Kramer, Alyssa, Shah, Harsh, Gannaban, Ritchel B., Zabet-Moghaddam, Masoud, Huebinger, Ryan M., Hegde, Vijay K., MohanKumar, Sheba M. J., MohanKumar, Puliyur S. et al. · 2022 · Cells
  7. Sulfhydration of AKT triggers Tau-phosphorylation by activating glycogen synthase kinase 3β in Alzheimer’s disease
    Sen, Tanusree, Saha, Pampa, Jiang, Tong, Sen, Nilkantha · 2020 · Proceedings of the National Academy of Sciences
  8. Bassoon contributes to tau-seed propagation and neurotoxicity
    Martinez, Pablo, Patel, Henika, You, Yanwen, Jury, Nur, Perkins, Abigail, Lee-Gosselin, Audrey, Taylor, Xavier, You, Yingjian, Viana Di Prisco, Gonzalo, Huang, Xiaoqing et al. · 2022 · Nature Neuroscience
  9. In Vivo Visualization of Tau Accumulation, Microglial Activation, and Brain Atrophy in a Mouse Model of Tauopathy rTg4510
    Ai Ishikawa, Masaki Tokunaga, Jun Maeda, Takeharu Minamihisamatsu, Masafumi Shimojo, Hiroyuki Takuwa, Maiko Ono, Ruiqing Ni, Shigeki Hirano, Satoshi Kuwabara et al. · 2018 · Journal of Alzheimer s Disease
  10. Tau-induced pathology in epilepsy and dementia: notions from patients and animal models.
    Sánchez, Marina, García-Cabrero, Ana, Sánchez-Elexpuru, Gentzane, Burgos, Daniel, Serratosa, José · 2018 · International Journal of Molecular Sciences
  11. Integrative approach to sporadic Alzheimer’s disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau
    Audrain, Mickael, Haure-Mirande, Jean-Vianney, Wang, Minghui, Kim, Soong Ho, Fanutza, Tomas, Chakrabarty, Paramita, Fraser, Paul, St George-Hyslop, Peter H., Golde, Todd E., Blitzer, Robert D. et al. · 2019 · Molecular Psychiatry
  12. The cargo receptor SQSTM1 ameliorates neurofibrillary tangle pathology and spreading through selective targeting of pathological MAPT (microtubule associated protein tau)
    Yin Xu, Sheng Zhang, Hui Zheng · 2018 · Autophagy
  13. Activated cofilin exacerbates tau pathology by impairing tau-mediated microtubule dynamics
    Jung A. Woo, Tian Liu, Cenxiao C. Fang, Sara Cazzaro, Teresa R. Kee, Patrick LePochat, Ksenia Yrigoin, Courtney Penn, Xingyu Zhao, Xinming Wang et al. · 2019 · Communications Biology
  14. Trehalose against Alzheimer's Disease: Insights into a Potential Therapy
    Masoomeh Khalifeh, Morgayn I. Read, George Emilio Barreto, Amirhossein Sahebkar · 2020 · BioEssays
  15. New approaches to the treatment of frontotemporal lobar degeneration
    Keith A. Vossel, Bruce L. Miller · 2008 · Current Opinion in Neurology
  16. Neuroinflammation in Alzheimer's disease: an understanding of physiology and pathology
    Magisetty Obulesu, M. Jhansilakshmi · 2013 · International Journal of Neuroscience
  17. Animal models of dementia
    Erik D. Roberson, Aimee W. Kao · 2009 · Cambridge University Press eBooks
  18. Modulation of adult-born neurons in the inflamed hippocampus
    Karim Bélarbi, Susanna Rosi · 2013 · Frontiers in Cellular Neuroscience
  19. Cofilin Signaling in the CNS Physiology and Neurodegeneration
    Jannatun Nayem Namme, Asim Kumar Bepari, Hirohide Takebayashi · 2021 · International Journal of Molecular Sciences
  20. Tau and neurodegeneration
    Michel Goedert, R. Anthony Crowther, Sjors H. W. Scheres, Maria Grazia Spillantini · 2023 · Cytoskeleton
  21. In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds
