Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model

Yoshiyama, Yasumasa, Higuchi, Makoto, Zhang, Bin, Huang, Shu-Ming, Iwata, Nobuhisa, Saido, Takaomi C., Maeda, Jun, Suhara, Tetsuya +2 more·2007·Neuron

DOI 10.1016/j.neuron.2007.01.010

Cited by (1,029)

Items 201–300 of 1,029

Intersection of pathological tau and microglia at the synapse
Vogels, Thomas, Murgoci, Adriana-Natalia, Hromádka, Tomáš · 2019 · Acta Neuropathologica Communications
Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice
Peeraer, Eve, Bottelbergs, Astrid, Van Kolen, Kristof, Stancu, Ilie-Cosmin, Vasconcelos, Bruno, Mahieu, Michel, Duytschaever, Hilde, Ver Donck, Luc, Torremans, An, Sluydts, Ellen et al. · 2015 · Neurobiology of Disease
Mouse Models of Alzheimer’s Disease
Yokoyama, Miyabishara, Kobayashi, Honoka, Tatsumi, Lisa, Tomita, Taisuke · 2022 · Frontiers in Molecular Neuroscience
Human neural stem cells improve cognition and promote synaptic growth in two complementary transgenic models of Alzheimer's disease and neuronal loss
Rahasson R. Ager, Joy L. Davis, Andy Agazaryan, Francisca Benavente, Wayne W. Poon, Frank M. LaFerla, Mathew M. Blurton-Jones · 2014 · Hippocampus
Axonal degeneration in Alzheimer's disease: When signaling abnormalities meet the axonal transport system
Nicholas M. Kanaan, Gustavo F. Pigino, Scott T. Brady, Orly Lazarov, Lester I. Binder, Gerardo A. Morfini · 2012 · Experimental Neurology
Inflammation in the early stages of neurodegenerative pathology
Preeti J. Khandelwal, Alexander M. Herman, Charbel Moussa · 2011 · Journal of Neuroimmunology
Transcriptional and epigenetic decoding of the microglial aging process
Xiaoyu Li, Yuxin Li, Yuxiao Jin, Yuheng Zhang, Jingchuan Wu, Zhen Xu, Yubin Huang, Lin Cai, Shuai Gao, Taohui Liu et al. · 2023 · Nature Aging
Inflammation Induced by Infection Potentiates Tau Pathological Features in Transgenic Mice
Sy, Michael, Kitazawa, Masashi, Medeiros, Rodrigo, Whitman, Lucia, Cheng, David, Lane, Thomas E., LaFerla, Frank M. · 2011 · The American Journal of Pathology
Caspase-3 Is Enriched in Postsynaptic Densities and Increased in Alzheimer's Disease
Natalia Louneva, Julia Wanda Cohen, Liying Han, Konrad Talbot, Robert S. Wilson, David Alan Bennett, John Q. Trojanowski, Steven Edward Arnold · 2008 · American Journal Of Pathology
Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model
Meilandt, William J., Ngu, Hai, Gogineni, Alvin, Lalehzadeh, Guita, Lee, Seung-Hye, Srinivasan, Karpagam, Imperio, Jose, Wu, Tiffany, Weber, Martin, Kruse, Agatha J. et al. · 2020 · The Journal of Neuroscience
Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer’s disease and tauopathies
Mark M. Yarchoan, Jon B. Toledo, Edward B. Lee, Zoe Arvanitakis, Hala Kazi, Li-Ying Han, Natalia Louneva, Virginia M.‐Y. Lee, Sangwon F. Kim, John Q. Trojanowski et al. · 2014 · Acta Neuropathologica
Updates in Alzheimer's disease: from basic research to diagnosis and therapies
Enjie Liu, Yao Zhang, Jian–Zhi Wang · 2024 · Translational Neurodegeneration
CX3CL1/CX3CR1 signaling targets for the treatment of neurodegenerative diseases
Meena S. Subbarayan, Aurélie Joly‐Amado, Paula C. Bickford, Kevin R. Nash · 2021 · Pharmacology & Therapeutics
APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints
Yin, Zhuoran, Rosenzweig, Neta, Kleemann, Kilian L., Zhang, Xiaoming, Brandão, Wesley, Margeta, Milica A., Schroeder, Caitlin, Sivanathan, Kisha N., Silveira, Sebastian, Gauthier, Christian et al. · 2023 · Nature Immunology
Traumatic Brain Injury Induces Tau Aggregation and Spreading
Edwards, George, Zhao, Jing, Dash, Pramod K., Soto, Claudio, Moreno-Gonzalez, Ines · 2020 · Journal of Neurotrauma
