Dendritic spine actin cytoskeleton in autism spectrum disorder
Abstract
Dendritic spines are small actin-rich protrusions from neuronal dendrites that form the postsynaptic part of most excitatory synapses. Changes in the shape and size of dendritic spines correlate with the functional changes in excitatory synapses and are heavily dependent on the remodeling of the underlying actin cytoskeleton. Recent evidence implicates synapses at dendritic spines as important substrates of pathogenesis in neuropsychiatric disorders, including autism spectrum disorder (ASD). Although synaptic perturbations are not the only alterations relevant for these diseases, understanding the molecular underpinnings of the spine and synapse pathology may provide insight into their etiologies and could reveal new drug targets. In this review, we will discuss recent findings of defective actin regulation in dendritic spines associated with ASD.
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Genetic studies of ASD have revealed multigene variations that converge on synaptic dysfunction.
“ASD exhibits a strong genetic basis, and increasing evidence from inherited and de novo gene variations suggests a notable convergence on synapse pathophysiology in ASD, particularly dysfunction of excitatory synaptic transmission 1, 2.”
From Autism-like social deficit generated by Dock4 deficiency is rescued by restoration of Rac1 activity and NMDA receptor function. (2021) · cites this paper as [2]
Cites
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Kim, J., Kundu, M., Viollet, B., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2152 · Cited by 7,227 · see citing works
Rho GTPases and the Actin Cytoskeleton
Hall, A. (1998) · Science · doi:10.1126/science.279.5350.509 · Cited by 6,138 · see citing works
Synaptic, transcriptional and chromatin genes disrupted in autism
Study, T. D., De Rubeis, S., Autism, H. M. C. F., UK10K Consortium, The Autism Sequencing Consortium, He, X., Goldberg, A. P., Poultney, C. S., Samocha, K., Ercument Cicek, A., et al. (2014) · Nature · doi:10.1038/nature13772 · Cited by 2,746 · see citing works
The contribution of de novo coding mutations to autism spectrum disorder
Iossifov, I., O’Roak, B. J., Sanders, S. J., Ronemus, M., Krumm, N., Levy, D., Stessman, H. A., Witherspoon, K. T., Vives, L., Patterson, K. E., et al. (2014) · Nature · doi:10.1038/nature13908 · Cited by 2,585 · see citing works
Functional impact of global rare copy number variation in autism spectrum disorders
Pinto, D., Pagnamenta, A. T., Klei, L., Anney, R., Merico, D., Regan, R., Conroy, J., Magalhaes, T. R., Correia, C., Abrahams, B. S., et al. (2010) · Nature · doi:10.1038/nature09146 · Cited by 2,013 · see citing works
Neuroligins and neurexins link synaptic function to cognitive disease
Südhof, T. C. (2008) · Nature · doi:10.1038/nature07456 · Cited by 1,849 · see citing works
Structural Variation of Chromosomes in Autism Spectrum Disorder
Marshall, C. R., Noor, A., Vincent, J. B., Lionel, A. C., Feuk, L., Skaug, J., Shago, M., Moessner, R., Pinto, D., Ren, Y., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2007.12.009 · Cited by 1,815 · see citing works
Large recurrent microdeletions associated with schizophrenia.
GROUP, Stefansson, H., Rujescu, D., Cichon, S., Pietiläinen, O. P. H., Ingason, A., Steinberg, S., Fossdal, R., Sigurdsson, E., Sigmundsson, T., et al. (2008) · Nature · doi:10.1038/nature07229 · Cited by 1,745 · see citing works
De novo mutations in schizophrenia implicate synaptic networks
Fromer, M., Pocklington, A. J., Kavanagh, D. H., Williams, H. J., Dwyer, S., Gormley, P., Georgieva, L., Rees, E., Palta, P., Ruderfer, D. M., et al. (2014) · Nature · doi:10.1038/nature12929 · Cited by 1,617 · see citing works
Durand, C. M., Betancur, C., Boeckers, T. M., Bockmann, J., Chaste, P., Fauchereau, F., Nygren, G., Rastam, M., Gillberg, I. C., Anckarsäter, H., et al. (2007) · Nature Genetics · doi:10.1038/ng1933 · Cited by 1,602 · see citing works
PDZ domain proteins of synapses
Kim, E., & Sheng, M. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1517 · Cited by 1,566 · see citing works
Absence of expression of the FMR-1 gene in fragile X syndrome
Pieretti, M., Zhang, F., Fu, Y.-H., Warren, S. T., Oostra, B. A., Caskey, C. T., & Nelson, D. L. (1991) · Cell · doi:10.1016/0092-8674(91)90125-i · Cited by 1,476 · see citing works
De Novo Gene Disruptions in Children on the Autistic Spectrum
Iossifov, I., Ronemus, M., Levy, D., Wang, Z., Hakker, I., Rosenbaum, J., Yamrom, B., Lee, Y.-H., Narzisi, G., Leotta, A., et al. (2012) · Neuron · doi:10.1016/j.neuron.2012.04.009 · Cited by 1,446 · see citing works
Insights into autism spectrum disorder genomic architecture and biology from 71 risk loci
Sanders, S. J., He, X., Willsey, A. J., Ercan-Sencicek, A. G., Samocha, K. E., Cicek, A. E., Murtha, M. T., Bal, V. H., Bishop, S. L., Dong, S., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.09.016 · Cited by 1,430 · see citing works
Autism genome-wide copy number variation reveals ubiquitin and neuronal genes
Glessner, J. T., Wang, K., Cai, G., Korvatska, O., Kim, C. E., Wood, S., Zhang, H., Estes, A., Brune, C. W., Bradfield, J. P., et al. (2009) · Nature · doi:10.1038/nature07953 · Cited by 1,421 · see citing works
Mapping autism risk loci using genetic linkage and chromosomal rearrangements
The Autism Genome Project Consortium (2007) · Nature Genetics · doi:10.1038/ng1985 · Cited by 1,402 · see citing works
A polygenic burden of rare disruptive mutations in schizophrenia
Purcell, S. M., Moran, J. L., Fromer, M., Ruderfer, D., Solovieff, N., Roussos, P., O’Dushlaine, C., Chambert, K., Bergen, S. E., Kähler, A., et al. (2014) · Nature · doi:10.1038/nature12975 · Cited by 1,385 · see citing works
Reversal of Neurological Defects in a Mouse Model of Rett Syndrome
Guy, J., Gan, J., Selfridge, J., Cobb, S., & Bird, A. (2007) · Science · doi:10.1126/science.1138389 · Cited by 1,230 · see citing works
Exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutations
O'Roak, B. J., Deriziotis, P., Lee, C., Vives, L., Schwartz, J. J., Girirajan, S., Karakoc, E., MacKenzie, A. P., Ng, S. B., Baker, C., et al. (2011) · Nature Genetics · doi:10.1038/ng.835 · Cited by 1,203 · see citing works
Stably maintained dendritic spines are associated with lifelong memories
Yang, G., Pan, F., & Gan, W.-B. (2009) · Nature · doi:10.1038/nature08577 · Cited by 1,182 · see citing works
Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits
Tang, G., Gudsnuk, K., Kuo, S.-H., Cotrina, M. L., Rosoklija, G., Sosunov, A., Sonders, M. S., Kanter, E., Castagna, C., Yamamoto, A., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.07.040 · Cited by 1,146 · see citing works
Fragile X Syndrome: Loss of Local mRNA Regulation Alters Synaptic Development and Function
Bassell, G. J., & Warren, S. T. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.004 · Cited by 1,051 · see citing works
Naisbitt, S., Kim, E., Tu, J. C., Xiao, B., Sala, C., Valtschanoff, J., Weinberg, R. J., Worley, P. F., & Sheng, M. (1999) · Neuron · doi:10.1016/s0896-6273(00)80809-0 · Cited by 1,009 · see citing works
The Postsynaptic Architecture of Excitatory Synapses: A More Quantitative View
Sheng, M., & Hoogenraad, C. C. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.060805.160029 · Cited by 1,003 · see citing works
Common genetic variants on 5p14.1 associate with autism spectrum disorders
Wang, K., Zhang, H., Ma, D., Bucan, M., Glessner, J. T., Abrahams, B. S., Salyakina, D., Imielinski, M., Bradfield, J. P., Sleiman, P. M. A., et al. (2009) · Nature · doi:10.1038/nature07999 · Cited by 989 · see citing works
The role of the Rho GTPases in neuronal developmentPreprint
Govek, E., Newey, S. E., & Aelst, L. V. (2005) · Genes & Development · doi:10.1101/gad.1256405 · Cited by 986 · see citing works
Kempermann, G., Gast, D., Kronenberg, G., Yamaguchi, M., & Gage, F. H. (2002) · Development · doi:10.1242/dev.00203 · Cited by 983 · see citing works
From the genetic architecture to synaptic plasticity in autism spectrum disorder
Bourgeron, T. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3992 · Cited by 975 · see citing works
The WASP-WAVE protein network: Connecting the membrane to the cytoskeleton.
