The DOI matches its Crossref record; 72 of the 73 references it cites were found in a registry or an index.
Coherent Theta Oscillations and Reorganization of Spike Timing in the Hippocampal- Prefrontal Network upon Learning
Open accessAbstract
To study the interplay between hippocampus and medial prefrontal cortex (Pfc) and its importance for learning and memory consolidation, we measured the coherence in theta oscillations between these two structures in rats learning new rules on a Y maze. Coherence peaked at the choice point, most strongly after task rule acquisition. Simultaneously, Pfc pyramidal neurons reorganized their phase, concentrating at hippocampal theta trough, and synchronous cell assemblies emerged. This synchronous state may result from increased inhibition exerted by interneurons on pyramidal cells, as measured by cross-correlation, and could be modulated by dopamine: we found similar hippocampal-Pfc theta coherence increases and neuronal phase shifts following local administration of dopamine in Pfc of anesthetized rats. Pfc cell assemblies emerging during high coherence were preferentially replayed during subsequent sleep, concurrent with hippocampal sharp waves. Thus, hippocampal/prefrontal coherence could lead to synchronization of reward predicting activity in prefrontal networks, tagging it for subsequent memory consolidation.
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“In rats, prefrontal cell assemblies that fired during learning when EEG theta coherence between the prefrontal cortex and hippocampus was increased showed a distinctly increased probability to be reactivated during subsequent SWS (73).”
From About Sleep's Role in Memory (2013) · cites this paper as [73]
In the citing paper
“the theta coherence between the PFC and hippocampus was increased, especially after rats had learned how to reliably procure food”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Benchenane et al., 2010
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Hebb, D. O. (2005) · doi:10.4324/9781410612403 · Cited by 9,825
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Fries, P. (2005) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2005.08.011 · Cited by 4,284
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Dynamic functional connectivity: Promise, issues, and interpretations
Hutchison, R. M., Womelsdorf, T., Allen, E. A., Bandettini, P. A., Calhoun, V. D., Corbetta, M., Della Penna, S., Duyn, J. H., Glover, G. H., Gonzalez-Castillo, J., et al. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.05.079 · Cited by 2,962
Rasch, B., & Born, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00032.2012 · Cited by 2,783
Frontal theta as a mechanism for cognitive control
Cavanagh, J. F., & Frank, M. J. (2014) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2014.04.012 · Cited by 2,726
The functional role of cross-frequency coupling
Canolty, R. T., & Knight, R. T. (2010) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.09.001 · Cited by 2,101
Vinck, M., Oostenveld, R., van Wingerden, M., Battaglia, F., & Pennartz, C. M. A. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.01.055 · Cited by 1,753
Metadata
- Authors
- Benchenane, K., Peyrache, A., Khamassi, M., Tierney, P. L., Gioanni, Y., Battaglia, F. P., & Wiener, S. I.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- McGovern Institute for Brain Research (US)
- Inserm (FR)
- Corresponding author
- Benchenane, Karim
- Battaglia, Francesco P.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 66
- Issue
- 6
- Pages
- 921-936
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2130674184
- Cited by
- 872
- References
- 73
- Citations by year
- 2026: 35 · 2025: 53 · 2024: 55 · 2023: 41 · 2022: 45 · 2021: 70 · 2020: 65 · 2019: 49 · 2018: 61 · 2017: 88 · 2016: 57 · 2015: 60 · 2014: 55 · 2013: 57 · 2012: 34
- FWCI
- 26.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- UvA-DARE (University of Amsterdam) (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- HAL (submittedVersion, other-oa)
- UvA-DARE (University of Amsterdam) (submittedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Elsevier eBooks
- Funders
- Johns Hopkins University
- Fondation Fyssen
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- hippocampus, medial prefrontal cortex, theta oscillations, neural coherence, spike timing, rule induction, Y-maze, memory consolidation, dopamine, interneurons, pyramidal neurons, sharp-wave ripples, reward prediction
- MeSH terms
- Action Potentials, Animals, Behavior, Animal, Dopamine, Hippocampus, Male, Neural Inhibition, Neural Pathways, Neurons, Periodicity, Reward, Spectrum Analysis, Time Factors, Prefrontal Cortex, Maze Learning, Rats, Long-Evans, Principal Component Analysis, Rats
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