Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model

Yoshiyama, Yasumasa, Higuchi, Makoto, Zhang, Bin, Huang, Shu-Ming, Iwata, Nobuhisa, Saido, Takaomi C., Maeda, Jun, Suhara, Tetsuya +2 more·2007·Neuron

Cited by (1,029)

Items 801–900 of 1,029

  1. Inhibitory RNA Aptamers of Tau Oligomerization and Their Neuroprotective Roles against Proteotoxic Stress
    Ji Hyeon Kim, Eun-Kyoung Kim, Won Hoon Choi, Jee‐Young Lee, Jung Hoon Lee, Hyojin Lee, Dong‐Eun Kim, Young Ho Suh, Min Jae Lee · 2016 · Molecular Pharmaceutics
  2. G2019S LRRK2 enhances the neuronal transmission of tau in the mouse brain
    An Phu Tran Nguyen, Guillaume Daniel, Pamela Valdés, Md. Shariful Islam, Bernard Laurent Schneider, Darren J. Moore · 2017 · Human Molecular Genetics
  3. Mutual Relationship between Tau and Central Insulin Signalling: Consequences for AD and Tauopathies?
    Maud Gratuze, Aurélie Joly‐Amado, Didier Vieau, Luc Buée, David L Blum · 2018 · Neuroendocrinology
  4. Role of TREM2 in Alzheimer's Disease and its Consequences on β- Amyloid, Tau and Neurofibrillary Tangles
    Anurag Kumar Singh, Gaurav Mishra, Anand Maurya, Rajendra Awasthi, Komal Kumari, Abhimanyu Thakur, Arati Rai, Gopal Kumar Rai, Bhupesh Sharma, Giriraj Thirupathirao Kulkarni et al. · 2019 · Current Alzheimer Research
  5. Targeting innate immunity to protect and cure Alzheimer’s disease: opportunities and pitfalls
    Giulia Cisbani, Serge Rivest · 2021 · Molecular Psychiatry
  6. Disruption of nuclear envelope integrity as a possible initiating event in tauopathies
    Marine Prissette, Wen Fury, Matthew Koss, Claudia Racioppi, Daria Fedorova, Ella Dragileva, Georgia Clarke, Taylor Pohl, John Dugan, Diana Ahrens et al. · 2022 · Cell Reports
  7. The multifaceted role of WNT signaling in Alzheimer’s disease onset and age-related progression.
    Kostes, William W., Brafman, David A. · 2023 · Cells
  8. Genetic risk factors for Alzheimer disease: emerging roles of microglia in disease pathomechanisms
    Takatori, Sho, Wang, Wenbo, Iguchi, Akihiro, Tomita, Taisuke · 2019 · Advances in Experimental Medicine and Biology
  9. Combining P301L and S320F tau variants produces a novel accelerated model of tauopathy
    Koller, Emily J, Gonzalez De La Cruz, Elsa, Machula, Timothy, Ibanez, Kristen R, Lin, Wen-Lang, Williams, Tosha, Riffe, Cara J, Ryu, Daniel, Strang, Kevin H, Liu, Xuefei et al. · 2019 · Human Molecular Genetics
  10. Cannabinoid receptor CB2 ablation protects against TAU induced neurodegeneration
    Marcos Galán-Ganga, Carmen Rodríguez‐Cueto, Jesús Merchán‐Rubira, Félix Hernández, Jesús Ávila, María Posada-Ayala, José Luis Lanciego, Enrique Luengo, Manuela G. López, Alberto Rábano et al. · 2021 · Acta Neuropathologica Communications
  11. Functional Neurophysiological Biomarkers of Early-Stage Alzheimer’s Disease: A Perspective of Network Hyperexcitability in Disease Progression
    Sean Tok, Abdallah Ahnaou, Wilhelmus H. I. M. Drinkenburg · 2021 · Journal of Alzheimer s Disease
  12. Multivalent Tau/PSD-95 interactions arrest in vitro condensates and clusters mimicking the postsynaptic density