Takenawa, T., & Suetsugu, S. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2069 · Cited by 947 · see citing works
Willsey, A. J., Sanders, S. J., Li, M., Dong, S., Tebbenkamp, A. T., Muhle, R. A., Reilly, S. K., Lin, L., Fertuzinhos, S., Miller, J. A., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.020 · Cited by 934 · see citing works
Actin in action: the interplay between the actin cytoskeleton and synaptic efficacy.
Cingolani, L. A., & Goda, Y. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2373 · Cited by 831 · see citing works
Advancing the understanding of autism disease mechanisms through genetics
de la Torre-Ubieta, L., Won, H., Stein, J. L., & Geschwind, D. H. (2016) · Nature Medicine · doi:10.1038/nm.4071 · Cited by 827 · see citing works
Actin in dendritic spines: connecting dynamics to function
Hotulainen, P., & Hoogenraad, C. C. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201003008 · Cited by 815 · see citing works
Self-citationZoghbi, H. Y., & Bear, M. F. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a009886 · Cited by 797 · see citing works
Increased dendritic spine densities on cortical projection neurons in autism spectrum disorders
Hutsler, J. J., & Zhang, H. (2010) · Brain Research · doi:10.1016/j.brainres.2009.09.120 · Cited by 765 · see citing works
Utrophin–dystrophin-deficient mice as a model for Duchenne muscular dystrophy
Deconinck, A. E., Rafael, J. A., Skinner, J. A., Brown, S. C., Potter, A. C., Metzinger, L., Watt, D. J., Dickson, J. G., Tinsley, J. M., & Davies, K. E. (1997) · Cell · doi:10.1016/s0092-8674(00)80532-2 · Cited by 752 · see citing works
Regulation of Dendritic Spine Morphology and Synaptic Function by Shank and Homer
Sala, C., Piëch, V., Wilson, N. R., Passafaro, M., Liu, G., & Sheng, M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00339-7 · Cited by 716 · see citing works
Rare de novo and transmitted copy-number variation in autistic spectrum disorders
Levy, D., Ronemus, M., Yamrom, B., Lee, Y.-H., Leotta, A., Kendall, J., Marks, S., Lakshmi, B., Pai, D., Ye, K., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.015 · Cited by 712 · see citing works
Gilman, S. R., Iossifov, I., Levy, D., Ronemus, M., Wigler, M., & Vitkup, D. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.021 · Cited by 701 · see citing works
Genetics of autism spectrum disorders
Geschwind, D. H. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.07.003 · Cited by 696 · see citing works
Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function
Won, H., Lee, H.-R., Gee, H. Y., Mah, W., Kim, J.-I., Lee, J., Ha, S., Chung, C., Jung, E. S., Cho, Y. S., et al. (2012) · Nature · doi:10.1038/nature11208 · Cited by 695 · see citing works
SHANK proteins: roles at the synapse and in autism spectrum disorder
Monteiro, P., & Feng, G. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.183 · Cited by 681 · see citing works
Actin Cytoskeleton Regulation in Neuronal Morphogenesis and Structural Plasticity
Luo, L. (2002) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.18.031802.150501 · Cited by 658 · see citing works
Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2
Schmeisser, M. J., Ey, E., Wegener, S., Bockmann, J., Stempel, A. V., Kuebler, A., Janssen, A.-L., Udvardi, P. T., Shiban, E., Spilker, C., et al. (2012) · Nature · doi:10.1038/nature11015 · Cited by 638 · see citing works
SynGAP: a Synaptic RasGAP that Associates with the PSD-95/SAP90 Protein Family
Kim, J. H., Liao, D., Lau, L.-F., & Huganir, R. L. (1998) · Neuron · doi:10.1016/s0896-6273(00)81008-9 · Cited by 634 · see citing works
Human-specific gene <i>ARHGAP11B</i> promotes basal progenitor amplification and neocortex expansion
Florio, M., Albert, M., Taverna, E., Namba, T., Brandl, H., Lewitus, E., Haffner, C., Sykes, A., Wong, F. K., Peters, J., et al. (2015) · Science · doi:10.1126/science.aaa1975 · Cited by 632 · see citing works
Leblond, C. S., Nava, C., Polge, A., Gauthier, J., Huguet, G., Lumbroso, S., Giuliano, F., Stordeur, C., Depienne, C., Mouzat, K., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004580 · Cited by 630 · see citing works
Labelling and optical erasure of synaptic memory traces in the motor cortex
Hayashi-Takagi, A., Yagishita, S., Nakamura, M., Shirai, F., Wu, Y. I., Loshbaugh, A. L., Kuhlman, B., Hahn, K. M., & Kasai, H. (2015) · Nature · doi:10.1038/nature15257 · Cited by 624 · see citing works
Modulation of gelsolin function by phosphatidylinositol 4,5-bisphosphate
Janmey, P. A., & Stossel, T. P. (1987) · Nature · doi:10.1038/325362a0 · Cited by 622 · see citing works
Molecular mechanisms of dendritic spine morphogenesis
Tada, T., & Sheng, M. (2006) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.12.001 · Cited by 615 · see citing works
The Fragile X Syndrome Protein Represses Activity-Dependent Translation through CYFIP1, a New 4E-BP
Napoli, I., Mercaldo, V., Boyl, P. P., Eleuteri, B., Zalfa, F., De Rubeis, S., Di Marino, D., Mohr, E., Massimi, M., Falconi, M., et al. (2008) · Cell · doi:10.1016/j.cell.2008.07.031 · Cited by 609 · see citing works
The Postsynaptic Organization of Synapses
Sheng, M., & Kim, E. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005678 · Cited by 603 · see citing works
Mutations causing syndromic autism define an axis of synaptic pathophysiology
Auerbach, B. D., Osterweil, E. K., & Bear, M. F. (2011) · Nature · doi:10.1038/nature10658 · Cited by 592 · see citing works
A Synaptic Ras-GTPase Activating Protein (p135 SynGAP) Inhibited by CaM Kinase II
Chen, H.-J., Rojas-Soto, M., Oguni, A., & Kennedy, M. B. (1998) · Neuron · doi:10.1016/s0896-6273(00)80471-7 · Cited by 590 · see citing works
Trajectory of development in adolescents and adults with autism
Seltzer, M. M., Shattuck, P. T., Abbeduto, L., & Greenberg, J. S. (2004) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/mrdd.20038 · Cited by 589 · see citing works
The Shank family of scaffold proteins
Sheng, M., & Kim, E. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.11.1851 · Cited by 578 · see citing works
Disruption of neurexin 1 associated with autism spectrum disorder
Kim, H.-G., Kishikawa, S., Higgins, A. W., Seong, I.-S., Donovan, D. J., Shen, Y., Lally, E., Weiss, L. A., Najm, J., Kutsche, K., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2007.09.011 · Cited by 578 · see citing works
Mutations in the SHANK2 synaptic scaffolding gene in autism spectrum disorder and mental retardation
Berkel, S., Marshall, C. R., Weiss, B., Howe, J., Roeth, R., Moog, U., Endris, V., Roberts, W., Szatmari, P., Pinto, D., et al. (2010) · Nature Genetics · doi:10.1038/ng.589 · Cited by 563 · see citing works
Oligophrenin-1 encodes a rhoGAP protein involved in X-linked mental retardation
Billuart, P., Bienvenu, T., Ronce, N., Portes, V. D., Vinet, M. C., Zemni, R., Crollius, H. R., Carrié, A., Fauchereau, F., Chery, M., et al. (1998) · Nature · doi:10.1038/31940 · Cited by 560 · see citing works
Neuroligin 2 is exclusively localized to inhibitory synapses
Varoqueaux, F., Jamain, S., & Brose, N. (2004) · European Journal of Cell Biology · doi:10.1078/0171-9335-00410 · Cited by 552 · see citing works
Dictenberg, J. B., Swanger, S. A., Antar, L. N., Singer, R. H., & Bassell, G. J. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.04.003 · Cited by 511 · see citing works
Poulopoulos, A., Aramuni, G., Meyer, G., Soykan, T., Hoon, M., Papadopoulos, T. G., Zhang, M., Paarmann, I., Fuchs, C., Harvey, K., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.08.023 · Cited by 503 · see citing works
Modeling Autism by SHANK Gene Mutations in Mice
Jiang, Y.-H., & Ehlers, M. D. (2013) · Neuron · doi:10.1016/j.neuron.2013.03.016 · Cited by 488 · see citing works
Peng, J., Kim, M. J., Cheng, D., Duong, D. M., Gygi, S. P., & Sheng, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400103200 · Cited by 473 · see citing works
