Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model
Yoshiyama, Yasumasa, Higuchi, Makoto, Zhang, Bin, Huang, Shu-Ming, Iwata, Nobuhisa, Saido, Takaomi C., Maeda, Jun, Suhara, Tetsuya +2 more·2007·Neuron
Cited by (1,029)
Items 801–900 of 1,029
- Inhibitory RNA Aptamers of Tau Oligomerization and Their Neuroprotective Roles against Proteotoxic StressJi Hyeon Kim, Eun-Kyoung Kim, Won Hoon Choi, Jee‐Young Lee, Jung Hoon Lee, Hyojin Lee, Dong‐Eun Kim, Young Ho Suh, Min Jae Lee · 2016 · Molecular Pharmaceutics
- G2019S LRRK2 enhances the neuronal transmission of tau in the mouse brainAn Phu Tran Nguyen, Guillaume Daniel, Pamela Valdés, Md. Shariful Islam, Bernard Laurent Schneider, Darren J. Moore · 2017 · Human Molecular Genetics
- Mutual Relationship between Tau and Central Insulin Signalling: Consequences for AD and Tauopathies?Maud Gratuze, Aurélie Joly‐Amado, Didier Vieau, Luc Buée, David L Blum · 2018 · Neuroendocrinology
- Role of TREM2 in Alzheimer's Disease and its Consequences on β- Amyloid, Tau and Neurofibrillary TanglesAnurag Kumar Singh, Gaurav Mishra, Anand Maurya, Rajendra Awasthi, Komal Kumari, Abhimanyu Thakur, Arati Rai, Gopal Kumar Rai, Bhupesh Sharma, Giriraj Thirupathirao Kulkarni et al. · 2019 · Current Alzheimer Research
- Targeting innate immunity to protect and cure Alzheimer’s disease: opportunities and pitfallsGiulia Cisbani, Serge Rivest · 2021 · Molecular Psychiatry
- Disruption of nuclear envelope integrity as a possible initiating event in tauopathiesMarine Prissette, Wen Fury, Matthew Koss, Claudia Racioppi, Daria Fedorova, Ella Dragileva, Georgia Clarke, Taylor Pohl, John Dugan, Diana Ahrens et al. · 2022 · Cell Reports
- The multifaceted role of WNT signaling in Alzheimer’s disease onset and age-related progression.Kostes, William W., Brafman, David A. · 2023 · Cells
- Genetic risk factors for Alzheimer disease: emerging roles of microglia in disease pathomechanismsTakatori, Sho, Wang, Wenbo, Iguchi, Akihiro, Tomita, Taisuke · 2019 · Advances in Experimental Medicine and Biology
- Combining P301L and S320F tau variants produces a novel accelerated model of tauopathyKoller, Emily J, Gonzalez De La Cruz, Elsa, Machula, Timothy, Ibanez, Kristen R, Lin, Wen-Lang, Williams, Tosha, Riffe, Cara J, Ryu, Daniel, Strang, Kevin H, Liu, Xuefei et al. · 2019 · Human Molecular Genetics
- Cannabinoid receptor CB2 ablation protects against TAU induced neurodegenerationMarcos Galán-Ganga, Carmen Rodríguez‐Cueto, Jesús Merchán‐Rubira, Félix Hernández, Jesús Ávila, María Posada-Ayala, José Luis Lanciego, Enrique Luengo, Manuela G. López, Alberto Rábano et al. · 2021 · Acta Neuropathologica Communications
- Functional Neurophysiological Biomarkers of Early-Stage Alzheimer’s Disease: A Perspective of Network Hyperexcitability in Disease ProgressionSean Tok, Abdallah Ahnaou, Wilhelmus H. I. M. Drinkenburg · 2021 · Journal of Alzheimer s Disease
- Multivalent Tau/PSD-95 interactions arrest in vitro condensates and clusters mimicking the postsynaptic densityZheng Shen, Daxiao Sun, Adriana Savastano, Sára Joana Varga, Maria‐Sol Cima‐Omori, Stefan Becker, Alf Honigmann, Markus Zweckstetter · 2023 · Nature Communications
