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Snapin-Regulated Late Endosomal Transport Is Critical for Efficient Autophagy-Lysosomal Function in Neurons
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In yeast, Atg8 amounts increase at least 10-fold when autophagy is induced.
“In yeast, Atg8 amounts increase at least 10-fold when autophagy is induced [206].”
From Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1 (2021) · cites this paper as [206]
The use of a radioactive pulse-chase analysis, which assesses complete autophagic flux, provides an alternative to lysosomal protease inhibitors.
“The use of a radioactive pulse-chase analysis, which assesses complete autophagic flux, provides an alternative to lysosomal protease inhibitors [206].”
From Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1 (2021) · cites this paper as [206]
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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.
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Termination of autophagy and reformation of lysosomes regulated by mTOR
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
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Self-citationGuidelines for the use and interpretation of assays for monitoring autophagy
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Self-citationGuidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1
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Self-citationAutophagosomes initiate distally and mature during transport toward the cell soma in primary neurons
Maday, S., Wallace, K. E., & Holzbaur, E. L. F. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201106120 · Cited by 681
Motile axonal mitochondria contribute to the variability of presynaptic strength
Sun, T., Qiao, H., Pan, P.-Y., Chen, Y., & Sheng, Z.-H. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.06.040 · Cited by 263
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Self-citationFerritin is secreted via 2 distinct nonclassical vesicular pathways
Truman-Rosentsvit, M., Berenbaum, D., Spektor, L., Cohen, L. A., Belizowsky-Moshe, S., Lifshitz, L., Ma, J., Li, W., Kesselman, E., Abutbul-Ionita, I., et al. (2018) · Blood · doi:10.1182/blood-2017-02-768580 · Cited by 223
The Autophagy Lysosomal Pathway and Neurodegeneration
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“Two modifiers of tau toxicity—Atg6 and Dlic2 (dynein light chain 2)—were also recently identified as modifiers of lysosomal/autophagic vacuole trafficking (193), and dynein appears to be the motor protein most responsible for this trafficking (194,195).”
BackgroundThe Journey of the Synaptic Autophagosome: A Cell Biological Perspective
Kargbo-Hill, S. E., & Colón-Ramos, D. A. (2020) · Neuron · doi:10.1016/j.neuron.2020.01.018 · Cited by 72
Sphingosine kinase 1-associated autophagy differs between neurons and astrocytes
Moruno-Manchon, J. F., Uzor, N.-E., Ambati, C. R., Shetty, V., Putluri, N., Jagannath, C., McCullough, L. D., & Tsvetkov, A. S. (2018) · Cell Death & Disease · doi:10.1038/s41419-018-0599-5 · Cited by 36
Metadata
- Authors
- Cai, Q., Lu, L., Tian, J.-H., Zhu, Y.-B., Qiao, H., & Sheng, Z.-H.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 68
- Issue
- 1
- Pages
- 73-86
- ISSN
- 0896-6273
- PMC
- PMC2953270
- Cited by
- 233
- References
- 4
- Language
- en
- Licence
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke
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