Rapid turnover of actin in dendritic spines and its regulation by activity
Star, E. N., Kwiatkowski, D. J., & Murthy, V. N. (2002) · Nature Neuroscience · doi:10.1038/nn811 · Cited by 465 · see citing works
Type IIx myosin heavy chain transcripts are expressed in type IIb fibers of human skeletal muscle
Smerdu, V., Karsch‐Mizrachi, I., Campione, M., Leinwand, L. A., & Schiaffino, S. (1994) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1994.267.6.c1723 · Cited by 456 · see citing works
Glutamate receptors regulate actin-based plasticity in dendritic spines
Fischer, M., Kaech, S., Wagner, U., Brinkhaus, H., & Matus, A. (2000) · Nature Neuroscience · doi:10.1038/78791 · Cited by 446 · see citing works
Silverman, J. L., Tolu, S. S., Barkan, C. L., & Crawley, J. N. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.201 · Cited by 438 · see citing works
Kaminsky, E. B., Kaul, V., Paschall, J., Church, D. M., Bunke, B., Kunig, D., Moreno-De-Luca, D., Moreno-De-Luca, A., Mulle, J. G., Warren, S. T., et al. (2011) · Genetics in Medicine · doi:10.1097/gim.0b013e31822c79f9 · Cited by 437 · see citing works
Leblond, C. S., Heinrich, J., Delorme, R., Proepper, C., Betancur, C., Huguet, G., Konyukh, M., Chaste, P., Ey, E., Rastam, M., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002521 · Cited by 429 · see citing works
α‐actinin revisited: A fresh look at an old player
Otey, C. A., & Carpén, O. (2004) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.20007 · Cited by 421 · see citing works
Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1
Hayashi-Takagi, A., Takaki, M., Graziane, N., Seshadri, S., Murdoch, H., Dunlop, A. J., Makino, Y., Seshadri, A. J., Ishizuka, K., Srivastava, D. P., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2487 · Cited by 399 · see citing works
Rho family GTPases: Key players in neuronal development, neuronal survival, and neurodegeneration
Stankiewicz, T. R., & Linseman, D. A. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00314 · Cited by 391 · see citing works
Hippocampus in autism: a Golgi analysis
Raymond, G. V., Bauman, M. L., & Kemper, T. L. (1995) · Acta Neuropathologica · doi:10.1007/s004010050401 · Cited by 387 · see citing works
Clement, J. P., Aceti, M., Creson, T. K., Ozkan, E. D., Shi, Y., Reish, N. J., Almonte, A. G., Miller, B. H., Wiltgen, B. J., Miller, C. A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.08.045 · Cited by 385 · see citing works
LRRTM2 Interacts with Neurexin1 and Regulates Excitatory Synapse Formation
de Wit, J., Sylwestrak, E., O’Sullivan, M. L., Otto, S. J., Tiglio, K., Savas, J. N., Yates, J. R., Comoletti, D., Taylor, P., & Ghosh, A. (2009) · Neuron · doi:10.1016/j.neuron.2009.12.019 · Cited by 376 · see citing works
Kalirin-7 Controls Activity-Dependent Structural and Functional Plasticity of Dendritic Spines
Xie, Z., Srivastava, D. P., Photowala, H., Kai, L., Cahill, M. E., Woolfrey, K. M., Shum, C. Y., Surmeier, D. J., & Penzes, P. (2007) · Neuron · doi:10.1016/j.neuron.2007.10.005 · Cited by 373 · see citing works
The Pathophysiology of Fragile X (and What It Teaches Us about Synapses)
Bhakar, A. L., Dölen, G., & Bear, M. F. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-153138 · Cited by 370 · see citing works
LRRTM2 Functions as a Neurexin Ligand in Promoting Excitatory Synapse Formation
Ko, J., Fuccillo, M. V., Malenka, R. C., & Südhof, T. C. (2009) · Neuron · doi:10.1016/j.neuron.2009.12.012 · Cited by 369 · see citing works
Hotulainen, P., Llano, O., Smirnov, S., Tanhuanpää, K., Faix, J., Rivera, C., & Lappalainen, P. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200809046 · Cited by 360 · see citing works
Self-citationDe novo genic mutations among a Chinese autism spectrum disorder cohort
Wang, T., Guo, H., Xiong, B., Stessman, H. A. F., Wu, H., Coe, B. P., Turner, T. N., Liu, Y., Zhao, W., Hoekzema, K., et al. (2016) · Nature Communications · doi:10.1038/ncomms13316 · Cited by 359 · see citing works
Autistic behavior in children with fragile X syndrome: Prevalence, stability, and the impact of FMRP
Hatton, D. D., Sideris, J., Skinner, M., Mankowski, J., Bailey, D. B., Roberts, J., & Mirrett, P. (2006) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.31286 · Cited by 359 · see citing works
Herbert, M. R. (2010) · Current Opinion in Neurology · doi:10.1097/wco.0b013e328336a01f · Cited by 356 · see citing works
Schenck, A., Bardoni, B., Moro, A., Bagni, C., & Mandel, J.-L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151231598 · Cited by 356 · see citing works
The postsynaptic density proteins Homer and Shank form a polymeric network structure
Hayashi, M. K., Tang, C., Verpelli, C., Narayanan, R., Stearns, M. H., Xu, R.-M., Li, H., Sala, C., & Hayashi, Y. (2009) · Cell · doi:10.1016/j.cell.2009.01.050 · Cited by 356 · see citing works
Guerrier, S., Coutinho‐Budd, J., Sassa, T., Gresset, A., Jordan, N. V., Chen, K., Jin, W., Frost, A. S., & Polleux, F. (2009) · Cell · doi:10.1016/j.cell.2009.06.047 · Cited by 353 · see citing works
SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties
Han, K., Holder, J. L., Schaaf, C. P., Lu, H., Chen, H., Kang, H., Tang, J., Wu, Z., Hao, S., Cheung, S. W., et al. (2013) · Nature · doi:10.1038/nature12630 · Cited by 351 · see citing works
Rho GTPases, dendritic structure, and mental retardation
Newey, S. E., Velamoor, V., Govek, E., & Van Aelst, L. (2005) · Journal of Neurobiology · doi:10.1002/neu.20153 · Cited by 351 · see citing works
Hung, A. Y., Futai, K., Sala, C., Valtschanoff, J. G., Ryu, J., Woodworth, M. A., Kidd, F. L., Sung, C. C., Miyakawa, T., Bear, M. F., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3032-07.2008 · Cited by 350 · see citing works
Fragile X syndrome and autism at the intersection of genetic and neural networks
Belmonte, M. K., & Bourgeron, T. (2006) · Nature Neuroscience · doi:10.1038/nn1765 · Cited by 345 · see citing works
Recurrent de novo mutations implicate novel genes underlying simplex autism risk
O'Roak, B. J., Stessman, H. A., Boyle, E. A., Witherspoon, K. T., Martin, B., Lee, C., Vives, L., Baker, C., Hiatt, J. B., Nickerson, D. A., et al. (2014) · Nature Communications · doi:10.1038/ncomms6595 · Cited by 336 · see citing works
Okamoto, K.-I., Narayanan, R., Lee, S. H., Murata, K., & Hayashi, Y. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701656104 · Cited by 328 · see citing works
Abbott, M.-A., Wells, D. G., & Fallon, J. R. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-17-07300.1999 · Cited by 327 · see citing works
Fragile X syndrome: causes, diagnosis, mechanisms, and therapeutics
Bagni, C., Tassone, F., Neri, G., & Hagerman, R. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63141 · Cited by 321 · see citing works
Novel de novo SHANK3 mutation in autistic patients
Gauthier, J., Spiegelman, D., Piton, A., Lafrenière, R. G., Laurent, S., St‐Onge, J., Lapointe, L., Hamdan, F. F., Cossette, P., Mottron, L., et al. (2009) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30822 · Cited by 321 · see citing works
SHANK1 Deletions in Males with Autism Spectrum Disorder
Sato, D., Lionel, A. C., Leblond, C. S., Prasad, A., Pinto, D., Walker, S., O'Connor, I., Russell, C., Drmic, I. E., Hamdan, F. F., et al. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2012.03.017 · Cited by 318 · see citing works
Wang, X., Bey, A. L., Katz, B. M., Badea, A., Kim, N., David, L. K., Duffney, L. J., Kumar, S., Mague, S. D., Hulbert, S. W., et al. (2016) · Nature Communications · doi:10.1038/ncomms11459 · Cited by 318 · see citing works
Synaptic vesicle recycling: steps and principles
Rizzoli, S. O. (2014) · The EMBO Journal · doi:10.1002/embj.201386357 · Cited by 317 · see citing works
Durand, C. M., Perroy, J., Loll, F., Perrais, D., Fagni, L., Bourgeron, T., Montcouquiol, M., & Sans, N. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.57 · Cited by 316 · see citing works