    Naoto Watamura, Martha S. Foiani, Sumi Bez, Mathieu Bourdenx, Alessia Santambrogio, Claire Frodsham, Elena Camporesi, Gunnar Brinkmalm, Henrik Zetterberg, Saisha Patel et al. · 2024 · Nature Neuroscience
  22. Neuronal c-Abl Overexpression Leads to Neuronal Loss and Neuroinflammation in the Mouse Forebrain
    Sarah D. Schlatterer, Matthew A. Tremblay, Christopher M. Acker, Peter Davies · 2011 · Journal of Alzheimer s Disease
  23. Pathogenesis of Alzheimer’s Disease
    Rudy J. Castellani, George L. Perry · 2014 · Springer eBooks
  24. Insulin deprivation induces PP2A inhibition and tau hyperphosphorylation in hTau mice, a model of Alzheimer’s disease-like tau pathology
    Maud Gratuze, Jacinthe Julien, Franck R. Petry, Françoise Morin, Emmanuel Planel · 2017 · Scientific Reports
  25. Genetically Engineered iPSC-Derived FTDP-17 MAPT Neurons Display Mutation-Specific Neurodegenerative and Neurodevelopmental Phenotypes
    An Verheyen, Annick Diels, Joke Reumers, Kirsten Van Hoorde, Ilse Van den Wyngaert, Constantin van Outryve d’Ydewalle, An De Bondt, Jacobine Kuijlaars, Louis De Muynck, Ronald De Hoogt et al. · 2018 · Stem Cell Reports
  26. Microglia: Friend and foe in tauopathy
    Odfalk, Kristian F., Bieniek, Kevin F., Hopp, Sarah C. · 2022 · Progress in Neurobiology
  27. Linking APOE-ε4, blood-brain barrier dysfunction, and inflammation to Alzheimer's pathology
    Joost M. Riphagen, Inez H.G.B. Ramakers, Whitney M. Freeze, Linda H.G. Pagen, Bernard Jimmy Hanseeuw, Marcel M. Verbeek, Frans R.J. Verhey, Heidi I.L. Jacobs · 2019 · Neurobiology of Aging
  28. Reactive or transgenic increase in microglial TYROBP reveals a TREM2‐independent TYROBP–APOE link in wild‐type and Alzheimer's‐related mice
    Audrain, Mickael, Haure‐Mirande, Jean‐Vianney, Mleczko, Justyna, Wang, Minghui, Griffin, Jennifer K., St George‐Hyslop, Peter H., Fraser, Paul, Zhang, Bin, Gandy, Sam, Ehrlich, Michelle E. · 2021 · Alzheimer's & Dementia
  29. Modulation of Glial Function in Health, Aging, and Neurodegenerative Disease
    Kendra L. Hanslik, Kaitlyn M. Marino, Tyler Kent Ulland · 2021 · Frontiers in Cellular Neuroscience
  30. Audiovisual gamma stimulation for the treatment of neurodegeneration
    Cristina Blanco‐Duque, Diane Chan, Martin C. Kahn, Mitchell H. Murdock, Li‐Huei Tsai · 2023 · Journal of Internal Medicine
  31. Characterization of Brain-Penetrant Pyrimidine-Containing Molecules with Differential Microtubule-Stabilizing Activities Developed as Potential Therapeutic Agents for Alzheimer’s Disease and Related Tauopathies
    Jane Kovalevich, Anne‐Sophie Cornec, Yuemang Yao, Michael James, Alex Crowe, V. M.- Y. Lee, John Q. Trojanowski, Amos B. Smith, Carlo Ballatore, Kurt R. Brunden · 2016 · Journal of Pharmacology and Experimental Therapeutics
  32. TREM2 Ameliorates Neuronal Tau Pathology Through Suppression of Microglial Inflammatory Response
    Teng Jiang, Yingdong Zhang, Qing Gao, Zhou Ou, Pengyu Gong, Jian‐Quan Shi, Liang Wu, Junshan Zhou · 2018 · Inflammation
  33. Pathological tau drives ectopic nuclear speckle scaffold protein SRRM2 accumulation in neuron cytoplasm in Alzheimer’s disease
    McMillan, Pamela J., Strovas, Timothy J., Baum, Misa, Mitchell, Brooke K., Eck, Randall J., Hendricks, Nzinga, Wheeler, Jeanna M., Latimer, Caitlin S., Keene, C. Dirk, Kraemer, Brian C. · 2021 · Acta Neuropathologica Communications