- Skeletal muscle TFEB signaling promotes central nervous system function and reduces neuroinflammation during aging and neurodegenerative diseaseIan Matthews, Allison Birnbaum, A. Gromova, Amy Huang, Kai-Lin Liu, Eleanor A. Liu, Kristen Coutinho, M. McGraw, D. Patterson, M. T. Banks et al. · 2023 · bioRxiv
- Spatial mapping of the brain metabolome lipidome and glycomeHarrison A. Clarke, Xin Ma, Cameron J. Shedlock, Terrymar Medina, Tara R. Hawkinson, Lei Wu, Roberto A. Ribas, Shannon B. Keohane, Sakthivel Ravi, Jennifer L. Bizon et al. · 2025 · Nature Communications
- Microglial p53 activation is detrimental to neuronal synapses during activation-induced inflammation: Implications for neurodegenerationJoseph D. Jebelli, Claudie Hooper, Jennifer M. Pocock · 2014 · Neuroscience Letters
- Tau phosphorylation‐associated spine regression does not impair hippocampal‐dependent memory in hibernating golden hamstersTorsten Bullmann, Gudrun Seeger, Jens Stieler, János Hanics, Katja Reimann, Tanja Petra Kretzschmann, Isabel Hilbrich, Max Holzer, Alán Alpár, Thomas Arendt · 2015 · Hippocampus
- Kinetics of human mutant tau prion formation in the brains of 2 transgenic mouse linesWoerman, Amanda L., Patel, Smita, Kazmi, Sabeen A., Oehler, Abby, Freyman, Yevgeniy, Espiritu, Lloyd, Cotter, Robert, Castaneda, Julian A., Olson, Steven H., Prusiner, Stanley B. · 2017 · JAMA Neurology
- Recent developments with tau-based drug discoveryKhalid Iqbal, Fei Liu, Cheng‐Xin Gong · 2018 · Expert Opinion on Drug Discovery
- A brain-penetrant triazolopyrimidine enhances microtubule-stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy modelBin Zhang, Yuemang Yao, Anne‐Sophie Cornec, Killian Oukoloff, Michael J. James, Pyry P. Koivula, John Q. Trojanowski, Amos B. Smith, Virginia M.‐Y. Lee, Carlo Ballatore et al. · 2018 · Molecular Neurodegeneration
- Impaired tau–microtubule interactions are prevalent among pathogenic tau variants arising from missense mutationsYuxing Xia, Zachary A. Sorrentino, Justin D. Kim, Kevin H. Strang, Cara J. Riffe, Benoit I. Giasson · 2019 · Journal of Biological Chemistry
- β-Arrestin2 oligomers impair the clearance of pathological tau and increase tau aggregatesJung A. Woo, Tian Liu, Cenxiao C. Fang, Maria A. Castaño, Teresa R. Kee, Ksenia Yrigoin, Yan Yan, Sara Cazzaro, Jenet K. Matlack, Xinming Wang et al. · 2020 · Proceedings of the National Academy of Sciences
- Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathologyLeslie A. Sandusky‐Beltran, Andrii Kovalenko, Devon S. Placides, Kevin Ratnasamy, Chao Ma, Jerry B. Hunt, Huimin Liang, John Ivan T. Calahatian, Camilla A. Michalski, Margaret L. Fahnestock et al. · 2021 · Journal of Clinical Investigation
- In vivo PET imaging of neuroinflammation in familial frontotemporal dementiaMalpetti, Maura, Rittman, Timothy, Jones, Peter Simon, Cope, Thomas Edmund, Passamonti, Luca, Bevan-Jones, William Richard, Patterson, Karalyn, Fryer, Tim D, Hong, Young T, Aigbirhio, Franklin I et al. · 2021 · Journal of Neurology, Neurosurgery & Psychiatry
