Effect of the nigrostriatal dopamine system on acquired neural responses in the striatum of behaving monkeys
Abstract
Dysfunction of the nigrostriatal dopamine system results in marked disorders of movement such as occur in Parkinson's disease. Functions of this dopamine-containing projection system were examined in monkeys trained in a classical conditioning task, and the effects of striatal dopamine depletion were tested. Unilateral dopamine loss substantially reduced the acquired sensory responsiveness of striatal neurons monitored electrophysiologically. This effect was ipsilateral and selective, and could be reversed by apomorphine. These results suggest that the primate nigrostriatal system modulates expression of neuronal response plasticity in the striatum during sensorimotor learning.
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Dopamine depletion prevents the acquisition of sensory responses in striatal cells.
“As this model predicts, sensory responses are acquired in striatal cells over the course of reinforcement learning, and dopamine depletion prevents the acquisition of these responses [37, 39].”
From Cortical and basal ganglia contributions to habit learning and automaticity (2010) · cites this paper as [39]
Sensory responses are acquired in striatal cells over the course of reinforcement learning.
“As this model predicts, sensory responses are acquired in striatal cells over the course of reinforcement learning, and dopamine depletion prevents the acquisition of these responses [37, 39].”
From Cortical and basal ganglia contributions to habit learning and automaticity (2010) · cites this paper as [39]
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- Authors
- Aosaki, T., Graybiel, A. M., & Kimura, M.
- Affiliations
- Massachusetts Institute of Technology (US)
- The University of Osaka (JP)
- Venue
- Science
- Published
- 1994-07-15
- Volume
- 265
- Issue
- 5170
- Pages
- 412-415
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2076464393
- Cited by
- 427
- References
- 31
- Citations by year
- 2026: 12 · 2025: 16 · 2024: 10 · 2023: 4 · 2022: 18 · 2021: 9 · 2020: 10 · 2019: 12 · 2018: 10 · 2017: 13 · 2016: 15 · 2015: 13 · 2014: 9 · 2013: 9 · 2012: 12
- FWCI
- 4.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01 NS25529, R01NS025529)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- nigrostriatal dopamine system, striatum, dopamine depletion, sensorimotor learning, classical conditioning, apomorphine, Parkinson's disease, primate behavior
- MeSH terms
- Action Potentials, Animals, Apomorphine, Behavior, Animal, Conditioning, Classical, Corpus Striatum, Dopamine, Haloperidol, Macaca, Male, Neuronal Plasticity, Neurons, Substantia Nigra, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
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