    Zheng Shen, Daxiao Sun, Adriana Savastano, Sára Joana Varga, Maria‐Sol Cima‐Omori, Stefan Becker, Alf Honigmann, Markus Zweckstetter · 2023 · Nature Communications
  13. Skeletal muscle TFEB signaling promotes central nervous system function and reduces neuroinflammation during aging and neurodegenerative disease
    Ian Matthews, Allison Birnbaum, A. Gromova, Amy Huang, Kai-Lin Liu, Eleanor A. Liu, Kristen Coutinho, M. McGraw, D. Patterson, M. T. Banks et al. · 2023 · bioRxiv
  14. Spatial mapping of the brain metabolome lipidome and glycome
    Harrison A. Clarke, Xin Ma, Cameron J. Shedlock, Terrymar Medina, Tara R. Hawkinson, Lei Wu, Roberto A. Ribas, Shannon B. Keohane, Sakthivel Ravi, Jennifer L. Bizon et al. · 2025 · Nature Communications
  15. Microglial p53 activation is detrimental to neuronal synapses during activation-induced inflammation: Implications for neurodegeneration
    Joseph D. Jebelli, Claudie Hooper, Jennifer M. Pocock · 2014 · Neuroscience Letters
  16. Tau phosphorylation‐associated spine regression does not impair hippocampal‐dependent memory in hibernating golden hamsters
    Torsten Bullmann, Gudrun Seeger, Jens Stieler, János Hanics, Katja Reimann, Tanja Petra Kretzschmann, Isabel Hilbrich, Max Holzer, Alán Alpár, Thomas Arendt · 2015 · Hippocampus
  17. Kinetics of human mutant tau prion formation in the brains of 2 transgenic mouse lines
    Woerman, Amanda L., Patel, Smita, Kazmi, Sabeen A., Oehler, Abby, Freyman, Yevgeniy, Espiritu, Lloyd, Cotter, Robert, Castaneda, Julian A., Olson, Steven H., Prusiner, Stanley B. · 2017 · JAMA Neurology
  18. Recent developments with tau-based drug discovery
    Khalid Iqbal, Fei Liu, Cheng‐Xin Gong · 2018 · Expert Opinion on Drug Discovery
  19. A brain-penetrant triazolopyrimidine enhances microtubule-stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy model
    Bin Zhang, Yuemang Yao, Anne‐Sophie Cornec, Killian Oukoloff, Michael J. James, Pyry P. Koivula, John Q. Trojanowski, Amos B. Smith, Virginia M.‐Y. Lee, Carlo Ballatore et al. · 2018 · Molecular Neurodegeneration
  20. Impaired tau–microtubule interactions are prevalent among pathogenic tau variants arising from missense mutations
    Yuxing Xia, Zachary A. Sorrentino, Justin D. Kim, Kevin H. Strang, Cara J. Riffe, Benoit I. Giasson · 2019 · Journal of Biological Chemistry
  21. β-Arrestin2 oligomers impair the clearance of pathological tau and increase tau aggregates
    Jung A. Woo, Tian Liu, Cenxiao C. Fang, Maria A. Castaño, Teresa R. Kee, Ksenia Yrigoin, Yan Yan, Sara Cazzaro, Jenet K. Matlack, Xinming Wang et al. · 2020 · Proceedings of the National Academy of Sciences
  22. Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology
    Leslie A. Sandusky‐Beltran, Andrii Kovalenko, Devon S. Placides, Kevin Ratnasamy, Chao Ma, Jerry B. Hunt, Huimin Liang, John Ivan T. Calahatian, Camilla A. Michalski, Margaret L. Fahnestock et al. · 2021 · Journal of Clinical Investigation
  23. In vivo PET imaging of neuroinflammation in familial frontotemporal dementia
