Cited by 533Cognitive Abilities and TestingNeural and Behavioral Psychology StudiesNeural dynamics and brain function

The neuroscience of working memory capacity and training

Constantinidis, Christos, Klingberg, Torkel·2016·Nature Reviews Neuroscience

Abstract

Working memory - the ability to maintain and manipulate information over a period of seconds - is a core component of higher cognitive functions. The storage capacity of working memory is limited but can be expanded by training, and evidence of the neural mechanisms underlying this effect is accumulating. Human imaging studies and neurophysiological recordings in non-human primates, together with computational modelling studies, reveal that training increases the activity of prefrontal neurons and the strength of connectivity in the prefrontal cortex and between the prefrontal and parietal cortex. Dopaminergic transmission could have a facilitatory role. These changes more generally inform us of the plasticity of higher cognitive functions.

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Crossref · 10.1038/nrn.2016.43

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145 of 145 references verified0 citation errors · 0 not checkable

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  • Working memory impairment is prevalent across neuropsychiatric and neurological conditions and is among the most sensitive early indicators of cognitive function decline, with links to everyday functional limitations and reduced quality of life.

    “Working memory impairment is prevalent across neuropsychiatric and neurological conditions and is among the most sensitive early indicators of cognitive function decline, with clear links to everyday functional limitations and reduced quality of life10–13.”

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Authors
Constantinidis, C., & Klingberg, T.
Affiliations
  • Wake Forest University Health Sciences (US)
  • Karolinska Institutet (SE)
Corresponding author
Klingberg, Torkel
Venue
Nature Reviews Neuroscience
Published
2016-05-26
Volume
17
Issue
7
Pages
438-449
ISSN
  • 1471-003X (ISSN-L)
  • 1471-0048
OpenAlex
W2400660831
Cited by
533
References
145
Citations by year
2026: 35 · 2025: 62 · 2024: 64 · 2023: 45 · 2022: 45 · 2021: 67 · 2020: 60 · 2019: 54 · 2018: 60 · 2017: 36 · 2016: 4 · 2013: 1
FWCI
6.81
Type
journal article
Language
en
Open access
closed
Locations
  • Nature reviews. Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Eye Institute (R01EY017077)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
working memory, working memory capacity, cognitive training, prefrontal cortex, parietal cortex, dopamine signaling, neuroplasticity, computational modelling, non-human primates
MeSH terms
Animals, Brain, Brain Mapping, Humans, Learning, Memory, Neural Pathways, Neurons

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