- Interaction between Alzheimer’s Disease and Cerebral Small Vessel Disease: A Review Focused on Neuroimaging MarkersSi Eun Kim, Hee Jin Kim, Hyemin Jang, Michael Walter Weiner, Charles S DeCarli, Duk Lyul Na, Sang Won Seo · 2022 · International Journal of Molecular Sciences
- The Putative Role of Neuroinflammation in the Interaction between Traumatic Brain Injuries, Sleep, Pain and Other Neuropsychiatric Outcomes: A State-of-the-Art ReviewAlberto Herrero Babiloni, Andrée‐Ann Baril, Camille Charlebois‐Plante, Marianne Jodoin, Erlan Sanchez, Liesbet De Baets, Caroline Arbour, Gilles J Lavigne, Nadia Gosselin, Louis De Beaumont · 2023 · Journal of Clinical Medicine
- Identical tau filaments in subacute sclerosing panencephalitis and chronic traumatic encephalopathyChao Qi, Masato Hasegawa, Masaki Takao, Motoko Sakai, Mayasuki Sasaki, Masashi Mizutani, Akio Akagi, Yasushi Iwasaki, Hiroaki Miyahara, Mari Yoshida et al. · 2023 · Acta Neuropathologica Communications
- Vibrotactile stimulation at gamma frequency mitigates pathology related to neurodegeneration and improves motor functionHo‐Jun Suk, Nicole E. Buie, Guojie Xu, Arit Banerjee, Edward S. Boyden, Li‐Huei Tsai · 2023 · Frontiers in Aging Neuroscience
- Glucose Transport and Utilization in the Hippocampus: From Neurophysiology to Diabetes-Related Development of DementiaCaio Yogi Yonamine, Maria Luiza Estimo Michalani, Rafael Junges Moreira, Ubiratan Fabres Machado · 2023 · International Journal of Molecular Sciences
- Granzyme K+ CD8 T cells slow tauopathy progression by targeting microgliaHannah D. Mason, Yvonne L. Latour, Christopher T. Boughter, Kory R. Johnson, Dragan Maric, Cayce Dorrier, Vivian A. Guedes, Chen Lai, Patrick C. Duncker, Alexis M. Johnson et al. · 2025 · Nature Immunology
- SIRT1 Regulates Cognitive Performance and Ability of Learning and Memory in Diabetic and Nondiabetic ModelsYue Cao, Zi Yan, Tong Zhou, Guixia Wang · 2017 · Journal of Diabetes Research
- Neuroimmune Tau Mechanisms: Their Role in the Progression of Neuronal DegenerationNicole Cortés, V. Andrade, L. Guzmán-Martínez, M. Estrella, R. Maccioni · 2018 · International Journal of Molecular Sciences
- Understanding the Pathophysiological Actions of Tau Oligomers: A Critical Review of Current Electrophysiological ApproachesEmily Hill, Mark John Wall, Kevin G. Moffat, Thomas K. Karikari · 2020 · Frontiers in Molecular Neuroscience
- Quantifying regional α ‐synuclein, amyloid β, and tau accumulation in lewy body dementiaRebecca L. Miller, Dhruva D. Dhavale, Jennifer Y. O’Shea, Kristin M. Andruska, Jialu Liu, Erin E. Franklin, Chandana Buddhala, Susan K. Loftin, John R. Cirrito, Richard J. Perrin et al. · 2022 · Annals of Clinical and Translational Neurology
- Modeling of Tau-Mediated Synaptic and Neuronal Degeneration in Alzheimer's DiseaseTomasz Jaworski, Sebastian Kügler, Fred VAN LEUVEN · 2010 · International Journal of Alzheimer s Disease
- Regulation of cell distancing in peri-plaque glial nets by Plexin-B1 affects glial activation and amyloid compaction in Alzheimer’s diseaseHuang, Yong, Wang, Minghui, Ni, Haofei, Zhang, Jinglong, Li, Aiqun, Hu, Bin, Junqueira Alves, Chrystian, Wahane, Shalaka, Rios de Anda, Mitzy, Ho, Lap et al. · 2024 · Nature Neuroscience
