Myosin IIb regulates actin dynamics during synaptic plasticity and memory formation
Open accessAbstract
Reorganization of the actin cytoskeleton is essential for synaptic plasticity and memory formation. Presently, the mechanisms that trigger actin dynamics during these brain processes are poorly understood. In this study, we show that myosin II motor activity is downstream of LTP induction and is necessary for the emergence of specialized actin structures that stabilize an early phase of LTP. We also demonstrate that myosin II activity contributes importantly to an actin-dependent process that underlies memory consolidation. Pharmacological treatments that promote actin polymerization reversed the effects of a myosin II inhibitor on LTP and memory. We conclude that myosin II motors regulate plasticity by imparting mechanical forces onto the spine actin cytoskeleton in response to synaptic stimulation. These cytoskeletal forces trigger the emergence of actin structures that stabilize synaptic plasticity. Our studies provide a mechanical framework for understanding cytoskeletal dynamics associated with synaptic plasticity and memory formation.
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Stimulation of NMDA receptors during the LTP induction activates Rho GTPases signaling pathway that regulate myosin II motors.
“stimulation of NMDA receptors during the LTP induction activates Rho GTPases signaling pathway that regulate myosin II motors (Rex et al., 2010).”
From Apolipoprotein E in Synaptic Plasticity and Alzheimer’s Disease: Potential Cellular and Molecular Mechanisms (2014) · cites this paper as Rex et al., 2010
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Self-citation
- Authors
- Rex, C. S., Gavin, C. F., Rubio, M. D., Kramar, E. A., Chen, L. Y., Jia, Y., Huganir, R. L., Muzyczka, N., Gall, C. M., Miller, C. A., Lynch, G., & Rumbaugh, G.
- Affiliations
- University of California, Irvine (US)
- University of Alabama at Birmingham (US)
- Howard Hughes Medical Institute (US)
- University of Florida (US)
- Corresponding author
- Rumbaugh, Gavin
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2010-08
- Volume
- 67
- Issue
- 4
- Pages
- 603-617
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC2929390
- OpenAlex
- W2103076822
- Cited by
- 213
- References
- 7
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 13 · 2023: 10 · 2022: 6 · 2021: 12 · 2020: 14 · 2019: 9 · 2018: 15 · 2017: 19 · 2016: 16 · 2015: 16 · 2014: 20 · 2013: 16 · 2012: 19
- FWCI
- 6.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1081 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- U.S. Public Health Service (NINDS 045540)
- National Institute on Aging (AG00096, T32AG000096)
- National Heart, Lung, and Blood Institute (P01HL059412)
- National Institute of Mental Health (MH083396, F31MH083396)
- National Institute on Drug Abuse (R00DA024761)
- National Institute of Neurological Disorders and Stroke (P01NS045260, NS05182, NS-45260, R01NS064079, NS064079)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Keywords
- myosin IIB, actin dynamics, actin cytoskeleton, synaptic plasticity, long-term potentiation, memory consolidation, dendritic spines, actin polymerization, mechanical forces, motor proteins, actin structure
- MeSH terms
- Actins, Animals, Hippocampus, Male, Memory, Models, Neurological, Myosins, Neuronal Plasticity, Phosphorylation, Synapses, Time Factors, Receptors, N-Methyl-D-Aspartate, Rats, Sprague-Dawley, Long-Term Potentiation, Myosin Light Chains, Excitatory Postsynaptic Potentials, Nonmuscle Myosin Type IIB, Dendritic Spines, Rats, In Vitro Techniques
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