  34. Molecular mechanisms of amyloid formation in living systems
    Tessa Sinnige · 2022 · Chemical Science
  35. Cryo-EM structures of tau filaments from the brains of mice transgenic for human mutant P301S Tau
    Manuel Schweighauser, Alexey G. Murzin, Jennifer A. Macdonald, Isabelle Lavenir, R. Anthony Crowther, Sjors H. W. Scheres, Michel Goedert · 2023 · Acta Neuropathologica Communications
  36. Genetic Rodent Models of Amyotrophic Lateral Sclerosis
    Ludo Van Den Bosch · 2011 · BioMed Research International
  37. Interaction between -Synuclein and Other Proteins in Neurodegenerative Disorders
    K. A. Jellinger · 2011 · The Scientific World JOURNAL
  38. SRPK2 Phosphorylates Tau and Mediates the Cognitive Defects in Alzheimer's Disease
    Hong Yi, Chi Bun Chan, Il‐Sun Kwon, Xuekun Li, Mingke Song, Hyun-Pil Lee, Xia Liu, Pradoldej M Sompol, Peng Jin, Hyoung‐gon Lee et al. · 2012 · Journal of Neuroscience
  39. PI31 Is an Adaptor Protein for Proteasome Transport in Axons and Required for Synaptic Development
    Kai Liu, Sandra K. Jones, Adi Minis, Jose Rodriguez, Henrik Molina, Hermann Steller · 2019 · Developmental Cell
  40. Does inflammation precede tau aggregation in early Alzheimer's disease? A PET study
    Parbo, Peter, Ismail, Rola, Sommerauer, Michael, Stokholm, Morten G., Hansen, Allan K., Hansen, Kim V., Amidi, Ali, Schaldemose, Jeppe L., Gottrup, Hanne, Brændgaard, Hans et al. · 2018 · Neurobiology of Disease
  41. Animal Models of Metabolic Disorders in the Study of Neurodegenerative Diseases: An Overview
    Andreza Fabro De Bem, Rachel Krolow, Hémelin Resende Farias, Victória Linden de Rezende, Daniel Pens Gelain, José Cláudio Fonseca Moreira, João M. N. Duarte, Jade de Oliveira · 2021 · Frontiers in Neuroscience
  42. Sources and triggers of oxidative damage in neurodegeneration
    Plamena R. Angelova · 2021 · Free Radical Biology and Medicine
  43. Mapping neuroinflammation in frontotemporal dementia with molecular PET imaging
    Zhang, Jing · 2015 · Journal of Neuroinflammation
  44. Strategies, Development, and Pitfalls of Therapeutic Options for Alzheimer's Disease
    C. Haas · 2012 · Journal of Alzheimer's Disease
  45. Synaptic activity protects against AD and FTD-like pathology via autophagic-lysosomal degradation
    Yvette Akwa, Elise Gondard, A Mann, Estibaliz Capetillo‐Zarate, Elena M Alberdi, Carlos Matute, Serge Marty, Thomas Vaccari, Andrés M. Lozano, E.E. Baulieu et al. · 2017 · Molecular Psychiatry
  46. PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment
    Alzheimer’s Disease Neuroimaging Initiative (ADNI), Kleineidam, Luca, Chouraki, Vincent, Próchnicki, Tomasz, van der Lee, Sven J., Madrid-Márquez, Laura, Wagner-Thelen, Holger, Karaca, Ilker, Weinhold, Leonie, Wolfsgruber, Steffen et al. · 2020 · Acta Neuropathologica
  47. Activated CX3CL1/Smad2 Signals Prevent Neuronal Loss and Alzheimer's Tau Pathology-Mediated Cognitive Dysfunction
    Fan, Qingyuan, He, Wanxia, Gayen, Manoshi, Benoit, Marc Robert, Luo, Xiaoyang, Hu, Xiangyou, Yan, Riqiang · 2020 · The Journal of Neuroscience
  48. Impaired plasticity of cortical dendritic spines in P301S tau transgenic mice
    Nadine A. Hoffmann, Mario M. Dorostkar, Sonja Blumenstock, Michel Goedert, Jochen Wolfgang Herms · 2013 · Acta Neuropathologica Communications