- Tau–RNA complexes inhibit microtubule polymerization and drive disease-relevant conformation changePamela J. McMillan, Sarah J. Benbow, Rikki L. Uhrich, Aleen D. Saxton, Misa Baum, Timothy J. Strovas, Jeanna M. Wheeler, Jeremy D. Baker, Nicole F. Liachko, Christopher Dirk Keene et al. · 2023 · Brain
- Limitations of human tau-expressing mouse models and novel approaches of mouse modeling for tauopathyNaruhiko Sahara, Rin Yanai · 2023 · Frontiers in Neuroscience
- Reversibility of Tau-Related Cognitive Defects in a Regulatable FTD Mouse ModelAstrid Sydow, Ann Van der Jeugd, Fang Zheng, Tariq Ahmed, Detlef Balschun, Olga M. Petrova, Dagmar Drexler, Lepu Zhou, Gabriele M. Rune, Eckhard Mandelkow� et al. · 2011 · Journal of Molecular Neuroscience
- Age-dependent neuroinflammation and cognitive decline in a novel Ala152Thr-Tau transgenic mouse model of PSP and ADAstrid Sydow, Katja Hochgräfe, Stefanie Könen, Daniela Cadinu, Dorthe Matenia, Olga M. Petrova, Maria Joseph, Frank J.A. Dennissen, Eva‐Maria Mandelkow · 2016 · Acta Neuropathologica Communications
- Formulated Chinese Medicine Shaoyao Gancao Tang Reduces Tau Aggregation and Exerts Neuroprotection through Anti‐Oxidation and Anti‐InflammationI‐Cheng Chen, Te‐Hsien Lin, Yu-Hsuan Hsieh, Chih‐Ying Chao, Yih‐Ru Wu, Kuo‐Hsuan Chang, Ming-Chung Lee, Guey‐Jen Lee‐Chen, Chiung‐Mei Chen · 2018 · Oxidative Medicine and Cellular Longevity
- Sex Differences in Alzheimer’s Disease: Where Do We Stand?André de Macêdo Medeiros, Regina H. Silva · 2018 · Journal of Alzheimer s Disease
- Passive immunotherapy for N-truncated tau ameliorates the cognitive deficits in two mouse Alzheimer’s disease modelsVeronica Corsetti, Antonella Borreca, Valentina Latina, Giacomo Giacovazzo, Annabella Pignataro, Paraskevi Krashia, Francesca Natale, Sara Cocco, Marco Rinaudo, Francesca Malerba et al. · 2020 · Brain Communications
- Isoform‐specific upregulation of FynT kinase expression is associated with tauopathy and glial activation in Alzheimer's disease and Lewy body dementiasClara Y. B. Low, Jasinda H. Lee, Frances Ting Wei Lim, Chingli Lee, Clive G. Ballard, Paul T. Francis, Mitchell K.P. Lai, Michelle G. K. Tan · 2020 · Brain Pathology
- Broad activation of the Parkin pathway induces synaptic mitochondrial deficits in early tauopathyYu Young Jeong, Sinsuk Han, Nuo Jia, Mingyang Zhang, Preethi Sheshadri, Prasad Tammineni, Jasmine Cheung, Marialaina Nissenbaum, Sindhuja S Baskar, Kelvin Y. Kwan et al. · 2021 · Brain
- Further understanding of tau phosphorylation: implications for therapyMedina, Miguel, Avila, Jesús · 2015 · Expert Review of Neurotherapeutics
- Pharmacogenetic neuronal stimulation increases human tau pathology and trans-synaptic spread of tau to distal brain regions in miceMark K. Schultz, Renee C. Gentzel, Marija Usenovic, Cheryl A. Gretzula, C. Ware, Sophie Parmentier‐Batteur, Joel B. Schachter, Hatim A. Zariwala · 2018 · Neurobiology of Disease
- Contribution of the astrocytic tau pathology to synapse loss in progressive supranuclear palsy and corticobasal degenerationNils Briel, Katrin Pratsch, Sigrun Roeber, Thomas Arzberger, Jochen Wolfgang Herms · 2020 · Brain Pathology