    Malpetti, Maura, Rittman, Timothy, Jones, Peter Simon, Cope, Thomas Edmund, Passamonti, Luca, Bevan-Jones, William Richard, Patterson, Karalyn, Fryer, Tim D, Hong, Young T, Aigbirhio, Franklin I et al. · 2021 · Journal of Neurology, Neurosurgery & Psychiatry
  24. Interaction between Alzheimer’s Disease and Cerebral Small Vessel Disease: A Review Focused on Neuroimaging Markers
    Si Eun Kim, Hee Jin Kim, Hyemin Jang, Michael Walter Weiner, Charles S DeCarli, Duk Lyul Na, Sang Won Seo · 2022 · International Journal of Molecular Sciences
  25. The Putative Role of Neuroinflammation in the Interaction between Traumatic Brain Injuries, Sleep, Pain and Other Neuropsychiatric Outcomes: A State-of-the-Art Review
    Alberto Herrero Babiloni, Andrée‐Ann Baril, Camille Charlebois‐Plante, Marianne Jodoin, Erlan Sanchez, Liesbet De Baets, Caroline Arbour, Gilles J Lavigne, Nadia Gosselin, Louis De Beaumont · 2023 · Journal of Clinical Medicine
  26. Identical tau filaments in subacute sclerosing panencephalitis and chronic traumatic encephalopathy
    Chao Qi, Masato Hasegawa, Masaki Takao, Motoko Sakai, Mayasuki Sasaki, Masashi Mizutani, Akio Akagi, Yasushi Iwasaki, Hiroaki Miyahara, Mari Yoshida et al. · 2023 · Acta Neuropathologica Communications
  27. Vibrotactile stimulation at gamma frequency mitigates pathology related to neurodegeneration and improves motor function
    Ho‐Jun Suk, Nicole E. Buie, Guojie Xu, Arit Banerjee, Edward S. Boyden, Li‐Huei Tsai · 2023 · Frontiers in Aging Neuroscience
  28. Glucose Transport and Utilization in the Hippocampus: From Neurophysiology to Diabetes-Related Development of Dementia
    Caio Yogi Yonamine, Maria Luiza Estimo Michalani, Rafael Junges Moreira, Ubiratan Fabres Machado · 2023 · International Journal of Molecular Sciences
  29. Granzyme K+ CD8 T cells slow tauopathy progression by targeting microglia
    Hannah D. Mason, Yvonne L. Latour, Christopher T. Boughter, Kory R. Johnson, Dragan Maric, Cayce Dorrier, Vivian A. Guedes, Chen Lai, Patrick C. Duncker, Alexis M. Johnson et al. · 2025 · Nature Immunology
  30. SIRT1 Regulates Cognitive Performance and Ability of Learning and Memory in Diabetic and Nondiabetic Models
    Yue Cao, Zi Yan, Tong Zhou, Guixia Wang · 2017 · Journal of Diabetes Research
  31. Neuroimmune Tau Mechanisms: Their Role in the Progression of Neuronal Degeneration
    Nicole Cortés, V. Andrade, L. Guzmán-Martínez, M. Estrella, R. Maccioni · 2018 · International Journal of Molecular Sciences
  32. Understanding the Pathophysiological Actions of Tau Oligomers: A Critical Review of Current Electrophysiological Approaches
    Emily Hill, Mark John Wall, Kevin G. Moffat, Thomas K. Karikari · 2020 · Frontiers in Molecular Neuroscience
  33. Quantifying regional α ‐synuclein, amyloid β, and tau accumulation in lewy body dementia
    Rebecca L. Miller, Dhruva D. Dhavale, Jennifer Y. O’Shea, Kristin M. Andruska, Jialu Liu, Erin E. Franklin, Chandana Buddhala, Susan K. Loftin, John R. Cirrito, Richard J. Perrin et al. · 2022 · Annals of Clinical and Translational Neurology
  34. Modeling of Tau-Mediated Synaptic and Neuronal Degeneration in Alzheimer's Disease
    Tomasz Jaworski, Sebastian Kügler, Fred VAN LEUVEN · 2010 · International Journal of Alzheimer s Disease