Schenck, A., Bardoni, B., Langmann, C., Harden, N., Mandel, J.-L., & Giangrande, A. (2003) · Neuron · doi:10.1016/s0896-6273(03)00354-4 · Cited by 316 · see citing works
Systematic resequencing of X-chromosome synaptic genes in autism spectrum disorder and schizophrenia
Piton, A., Gauthier, J., Hamdan, F. F., Lafrenière, R. G., Yang, Y., Henrion, É., Laurent, S. B., Noreau, A., Thibodeau, P., Karemera, L., et al. (2010) · Molecular Psychiatry · doi:10.1038/mp.2010.54 · Cited by 312 · see citing works
Cukier, H. N., Dueker, N., Slifer, S. H., Lee, J. M., Whitehead, P. L., Lalanne, E., Leyva, N., Konidari, I., Gentry, R. C., Hulme, W. F., et al. (2014) · Molecular Autism · doi:10.1186/2040-2392-5-1 · Cited by 312 · see citing works
Filopodia are required for cortical neurite initiation
Dent, E. W., Kwiatkowski, A. V., Mebane, L. M., Philippar, U., Barzik, M., Rubinson, D. A., Gupton, S. L., van Veen, J. E., Furman, C., Zhang, J., et al. (2007) · Nature Cell Biology · doi:10.1038/ncb1654 · Cited by 309 · see citing works
Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology
Kim, Y., Sung, J. Y., Ceglia, I., Lee, K.-W., Ahn, J.-H., Halford, J. M., Kim, A. M., Kwak, S. P., Park, J. B., Ho Ryu, S., et al. (2006) · Nature · doi:10.1038/nature04976 · Cited by 307 · see citing works
Mechanisms of Synapse Assembly and Disassembly
Goda, Y., & Davis, G. W. (2003) · Neuron · doi:10.1016/s0896-6273(03)00608-1 · Cited by 297 · see citing works
Rapid spine stabilization and synaptic enhancement at the onset of behavioural learning
Roberts, T. F., Tschida, K. A., Klein, M. E., & Mooney, R. (2010) · Nature · doi:10.1038/nature08759 · Cited by 296 · see citing works
De Rubeis, S., Pasciuto, E., Li, K. W., Fernández, E., Di Marino, D., Buzzi, A., Ostroff, L. E., Klann, E., Zwartkruis, F. J. T., Komiyama, N. H., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.06.039 · Cited by 296 · see citing works
The X-linked mental retardation protein oligophrenin-1 is required for dendritic spine morphogenesis
Govek, E.-E., Newey, S. E., Akerman, C. J., Cross, J. R., Van der Veken, L., & Van Aelst, L. (2004) · Nature Neuroscience · doi:10.1038/nn1210 · Cited by 293 · see citing works
Shank Expression Is Sufficient to Induce Functional Dendritic Spine Synapses in Aspiny Neurons
Roussignol, G., Ango, F., Romorini, S., Tu, J. C., Sala, C., Worley, P. F., Bockaert, J., & Fagni, L. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4354-04.2005 · Cited by 293 · see citing works
Girirajan, S., Dennis, M. Y., Baker, C. A., Malig, M., Coe, B. P., Campbell, C. D., Mark, K. M. K., Vu, T. H., Alkan, C., Cheng, Z., et al. (2013) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2012.12.016 · Cited by 292 · see citing works
Dendritic spine formation and stabilization
Yoshihara, Y., De Roo, M., & Muller, D. (2009) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.05.013 · Cited by 292 · see citing works
Krapivinsky, G., Medina, I., Krapivinsky, L., Gapon, S., & Clapham, D. E. (2004) · Neuron · doi:10.1016/j.neuron.2004.08.003 · Cited by 287 · see citing works
Truncating mutations in NRXN2 and NRXN1 in autism spectrum disorders and schizophrenia
Gauthier, J., Siddiqui, T. J., Huashan, P., Yokomaku, D., Hamdan, F. F., Champagne, N., Lapointe, M., Spiegelman, D., Noreau, A., Lafrenière, R. G., et al. (2011) · Human Genetics · doi:10.1007/s00439-011-0975-z · Cited by 286 · see citing works
Krupp, J., Vissel, B., Thomas, C. G., Heinemann, S. F., & Westbrook, G. L. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-04-01165.1999 · Cited by 283 · see citing works
Autism-like Deficits in Shank3-Deficient Mice Are Rescued by Targeting Actin Regulators
Duffney, L. J., Zhong, P., Wei, J., Matas, E., Cheng, J., Qin, L., Ma, K., Dietz, D. M., Kajiwara, Y., Buxbaum, J. D., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.04.064 · Cited by 281 · see citing works
Collybistin, a newly identified brain-specific GEF, induces submembrane clustering of gephyrin
Kins, S., Betz, H., & Kirsch, J. (2000) · Nature Neuroscience · doi:10.1038/71096 · Cited by 281 · see citing works
Hendriksen, J. G. M., & Vles, J. S. H. (2008) · Journal of Child Neurology · doi:10.1177/0883073807309775 · Cited by 281 · see citing works
van Woerden, G. M., Harris, K. D., Hojjati, M. R., Gustin, R. M., Qiu, S., de Avila Freire, R., Jiang, Y.-H., Elgersma, Y., & Weeber, E. J. (2007) · Nature Neuroscience · doi:10.1038/nn1845 · Cited by 281 · see citing works
Fragile-X syndrome and fragile X-associated tremor/ataxia syndrome: two faces of FMR1
Jacquemont, S., Hagerman, R. J., Hagerman, P. J., & Leehey, M. A. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70676-7 · Cited by 277 · see citing works
Nishimura, Y., Martin, C. L., Vazquez-Lopez, A., Spence, S. J., Alvarez-Retuerto, A. I., Sigman, M., Steindler, C., Pellegrini, S., Schanen, N. C., Warren, S. T., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm116 · Cited by 276 · see citing works
High frequency of neurexin 1β signal peptide structural variants in patients with autism
Feng, J., Schroer, R. J., Jin, Y., Song, W., Yang, C., Bockholt, A., Cook, E. H., Skinner, C. D., Schwartz, C. E., & Sommer, S. S. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.08.017 · Cited by 271 · see citing works
Partial rescue of MeCP2 deficiency by postnatal activation of MeCP2
Giacometti, E., Luikenhuis, S., Beard, C., & Jaenisch, R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610593104 · Cited by 271 · see citing works
Activity-Dependent Redistribution and Essential Role of Cortactin in Dendritic Spine Morphogenesis
Hering, H., & Sheng, M. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-37-11759.2003 · Cited by 269 · see citing works
Berryer, M. H., Hamdan, F. F., Klitten, L. L., Møller, R. S., Carmant, L., Schwartzentruber, J., Patry, L., Dobrzeniecka, S., Rochefort, D., Neugnot-Cerioli, M., et al. (2013) · Human Mutation · doi:10.1002/humu.22248 · Cited by 266 · see citing works
Control of synapse development and plasticity by Rho GTPase regulatory proteins
Tolias, K. F., Duman, J. G., & Um, K. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.04.011 · Cited by 261 · see citing works
Dolan, B. M., Duron, S. G., Campbell, D. A., Vollrath, B., Rao, B. S. S., Ko, H.-Y., Lin, G. G., Govindarajan, A., Choi, S.-Y., & Tonegawa, S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219383110 · Cited by 260 · see citing works
SynGAP regulates synaptic strength and mitogen-activated protein kinases in cultured neurons
Rumbaugh, G., Adams, J. P., Kim, J. H., & Huganir, R. L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600084103 · Cited by 260 · see citing works
Boeckers, T. M., Kreutz, M. R., Winter, C., Zuschratter, W., Smalla, K.-H., Sanmarti-Vila, L., Wex, H., Langnaese, K., Bockmann, J., Garner, C. C., et al. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-15-06506.1999 · Cited by 257 · see citing works
Synaptic vesicle pools: an update
Denker (2010) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2010.00135 · Cited by 248 · see citing works
Review of the mechanism of processive actin filament elongation by formins
Paul, A. S., & Pollard, T. D. (2009) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.20379 · Cited by 245 · see citing works
p140Sra-1 (specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase
Kobayashi, K., Kuroda, S., Fukata, M., Nakamura, T., Nagase, T., Nomura, N., Matsuura, Y., Yoshida-Kubomura, N., Iwamatsu, A., & Kaibuchi, K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.1.291 · Cited by 244 · see citing works
Monsuur, A. J., de Bakker, P. I. W., Alizadeh, B. Z., Zhernakova, A., Bevova, M. R., Strengman, E., Franke, L., Slot, R. V. ‘., van Belzen, M. J., Lavrijsen, I. C. M., et al. (2005) · Nature Genetics · doi:10.1038/ng1680 · Cited by 243 · see citing works