- Porphyromonas gingivalis-Induced Neuroinflammation in Alzheimer’s DiseaseIngar Olsen · 2021 · Frontiers in Neuroscience
- Compensating for synaptic loss in Alzheimer’s diseaseKamal Abuhassan, Damien Coyle, Ammar Belatreche, Liam Maguire · 2013 · Journal of Computational Neuroscience
- In vivo functional brain mapping in a conditional mouse model of human tauopathy (taup301l) reveals reduced neural activity in memory formation structuresPablo D. Pérez, Gabrielle Hall, Tetsuya Kimura, Yan Ren, Rachel M. Bailey, Jada M. Lewis, Marcelo Febo, Naruhiko Sahara · 2013 · Molecular Neurodegeneration
- Chaperone-dependent Neurodegeneration: A Molecular Perspective on Therapeutic InterventionAaron Carman Sarah Kishinevsky, John Koren III Wenjie Lou · 2013 · Journal of Alzheimer’s Disease & Parkinsonism
- Imbalanced Expression of Tau and Tubulin Induces Neuronal Dysfunction in C. elegans Models of TauopathyT. Miyasaka, Yuki Shinzaki, S. Yoshimura, Sawako Yoshina, E. Kage-Nakadai, S. Mitani, Y. Ihara · 2018 · Frontiers in Neuroscience
- The Dual Role of Microglia in the Progression of Alzheimer's DiseaseKate M. Onuska · 2020 · Journal of Neuroscience
- Glial cells and adaptive immunity in frontotemporal dementia with tau pathologyIain James Hartnell, David L Blum, James A. R. Nicoll, Guillaume Dorothée, Delphine Boche · 2020 · Brain
- Seed-competent tau monomer initiates pathology in a tauopathy mouse modelHilda Mirbaha, Dailu Chen, Vishruth Mullapudi, Sandi Jo Terpack, Charles L. White, Łukasz A. Joachimiak, Marc I. Diamond · 2022 · Journal of Biological Chemistry
- Loss of forebrain BIN1 attenuates hippocampal pathology and neuroinflammation in a tauopathy modelMoorthi Ponnusamy, Shuai Wang, Melike Yuksel, Mitchell T. Hansen, Danielle M. Blazier, Joseph D. McMillan, Xiaolin Zhang, Eric B. Dammer, Lisa A. Collier, Gopal Thinakaran · 2022 · Brain
- Zebrafish models of TauopathyQing Bai, Edward A. Burton · 2010 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Recent Development in the Understanding of Molecular and Cellular Mechanisms Underlying the Etiopathogenesis of Alzheimer’s DiseaseAtefeh Afsar, Maria del Carmen Chacon Castro, Adedamola Saidi Soladogun, Zhang Li · 2023 · International Journal of Molecular Sciences
- Alzheimer’s Disease: Understanding Motor ImpairmentsJesús Andrade-Guerrero, Humberto Martínez-Orozco, Marcos M. Villegas-Rojas, Alberto Santiago-Balmaseda, Karen M. Delgado-Minjares, Isaac Pérez‐Segura, Mauricio T. Baéz-Cortés, Miguel A. Del Toro-Colín, Magdalena Guerra‐Crespo, Óscar Arias-Carrión et al. · 2024 · Brain Sciences
- A Lifespan Observation of a Novel Mouse Model: In Vivo Evidence Supports Aβ Oligomer HypothesisYichi Zhang, Lu Lu, Jianping Jia, Longfei Jia, Changiz Geula, Jin-Jing Pei, Qing Xu, Wei Qin, Rui‐Qin Liu, Dan Li et al. · 2014 · PLoS ONE
- Wild type TDP-43 induces neuro-inflammation and alters APP metabolism in lentiviral gene transfer modelsAlexander M. Herman, Preeti J. Khandelwal, George William Rebeck, Charbel Moussa · 2012 · Experimental Neurology