  35. Regulation of cell distancing in peri-plaque glial nets by Plexin-B1 affects glial activation and amyloid compaction in Alzheimer’s disease
    Huang, Yong, Wang, Minghui, Ni, Haofei, Zhang, Jinglong, Li, Aiqun, Hu, Bin, Junqueira Alves, Chrystian, Wahane, Shalaka, Rios de Anda, Mitzy, Ho, Lap et al. · 2024 · Nature Neuroscience
  36. Tau–RNA complexes inhibit microtubule polymerization and drive disease-relevant conformation change
    Pamela J. McMillan, Sarah J. Benbow, Rikki L. Uhrich, Aleen D. Saxton, Misa Baum, Timothy J. Strovas, Jeanna M. Wheeler, Jeremy D. Baker, Nicole F. Liachko, Christopher Dirk Keene et al. · 2023 · Brain
  37. Limitations of human tau-expressing mouse models and novel approaches of mouse modeling for tauopathy
    Naruhiko Sahara, Rin Yanai · 2023 · Frontiers in Neuroscience
  38. Reversibility of Tau-Related Cognitive Defects in a Regulatable FTD Mouse Model
    Astrid Sydow, Ann Van der Jeugd, Fang Zheng, Tariq Ahmed, Detlef Balschun, Olga M. Petrova, Dagmar Drexler, Lepu Zhou, Gabriele M. Rune, Eckhard Mandelkow� et al. · 2011 · Journal of Molecular Neuroscience
  39. Age-dependent neuroinflammation and cognitive decline in a novel Ala152Thr-Tau transgenic mouse model of PSP and AD
    Astrid Sydow, Katja Hochgräfe, Stefanie Könen, Daniela Cadinu, Dorthe Matenia, Olga M. Petrova, Maria Joseph, Frank J.A. Dennissen, Eva‐Maria Mandelkow · 2016 · Acta Neuropathologica Communications
  40. Formulated Chinese Medicine Shaoyao Gancao Tang Reduces Tau Aggregation and Exerts Neuroprotection through Anti‐Oxidation and Anti‐Inflammation
    I‐Cheng Chen, Te‐Hsien Lin, Yu-Hsuan Hsieh, Chih‐Ying Chao, Yih‐Ru Wu, Kuo‐Hsuan Chang, Ming-Chung Lee, Guey‐Jen Lee‐Chen, Chiung‐Mei Chen · 2018 · Oxidative Medicine and Cellular Longevity
  41. Sex Differences in Alzheimer’s Disease: Where Do We Stand?
    André de Macêdo Medeiros, Regina H. Silva · 2018 · Journal of Alzheimer s Disease
  42. Passive immunotherapy for N-truncated tau ameliorates the cognitive deficits in two mouse Alzheimer’s disease models
    Veronica Corsetti, Antonella Borreca, Valentina Latina, Giacomo Giacovazzo, Annabella Pignataro, Paraskevi Krashia, Francesca Natale, Sara Cocco, Marco Rinaudo, Francesca Malerba et al. · 2020 · Brain Communications
  43. Isoform‐specific upregulation of FynT kinase expression is associated with tauopathy and glial activation in Alzheimer's disease and Lewy body dementias
    Clara Y. B. Low, Jasinda H. Lee, Frances Ting Wei Lim, Chingli Lee, Clive G. Ballard, Paul T. Francis, Mitchell K.P. Lai, Michelle G. K. Tan · 2020 · Brain Pathology
  44. Broad activation of the Parkin pathway induces synaptic mitochondrial deficits in early tauopathy
    Yu Young Jeong, Sinsuk Han, Nuo Jia, Mingyang Zhang, Preethi Sheshadri, Prasad Tammineni, Jasmine Cheung, Marialaina Nissenbaum, Sindhuja S Baskar, Kelvin Y. Kwan et al. · 2021 · Brain
  45. Further understanding of tau phosphorylation: implications for therapy
    Medina, Miguel, Avila, Jesús · 2015 · Expert Review of Neurotherapeutics