Direct Measure of the De Novo Mutation Rate in Autism and Schizophrenia Cohorts
Awadalla, P., Gauthier, J., Myers, R. A., Casals, F., Hamdan, F. F., Griffing, A. R., Côté, M., Henrion, É., Spiegelman, D., Tarabeux, J., et al. (2010) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.07.019 · Cited by 235 · see citing works
Rho GTPases and activity-dependent dendrite development
Aelst, L. V., & Cline, H. T. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.05.012 · Cited by 234 · see citing works
Landrigan, P. J., Lambertini, L., & Birnbaum, L. S. (2012) · Environmental Health Perspectives · doi:10.1289/ehp.1104285 · Cited by 230 · see citing works
Choi, J., Ko, J., Rácz, B., Burette, A., Lee, J.-R., Kim, S.-H., Na, M., Lee, H. W., Kim, K., Weinberg, R. J., et al. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3212-04.2005 · Cited by 224 · see citing works
Wöhr, M., Roullet, F. I., Hung, A. Y., Sheng, M., & Crawley, J. N. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020631 · Cited by 220 · see citing works
Postsynaptic Abnormalities at the Neuromuscular Junctions of Utrophin-deficient Mice
Deconinck, A. E., Potter, A. C., Tinsley, J. M., Wood, S. J., Vater, R., Young, C., Metzinger, L., Vincent, A. C., Slater, C. R., & Davies, K. E. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.136.4.883 · Cited by 218 · see citing works
Sociability and motor functions in Shank1 mutant mice
Silverman, J. L., Turner, S. M., Barkan, C. L., Tolu, S. S., Saxena, R., Hung, A. Y., Sheng, M., & Crawley, J. N. (2011) · Brain Research · doi:10.1016/j.brainres.2010.09.026 · Cited by 218 · see citing works
A WAVE-1 and WRP Signaling Complex Regulates Spine Density, Synaptic Plasticity, and Memory
Soderling, S. H., Guire, E. S., Kaech, S., White, J., Zhang, F., Schutz, K., Langeberg, L. K., Banker, G., Raber, J., & Scott, J. D. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3209-06.2006 · Cited by 217 · see citing works
Genome-wide characteristics of de novo mutations in autism
Yuen, R. K., Merico, D., Cao, H., Pellecchia, G., Alipanahi, B., Thiruvahindrapuram, B., Tong, X., Sun, Y., Cao, D., Zhang, T., et al. (2016) · npj Genomic Medicine · doi:10.1038/npjgenmed.2016.27 · Cited by 216 · see citing works
Myosin IIb regulates actin dynamics during synaptic plasticity and memory formation
Rex, C. S., Gavin, C. F., Rubio, M. D., Kramar, E. A., Chen, L. Y., Jia, Y., Huganir, R. L., Muzyczka, N., Gall, C. M., Miller, C. A., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.07.016 · Cited by 213 · see citing works
The novel Rho-GTPase activating gene MEGAP / srGAP3 has a putative role in severe mental retardation
Endris, V., Wogatzky, B., Leimer, U., Bartsch, D., Zatyka, M., Latif, F., Maher, E. R., Tariverdian, G., Kirsch, S., Karch, D., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162241099 · Cited by 208 · see citing works
Li, J., Cai, T., Jiang, Y. W., Chen, H., He, X., Chen, C., Li, X., Shao, Q., Xia, R., Li, Z., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.40 · Cited by 208 · see citing works
A Discovery Resource of Rare Copy Number Variations in Individuals with Autism Spectrum Disorder
Prasad, A., Merico, D., Thiruvahindrapuram, B., Wei, J., Lionel, A. C., Sato, D., Rickaby, J., Lu, C., Szatmari, P., Roberts, W., et al. (2012) · G3 Genes|Genomes|Genetics · doi:10.1534/g3.112.004689 · Cited by 206 · see citing works
Rare Deletions at the Neurexin 3 Locus in Autism Spectrum Disorder
Vaags, A. K., Lionel, A. C., Sato, D., Goodenberger, M. L., Stein, Q., Curran, S. R., Ogilvie, C. M., Ahn, J. W., Drmic, I., Senman, L., et al. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.11.025 · Cited by 205 · see citing works
Identification of fodrin as a major calmodulin-binding protein in postsynaptic density preparations.
Carlin, R. K., Bartelt, D. C., & Siekevitz, P. (1983) · The Journal of Cell Biology · doi:10.1083/jcb.96.2.443 · Cited by 204 · see citing works
SynGAP regulates spine formation
Vazquez, L. E., Chen, H.-J., Sokolova, I., Knuesel, I., & Kennedy, M. B. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3213-04.2004 · Cited by 203 · see citing works
SHARPIN is an endogenous inhibitor of β1-integrin activation
Rantala, J. K., Pouwels, J., Pellinen, T., Veltel, S., Laasola, P., Mattila, E., Potter, C. S., Duffy, T., Sundberg, J. P., Kallioniemi, O., et al. (2011) · Nature Cell Biology · doi:10.1038/ncb2340 · Cited by 201 · see citing works
Verpelli, C., Dvoretskova, E., Vicidomini, C., Rossi, F., Chiappalone, M., Schoen, M., Di Stefano, B., Mantegazza, R., Broccoli, V., Böckers, T. M., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.258384 · Cited by 197 · see citing works
Papadopoulos, T. G., Körte, M., Eulenburg, V., Kubota, H., Retiounskaia, M., Harvey, R. J., Harvey, K., O’Sullivan, G. A., Laube, B., Hülsmann, S., et al. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601819 · Cited by 195 · see citing works
Characterization of Autism in Young Children With Tuberous Sclerosis Complex
Jeste, S., Şahin, M., Bolton, P., Ploubidis, G. B., & Humphrey, A. (2007) · Journal of Child Neurology · doi:10.1177/0883073807309788 · Cited by 195 · see citing works
The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling
Soderling, S. H., Binns, K. L., Wayman, G. A., Davee, S. M., Ong, S. H., Pawson, T. J., & Scott, J. D. (2002) · Nature Cell Biology · doi:10.1038/ncb886 · Cited by 194 · see citing works
Association of DISC1 with autism and Asperger syndrome
Kilpinen, H., Ylisaukko‐oja, T., Hennah, W., Palo, O. M., Varilo, T., Vanhala, R., Wendt, T. N., von Wendt, L., Paunio, T., & Peltonen, L. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002031 · Cited by 193 · see citing works
Myosin motors at neuronal synapses: drivers of membrane transport and actin dynamics
Kneussel, M., & Wagner, W. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3445 · Cited by 191 · see citing works
Kenny, E. M., Cormican, P., Furlong, S., Heron, E. A., Kenny, G., Fahey, C., Kelleher, E., Ennis, S., Tropea, D., Anney, R., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.127 · Cited by 190 · see citing works
Expression of the Murine Duchenne Muscular Dystrophy Gene in Muscle and Brain
Chamberlain, J. S., Pearlman, J. A., Muzny, D. M., Gibbs, R. A., Ranier, J. E., Reeves, A. A., & Caskey, C. T. (1988) · Science · doi:10.1126/science.3347839 · Cited by 190 · see citing works
Pathania, M., Davenport, E. C., Muir, J., Sheehan, D. F., López-Doménech, G., & Kittler, J. T. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.16 · Cited by 189 · see citing works
Bittel, D. C., Kibiryeva, N., & Butler, M. G. (2006) · Pediatrics · doi:10.1542/peds.2006-0424 · Cited by 188 · see citing works
De Novo SYNGAP1 Mutations in Nonsyndromic Intellectual Disability and Autism
Hamdan, F. F., Daoud, H., Piton, A., Gauthier, J., Dobrzeniecka, S., Krebs, M.-O., Joober, R., Lacaille, J.-C., Nadeau, A., Milunsky, J. M., et al. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.11.015 · Cited by 187 · see citing works
α-actinins and the DMD protein contain spectrin-like repeats
Davison, M. D., & Critchley, D. R. (1988) · Cell · doi:10.1016/0092-8674(88)90503-x · Cited by 183 · see citing works
Mehta, M. V., Gandal, M. J., & Siegel, S. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026077 · Cited by 182 · see citing works
Neuroligin-1–dependent competition regulates cortical synaptogenesis and synapse number
Kwon, H., Kozorovitskiy, Y., Oh, W., Peixoto, R. T., Akhtar, N., Saulnier, J. L., Gu, C., & Sabatini, B. L. (2012) · Nature Neuroscience · doi:10.1038/nn.3256 · Cited by 181 · see citing works
Walikonis, R. S., Oguni, A., Khorosheva, E. M., Jeng, C.-J., Asuncion, F. J., & Kennedy, M. B. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-02-00423.2001 · Cited by 181 · see citing works
A novel type of myosin implicated in signalling by rho family GTPases.