- Alzheimer’s disease pathological lesions activate the spleen tyrosine kinaseJonas Elias Schweig, Hailan Yao, David Beaulieu‐Abdelahad, Ghania Ait‐Ghezala, Benoit Mouzon, Fiona Crawford, MICHAEL J. MULLAN, Daniel Paris · 2017 · Acta Neuropathologica Communications
- Piper sarmentosum Roxb. confers neuroprotection on beta-amyloid (Aβ)-induced microglia-mediated neuroinflammation and attenuates tau hyperphosphorylation in SH-SY5Y cellsEmilia Tze Ying Yeo, Kelly Wang Ling Wong, Mun Ling See, Ka Yan Wong, Sook Yee Gan, Elaine Wan Ling Chan · 2018 · Journal of Ethnopharmacology
- Synthesis and evaluation of pyrazine and quinoxaline fluorophores for in vivo detection of cerebral tau tangles in Alzheimer's modelsBiyue Zhu, Ting Zhang, Qian Jiang, Ying Li, Yu Fu, Jiapei Dai, Ge Li, Qingrong Qi, Yan Cheng · 2018 · Chemical Communications
- Galantamine reversed early postoperative cognitive deficit via alleviating inflammation and enhancing synaptic transmission in mouse hippocampusTianhai Wang, Hongge Zhu, Yanshen Hou, Weixin Gu, Haichuan Wu, Yiwen Luan, Cheng Xiao, Chunyi Zhou · 2018 · European Journal of Pharmacology
- Long Term Gene Expression in Human Induced Pluripotent Stem Cells and Cerebral Organoids to Model a Neurodegenerative DiseaseFérid Nassor, Rafika Jarray, Denis S.F. Biard, Auriane Maïza, Dulce Papy-García, Serena Pavoni, Jean‐Philippe Deslys, Frank Yates · 2020 · Frontiers in Cellular Neuroscience
- Single cell transcriptomic profiling of a neuron-astrocyte assembloid tauopathy modelHannah Rickner, Lulu Jiang, Rui Hong, Nicholas K. O’Neill, Chromewell A. Mojica, Benjamin J. Snyder, Lushuang Zhang, Dipan Shaw, Maria Medalla, Benjamin L. Wolozin et al. · 2022 · Nature Communications
- Immunohistochemical analysis of tau phosphorylation and astroglial activation with enhanced leptin receptor expression in diet-induced obesity mouse hippocampusShunsuke Koga, Ayako Kojima, Satoshi Kuwabara, Yasumasa Yoshiyama · 2014 · Neuroscience Letters
- Hippocampal ‘zipper’ slice studies reveal a necessary role for calcineurin in the increased activity of L-type Ca2+ channels with agingChristopher Mark Norris, Eric M. Blalock, Kuey-Chu Chen, Nada M. Porter, Olivier Thibault, Susan D. Kraner, Philip W. Landfield · 2008 · Neurobiology of Aging
- Tau‐tubulin kinase 1 enhances prefibrillar tau aggregation and motor neuron degeneration in P301L FTDP‐17 tau‐mutant miceJiqing Xu, Shinji Sato, Satoshi Okuyama, Russell J. Swan, Michael T. Jacobsen, Elena Strunk, Tsuneya Ikezu · 2010 · The FASEB Journal
- The fornix provides multiple biomarkers to characterize circuit disruption in a mouse model of Alzheimer’s disease.Badea, Alexandra, Kane, Lauren, Anderson, Robert J., Qi, Yi, Foster, Mark, Cofer, Gary P., Medvitz, Neil, Buckley, Anne F., Badea, Andreas K., Wetsel, William C. et al. · 2016 · NeuroImage
- Calmodulin and Its Binding Proteins in Parkinson’s DiseaseAnastasiia Bohush, Wiesława Leśniak, Serge Weis, Anna Filipek · 2021 · International Journal of Molecular Sciences
- Interleukin 1β triggers synaptic and memory deficits in Herpes simplex virus type-1-infected mice by downregulating the expression of synaptic plasticity-related genes via the epigenetic MeCP2/HDAC4 complexDomenica Donatella Li Puma, Claudia Colussi, Bruno Bandiera, Giulia Puliatti, Marco Rinaudo, Sara Cocco, Fabiola Paciello, Agnese Re, Cristian Ripoli, Giovanna De Chiara et al. · 2023 · Cellular and Molecular Life Sciences