  46. Pharmacogenetic neuronal stimulation increases human tau pathology and trans-synaptic spread of tau to distal brain regions in mice
    Mark K. Schultz, Renee C. Gentzel, Marija Usenovic, Cheryl A. Gretzula, C. Ware, Sophie Parmentier‐Batteur, Joel B. Schachter, Hatim A. Zariwala · 2018 · Neurobiology of Disease
  47. Contribution of the astrocytic tau pathology to synapse loss in progressive supranuclear palsy and corticobasal degeneration
    Nils Briel, Katrin Pratsch, Sigrun Roeber, Thomas Arzberger, Jochen Wolfgang Herms · 2020 · Brain Pathology
  48. Porphyromonas gingivalis-Induced Neuroinflammation in Alzheimer’s Disease
    Ingar Olsen · 2021 · Frontiers in Neuroscience
  49. Compensating for synaptic loss in Alzheimer’s disease
    Kamal Abuhassan, Damien Coyle, Ammar Belatreche, Liam Maguire · 2013 · Journal of Computational Neuroscience
  50. In vivo functional brain mapping in a conditional mouse model of human tauopathy (taup301l) reveals reduced neural activity in memory formation structures
    Pablo D. Pérez, Gabrielle Hall, Tetsuya Kimura, Yan Ren, Rachel M. Bailey, Jada M. Lewis, Marcelo Febo, Naruhiko Sahara · 2013 · Molecular Neurodegeneration
  51. Chaperone-dependent Neurodegeneration: A Molecular Perspective on Therapeutic Intervention
    Aaron Carman Sarah Kishinevsky, John Koren III Wenjie Lou · 2013 · Journal of Alzheimer’s Disease & Parkinsonism
  52. Imbalanced Expression of Tau and Tubulin Induces Neuronal Dysfunction in C. elegans Models of Tauopathy
    T. Miyasaka, Yuki Shinzaki, S. Yoshimura, Sawako Yoshina, E. Kage-Nakadai, S. Mitani, Y. Ihara · 2018 · Frontiers in Neuroscience
  53. The Dual Role of Microglia in the Progression of Alzheimer's Disease
    Kate M. Onuska · 2020 · Journal of Neuroscience
  54. Glial cells and adaptive immunity in frontotemporal dementia with tau pathology
    Iain James Hartnell, David L Blum, James A. R. Nicoll, Guillaume Dorothée, Delphine Boche · 2020 · Brain
  55. Seed-competent tau monomer initiates pathology in a tauopathy mouse model
    Hilda Mirbaha, Dailu Chen, Vishruth Mullapudi, Sandi Jo Terpack, Charles L. White, Łukasz A. Joachimiak, Marc I. Diamond · 2022 · Journal of Biological Chemistry
  56. Loss of forebrain BIN1 attenuates hippocampal pathology and neuroinflammation in a tauopathy model
    Moorthi Ponnusamy, Shuai Wang, Melike Yuksel, Mitchell T. Hansen, Danielle M. Blazier, Joseph D. McMillan, Xiaolin Zhang, Eric B. Dammer, Lisa A. Collier, Gopal Thinakaran · 2022 · Brain
  57. Zebrafish models of Tauopathy
    Qing Bai, Edward A. Burton · 2010 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  58. Recent Development in the Understanding of Molecular and Cellular Mechanisms Underlying the Etiopathogenesis of Alzheimer’s Disease
    Atefeh Afsar, Maria del Carmen Chacon Castro, Adedamola Saidi Soladogun, Zhang Li · 2023 · International Journal of Molecular Sciences
  59. Alzheimer’s Disease: Understanding Motor Impairments
    Jesús Andrade-Guerrero, Humberto Martínez-Orozco, Marcos M. Villegas-Rojas, Alberto Santiago-Balmaseda, Karen M. Delgado-Minjares, Isaac Pérez‐Segura, Mauricio T. Baéz-Cortés, Miguel A. Del Toro-Colín, Magdalena Guerra‐Crespo, Óscar Arias-Carrión et al. · 2024 · Brain Sciences
