The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Computerized Cognitive Training Restores Neural Activity within the Reality Monitoring Network in Schizophrenia
Open accessAbstract
SUMMARY Schizophrenia patients suffer from severe cognitive deficits, such as impaired reality monitoring. Reality monitoring is the ability to distinguish the source of internal experiences from outside reality. During reality monitoring tasks, schizophrenia patients make errors identifying “I made it up” items, and even during accurate performance, they show abnormally low activation of the medial prefrontal cortex (mPFC), a region that supports self-referential cognition. We administered 80 hours of computerized training of cognitive processes to schizophrenia patients and found improvement in reality monitoring that correlated with increased mPFC activity. In contrast, patients in a computer games control condition did not show any behavioral or neural improvements. Notably, recovery in mPFC activity after training was associated with improved social functioning six months later. These findings demonstrate that a serious behavioral deficit in schizophrenia, and its underlying neural dysfunction, can be improved by well-designed computerized cognitive training, resulting in better quality of life.
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Cites
The Positive and Negative Syndrome Scale (PANSS) for schizophrenia.
Kay, S. R., Fiszbein, A., & Opler, L. A. (1987) · Schizophrenia Bulletin · doi:10.1093/schbul/13.2.261 · Cited by 21,378
Meeting of minds: the medial frontal cortex and social cognition
Amodio, D. M., & Frith, C. D. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1884 · Cited by 3,782 · cited 2×
“…world’’ from ‘‘outside world’’ also support the representation of ‘‘self’’ and ‘‘other’’; indeed, the anterior rostral mPFC is particularly implicated in tagging information as being relevant to the ‘‘self’’ (Amodio and Frith, 2006; Ochsner et al., 2004, 2005; Vinogradov et al., 2006, 2008).”
What are the functional consequences of neurocognitive deficits in schizophrenia?
(1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.3.321 · Cited by 3,516
Functional neuroanatomy of emotion: A meta-analysis of emotion activation studies in PET and fMRI
Phan, K. L., Wager, T., Taylor, S. F., & Liberzon, I. (2002) · NeuroImage · doi:10.1006/nimg.2002.1087 · Cited by 3,502
Green, M. F., Kern, R. S., Braff, D. L., & Mintz, J. (2000) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a033430 · Cited by 2,999
Self-referential processing in our brain—A meta-analysis of imaging studies on the self
Northoff, G., Heinzel, A., de Greck, M., Bermpohl, F., Dobrowolny, H., & Panksepp, J. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.12.002 · Cited by 2,792
CORTICAL PLASTICITY: From Synapses to Maps
Buonomano, D. V., & Merzenich, M. M. (1998) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.21.1.149 · Cited by 2,083 · cited 2×
“Informed by the past two decades of systems neuroscience research into the learning mechanisms that drive sustained plastic changes in the cortex (Buonomano and Merzenich, 1998; Jenkins et al., 1990; Karni and Sagi, 1991; Merzenich et al., 1990), we predicted that—in order to improve higher order cognitive functions i…”
BackgroundKeefe, R. (2004) · Schizophrenia Research · doi:10.1016/j.schres.2003.09.011 · Cited by 1,573
Putting brain training to the test
Owen, A. M., Hampshire, A., Grahn, J. A., Stenton, R., Dajani, S., Burns, A. S., Howard, R. J., & Ballard, C. G. (2010) · Nature · doi:10.1038/nature09042 · Cited by 1,056
When Doors of Perception Close: Bottom-up Models of Disrupted Cognition in Schizophrenia
Javitt, D. C. (2009) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.032408.153502 · Cited by 503
Cited by
Do “brain-training” programs work?
Simons, D. J., Boot, W. R., Charness, N., Gathercole, S. E., Chabris, C. F., Hambrick, D. Z., & Stine-Morrow, E. A. L. (2016) · Psychological Science in the Public Interest · doi:10.1177/1529100616661983 · Cited by 1,183
The neuroscience of working memory capacity and training
Constantinidis, C., & Klingberg, T. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.43 · Cited by 533
Cho, K. K. A., Hoch, R., Lee, A. T., Patel, T., Rubenstein, J. L. R., & Sohal, V. S. (2015) · Neuron · doi:10.1016/j.neuron.2015.02.019 · Cited by 329
Brain mechanisms of reality monitoring
Simons, J. S., Garrison, J. R., & Johnson, M. K. (2017) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2017.03.012 · Cited by 202
Brookwell, M. L., Bentall, R. P., & Varese, F. (2013) · Psychological Medicine · doi:10.1017/s0033291712002760 · Cited by 171
Metadata
- Authors
- Subramaniam, K., Luks, T. L., Fisher, M., Simpson, G. V., Nagarajan, S., & Vinogradov, S.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 73
- Issue
- 4
- Pages
- 842-853
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2128593336
- Cited by
- 289
- References
- 13
- FWCI
- 19.67
- Type
- journal article
- Language
- en
- Open access
- bronze
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