- Targeting CaN/NFAT in Alzheimer’s brain degenerationJoanna Mackiewicz, Malwina Lisek, Tomasz Boczek · 2023 · Frontiers in Immunology
- Focus on senescence: Clinical significance and practical applicationsVirginia Boccardi, Miranda E. Orr, Maria Cristina Polidori, Carmelinda Ruggiero, Patrizia Mecocci · 2024 · Journal of Internal Medicine
- Characterizing molecular and synaptic signatures in mouse models of late‐onset Alzheimer's disease independent of amyloid and tau pathologyKevin P. Kotredes, Ravi S. Pandey, Scott A. Persohn, Kierra Elderidge, Charles P. Burton, Ethan W. Miner, Kathryn A. Haynes, Diogo Francisco da Silva dos Santos, Sean‐Paul Gerard Williams, Nicholas Heaton et al. · 2024 · Alzheimer s & Dementia
- Azure C Targets and Modulates Toxic Tau OligomersFilippa Lo Cascio, Rakez Kayed · 2018 · ACS Chemical Neuroscience
- Molecular Bases of Alzheimer’s Disease and Neurodegeneration: The Role of NeurogliaAntonina Luca, Carmela Calandra, Maria Luca · 2018 · Aging and Disease
- PKR kinase directly regulates tau expression and Alzheimer's disease‐related tau phosphorylationLasse Reimer, Cristine Betzer, Rikke Hahn Kofoed, Christiane Volbracht, Karina Fog, Chaitanya Kurhade, Emma Nilsson, Anna K. Överby, Poul Henning Jensen · 2020 · Brain Pathology
- The inhibition of LSD1 via sequestration contributes to tau-mediated neurodegenerationAmanda Engstrom, Alicia C. Walker, Rohitha A. Moudgal, Dexter A. Myrick, Stephanie M. Kyle, Yu Bai, M. Jordan Rowley, David J. Katz · 2020 · Proceedings of the National Academy of Sciences
- Critical Molecular and Cellular Contributors to Tau PathologyLiqing Song, Evan A. Wells, Anne Skaja Robinson · 2021 · Biomedicines
- Consequences of Hyperphosphorylated Tau in the Locus Coeruleus on Behavior and Cognition in a Rat Model of Alzheimer’s DiseaseMichael A. Kelberman, Claire R. Anderson, Eli Chlan, Jacki M. Rorabaugh, Katharine E. McCann, David Weinshenker · 2022 · Journal of Alzheimer s Disease
- Blocking Effects of Human Tau on Squid Giant Synapse Transmission and Its Prevention by T-817 MAHerman Moreno, Soonwook Choi, Eunah Yu, Janaína Brusco, Jesús Ávila, Jorge E. Moreira, Mutsuyuki Sugimori, Rodolfó R. Llinás · 2011 · Frontiers in Synaptic Neuroscience
- Bending Tau into Shape: The Emerging Role of Peptidyl-Prolyl Isomerases in TauopathiesJohn Koren, Umesh K. Jinwal, Zachary S. Davey, Janine Kiray, Karthik Arulselvam, Chad A. Dickey · 2011 · Molecular Neurobiology
- Pronounced microgliosis and neurodegeneration in aged rats after tau gene transferRonald L. Klein, Robert D. Dayton, Cynthia G. Diaczynsky, David B. Wang · 2009 · Neurobiology of Aging
- Reduction of the RNA Binding Protein TIA1 Exacerbates Neuroinflammation in TauopathyChelsey Jenna LeBlang, Maria Medalla, Nicholas William Nicoletti, Emma Catherine Hays, James Zhao, Jenifer E. Shattuck, Anna Lourdes Cruz, Benjamin L. Wolozin, Jennifer Irene Luebke · 2020 · Frontiers in Neuroscience