  49. Tau Filament Self-Assembly and Structure: Tau as a Therapeutic Target
    Sebastian Scott Oakley, Mahmoud Bukar Maina, Karen E. Marshall, Youssra K. Al‐Hilaly, Charlie Harrington, Claude M. Wischik, Louise C. Serpell · 2020 · Frontiers in Neurology
  50. Inflammation, tau pathology, and synaptic integrity associated with sleep spindles and memory prior to β-amyloid positivity
    Bryce A. Mander, Abhishek Dave, Kitty K. Lui, K.E. Sprecher, Destiny E. Berisha, Miranda G Chappel-Farley, Ivy Y. Chen, Brady A. Riedner, Margo B. Heston, Ivonne Suridjan et al. · 2022 · SLEEP
  51. Alzheimer’s disease-associated U1 snRNP splicing dysfunction causes neuronal hyperexcitability and cognitive impairment
    Ping‐Chung Chen, Xian Han, Timothy I. Shaw, Yingxue Fu, Huan Sun, Mingming Niu, Zhen Wang, Yun Jiao, Brett J.W. Teubner, Donnie M. Eddins et al. · 2022 · Nature Aging
  52. Cell-type-directed network-correcting combination therapy for Alzheimer’s disease
    Yaqiao Li, Carlota Pereda Serras, Jessica R. Blumenfeld, Min Xie, Yanxia Hao, Elise Deng, You Young Chun, Julia Holtzman, Alice An, Seo Yeon Yoon et al. · 2025 · Cell
  53. Role of Endoplasmic Reticulum Stress in Learning and Memory Impairment and Alzheimer's Disease-Like Neuropathology in the PS19 and APP<sup>Swe</sup>Mouse Models of Tauopathy and Amyloidosis
    Briggs, Denise Isabelle, Defensor, Erwin, Memar Ardestani, Pooneh, Yi, Bitna, Halpain, Michelle, Seabrook, Guy, Shamloo, Mehrdad · 2017 · eneuro
  54. Tissue magnetic susceptibility mapping as a marker of tau pathology in Alzheimer's disease
    James M. O’Callaghan, Holly E. Holmes, Nick M. Powell, Jack A. Wells, Ozama Ismail, Ian F. Harrison, Bernard M. Siow, Ross A. Johnson, Zeshan Ahmed, Abraham Fisher et al. · 2017 · NeuroImage
  55. Molecular Dysfunctions of Mitochondria-Associated Membranes (MAMs) in Alzheimer’s Disease
    Fanny Eysert, P. Kinoshita, A. Mary, Loan Vaillant-Beuchot, F. Checler, M. Chami · 2020 · International Journal of Molecular Sciences
  56. Validation of a rodent model of episodic memory
    Zhou, Wenyi, Crystal, Jonathon D. · 2011 · Animal Cognition
  57. Tangles, Toxicity, and Tau Secretion in AD – New Approaches to a Vexing Problem
    Kerry L. Gendreau, Garth F. Hall · 2013 · Frontiers in Neurology
  58. Pathological tau and reactive astrogliosis are associated with distinct functional deficits in a mouse model of tauopathy
    Henika Patel, Pablo Martínez, Abigail Perkins, Xavier Taylor, Nur Jury, David L. McKinzie, Cristian A. Lasagna‐Reeves · 2021 · Neurobiology of Aging
  59. Reverse electron transfer is activated during aging and contributes to aging and age‐related disease
    Suman Rimal, Ishaq Tantray, Yu Li, Tejinder Pal Khaket, Yanping Li, Sunil Bhurtel, Wen Li, Cici Zeng, Bingwei Lu · 2023 · EMBO Reports
  60. A Cdk5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes
    Ping‐Chieh Pao, Jinsoo Seo, Audrey Lee, Oleg Kritskiy, Debasis Patnaik, Jay Penney, Ravikiran M. Raju, Ute Geigenmüller, M. Catarina Silva, Diane E. Lucente et al. · 2023 · Proceedings of the National Academy of Sciences
  61. Limited cleavage of tau with matrix-metalloproteinase MMP-9, but not MMP-3, enhances tau oligomer formation
    Georg Nübling, Johannes Levin, B. Bader, Lars Israel, Kai Bötzel, Stefan Lorenzl, Armin Giese · 2012 · Experimental Neurology