Reinhard, J., Scheel, A. A., Diekmann, D., Hall, A., Ruppert, C., & Bähler, M. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07048.x · Cited by 180 · see citing works
Lesca, G., Rudolf, G., Labalme, A., Hirsch, É., Arzimanoglou, A. A., Genton, P., Motte, J. E., Martin, A. D. S., Valenti, M., Boulay, C., et al. (2012) · Epilepsia · doi:10.1111/j.1528-1167.2012.03559.x · Cited by 180 · see citing works
A Critical Role for Myosin IIB in Dendritic Spine Morphology and Synaptic Function
Ryu, J., Liu, L., Wong, T. P., Wu, D., Burette, A., Weinberg, R. J., Wang, Y. T., & Sheng, M. (2006) · Neuron · doi:10.1016/j.neuron.2005.12.017 · Cited by 179 · see citing works
Park, E., Na, M., Choi, J., Kim, S., Lee, J.-R., Yoon, J., Park, D., Sheng, M., & Kim, E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301052200 · Cited by 175 · see citing works
Arons, M. H., Thynne, C. J., Grabrucker, A. M., Li, D., Schoen, M., Cheyne, J. E., Boeckers, T. M., Montgomery, J. M., & Garner, C. C. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2215-12.2012 · Cited by 174 · see citing works
Regulation of cell structure and function by actin‐binding proteins: Villin's perspective
Khurana, S., & George, S. P. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.02.040 · Cited by 171 · see citing works
DiMario, F. J., Şahin, M., & Ebrahimi‐Fakhari, D. (2015) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2015.03.005 · Cited by 169 · see citing works
The Genetics of Autism: Key Issues, Recent Findings, and Clinical Implications
El-Fishawy, P., & State, M. W. (2010) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2009.12.002 · Cited by 166 · see citing works
Doornbos, M., Sikkema-Raddatz, B., Ruijvenkamp, C. A. L., Dijkhuizen, T., Bijlsma, E. K., Gijsbers, A. C. J., Hilhorst-Hofstee, Y., Hordijk, R., Verbruggen, K. T., Kerstjens-Frederikse, W. S. (., et al. (2009) · European Journal of Medical Genetics · doi:10.1016/j.ejmg.2009.03.010 · Cited by 165 · see citing works
Social deficits in IRSp53 mutant mice improved by NMDAR and mGluR5 suppression
Chung, W., Choi, S. Y., Lee, E., Park, H., Kang, J., Park, H., Choi, Y., Lee, D., Park, S.-G., Kim, R., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.3927 · Cited by 163 · see citing works
Low load for disruptive mutations in autism genes and their biased transmission
Iossifov, I., Levy, D., Allen, J., Ye, K., Ronemus, M., Lee, Y.-H., Yamrom, B., & Wigler, M. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1516376112 · Cited by 156 · see citing works
Lim, S., Sala, C., Yoon, J., Park, S., Kuroda, S., Sheng, M., & Kim, E. (2001) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2000.0940 · Cited by 151 · see citing works
The dendritic architecture of prefrontal pyramidal neurons in schizophrenic patients
Kalus, P., Muller, T. J., Zuschratter, W., & Senitz, D. (2000) · NeuroReport · doi:10.1097/00001756-200011090-00044 · Cited by 146 · see citing works
Kim, K., Lakhanpal, G., Lu, H. E., Khan, M., Suzuki, A., Kato Hayashi, M., Narayanan, R., Luyben, T. T., Matsuda, T., Nagai, T., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.07.023 · Cited by 145 · see citing works
Kalscheuer, V., Musante, L., Fang, C., Hoffmann, K., Fuchs, C., Carta, E., Deas, E., Venkateswarlu, K., Menzel, C., Ullmann, R., et al. (2009) · Human Mutation · doi:10.1002/humu.20814 · Cited by 138 · see citing works
A central role for the small GTPase Rac1 in hippocampal plasticity and spatial learning and memory
Haditsch, U., Leone, D. P., Farinelli, M., Chrostek‐Grashoff, A., Brakebusch, C., Mansuy, I. M., McConnell, S. K., & Palmer, T. D. (2009) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2009.04.005 · Cited by 137 · see citing works
Ozkan, E. D., Creson, T. K., Kramár, E. A., Rojas, C., Seese, R. R., Babyan, A. H., Shi, Y., Lucero, R., Xu, X., Noebels, J. L., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.05.015 · Cited by 137 · see citing works
Synaptic Scaffolding Proteins in Rat Brain
Böckers, T. M., Mameza, M. G., Kreutz, M. R., Bockmann, J., Weise, C., Buck, F., Richter, D., Gundelfinger, E. D., & Kreienkamp, H.-J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102454200 · Cited by 137 · see citing works
Signaling in adult neurogenesis: from stem cell niche to neuronal networks
Ninkovic, J., & Götz, M. (2007) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2007.04.006 · Cited by 136 · see citing works
Grove, M., Demyanenko, G., Echarri, A., Zipfel, P. A., Quiroz, M. E., Rodriguiz, R. M., Playford, M., Martensen, S. A., Robinson, M. R., Wetsel, W. C., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.24.10905-10922.2004 · Cited by 136 · see citing works
Association of Duchenne Muscular Dystrophy With Autism Spectrum Disorder
Wu, J. Y., Kuban, K., Allred, E. N., Shapiro, F., & Darras, B. T. (2005) · Journal of Child Neurology · doi:10.1177/08830738050200100201 · Cited by 135 · see citing works
Senut, M.-C., Sen, A., Cingolani, P., Shaik, A., Land, S. J., & Ruden, D. M. (2014) · Toxicological Sciences · doi:10.1093/toxsci/kfu028 · Cited by 135 · see citing works
Qualmann, B., Boeckers, T. M., Jeromin, M., Gundelfinger, E. D., & Kessels, M. M. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5479-03.2004 · Cited by 134 · see citing works
Robison, A. J., Bass, M. A., Jiao, Y., MacMillan, L. B., Carmody, L. C., Bartlett, R. K., & Colbran, R. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502191200 · Cited by 134 · see citing works
Integrated systems analysis reveals a molecular network underlying autism spectrum disorders
Li, J., Shi, M., Ma, Z., Zhao, S., Euskirchen, G., Ziskin, J., Urban, A., Hallmayer, J., & Snyder, M. (2014) · Molecular Systems Biology · doi:10.15252/msb.20145487 · Cited by 132 · see citing works
Aceti, M., Creson, T. K., Vaissiere, T., Rojas, C., Huang, W.-C., Wang, Y.-X., Petralia, R. S., Page, D. T., Miller, C. A., & Rumbaugh, G. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.08.001 · Cited by 129 · see citing works
SynGAP Regulates Steady-State and Activity-Dependent Phosphorylation of Cofilin
Carlisle, H. J., Manzerra, P., Marcora, E., & Kennedy, M. B. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4695-08.2008 · Cited by 128 · see citing works
Stamou, M., Streifel, K. M., Goines, P. E., & Lein, P. J. (2013) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2012.12.001 · Cited by 128 · see citing works
Stephenson, J. R., Wang, X., Perfitt, T. L., Parrish, W. P., Shonesy, B. C., Marks, C. R., Mortlock, D. P., Nakagawa, T., Sutcliffe, J. S., & Colbran, R. J. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.2068-16.2017 · Cited by 127 · see citing works
Nguyen, L. S., Jolly, L. A., Shoubridge, C., Chan, W.-K., Huang, L., Laumonnier, F., Raynaud, M., Hackett, A., Field, M. J., Rodriguez, J. D., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.163 · Cited by 126 · see citing works
SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras
Lilja, J., Zacharchenko, T., Γεωργιάδου, Μ., Jacquemet, G., Franceschi, N. D., Peuhu, E., Hamidi, H., Pouwels, J., Martens, V., Nia, F. H., et al. (2017) · Nature Cell Biology · doi:10.1038/ncb3487 · Cited by 125 · see citing works
Abelson interacting protein 1 (Abi‐1) is essential for dendrite morphogenesis and synapse formation
Proepper, C., Johannsen, S., Liebau, S., Dahl, J., Vaida, B., Bockmann, J., Kreutz, M. R., Gundelfinger, E. D., & Boeckers, T. M. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601569 · Cited by 124 · see citing works
Bockmann, J., Kreutz, M. R., Gundelfinger, E. D., & Böckers, T. M. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01204.x · Cited by 121 · see citing works
Two Genes Are Responsible for Griscelli Syndrome at the Same 15q21 Locus
Pastural, É., Ersoy, F., Yalman, N., Wulffraat, N. M., Grillo, E., Özkınay, F., Tezcan, İ., Gedikoğlu, G., Philippe, N., Fischer, A., et al. (2000) · Genomics · doi:10.1006/geno.1999.6081 · Cited by 120 · see citing works
Gregory, K. J., Dong, E. N., Meiler, J., & Conn, P. J. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.07.007 · Cited by 119 · see citing works
Oh, J. S., Manzerra, P., & Kennedy, M. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m314109200 · Cited by 118 · see citing works
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7 of the 341 references couldn’t be matched to a known paper.