Immunoexcitotoxicity as a central mechanism in chronic traumatic encephalopathy-A unifying hypothesis
Russell L. Blaylock, Joseph C. Maroon · 2011 · Surgical Neurology International
Microglial activation and tau burden predict cognitive decline in Alzheimer’s disease
Malpetti, Maura, Kievit, Rogier A, Passamonti, Luca, Jones, P Simon, Tsvetanov, Kamen A, Rittman, Timothy, Mak, Elijah, Nicastro, Nicolas, Bevan-Jones, W Richard, Su, Li et al. · 2020 · Brain
Lack of Widespread BBB Disruption in Alzheimer’s Disease Models: Focus on Therapeutic Antibodies
Bien-Ly, Nga, Boswell, C. Andrew, Jeet, Surinder, Beach, Thomas G., Hoyte, Kwame, Luk, Wilman, Shihadeh, Vera, Ulufatu, Sheila, Foreman, Oded, Lu, Yanmei et al. · 2015 · Neuron
Inhibition of tau fibrillization by oleocanthal via reaction with the amino groups of tau
Wenkai Li, Jeffrey B. Sperry, Alex Crowe, John Q. Trojanowski, Amos B. Smith, Virginia M.‐Y. Lee · 2009 · Journal of Neurochemistry
Microtubule Stabilizing Agents as Potential Treatment for Alzheimer’s Disease and Related Neurodegenerative Tauopathies
Carlo Ballatore, Kurt R. Brunden, Donna M. Huryn, John Q. Trojanowski, Virginia M.‐Y. Lee, Amos B. Smith · 2012 · Journal of Medicinal Chemistry
Altered brain energetics induces mitochondrial fission arrest in Alzheimer’s Disease
Liang Zhang, Sergey Trushin, Trace A. Christensen, Benjamin V. Bachmeier, Benjamin Gateno, Andreas Schroeder, Jia Yao, Kie Itoh, Hiromi Sesaki, Wayne W. Poon et al. · 2016 · Scientific Reports
Beneficial effects of caffeine in a transgenic model of Alzheimer's disease-like tau pathology.
Cyril Laurent, S. Eddarkaoui, Maxime J Derisbourg, A. Leboucher, D. Demeyer, Sébastien Carrier, Marion Schneider, M. Hamdane, C. Müller, L. Buée et al. · 2014 · Neurobiology of Aging
Tau local structure shields an amyloid-forming motif and controls aggregation propensity
Dailu Chen, Kenneth W. Drombosky, Zhiqiang Hou, Levent Sari, Omar M. Kashmer, Bryan D. Ryder, Valerie A. Perez, DaNae R. Woodard, Milo M. Lin, Marc I. Diamond et al. · 2019 · Nature Communications
Alzheimer’s disease as a synaptopathy: Evidence for dysfunction of synapses during disease progression
S. Meftah, Jian Gan · 2023 · Frontiers in Synaptic Neuroscience
Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases
Erik Nutma, Nurun Nahar Fancy, Maria Weinert, Stergios Tsartsalis, Manuel C. Marzin, Robert C. J. Muirhead, Irene N. Falk, Marjolein Breur, Joy de Bruin, David Hollaus et al. · 2023 · Nature Communications
Caspase-2 cleavage of tau reversibly impairs memory
Zhao, Xiaohui, Kotilinek, Linda A, Smith, Benjamin, Hlynialuk, Chris, Zahs, Kathleen, Ramsden, Martin, Cleary, James, Ashe, Karen H · 2016 · Nature Medicine
Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo
Vasconcelos, Bruno, Stancu, Ilie-Cosmin, Buist, Arjan, Bird, Matthew, Wang, Peng, Vanoosthuyse, Alexandre, Van Kolen, Kristof, Verheyen, An, Kienlen-Campard, Pascal, Octave, Jean-Noël et al. · 2016 · Acta Neuropathologica
Chronic Traumatic Encephalopathy: The Neuropathological Legacy of Traumatic Brain Injury
Jennifer R. Hay, Victoria E. Johnson, Douglas H. Smith, William B. Stewart Jr. · 2016 · Annual Review of Pathology Mechanisms of Disease
TREM2 dependent and independent functions of microglia in Alzheimer’s disease
Hou, Jinchao, Chen, Yun, Grajales-Reyes, Gary, Colonna, Marco · 2022 · Molecular Neurodegeneration
Reactive astrocytes in Alzheimer’s disease: A double-edged sword
Chun, Heejung, Lee, C. Justin · 2018 · Neuroscience Research
Updates on mouse models of Alzheimer’s disease
Zhong, Michael Z., Peng, Thomas, Duarte, Mariana Lemos, Wang, Minghui, Cai, Dongming · 2024 · Molecular Neurodegeneration