  60. A Lifespan Observation of a Novel Mouse Model: In Vivo Evidence Supports Aβ Oligomer Hypothesis
    Yichi Zhang, Lu Lu, Jianping Jia, Longfei Jia, Changiz Geula, Jin-Jing Pei, Qing Xu, Wei Qin, Rui‐Qin Liu, Dan Li et al. · 2014 · PLoS ONE
  61. Wild type TDP-43 induces neuro-inflammation and alters APP metabolism in lentiviral gene transfer models
    Alexander M. Herman, Preeti J. Khandelwal, George William Rebeck, Charbel Moussa · 2012 · Experimental Neurology
  62. Alzheimer’s disease pathological lesions activate the spleen tyrosine kinase
    Jonas Elias Schweig, Hailan Yao, David Beaulieu‐Abdelahad, Ghania Ait‐Ghezala, Benoit Mouzon, Fiona Crawford, MICHAEL J. MULLAN, Daniel Paris · 2017 · Acta Neuropathologica Communications
  63. Piper sarmentosum Roxb. confers neuroprotection on beta-amyloid (Aβ)-induced microglia-mediated neuroinflammation and attenuates tau hyperphosphorylation in SH-SY5Y cells
    Emilia Tze Ying Yeo, Kelly Wang Ling Wong, Mun Ling See, Ka Yan Wong, Sook Yee Gan, Elaine Wan Ling Chan · 2018 · Journal of Ethnopharmacology
  64. Synthesis and evaluation of pyrazine and quinoxaline fluorophores for in vivo detection of cerebral tau tangles in Alzheimer's models
    Biyue Zhu, Ting Zhang, Qian Jiang, Ying Li, Yu Fu, Jiapei Dai, Ge Li, Qingrong Qi, Yan Cheng · 2018 · Chemical Communications
  65. Galantamine reversed early postoperative cognitive deficit via alleviating inflammation and enhancing synaptic transmission in mouse hippocampus
    Tianhai Wang, Hongge Zhu, Yanshen Hou, Weixin Gu, Haichuan Wu, Yiwen Luan, Cheng Xiao, Chunyi Zhou · 2018 · European Journal of Pharmacology
  66. Long Term Gene Expression in Human Induced Pluripotent Stem Cells and Cerebral Organoids to Model a Neurodegenerative Disease
    Férid Nassor, Rafika Jarray, Denis S.F. Biard, Auriane Maïza, Dulce Papy-García, Serena Pavoni, Jean‐Philippe Deslys, Frank Yates · 2020 · Frontiers in Cellular Neuroscience
  67. Single cell transcriptomic profiling of a neuron-astrocyte assembloid tauopathy model
    Hannah Rickner, Lulu Jiang, Rui Hong, Nicholas K. O’Neill, Chromewell A. Mojica, Benjamin J. Snyder, Lushuang Zhang, Dipan Shaw, Maria Medalla, Benjamin L. Wolozin et al. · 2022 · Nature Communications
  68. Immunohistochemical analysis of tau phosphorylation and astroglial activation with enhanced leptin receptor expression in diet-induced obesity mouse hippocampus
    Shunsuke Koga, Ayako Kojima, Satoshi Kuwabara, Yasumasa Yoshiyama · 2014 · Neuroscience Letters
  69. Hippocampal ‘zipper’ slice studies reveal a necessary role for calcineurin in the increased activity of L-type Ca2+ channels with aging
    Christopher Mark Norris, Eric M. Blalock, Kuey-Chu Chen, Nada M. Porter, Olivier Thibault, Susan D. Kraner, Philip W. Landfield · 2008 · Neurobiology of Aging
  70. Tau‐tubulin kinase 1 enhances prefibrillar tau aggregation and motor neuron degeneration in P301L FTDP‐17 tau‐mutant mice
    Jiqing Xu, Shinji Sato, Satoshi Okuyama, Russell J. Swan, Michael T. Jacobsen, Elena Strunk, Tsuneya Ikezu · 2010 · The FASEB Journal