  62. Concise Review: Can Stem Cells be Used to Treat or Model Alzheimer's Disease?
    Wesley W. Chen, Mathew M. Blurton-Jones · 2012 · Stem Cells
  63. Correcting abnormalities in miR‐124/PTPN1 signaling rescues tau pathology in Alzheimer’s disease
    Tongyao Hou, Yang Zhou, Ling‐Shuang Zhu, Xiong Wang, Pei Pang, Ding‐Qi Wang, Zhen‐Yu Liuyang, Heng‐Ye Man, Youming Lu, Ling‐Qiang Zhu et al. · 2020 · Journal of Neurochemistry
  64. Functional Integrity of Synapses in the Central Nervous System of Cognitively Intact Individuals with High Alzheimer’s Disease Neuropathology Is Associated with Absence of Synaptic Tau Oligomers
    Singh, Ayush, Allen, Dyron, Fracassi, Anna, Tumurbaatar, Batbayar, Natarajan, Chandramouli, Scaduto, Pietro, Woltjer, Randy, Kayed, Rakez, Limon, Agenor, Krishnan, Balaji et al. · 2020 · Journal of Alzheimer's Disease
  65. The Interplay Between Beta-Amyloid 1–42 (Aβ1–42)-Induced Hippocampal Inflammatory Response, p-tau, Vascular Pathology, and Their Synergistic Contributions to Neuronal Death and Behavioral Deficits
    Beatriz Calvo‐Flores Guzmán, Tessa Elizabeth Chaffey, Thulani Hansika Palpagama, Sarah Waters, Jordi Boix, Warren Perry Tate, Katie Peppercorn, Michael Dragunow, Henry John Waldvogel, Richard L. M. Faull et al. · 2020 · Frontiers in Molecular Neuroscience
  66. Crosstalk Between the NLRP3 Inflammasome/ASC Speck and Amyloid Protein Aggregates Drives Disease Progression in Alzheimer’s and Parkinson’s Disease
    Jonathan P. Hulse, Kiran Bhaskar · 2022 · Frontiers in Molecular Neuroscience
  67. Microglial activation in the frontal cortex predicts cognitive decline in frontotemporal dementia
    Maura Malpetti, Thomas Cope, Duncan Street, Peter Simon Jones, Frank Hubert Hezemans, Elijah Mak, Kamen A. Tsvetanov, Timothy Rittman, William Richard Bevan-Jones, Karalyn E. Patterson et al. · 2023 · Brain
  68. Neuronal identity defines α-synuclein and tau toxicity
    Roman Praschberger, Sabine Kuenen, Nils Schoovaerts, Natalie Kaempf, Jeevanjot Singh, Jasper Janssens, Jef Swerts, Eliana Nachman, Carles Calatayud, Stein Aerts et al. · 2023 · Neuron
  69. The Role of Glial Cells in Synaptic Dysfunction: Insights into Alzheimer's Disease Mechanisms
    Yang Yu, Ran Chen, Kaiyue Mao, Maoyan Deng, Zhigang Li · 2023 · Aging and Disease
  70. Inflammatory Risk Factors and Pathologies Associated with Alzheimers Disease
    Magdalena Sastre, Jill C. Richardson, Steve Gentleman, David James Brooks · 2011 · Current Alzheimer Research
  71. S-nitrosylation of E3 ubiquitin-protein ligase RNF213 alters non-canonical Wnt/Ca+2 signaling in the P301S mouse model of tauopathy
    Haitham Amal, Guanyu Gong, Elizabeta Gjoneska, Sarah M. Lewis, John S. Wishnok, Li‐Huei Tsai, Steven R. Tannenbaum · 2019 · Translational Psychiatry
  72. Single particle analysis of tau oligomer formation induced by metal ions and organic solvents
    Benedikt Bader, Georg Nübling, Anja Mehle, Simona Nobile, Hans A. Kretzschmar, Armin Giese · 2011 · Biochemical and Biophysical Research Communications
  73. Increased association between rough endoplasmic reticulum membranes and mitochondria in transgenic mice that express P301L tau