Anti‐tau antibody reduces insoluble tau and decreases brain atrophy
Yanamandra, Kiran, Jiang, Hong, Mahan, Thomas E., Maloney, Susan E., Wozniak, David F., Diamond, Marc I., Holtzman, David M. · 2015 · Annals of Clinical and Translational Neurology
Plasma microRNA biomarkers for detection of mild cognitive impairment
Sheinerman, Kira S., Tsivinsky, Vladimir G., Crawford, Fiona, Mullan, Michael J., Abdullah, Laila, Umansky, Samuil R. · 2012 · Aging
Phagocytic glial cells: sculpting synaptic circuits in the developing nervous system
Schafer, Dorothy P., Stevens, Beth · 2013 · Current Opinion in Neurobiology
Pathological Tau Disrupts Ongoing Network Activity
Menkes-Caspi, Noa, Yamin, Hagar G., Kellner, Vered, Spires-Jones, Tara L., Cohen, Dana, Stern, Edward A. · 2015 · Neuron
Specific Targeting of Tau Oligomers in Htau Mice Prevents Cognitive Impairment and Tau Toxicity Following Injection with Brain-Derived Tau Oligomeric Seeds
Diana Laura Castillo‐Carranza, Julia E. Gerson, Urmi Sengupta, Marcos Jair Guerrero‐Munoz, Cristian A. Lasagna‐Reeves, Rakez Kayed · 2014 · Journal of Alzheimer s Disease
Metal ions as modulators of protein conformation and misfolding in neurodegeneration
Sónia S. Leal, Hugo M. Botelho, Cláudio M. Gomes · 2012 · Coordination Chemistry Reviews
Neural stem cell therapy for neurodegenerative disorders: The role of neurotrophic support
Samuel E. Marsh, Mathew M. Blurton-Jones · 2017 · Neurochemistry International
Fluid Biomarkers for Synaptic Dysfunction and Loss
Camporesi, Elena, Nilsson, Johanna, Brinkmalm, Ann, Becker, Bruno, Ashton, Nicholas J, Blennow, Kaj, Zetterberg, Henrik · 2020 · Biomarker Insights
Automated quantification of neuronal networks and single-cell calcium dynamics using calcium imaging
Tapan P. Patel, Karen Man, Bonnie L. Firestein, David F. Meaney · 2015 · Journal of Neuroscience Methods
Transgenic mouse models of alzheimer disease: Developing a better model as a tool for therapeutic interventions.
Kitazawa, Masashi, Medeiros, Rodrigo, M. LaFerla, Frank · 2012 · Current Pharmaceutical Design
RETRACTED: Intranasal insulin prevents cognitive decline, cerebral atrophy and white matter changes in murine type I diabetic encephalopathy
George J. Francis, Jose A. Martinez, Wei Q Liu, Kevin Xu, Amit B. Ayer, Jared M. Fine, Ursula I. Tuor, Gordon W. Glazner, Leah R. Hanson, William H. Frey et al. · 2008 · Brain · Retracted
Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy
Antonio Cuadrado, Sebastian Kügler, Isabel Lastres‐Becker · 2017 · Redox Biology
BIN1 favors the spreading of Tau via extracellular vesicles
Crotti, Andrea, Sait, Hameetha Rajamohamend, McAvoy, Kathleen M., Estrada, Karol, Ergun, Ayla, Szak, Suzanne, Marsh, Galina, Jandreski, Luke, Peterson, Michael, Reynolds, Taylor L. et al. · 2019 · Scientific Reports
Tau Protein and Its Role in Blood–Brain Barrier Dysfunction
Alena Michalicová, Petra Majerová, Andrej Kováč · 2020 · Frontiers in Molecular Neuroscience
Tau prions from Alzheimer’s disease and chronic traumatic encephalopathy patients propagate in cultured cells
Amanda L. Woerman, Atsushi Aoyagi, Smita S. Patel, Sabeen A. Kazmi, Iryna V. Lobach, Lea T. Grinberg, Ann Carolyn McKee, William W. Seeley, Steven H. Olson, Stanley B. Prusiner · 2016 · Proceedings of the National Academy of Sciences
Inhibition of EHMT1/2 rescues synaptic and cognitive functions for Alzheimer’s disease
Zheng, Yan, Liu, Aiyi, Wang, Zi-Jun, Cao, Qing, Wang, Wei, Lin, Lin, Ma, Kaijie, Zhang, Freddy, Wei, Jing, Matas, Emmanuel et al. · 2019 · Brain
‘Too much good news’ – are Alzheimer mouse models trying to tell us how to prevent, not cure, Alzheimer's disease?