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A synaptic perspective of fragile X syndrome and autism spectrum Disorders.
Bagni, C., & Zukin, R. S. (2019) · Neuron · doi:10.1016/j.neuron.2019.02.041 · Cited by 326 · see citing works
Plasticity of Spine Structure: Local Signaling, Translation and Cytoskeletal Reorganization
Nakahata, Y., & Yasuda, R. (2018) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2018.00029 · Cited by 209 · see citing works
Borovac, J., Bosch, M., & Okamoto, K. (2018) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2018.07.001 · Cited by 181 · see citing works
Carmona, A., Roudeau, S., & Ortega, R. (2021) · Toxics · doi:10.3390/toxics9090198 · Cited by 114 · see citing works
Integrin activity in neuronal connectivity
Lilja, J., & Ivaska, J. (2018) · Journal of Cell Science · doi:10.1242/jcs.212803 · Cited by 103 · see citing works
Guo, D., Peng, Y., Wang, L., Sun, X., Wang, X., Liang, C., Yang, X., Li, S., Xu, J., Ye, W.-C., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-019-0472-7 · Cited by 102 · see citing works
Guo, D., Yang, X., & Shi, L. (2020) · Cells · doi:10.3390/cells9040835 · Cited by 73 · see citing works
LIM-Kinases in Synaptic Plasticity, Memory, and Brain Diseases
Zablah, Y. B., Zhang, H., Gugustea, R., & Jia, Z. (2021) · Cells · doi:10.3390/cells10082079 · Cited by 56 · see citing works
Neuronal and glial cell number is altered in a cortical layer-specific manner in autism
Falcone, C., Mevises, N.-Y., Hong, T., Dufour, B. D., Chen, X., Noctor, S. C., & Martínez‐Cerdeño, V. (2021) · Autism · doi:10.1177/13623613211014408 · Cited by 47 · see citing works
Tian, C., Paskus, J. D., Fingleton, E., Roche, K. W., & Herring, B. E. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.3148-20.2021 · Cited by 37 · see citing works
Phase separation-mediated actin bundling by the postsynaptic density condensates
Chen, X., Jia, B., Zhu, S., & Zhang, M. (2023) · eLife · doi:10.7554/elife.84446 · Cited by 36 · see citing works
Imbalance of synaptic actin dynamics as a key to fragile X syndrome?
Michaelsen‐Preusse, K., Feuge, J., & Körte, M. (2018) · The Journal of Physiology · doi:10.1113/jp275571 · Cited by 35 · see citing works
Actin cytoskeleton dynamics in stem cells from autistic individuals
Griesi‐Oliveira, K., Suzuki, Â. M., Alves, A. Y., Mafra, A. C. C. N., Yamamoto, G. L., Ezquina, S., Magalhães, Y. T., Forti, F. L., Sertie, A. L., Zachi, E. C., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-29309-6 · Cited by 37 · see citing works
An Intellectual Disability-Related Missense Mutation in Rac1 Prevents LTP Induction
Tian, C., Kay, Y., Sadybekov, A., Rao, S., Katritch, V., & Herring, B. E. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00223 · Cited by 35 · see citing works
Rac-maninoff and Rho-vel: The symphony of Rho-GTPase signaling at excitatory synapses
Duman, J. G., Blanco, F. A., Cronkite, C. A., Ru, Q., Erikson, K., Mulherkar, S. A., Saifullah, A. B., Firozi, K., & Tolias, K. F. (2021) · Small GTPases · doi:10.1080/21541248.2021.1885264 · Cited by 33 · see citing works
Guzmán-Muñoz, E., Concha‐Cisternas, Y., Jofré‐Saldía, E., Castillo-Paredes, A., Molina-Márquez, I., & Sepulveda, R. A. Y. (2025) · Brain Sciences · doi:10.3390/brainsci15111238 · Cited by 34 · see citing works
Barón-Mendoza, I., Garcı́a, O., Calvo‐Ochoa, E., Rebollar-García, J. O., Garzón-Cortés, D., Haro, R., & González‐Arenas, A. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.06.004 · Cited by 27 · see citing works
SHANK3 conformation regulates direct actin binding and crosstalk with Rap1 signaling
Salomaa, S. I., Miihkinen, M., Kremneva, E., Paatero, I., Lilja, J., Jacquemet, G., Vuorio, J., Antenucci, L., Kogan, K., Nia, F. H., et al. (2021) · Current Biology · doi:10.1016/j.cub.2021.09.022 · Cited by 25 · see citing works
Recent Developments in Autism Genetic Research: A Scientometric Review from 2018 to 2022
Lim, M., Carollo, A., Dimitriou, D., & Esposito, G. (2022) · Genes · doi:10.3390/genes13091646 · Cited by 23 · see citing works
Neuronal morphology alterations in autism and possible role of oxytocin
Falougy, H. E., Filová, B., Ostatníková, D., Bačová, Z., & Bakoš, J. (2019) · Endocrine Regulations · doi:10.2478/enr-2019-0006 · Cited by 22 · see citing works
Regulation of Neural Circuit Development by Cadherin-11 Provides Implications for Autism
Frei, J. A., Niescier, R. F., Bridi, M. S., Durens, M., Nestor, J. E., Kilander, M. B. C., Yuan, X., Dykxhoorn, D. M., Nestor, M. W., Huang, S., et al. (2021) · eNeuro · doi:10.1523/eneuro.0066-21.2021 · Cited by 21 · see citing works
Hlushchenko, I., Khanal, P., Abouelezz, A., Paavilainen, V. O., & Hotulainen, P. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00217 · Cited by 21 · see citing works
Self-citationLopez, E. G., Lopez, J. A., Hagen, J., Sheffer, R. N., Meiner, V., & Lee, A. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.003681 · Cited by 20 · see citing works
Post-Synapses in the Brain: Role of Dendritic and Spine Structures
Meldolesi, J. (2022) · Biomedicines · doi:10.3390/biomedicines10081859 · Cited by 19 · see citing works
Sun, W., Yang, J., Hong, Y., Yuan, H., Wang, J., Zhang, Y., Lu, X., Jin, C., Wu, S., & Cai, Y. (2019) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-019-00748-7 · Cited by 19 · see citing works
Molecular Dissection of Neurobeachin Function at Excitatory Synapses
Repetto, D., Brockhaus, J., Rhee, H. J., Lee, C., Kilimann, M. W., Rhee, J., Northoff, L. M., Guo, W., Reißner, C., & Missler, M. (2018) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2018.00028 · Cited by 17 · see citing works
Roesler, M. K., Lombino, F. L., Freitag, S., Schweizer, M., Hermans‐Borgmeyer, I., Schwarz, J. R., Kneussel, M., & Wagner, W. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00330 · Cited by 17 · see citing works
Mignogna, M. L., Musardo, S., Ranieri, G., Gelmini, S., Espinosa, P., Marra, P., Belloli, S., Murtaj, V., Moresco, R. M., Bellone, C., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01155-5 · Cited by 17 · see citing works
Natarajaseenivasan, K., Shanmughapriya, S., Velusamy, P., Sayre, M., Garcia, A., Gomez, N. M., & Langford, D. (2020) · Translational Neurodegeneration · doi:10.1186/s40035-020-00211-4 · Cited by 15 · see citing works
CACNA1D-Related Channelopathies: From Hypertension to Autism
Ortner, N. J. (2023) · Handbook of experimental pharmacology · doi:10.1007/164_2022_626 · Cited by 15 · see citing works
iTRAQ-Based Proteomics Analysis of Rat Cerebral Cortex Exposed to Valproic Acid before Delivery
Jing, L., Zhang, K., Cao, X., Zhao, Y., Khan, N. U., Liu, X., Tang, X., Chen, M., Zhang, H., & Shen, L. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.1c00800 · Cited by 14 · see citing works
Wang, J., Xu, C., Liu, C., Zhou, Q., Chao, G., & Jin, Y. (2022) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2022.110314 · Cited by 14 · see citing works
Wang, X., Xu, M., Xu, Q., Yang, F., Tang, H., Shao, C., Wang, L., Wang, Y., Deng, J., & Wang, S. (2021) · Frontiers in Bioscience-Landmark · doi:10.52586/4947 · Cited by 12 · see citing works
