Frequency-dependent modulation of dopamine release by nicotine
Abstract
Although nicotine activation of dopamine release is implicated in addiction, it also desensitizes nicotinic acetylcholine receptors (nAChRs), leading to a prolonged depression of evoked dopamine release. Here we show that nicotine's effects depend on the firing pattern of dopamine neurons, so that while desensitization of nAChRs indeed curbs dopamine released by stimuli emulating tonic firing, it allows a rapid rise in dopamine from stimuli emulating phasic firing patterns associated with incentive/salience paradigms. Nicotine may thus enhance the contrast of dopamine signals associated with behavioral cues.
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Desensitization of β2* nAChRs on DA terminals in the NAc leads to decreased transmission of tonic DA neuronal firing, but maintained release of DA in response to phasic DA neuronal firing.
“desensitization of β2* nAChRs on DA terminals in the NAc leading to decreased transmission of tonic DA neuronal firing, but maintained release of DA in response to phasic DA neuronal firing (Rice and Cragg, 2004; Zhang and Sulzer, 2004)”
From It is not “either/or”: Activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood (2008) · cites this paper as Zhang and Sulzer, 2004
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- Authors
- Zhang, H., & Sulzer, D.
- Affiliations
- Columbia University (US)
- New York State Psychiatric Institute (US)
- Corresponding author
- Sulzer, David
- Venue
- Nature Neuroscience
- Published
- 2004-05-16
- Volume
- 7
- Issue
- 6
- Pages
- 581-582
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W1977353877
- Cited by
- 361
- References
- 15
- Citations by year
- 2026: 4 · 2025: 20 · 2024: 11 · 2023: 10 · 2022: 20 · 2021: 11 · 2020: 18 · 2019: 14 · 2018: 23 · 2017: 13 · 2016: 19 · 2015: 18 · 2014: 24 · 2013: 13 · 2012: 19
- FWCI
- 4.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Keywords
- nicotine, dopamine release, tonic firing, phasic firing, incentive salience, behavioral addiction
- MeSH terms
- Action Potentials, Animals, Dopamine, Nicotine, Nucleus Accumbens, Receptors, Nicotinic, Mice, In Vitro Techniques
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