Kathleen R. Zahs, Karen H. Ashe · 2010 · Trends in Neurosciences
Alzheimer disease pathology as a host response
Castellani, Rudy J., Lee, Hyoung-gon, Zhu, Xiongwei, Perry, George, Smith, Mark A. · 2008 · Journal of Neuropathology & Experimental Neurology
Tau accumulation induces synaptic impairment and memory deficit by calcineurin-mediated inactivation of nuclear CaMKIV/CREB signaling
Yaling Yin, Di Gao, Yali Wang, Zhi-Hao Wang, Xin Wang, Jinwang Ye, Dongqin Wu, Lin Fang, Guilin Pi, Ying Yang et al. · 2016 · Proceedings of the National Academy of Sciences
Microglial activation in Alzheimer's disease: an (R)-[11C]PK11195 positron emission tomography study
Alie Schuitemaker, Marc A Kropholler, Ronald Boellaard, Wiesje M. van der Flier, Reina W. Kloet, Thalia F. van der Doef, Dirk L. Knol, Albert D. Windhorst, Gert Luurtsema, Frederik Barkhof et al. · 2012 · Neurobiology of Aging
Tauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment options
Albert Christian Ludolph, Jan Kassubek, G. Bernhard Landwehrmeyer, E. Mandelkow, Eva‐Maria Mandelkow, David John Burn, Dominique Caparros-Lefebvre, Kirk A. Frey, Justo Garcı́a de Yébenes, Thomas Gasser et al. · 2009 · European Journal of Neurology
Interactions between APP secretases and inflammatory mediators
Magdalena Sastre, Jochen Walter, Steve Gentleman · 2008 · Journal of Neuroinflammation
MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways
Rachid El Fatimy, Shaomin Li, Zhicheng Chen, Tasnim Mushannen, Sree Gongala, Zhiyun Wei, Darrick T. Balu, Rosalia Rabinovsky, Adam Cantlon, Abdallah Elkhal et al. · 2018 · Acta Neuropathologica
Imaging of Peripheral Benzodiazepine Receptor Expression as Biomarkers of Detrimental versus Beneficial Glial Responses in Mouse Models of Alzheimer's and Other CNS Pathologies
Ji, Bin, Maeda, Jun, Sawada, Makoto, Ono, Maiko, Okauchi, Takashi, Inaji, Motoki, Zhang, Ming-Rong, Suzuki, Kazutoshi, Ando, Kiyoshi, Staufenbiel, Matthias et al. · 2008 · The Journal of Neuroscience
Cerebrospinal fluid neurogranin concentration in neurodegeneration: relation to clinical phenotypes and neuropathology
Erik Portelius, Bob Olsson, Kina Höglund, Nicholas C. Cullen, Hlin Kvartsberg, Ulf Andréasson, Henrik Zetterberg, Åsa Sandelius, Leslie M. J. Shaw, Virginia M.‐Y. Lee et al. · 2018 · Acta Neuropathologica
TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration
Zhong, Li, Sheng, Xuan, Wang, Wanbing, Li, Yanzhong, Zhuo, Rengong, Wang, Kai, Zhang, Lianshuai, Hu, Dan-Dan, Hong, Yujuan, Chen, Linting et al. · 2023 · Immunity
Tau Mutations in Neurodegenerative Diseases
Michael S. Wolfe · 2008 · Journal of Biological Chemistry
Tau Oligomers: The Toxic Player at Synapses in Alzheimer’s Disease
Guerrero-Muñoz, Marcos J., Gerson, Julia, Castillo-Carranza, Diana L. · 2015 · Frontiers in Cellular Neuroscience
Tau Oligomers Associate with Inflammation in the Brain and Retina of Tauopathy Mice and in Neurodegenerative Diseases