Tang, X., Ran, X., Liang, Z., Zhuang, H., Yan, X., Feng, C., Qureshi, A., Gao, Y. L., & Shen, L. (2024) · Clinica Chimica Acta · doi:10.1016/j.cca.2024.120018 · Cited by 12 · see citing works
Niego, A., & Benítez‐Burraco, A. (2020) · Autism · doi:10.1177/1362361320965074 · Cited by 12 · see citing works
Dai, L., Weiss, R. B., Dunn, D. M., Ramirez, A., Paul, S., & Korenberg, J. R. (2021) · Human Molecular Genetics · doi:10.1093/hmg/ddab041 · Cited by 10 · see citing works
Abnormal dendritic morphology in the cerebellum of cyclooxygenase‐2 − knockin mice
Kissoondoyal, A., Rai‐Bhogal, R., & Crawford, D. A. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15454 · Cited by 9 · see citing works
Integrated analysis of miRNA and mRNA expression profiles in the brains of BTBR mice
Wang, M., He, J., Zhou, Y., Lv, N., Zhao, M., Wei, H., & Li, R. (2020) · International Journal of Developmental Neuroscience · doi:10.1002/jdn.10019 · Cited by 8 · see citing works
Dendritic effects of genetically encoded actin-labeling probes in cultured hippocampal neurons
Ignácz, A., Nagy-Herczeg, D., Haußer, A., & Schlett, K. (2023) · Molecular Biology of the Cell · doi:10.1091/mbc.e22-08-0331 · Cited by 7 · see citing works
Granak, S., Tuckova, K., Kútna, V., Vojtěchová, I., Bajkova, L., Petrásek, T., & Ovsepian, S. V. (2022) · European Journal of Neuroscience · doi:10.1111/ejn.15864 · Cited by 7 · see citing works
The epigenetic regulation of synaptic genes contributes to the etiology of autism
Srančíková, A., Bačová, Z., & Bakoš, J. (2021) · Reviews in the Neurosciences · doi:10.1515/revneuro-2021-0014 · Cited by 7 · see citing works
Lee, H., Ko, K., Kim, S., Lee, G. Q., Kim, S., Lee, J., Song, D.-Y., Bong, G., Han, J. H., Lee, J., et al. (2026) · Genome biology · doi:10.1186/s13059-026-04041-x · Cited by 5 · see citing works
Distinct Alterations in Dendritic Spine Morphology in the Absence of β-Neurexins
Mohrmann, L., Seebach, J., Missler, M., & Rohlmann, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021285 · Cited by 5 · see citing works
Dyggve-Melchior-Clausen Syndrome Caused by a Novel Frameshift Variant in a Japanese Patient
Obara, K., Abe, E., & Toyoshima, I. (2022) · Molecular Syndromology · doi:10.1159/000521516 · Cited by 5 · see citing works
Qin, Y., Zhang, X., Liu, Y., Ma, Z., Tao, S., Li, Y., Peng, R., Wang, F., Wang, J., Feng, J., et al. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02626-9 · Cited by 5 · see citing works
Carriba, P., Wyatt, S. L., & Davies, A. M. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00254 · Cited by 5 · see citing works
Morfología Neuronal en el Trastorno del Espectro Autista
Vásquez, B., & del Sol, M. (2020) · International Journal of Morphology · doi:10.4067/s0717-95022020000501513 · Cited by 4 · see citing works
Bareli, T., Ahdoot, H. L., Ben‐Moshe, H., Barnea, R., Warhaftig, G., Maayan, R., Roska, P., Weizman, A., & Yadid, G. (2021) · Addiction Biology · doi:10.1111/adb.13014 · Cited by 4 · see citing works
Analysis of neuronal activity impairment in iPSC-derived neurons from idiopathic autism patients
Kern, A., Román, V., Orbán, T. I., Pál, I., Nagy, J., Lévay, G. I., Lendvai, B., & Némethy, Z. (2025) · iScience · doi:10.1016/j.isci.2025.113615 · Cited by 3 · see citing works
Disentangling the role of tau pathology in autism spectrum disorders
Villavicencio-Tejo, F., Olesen, M. A., Moya, M. L., & Quintanilla, R. A. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111496 · Cited by 4 · see citing works
Xia, J., Bajpai, A. K., Liu, Y., Yu, L., Dong, Y., Li, F., Chen, F., Lu, L., & Feng, S. (2025) · Genes · doi:10.3390/genes16050605 · Cited by 3 · see citing works
Niego, A., & Benítez‐Burraco, A. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.03.15.992479 · Cited by 2 · see citing works
Regulation of actin dynamics by phosphoinositides: Focus on postsynaptic plasticity
Albanesi, J. P., Liou, J., Jui-Yu-Yeh, & Yin, H. L. (2026) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2026.159726 · Cited by 1 · see citing works
Hastings, M. H., Gilbert, J. P., Huo, Y., & Man, H. (2023) · Springer eBooks · doi:10.1007/978-3-031-20792-1_5 · Cited by 1 · see citing works
Impact of Abl2/Arg deficiency on anxiety and depressive behaviors in mice
Yao, X., Chen, R., Chen, H., Koleske, A. J., & Xiao, X. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.115022 · Cited by 1 · see citing works
Prenatal Exposure to Azadiradione Leads to Developmental Disabilities
Jana, S., Das, S., Giri, B., Archak, R., Bandyopadhyay, S., & Jana, N. R. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04493-x · Cited by 1 · see citing works
Castillo, E. D. M., Quiróz, U., Milflores, L., Reyes, R., & Flores, G. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1530692 · Cited by 1 · see citing works
Conformational dynamics regulate SHANK3 actin and Rap1 bindingPreprint
Salomaa, S. I., Miihkinen, M., Kremneva, E., Paatero, I., Lilja, J., Jacquemet, G., Vuorio, J., Antenucci, L., Nia, F. H., Hollós, P., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.11.12.379222 · Cited by 1 · see citing works
Comparative analysis of actin visualization by genetically encoded probes in cultured neuronsPreprint
Ignácz, A., Nagy-Herczeg, D., Haußer, A., & Schlett, K. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.08.12.503767 · Cited by 1 · see citing works
Kissoondoyal, A., Ho, K., Wong, C. T., & Crawford, D. A. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.12.562077 · Cited by 1 · see citing works
Rol de la Neuroglia en el Trastorno del Espectro Autista
Vásquez, B., & del Sol, M. (2021) · International Journal of Morphology · doi:10.4067/s0717-95022021000300920
Les nanotubes comme nouvelle voie de transfert et de propagation de la protéine Tau pathologique
Tardivel, M. (2017) · theses.fr (ABES) · doi:10.70675/0cfcd049z970ez4f2dz8417z195cfabdc00d
van Erp, M. L., Yuwattana, W., Poolcharoen, C., Saeliw, T., Roytrakul, S., Vanwong, N., Hu, V. W., Trairatvorakul, P., Chonchaiya, W., & Sarachana, T. (2026) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2026.101319
- Authors
- Joensuu, M., Lanoue, V., & Hotulainen, P.
- Affiliations
- The University of Queensland (AU)
- Minerva Foundation (FI)
- Corresponding author
- Hotulainen, Pirta
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2018-06
- Volume
- 84
- Issue
- Pt B
- Pages
- 362-381
- ISSN
- 0278-5846 (ISSN-L)
- OpenAlex
- W2751324602
- Cited by
- 65
- References
- 341
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 4 · 2023: 6 · 2022: 7 · 2021: 14 · 2020: 9 · 2019: 5 · 2018: 10 · 2017: 2
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Academy of Finland (298124)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Keywords
- dendritic spines, actin cytoskeleton, autism spectrum disorder, excitatory synapses, synaptic plasticity, actin regulation, neuropsychiatric disorders, therapeutic target
- MeSH terms
- Autism Spectrum Disorder, Animals, Humans, Actin Cytoskeleton, Synapses, Dendritic Spines
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