  71. The fornix provides multiple biomarkers to characterize circuit disruption in a mouse model of Alzheimer’s disease.
    Badea, Alexandra, Kane, Lauren, Anderson, Robert J., Qi, Yi, Foster, Mark, Cofer, Gary P., Medvitz, Neil, Buckley, Anne F., Badea, Andreas K., Wetsel, William C. et al. · 2016 · NeuroImage
  72. Calmodulin and Its Binding Proteins in Parkinson’s Disease
    Anastasiia Bohush, Wiesława Leśniak, Serge Weis, Anna Filipek · 2021 · International Journal of Molecular Sciences
  73. Interleukin 1β triggers synaptic and memory deficits in Herpes simplex virus type-1-infected mice by downregulating the expression of synaptic plasticity-related genes via the epigenetic MeCP2/HDAC4 complex
    Domenica Donatella Li Puma, Claudia Colussi, Bruno Bandiera, Giulia Puliatti, Marco Rinaudo, Sara Cocco, Fabiola Paciello, Agnese Re, Cristian Ripoli, Giovanna De Chiara et al. · 2023 · Cellular and Molecular Life Sciences
  74. Targeting CaN/NFAT in Alzheimer’s brain degeneration
    Joanna Mackiewicz, Malwina Lisek, Tomasz Boczek · 2023 · Frontiers in Immunology
  75. Focus on senescence: Clinical significance and practical applications
    Virginia Boccardi, Miranda E. Orr, Maria Cristina Polidori, Carmelinda Ruggiero, Patrizia Mecocci · 2024 · Journal of Internal Medicine
  76. Characterizing molecular and synaptic signatures in mouse models of late‐onset Alzheimer's disease independent of amyloid and tau pathology
    Kevin P. Kotredes, Ravi S. Pandey, Scott A. Persohn, Kierra Elderidge, Charles P. Burton, Ethan W. Miner, Kathryn A. Haynes, Diogo Francisco da Silva dos Santos, Sean‐Paul Gerard Williams, Nicholas Heaton et al. · 2024 · Alzheimer s & Dementia
  77. Azure C Targets and Modulates Toxic Tau Oligomers
    Filippa Lo Cascio, Rakez Kayed · 2018 · ACS Chemical Neuroscience
  78. Molecular Bases of Alzheimer’s Disease and Neurodegeneration: The Role of Neuroglia
    Antonina Luca, Carmela Calandra, Maria Luca · 2018 · Aging and Disease
  79. PKR kinase directly regulates tau expression and Alzheimer's disease‐related tau phosphorylation
    Lasse Reimer, Cristine Betzer, Rikke Hahn Kofoed, Christiane Volbracht, Karina Fog, Chaitanya Kurhade, Emma Nilsson, Anna K. Överby, Poul Henning Jensen · 2020 · Brain Pathology
  80. The inhibition of LSD1 via sequestration contributes to tau-mediated neurodegeneration
    Amanda Engstrom, Alicia C. Walker, Rohitha A. Moudgal, Dexter A. Myrick, Stephanie M. Kyle, Yu Bai, M. Jordan Rowley, David J. Katz · 2020 · Proceedings of the National Academy of Sciences
  81. Critical Molecular and Cellular Contributors to Tau Pathology
    Liqing Song, Evan A. Wells, Anne Skaja Robinson · 2021 · Biomedicines
  82. Consequences of Hyperphosphorylated Tau in the Locus Coeruleus on Behavior and Cognition in a Rat Model of Alzheimer’s Disease
    Michael A. Kelberman, Claire R. Anderson, Eli Chlan, Jacki M. Rorabaugh, Katharine E. McCann, David Weinshenker · 2022 · Journal of Alzheimer s Disease
  83. Blocking Effects of Human Tau on Squid Giant Synapse Transmission and Its Prevention by T-817 MA
    Herman Moreno, Soonwook Choi, Eunah Yu, Janaína Brusco, Jesús Ávila, Jorge E. Moreira, Mutsuyuki Sugimori, Rodolfó R. Llinás · 2011 · Frontiers in Synaptic Neuroscience
  84. Bending Tau into Shape: The Emerging Role of Peptidyl-Prolyl Isomerases in Tauopathies
    John Koren, Umesh K. Jinwal, Zachary S. Davey, Janine Kiray, Karthik Arulselvam, Chad A. Dickey · 2011 · Molecular Neurobiology
  85. Pronounced microgliosis and neurodegeneration in aged rats after tau gene transfer
    Ronald L. Klein, Robert D. Dayton, Cynthia G. Diaczynsky, David B. Wang · 2009 · Neurobiology of Aging