Ashley N. Nilson, Kelsey C. English, Julia E. Gerson, T. Barton Whittle, C. Nicolas Crain, Judy J Xue, Urmi Sengupta, Diana Laura Castillo‐Carranza, Wenbo Zhang, Praveena K. Gupta et al. · 2016 · Journal of Alzheimer s Disease
An aging, pathology burden, and glial senescence build-up hypothesis for late onset Alzheimer’s disease
Victor Z. Lau, Leanne M. Ramer, Marie‐Ève Tremblay · 2023 · Nature Communications
The β-Propensity of Tau Determines Aggregation and Synaptic Loss in Inducible Mouse Models of Tauopathy
Eckermann, Katrin, Mocanu, Maria-Magdalena, Khlistunova, Inna, Biernat, Jacek, Nissen, Astrid, Hofmann, Anne, Schönig, Kai, Bujard, Hermann, Haemisch, Andreas, Mandelkow, Eckhard et al. · 2007 · Journal of Biological Chemistry
P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice
Ruan, Zhi, Delpech, Jean-Christophe, Venkatesan Kalavai, Srinidhi, Van Enoo, Alicia A., Hu, Jianqiao, Ikezu, Seiko, Ikezu, Tsuneya · 2020 · Molecular Neurodegeneration
The Complex Interactions Between Obesity, Metabolism and the Brain
Romina María Uranga, Jeffrey N. Keller · 2019 · Frontiers in Neuroscience
Inhibition of p25/Cdk5 Attenuates Tauopathy in Mouse and iPSC Models of Frontotemporal Dementia
Jinsoo Seo, Oleg Kritskiy, Lauren Ashley Watson, Scarlett J. Barker, Dilip Chandra Dey, Waseem Khan Raja, Yuan-Ta Lin, Tak Ko, Sukhee Cho, Jay Penney et al. · 2017 · Journal of Neuroscience
Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK
Li, Yajuan, Munoz-Mayorga, Daniel, Nie, Yuhang, Kang, Ningxin, Tao, Yuren, Lagerwall, Jessica, Pernaci, Carla, Curtin, Genevieve, Coufal, Nicole G., Mertens, Jerome et al. · 2024 · Cell Metabolism
The intersection of amyloid beta and tau in glutamatergic synaptic dysfunction and collapse in Alzheimer's disease
Johanna L. Crimins, Amy M. Pooler, Manuela Polydoro, Jennifer Irene Luebke, Tara L. Spires‐Jones · 2013 · Ageing Research Reviews
The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies
Kurt R. Brunden, Yuemang Yao, Justin S. Potuzak, Nuria Ibarz Ferrer, Carlo Ballatore, Michael J. James, Anne‐Marie L. Hogan, John Q. Trojanowski, Amos B. Smith, Virginia M.‐Y. Lee · 2010 · Pharmacological Research
Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology
Karim Bélarbi, Sylvie Burnouf, Francisco-José Fernández-Gómez, Cyril Laurent, Sophie Lestavel, Martin Figeac, Audrey Sultan, Laëtitia Troquier, Antoine Leboucher, Raphaëlle Caillierez et al. · 2011 · Neurobiology of Disease
Behavioural and psychological symptoms of dementia in mouse models of Alzheimer’s disease-related pathology
Filip Kosel, Jessica M.S. Pelley, Tamara B. Franklin · 2020 · Neuroscience & Biobehavioral Reviews
Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPβ in Microglia
Ada Ndoja, Rohit Reja, Seung-Hye Lee, Joshua D. Webster, Hai Ngu, Christopher M. Rose, Donald S. Kirkpatrick, Zora D. Modrusan, Ying-Jiun Jasmine Chen, Debra L. Dugger et al. · 2020 · Cell
Methylene blue upregulates Nrf2/ARE genes and prevents tau-related neurotoxicity
