Cited by 361Nicotinic Acetylcholine Receptors StudyNeurotransmitter Receptor Influence on BehaviorSmoking Behavior and Cessation

Frequency-dependent modulation of dopamine release by nicotine

Zhang, Hui, Sulzer, David·2004·Nature Neuroscience

Abstract

Although nicotine activation of dopamine release is implicated in addiction, it also desensitizes nicotinic acetylcholine receptors (nAChRs), leading to a prolonged depression of evoked dopamine release. Here we show that nicotine's effects depend on the firing pattern of dopamine neurons, so that while desensitization of nAChRs indeed curbs dopamine released by stimuli emulating tonic firing, it allows a rapid rise in dopamine from stimuli emulating phasic firing patterns associated with incentive/salience paradigms. Nicotine may thus enhance the contrast of dopamine signals associated with behavioral cues.

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Crossref · 10.1038/nn1243

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Authors
Zhang, H., & Sulzer, D.
Affiliations
  • Columbia University (US)
  • New York State Psychiatric Institute (US)
Corresponding author
Sulzer, David
Venue
Nature Neuroscience
Published
2004-05-16
Volume
7
Issue
6
Pages
581-582
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
OpenAlex
W1977353877
Cited by
361
References
15
Citations by year
2026: 4 · 2025: 20 · 2024: 11 · 2023: 10 · 2022: 20 · 2021: 11 · 2020: 18 · 2019: 14 · 2018: 23 · 2017: 13 · 2016: 19 · 2015: 18 · 2014: 24 · 2013: 13 · 2012: 19
FWCI
4.82
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
Keywords
nicotine, dopamine release, tonic firing, phasic firing, incentive salience, behavioral addiction
MeSH terms
Action Potentials, Animals, Dopamine, Nicotine, Nucleus Accumbens, Receptors, Nicotinic, Mice, In Vitro Techniques

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