Cited by 227Neural dynamics and brain functionNeuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

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An Embedded Subnetwork of Highly Active Neurons in the Neocortex

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Yassin, Lina, Benedetti, Brett L., Jouhanneau, Jean-Sébastien, Wen, Jing A., Poulet, James F.A., Barth, Alison L.·2010·Neuron

DOI 10.1016/j.neuron.2010.11.029PMC PMC3022325

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Abstract

Video abstract Unbiased methods to assess the firing activity of individual neurons in the neocortex have revealed that a large proportion of cells fire at extremely low rates (<0.1 Hz), both in their spontaneous and evoked activity. Thus, firing in neocortical networks appears to be dominated by a small population of highly active neurons. Here, we use a fosGFP transgenic mouse to examine the properties of cells with a recent history of elevated activity. FosGFP-expressing layer 2/3 pyramidal cells fired at higher rates compared to fosGFP(-) neurons, both in vivo and in vitro. Elevated activity could be attributed to increased excitatory and decreased inhibitory drive to fosGFP(+) neurons. Paired-cell recordings indicated that fosGFP(+) neurons had a greater likelihood of being connected to each other. These findings indicate that highly active, interconnected neuronal ensembles are present in the neocortex and suggest these cells may play a role in the encoding of sensory information.

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Authors: Yassin, L., Benedetti, B. L., Jouhanneau, J.-S., Wen, J. A., Poulet, J. F. A., & Barth, A. L.
Affiliations: Center for the Neural Basis of Cognition (US)
Max Delbrück Center (DE)
Corresponding author: Barth, Alison L.
ORCID: Benedetti, Brett L.
Jouhanneau, Jean-Sébastien
Wen, Jing A.
Poulet, James F.A.
Barth, Alison L.
Venue: Neuron
Publisher: Elsevier BV
Published: 2010-12
Volume: 68
Issue: 6
Pages: 1043-1050
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2010.11.029
PMC: PMC3022325
OpenAlex: W2037158512
Cited by: 227
References: 47
Citations by year: 2026: 5 · 2025: 7 · 2024: 10 · 2023: 5 · 2022: 8 · 2021: 12 · 2020: 9 · 2019: 31 · 2018: 16 · 2017: 18 · 2016: 18 · 2015: 24 · 2014: 22 · 2013: 23 · 2012: 12
FWCI: 8.15
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 959 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
KiltHub Repository (submittedVersion)
MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
Figshare (submittedVersion, cc-by)
KiltHub Repository
Funders: National Institutes of Health (1z01da000171-01)
National Institute on Drug Abuse (DA 0171-88, R01DA017188)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: neocortex, layer 2/3 pyramidal cells, neuronal ensembles, spontaneous firing rate, neuronal connectivity
MeSH terms: Action Potentials, Animals, Animals, Newborn, Mice, Inbred C57BL, Mice, Transgenic, Nerve Net, Neurons, Neocortex, Mice

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An Embedded Subnetwork of Highly Active Neurons in the Neocortex

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