Cliona Stack, Shari Jainuddin, Ceyhan Elipenahli, Meri Gerges, Natalia N. Starkova, Anatoly A. Starkov, Mariona Jové, Manuel Portero‐Otín, Nathalie Launay, Aurora Pujol et al. · 2014 · Human Molecular Genetics
Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist
Litvinchuk, Alexandra, Suh, Jung H., Guo, Jing L., Lin, Karin, Davis, Sonnet S., Bien-Ly, Nga, Tycksen, Eric, Tabor, G. Travis, Remolina Serrano, Javier, Manis, Melissa et al. · 2024 · Neuron
Perforant path synaptic loss correlates with cognitive impairment and Alzheimer’s disease in the oldest-old
Robinson, John L., Molina-Porcel, Laura, Corrada, Maria M., Raible, Kevin, Lee, Edward B., Lee, Virginia M.-Y., Kawas, Claudia H., Trojanowski, John Q. · 2014 · Brain
Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia
Swarup, Vivek, Hinz, Flora I., Rexach, Jessica E., Noguchi, Ken-ichi, Toyoshiba, Hiroyoshi, Oda, Akira, Hirai, Keisuke, Sarkar, Arjun, Seyfried, Nicholas T., Cheng, Chialin et al. · 2019 · Nature Medicine
Relationship Between Tau Pathology and Neuroinflammation in Alzheimer's Disease
Mariajose Metcalfe, Maria E. Figueiredo‐Pereira · 2010 · Mount Sinai Journal of Medicine A Journal of Translational and Personalized Medicine
Role of the peripheral innate immune system in the development of Alzheimer's disease
Aurélie Y. Le Page, Gilles Dupuis, Eric H. Frost, Anis Larbi, Graham Pawelec, Jacek Maciej Witkowski, Tamàs Fülöp · 2017 · Experimental Gerontology
Accumulation of tau induced in neurites by microglial proinflammatory mediators
Gorlovoy, Philipp, Larionov, Sergey, Pham, Thao Thi Hien, Neumann, Harald · 2009 · The FASEB Journal
The activation of cannabinoid CB2 receptors stimulates in situ and in vitro beta-amyloid removal by human macrophages
Rosa Maria Tolón, Estefanía Núñez, María Ruth Pazos, Cristina Benito, Ana I. Castillo, José Antonio Martínez-Orgado, Julián Romero · 2009 · Brain Research
Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model
Cristian A. Lasagna‐Reeves, María de Haro, Shuang Hao, Jeehye Park, Maxime W.C. Rousseaux, Ismael Al‐Ramahi, Paymaan Jafar‐Nejad, Luis Vilanova-Velez, Lauren See, Antonia De Maio et al. · 2016 · Neuron
Soluble tau aggregates, not large fibrils, are the toxic species that display seeding and cross‐seeding behavior
Gaurav Ghag, Nemil N. Bhatt, Daniel V Cantu, Marcos Jair Guerrero‐Munoz, Anna Ellsworth, Urmi Sengupta, Rakez Kayed · 2018 · Protein Science
Environment and Gene Association With Obesity and Their Impact on Neurodegenerative and Neurodevelopmental Diseases
María Teresa Flores-Dorantes, Yael E. Díaz‐López, Ruth Gutiérrez‐Aguilar · 2020 · Frontiers in Neuroscience
Does modulation of tau hyperphosphorylation represent a reasonable therapeutic strategy for Alzheimer’s disease? From preclinical studies to the clinical trials
Basheer, Neha, Smolek, Tomáš, Hassan, Imtaiyaz, Liu, Fei, Iqbal, Khalid, Zilka, Norbert, Novak, Petr · 2023 · Molecular Psychiatry
Interneuron Accumulation of Phosphorylated tau Impairs Adult Hippocampal Neurogenesis by Suppressing GABAergic Transmission.