    Perreault, Sébastien, Bousquet, Olivier, Lauzon, Michel, Paiement, Jacques, Leclerc, Nicole · 2009 · Journal of Neuropathology &amp; Experimental Neurology
  74. A novel orally active HDAC6 inhibitor T-518 shows a therapeutic potential for Alzheimer’s disease and tauopathy in mice
    Tomohiro Onishi, Ryouta Maeda, Michiko Terada, Sho Sato, Takahiro Fujii, Masahiro Ito, Kentaro Hashikami, Tomohiro Kawamoto, Maiko Tanaka · 2021 · Scientific Reports
  75. Functions and dysfunctions of oligodendrocytes in neurodegenerative diseases
    Seung-Wan Han, Yunho Gim, Eun‐Hae Jang, Eun‐Mi Hur · 2022 · Frontiers in Cellular Neuroscience
  76. Polarized microtubule remodeling transforms the morphology of reactive microglia and drives cytokine release
    Max Adrian, Martin Weber, Ming‐Chi Tsai, Caspar Glock, Olga I. Kahn, Lilian Phu, Tommy K. Cheung, William J. Meilandt, Christopher M. Rose, Casper C. Hoogenraad · 2023 · Nature Communications
  77. CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis
    Avi J. Samelson, Nabeela Ariqat, Justin McKetney, Gita Rohanitazangi, C Bravo, Rudra Bose, Kyle J. Travaglini, Victor L. Lam, Darrin Goodness, Thomas Ta et al. · 2026 · Cell
  78. The Endocannabinoid System and Alzheimer’s Disease
    Cristina Benito, Estefanía Núñez, María Ruth Pazos, Rosa Maria Tolón, Julián Romero · 2007 · Molecular Neurobiology
  79. Longitudinal imaging reveals subhippocampal dynamics in glutamate levels associated with histopathologic events in a mouse model of tauopathy and healthy mice
    Rachelle L. Crescenzi, Catherine DeBrosse, Ravi Prakash Reddy Nanga, Matthew D. Byrne, Guruprasad Krishnamoorthy, Kevin D’Aquilla, Hari Nath, Knashawn H. Morales, Michiyo Iba, Hari Hariharan et al. · 2016 · Hippocampus
  80. Targeting psychologic stress signaling pathways in Alzheimer’s disease
    Hunter S. Futch, Cara L. Croft, Van Truong, Eric G. Krause, Todd Eliot Golde · 2017 · Molecular Neurodegeneration
  81. Expression of Tau Pathology-Related Proteins in Different Brain Regions: A Molecular Basis of Tau Pathogenesis
    Wen Hui Hu, Feng Wu, Yanchong Zhang, Cheng‐Xin Gong, Khalid Iqbal, Fei Liu · 2017 · Frontiers in Aging Neuroscience
  82. AAV-mediated expression of anti-tau scFvs decreases tau accumulation in a mouse model of tauopathy
    Ising, Christina, Gallardo, Gilbert, Leyns, Cheryl E.G., Wong, Connie H., Jiang, Hong, Stewart, Floy, Koscal, Lauren J., Roh, Joseph, Robinson, Grace O., Remolina Serrano, Javier et al. · 2017 · Journal of Experimental Medicine
  83. Ligand‐Based and Structure‐Based Investigation for Alzheimer’s Disease from Traditional Chinese Medicine
    Ken Liao, Kuen‐Bao Chen, Wen‐Yuan Lee, Mao-Feng Sun, Cheng-Chun Lee, Calvin Yu‐Chian Chen · 2014 · Evidence-based Complementary and Alternative Medicine
  84. Resveratrol Rescues Tau-Induced Cognitive Deficits and Neuropathology in a Mouse Model of Tauopathy
    Xiaoying Sun, Quan-xiu Dong, Jie Zhu, Xun Sun, Lifan Zhang, Mandy Qiu, Xiaolin Yu, Rui‐tian Liu · 2019 · Current Alzheimer Research
  85. Targeting tauopathy with engineered tau-degrading intrabodies
    Gilbert Gallardo, Connie Hau Yan Wong, Sara M. Ricardez Hernandez, Carolyn N. Mann, Kent Lin, Cheryl E. G. Leyns, Hong Jiang, David M. Holtzman · 2019 · Molecular Neurodegeneration