  86. Reduction of the RNA Binding Protein TIA1 Exacerbates Neuroinflammation in Tauopathy
    Chelsey Jenna LeBlang, Maria Medalla, Nicholas William Nicoletti, Emma Catherine Hays, James Zhao, Jenifer E. Shattuck, Anna Lourdes Cruz, Benjamin L. Wolozin, Jennifer Irene Luebke · 2020 · Frontiers in Neuroscience
  87. Synapses, Microglia, and Lipids in Alzheimer’s Disease
    Patrick Jarmo Paasila, Jason Abbas Aramideh, Greg Trevor Sutherland, Manuel B. Graeber · 2022 · Frontiers in Neuroscience
  88. Diffusion MRI tracks cortical microstructural changes during the early stages of Alzheimer’s disease
    Nicola Spotorno, Olof T. Strandberg, Erik Stomrud, Shorena Janelidze, Kaj Blennow, Markus Nilsson, Danielle van Westen, Oskar Hansson · 2023 · Brain
  89. Neuroinflammation of Microglial Regulation in Alzheimer’s Disease: Therapeutic Approaches
    Haiyun Chen, Yuhan Zeng, Dan Wang, Yichen Li, Jieyu Xing, Yuejia Zeng, Zheng Liu, Xinhua Zhou, Hui Jie Fan · 2024 · Molecules
  90. Microglia depletion reduces human neuronal APOE4-related pathologies in a chimeric Alzheimer’s disease model
    Antara T. Rao, Nuo Chen, Min Joo Kim, Jessica R. Blumenfeld, Oscar Yip, Zherui Liang, David M. Shostak, Yanxia Hao, Maxine R. Nelson, Nicole Koutsodendris et al. · 2024 · Cell stem cell
  91. Alzheimer’s disease patient-derived high-molecular-weight tau impairs bursting in hippocampal neurons
    Sam Harris, Robert A. Ellingford, J. Hartmann, Debanjan Dasgupta, Marten Kehring, Rikesh M. Rajani, David R. Graykowski, Noé Quittot, Dhanush Sivasankaran, Caitlin Commins et al. · 2025 · Cell
  92. Parkin reverses TDP ‐43‐induced cell death and failure of amino acid homeostasis
    Michaeline L. Hebron, Wenqiang Chen, Matthew Miessau, Irina Lonskaya, Charbel Moussa · 2013 · Journal of Neurochemistry
  93. MicroPET imaging and transgenic models: a blueprint for Alzheimer's disease clinical research
    Eduardo Rigon Zimmer, Maxime J. Parent, A. Claudio Cuello, Serge G. Gauthier, Pedro Rosa‐Neto · 2014 · Trends in Neurosciences
  94. Tau isoform expression and regulation in human cortical neurons
    Atul M. Deshpande, Khin May Win, Jorge A. Busciglio · 2008 · The FASEB Journal
  95. Imaging Multimodalities for Dissecting Alzheimer's Disease: Advanced Technologies of Positron Emission Tomography and Fluorescence Imaging
    Masafumi Shimojo, Makoto Higuchi, Tetsuya Suhara, Naruhiko Sahara · 2015 · Frontiers in Neuroscience
  96. Emerging Diagnostic and Therapeutic Strategies for Tauopathies
    David G. Coughlin, David John Irwin · 2017 · Current Neurology and Neuroscience Reports
  97. Brain 5‐lipoxygenase over‐expression worsens memory, synaptic integrity, and tau pathology in the P301S mice
    Alana N. Vagnozzi, Phillip F. Giannopoulos, Domenico Praticò · 2017 · Aging Cell
  98. Hepatitis B core VLP-based mis-disordered tau vaccine elicits strong immune response and alleviates cognitive deficits and neuropathology progression in Tau.P301S mouse model of Alzheimer’s disease and frontotemporal dementia
    Mei Ji, Xi-xiu Xie, Dong‐qun Liu, Xiaolin Yu, Yue Zhang, Lingxiao Louis Zhang, Shaowei Wang, Yaru Huang, Rui‐tian Liu · 2018 · Alzheimer s Research & Therapy
  99. Selection of a D-Enantiomeric Peptide Specifically Binding to PHF6 for Inhibiting Tau Aggregation in Transgenic Mice
    Xiancheng Zhang, Xiaoyu Zhang, Manli Zhong, Pu Zhao, Chuang Guo, You Li, Tao Wang, Huiling Gao · 2020 · ACS Chemical Neuroscience
  100. Mechanosensing and the Hippo Pathway in Microglia: A Potential Link to Alzheimer’s Disease Pathogenesis?
    Lucrezia Bruno, Simge Karagil, Almas Mahmood, Ahmed Elbediwy, Michael Stolinski, Francesca E. Mackenzie · 2021 · Cells