Jie Zheng, Hong-Lian Li, Na Tian, Fei Liu, Lu Wang, Ya-Ling Yin, Lu-Peng Yue, Longyu Ma, Y. Wan, Jian-Zhi Wang · 2020 · Cell Stem Cell
AD-linked R47H- <i>TREM2</i> mutation induces disease-enhancing microglial states via AKT hyperactivation
Sayed, Faten A., Kodama, Lay, Fan, Li, Carling, Gillian K., Udeochu, Joe C., Le, David, Li, Qingyun, Zhou, Lu, Wong, Man Ying, Horowitz, Rose et al. · 2021 · Science Translational Medicine
TREM2 Function in Alzheimer’s Disease and Neurodegeneration
Ulrich, Jason D., Holtzman, David M. · 2016 · ACS Chemical Neuroscience
Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer’s disease
Zhang, Zhentao, Obianyo, Obiamaka, Dall, Elfriede, Du, Yuhong, Fu, Haian, Liu, Xia, Kang, Seong Su, Song, Mingke, Yu, Shan-Ping, Cabrele, Chiara et al. · 2017 · Nature Communications
Progranulin expression in the developing and adult murine brain
Petkau, Terri L., Neal, S.J., Orban, P.C., MacDonald, J.L., Hill, A.M., Lu, G., Feldman, H.H., Mackenzie, I.R.A., Leavitt, B.R. · 2010 · Journal of Comparative Neurology
The role of pro-inflammatory S100A9 in Alzheimer’s disease amyloid-neuroinflammatory cascade
Chao Wang, Alexey G. Klechikov, Anna L. Gharibyan, Sebastian K.T.S. Wärmländer, Jüri Jarvet, Lina Zhao, Xueen Jia, S.K. Shankar, Anders Olofsson, Thomas Brännström et al. · 2013 · Acta Neuropathologica
TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau
Maxime W.C. Rousseaux, María de Haro, Cristian A. Lasagna‐Reeves, Antonia De Maio, Jeehye Park, Paymaan Jafar‐Nejad, Ismael Al‐Ramahi, Ajay Sharma, Lauren See, Nan Lü et al. · 2016 · eLife
Increased binding of peripheral benzodiazepine receptor in mild cognitive impairment–dementia converters measured by positron emission tomography with [11C]DAA1106
Yasuno, Fumihiko, Kosaka, Jun, Ota, Miho, Higuchi, Makoto, Ito, Hiroshi, Fujimura, Yota, Nozaki, Shoko, Takahashi, Sho, Mizukami, Katsuyoshi, Asada, Takashi et al. · 2012 · Psychiatry Research: Neuroimaging
Intracellular Aβ-oligomers and early inflammation in a model of Alzheimer's disease
Maria Teresa Ferretti, Martin Alejandro Bruno, Adriana Ducatenzeiler, William L. Klein, A. Claudio Cuello · 2011 · Neurobiology of Aging
Immunoglobulins and complement in postmortem multiple sclerosis tissue
Michael Harry Barnett, John D. E. Parratt, Eun‐Sook Cho, John W. Prineas · 2009 · Annals of Neurology
Who fans the flames of Alzheimer's disease brains? Misfolded tau on the crossroad of neurodegenerative and inflammatory pathways
Norbert Žilka, Zuzana Kazmerova, Santosh Jadhav, Peter Neradil, Aladár Maďari, Dominika Obetkova, Ondrej Bugos, Michal Novák · 2012 · Journal of Neuroinflammation
Tau-mediated synaptic and neuronal dysfunction in neurodegenerative disease
Tara E. Tracy, Li Gan · 2018 · Current Opinion in Neurobiology
Passive Immunization with Phospho-Tau Antibodies Reduces Tau Pathology and Functional Deficits in Two Distinct Mouse Tauopathy Models
Sethu Sankaranarayanan, Donna M. Barten, Laurel Vana, Nino Devidze, Ling Yang, Gregory W. Cadelina, Nina Hoque, Lynn B. DeCarr, Stefanie Keenan, Alan Lin et al. · 2015 · PLoS ONE
Widespread tau seeding activity at early Braak stages
Jennifer L. Furman, Jaime Vaquer‐Alicea, Charles L. White, Nigel J. Cairns, Peter T. Nelson, Marc I. Diamond · 2016 · Acta Neuropathologica
Cell-to-Cell Transmission of Tau and α-Synuclein
Norihito Uemura, Maiko T. Uemura, Kelvin C. Luk, Virginia M.‐Y. Lee, John Q. Trojanowski · 2020 · Trends in Molecular Medicine
Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice
Stancu, Ilie-Cosmin, Vasconcelos, Bruno, Ris, Laurence, Wang, Peng, Villers, Agnès, Peeraer, Eve, Buist, Arjan, Terwel, Dick, Baatsen, Peter, Oyelami, Tutu et al. · 2015 · Acta Neuropathologica
Sevoflurane Induces Tau Phosphorylation and Glycogen Synthase Kinase 3β Activation in Young Mice
Guorong Tao, Jie Zhang, Lei Zhang, Yuanlin Dong, Buwei Yu, Gregory J. Crosby, Deborah J. Culley, Yiying Zhang, Zhongcong Xie · 2014 · Anesthesiology