  86. NFATs and Alzheimer's Disease.
    Hafiz Mohmmad Abdul, Jennifer L. Furman, Michelle A. Sama, Diana M. Mathis, Christopher Mark Norris · 2010 · PubMed
  87. Differential cross-seeding properties of tau and α-synuclein in mouse models of tauopathy and synucleinopathy
    Tosha Williams, Zachary A. Sorrentino, Mary J. Weinrich, Benoit I. Giasson, Paramita Chakrabarty · 2020 · Brain Communications
  88. Mechanistic Studies Unravel the Complexity Inherent in Tau Aggregation Leading to Alzheimer’s Disease and the Tauopathies
    Gayathri Ramachandran, Jayant B. Udgaonkar · 2013 · Biochemistry
  89. Mechanisms of Tau Self-Aggregation and Neurotoxicity
    Gonzalo A. Farias, Alberto Cornejo, J. Jimenez, Leonardo Guzmán, Ricardo Benjamin Maccioni · 2011 · Current Alzheimer Research
  90. Early depletion of CA1 neurons and late neurodegeneration in a mouse tauopathy model
    Lone Helboe, Jan Egebjerg, Pernille Barkholt, Christiane Volbracht · 2017 · Brain Research
  91. Deficient neurotransmitter systems and synaptic function in frontotemporal lobar degeneration—Insights into disease mechanisms and current therapeutic approaches
    Nadine Huber, Sonja Korhonen, Dorit B. Hoffmann, Stina Leskelä, Hannah Rostalski, Anne Marja Remes, Paavo Honkakoski, Eino Solje, Annakaisa Haapasalo · 2021 · Molecular Psychiatry
  92. Tau pathogenesis is promoted by Aβ1-42 but not Aβ1-40
    Xiaoyan Hu, Xiaoling Li, Mingrui Zhao, Andrew Gottesdiener, Wenjie Luo, Steven M. Paul · 2014 · Molecular Neurodegeneration
  93. NSAIDs: how they work and their prospects as therapeutics in Alzheimer's disease
    Magdalena Sastre · 2010 · Frontiers in Aging Neuroscience
  94. Role of Liver X Receptor in AD Pathophysiology
    Adrián Gabriel Sandoval-Hernández, Luna Buitrago, Herman Moreno, Gloria Patricia Cardona‐Gómez, Gonzálo Arboleda · 2015 · PLoS ONE
  95. Functional analyses of major cancer-related signaling pathways in Alzheimer's disease etiology
    Jianping Guo, Ji Cheng, Brian J. North, Wenyi Wei · 2017 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
  96. Synthesis and in vitro characterization of a P2X7 radioligand [123I]TZ6019 and its response to neuroinflammation in a mouse model of Alzheimer disease
    Hongjun Jin, Junbin Han, Derek Resing, Hui Liu, Xuyi Yue, Rebecca L. Miller, Kathleen M. Schoch, Timothy M. Miller, Joel S. Perlmutter, Terrance M. Egan et al. · 2017 · European Journal of Pharmacology
  97. Chronic White Matter Degeneration, but No Tau Pathology at One-Year Post-Repetitive Mild Traumatic Brain Injury in a Tau Transgenic Model
    Benoit Mouzon, Corbin J. Bachmeier, Joseph O. Ojo, Christopher M. Acker, Scott Ferguson, Gogce C. Crynen, Peter Davies, MICHAEL J. MULLAN, William B. Stewart Jr., Fiona Crawford · 2018 · Journal of Neurotrauma
  98. <i>Tlr7</i> drives sex differences in age- and Alzheimer’s disease–related demyelination
    Lopez-Lee, Chloe, Kodama, Lay, Fan, Li, Zhu, Daphne, Zhu, Jingjie, Wong, Man Ying, Ye, Pearly, Norman, Kendra, Foxe, Nessa R., Ijaz, Laraib et al. · 2024 · Science
  99. Glial reactivity and T cell infiltration in frontotemporal lobar degeneration with tau pathology
    Iain James Hartnell, Declan Woodhouse, William Jasper, Luke Mason, Pavan Kaur Marwaha, Manon Graffeuil, Laurie C. Lau, Jeanette L. Norman, David S. Chatelet, Luc Buée et al. · 2023 · Brain
  100. Senescence-Accelerated Mice P8: A Tool to Study Brain Aging and Alzheimer's Disease in a Mouse Model
    Mercè Pallàs · 2012 · ISRN Cell Biology