The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Thalamic Gating of Corticostriatal Signaling by Cholinergic Interneurons
Open accessAbstract
SUMMARY Salient stimuli redirect attention and suppress ongoing motor activity. This attentional shift is thought to rely upon thalamic signals to the striatum to shift cortically driven action selection, but the network mechanisms underlying this interaction are unclear. Using a brain slice preparation that preserved cortico- and thalamostriatal connectivity, it was found that activation of thalamostriatal axons in a way that mimicked the response to salient stimuli induced a burst of spikes in striatal cholinergic interneurons that was followed by a pause lasting more than half a second. This patterned interneuron activity triggered a transient, presynaptic suppression of cortical input to both major classes of principal medium spiny neuron (MSN), that gave way to a prolonged enhancement of postsynaptic responsiveness in striatopallidal MSNs controlling motor suppression. This differential regulation of the corticostriatal circuitry provides a neural substrate for attentional shifts and cessation of ongoing motor activity with the appearance of salient environmental stimuli.
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Cites
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Cited by
Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior
Picciotto, M. R., Higley, M. J., & Mineur, Y. S. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.036 · Cited by 1,404
Striatal Dopamine Release Is Triggered by Synchronized Activity in Cholinergic Interneurons
Threlfell, S., Lalic, T., Platt, N. J., Jennings, K. A., Deisseroth, K., & Cragg, S. J. (2012) · Neuron · doi:10.1016/j.neuron.2012.04.038 · Cited by 845
Cachope, R., Mateo, Y., Mathur, B. N., Irving, J., Wang, H.-L., Morales, M., Lovinger, D. M., & Cheer, J. F. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.05.011 · Cited by 517
Striatal Circuits as a Common Node for Autism Pathophysiology
Fuccillo, M. V. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00027 · Cited by 269
Chuhma, N., Mingote, S., Moore, H., & Rayport, S. (2014) · Neuron · doi:10.1016/j.neuron.2013.12.027 · Cited by 233
Metadata
- Authors
- Ding, J. B., Guzman, J. N., Peterson, J. D., Goldberg, J. A., & Surmeier, D. J.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 67
- Issue
- 2
- Pages
- 294-307
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2048255799
- Cited by
- 475
- References
- 8
- FWCI
- 9.95
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ding, J. B., Guzman, J. N., Peterson, J. D., Goldberg, J. A., & Surmeier, D. J. (2010). Thalamic Gating of Corticostriatal Signaling by Cholinergic Interneurons. Neuron. https://doi.org/10.1016/j.neuron.2010.06.017
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