Cited by 65Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology ResearchAutism Spectrum Disorder Research

Dendritic spine actin cytoskeleton in autism spectrum disorder

Joensuu, Merja, Lanoue, Vanessa, Hotulainen, Pirta·2018·Progress in Neuro-Psychopharmacology and Biological Psychiatry

Abstract

Dendritic spines are small actin-rich protrusions from neuronal dendrites that form the postsynaptic part of most excitatory synapses. Changes in the shape and size of dendritic spines correlate with the functional changes in excitatory synapses and are heavily dependent on the remodeling of the underlying actin cytoskeleton. Recent evidence implicates synapses at dendritic spines as important substrates of pathogenesis in neuropsychiatric disorders, including autism spectrum disorder (ASD). Although synaptic perturbations are not the only alterations relevant for these diseases, understanding the molecular underpinnings of the spine and synapse pathology may provide insight into their etiologies and could reveal new drug targets. In this review, we will discuss recent findings of defective actin regulation in dendritic spines associated with ASD.

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Crossref · 10.1016/j.pnpbp.2017.08.023

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Authors
Joensuu, M., Lanoue, V., & Hotulainen, P.
Affiliations
  • The University of Queensland (AU)
  • Minerva Foundation (FI)
Corresponding author
Hotulainen, Pirta
Venue
Progress in Neuro-Psychopharmacology and Biological Psychiatry
Publisher
Elsevier BV
Published
2018-06
Volume
84
Issue
Pt B
Pages
362-381
ISSN
0278-5846 (ISSN-L)
OpenAlex
W2751324602
Cited by
65
References
341
Citations by year
2026: 3 · 2025: 5 · 2024: 4 · 2023: 6 · 2022: 7 · 2021: 14 · 2020: 9 · 2019: 5 · 2018: 10 · 2017: 2
FWCI
0.91
Type
journal article
Language
en
Open access
closed
Locations
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
Academy of Finland (298124)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Keywords
dendritic spines, actin cytoskeleton, autism spectrum disorder, excitatory synapses, synaptic plasticity, actin regulation, neuropsychiatric disorders, therapeutic target
MeSH terms
Autism Spectrum Disorder, Animals, Humans, Actin Cytoskeleton, Synapses, Dendritic Spines

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