- Synapses, Microglia, and Lipids in Alzheimer’s DiseasePatrick Jarmo Paasila, Jason Abbas Aramideh, Greg Trevor Sutherland, Manuel B. Graeber · 2022 · Frontiers in Neuroscience
- Diffusion MRI tracks cortical microstructural changes during the early stages of Alzheimer’s diseaseNicola Spotorno, Olof T. Strandberg, Erik Stomrud, Shorena Janelidze, Kaj Blennow, Markus Nilsson, Danielle van Westen, Oskar Hansson · 2023 · Brain
- Neuroinflammation of Microglial Regulation in Alzheimer’s Disease: Therapeutic ApproachesHaiyun Chen, Yuhan Zeng, Dan Wang, Yichen Li, Jieyu Xing, Yuejia Zeng, Zheng Liu, Xinhua Zhou, Hui Jie Fan · 2024 · Molecules
- Microglia depletion reduces human neuronal APOE4-related pathologies in a chimeric Alzheimer’s disease modelAntara T. Rao, Nuo Chen, Min Joo Kim, Jessica R. Blumenfeld, Oscar Yip, Zherui Liang, David M. Shostak, Yanxia Hao, Maxine R. Nelson, Nicole Koutsodendris et al. · 2024 · Cell stem cell
- Alzheimer’s disease patient-derived high-molecular-weight tau impairs bursting in hippocampal neuronsSam Harris, Robert A. Ellingford, J. Hartmann, Debanjan Dasgupta, Marten Kehring, Rikesh M. Rajani, David R. Graykowski, Noé Quittot, Dhanush Sivasankaran, Caitlin Commins et al. · 2025 · Cell
- Parkin reverses TDP ‐43‐induced cell death and failure of amino acid homeostasisMichaeline L. Hebron, Wenqiang Chen, Matthew Miessau, Irina Lonskaya, Charbel Moussa · 2013 · Journal of Neurochemistry
- MicroPET imaging and transgenic models: a blueprint for Alzheimer's disease clinical researchEduardo Rigon Zimmer, Maxime J. Parent, A. Claudio Cuello, Serge G. Gauthier, Pedro Rosa‐Neto · 2014 · Trends in Neurosciences
- Tau isoform expression and regulation in human cortical neuronsAtul M. Deshpande, Khin May Win, Jorge A. Busciglio · 2008 · The FASEB Journal
- Imaging Multimodalities for Dissecting Alzheimer's Disease: Advanced Technologies of Positron Emission Tomography and Fluorescence ImagingMasafumi Shimojo, Makoto Higuchi, Tetsuya Suhara, Naruhiko Sahara · 2015 · Frontiers in Neuroscience
- Emerging Diagnostic and Therapeutic Strategies for TauopathiesDavid G. Coughlin, David John Irwin · 2017 · Current Neurology and Neuroscience Reports
- Brain 5‐lipoxygenase over‐expression worsens memory, synaptic integrity, and tau pathology in the P301S miceAlana N. Vagnozzi, Phillip F. Giannopoulos, Domenico Praticò · 2017 · Aging Cell
- Hepatitis B core VLP-based mis-disordered tau vaccine elicits strong immune response and alleviates cognitive deficits and neuropathology progression in Tau.P301S mouse model of Alzheimer’s disease and frontotemporal dementiaMei Ji, Xi-xiu Xie, Dong‐qun Liu, Xiaolin Yu, Yue Zhang, Lingxiao Louis Zhang, Shaowei Wang, Yaru Huang, Rui‐tian Liu · 2018 · Alzheimer s Research & Therapy
- Selection of a D-Enantiomeric Peptide Specifically Binding to PHF6 for Inhibiting Tau Aggregation in Transgenic MiceXiancheng Zhang, Xiaoyu Zhang, Manli Zhong, Pu Zhao, Chuang Guo, You Li, Tao Wang, Huiling Gao · 2020 · ACS Chemical Neuroscience
- Mechanosensing and the Hippo Pathway in Microglia: A Potential Link to Alzheimer’s Disease Pathogenesis?Lucrezia Bruno, Simge Karagil, Almas Mahmood, Ahmed Elbediwy, Michael Stolinski, Francesca E. Mackenzie · 2021 · Cells