The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Photochemical Restoration of Visual Responses in Blind Mice
Open accessAbstract
Summary Retinitis pigmentosa (RP) and age-related macular degeneration (AMD) are degenerative blinding diseases caused by the death of rods and cones, leaving the remainder of the visual system intact but largely unable to respond to light. Here we show that, AAQ, a synthetic small molecule photoswitch, can restore light sensitivity to the retina and behavioral responses in vivo in mouse models of RP without exogenous gene delivery. Brief application of AAQ bestows prolonged light sensitivity on multiple types of retinal neurons, resulting in synaptically amplified responses and center-surround antagonism in arrays of retinal ganglion cells (RGCs). Intraocular injection of AAQ restores the pupillary light reflex and locomotory light avoidance responses in mice lacking retinal photoreceptors, indicating reconstitution of light signaling to brain circuits. AAQ and related photoswitch molecules present a new drug strategy for restoring retinal function in degenerative blinding diseases.
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Visual perception in a blind subject with a chronic microelectronic retinal prosthesis
Humayun, M. S., Weiland, J. D., Fujii, G. Y., Greenberg, R., Williamson, R., Little, J., Mech, B., Cimmarusti, V., Van Boemel, G., Dagnelie, G., et al. (2003) · Vision Research · doi:10.1016/s0042-6989(03)00457-7 · Cited by 856
Mechanisms underlying development of visual maps and receptive fields
Huberman, A. D., Feller, M. B., & Chapman, B. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125533 · Cited by 628
Ahuja, A. K., Dorn, J. D., Caspi, A., McMahon, M. J., Dagnelie, G., daCruz, L., Stanga, P., Humayun, M. S., Greenberg, R. J., & Argus II Study Group (2011) · British Journal of Ophthalmology · doi:10.1136/bjo.2010.179622 · Cited by 289
LiGluR restores visual responses in rodent models of inherited blindness
Caporale, N., Kolstad, K. D., Lee, T., Tochitsky, I., Dalkara, D., Trauner, D., Kramer, R., Dan, Y., Isacoff, E. Y., & Flannery, J. G. (2011) · Molecular Therapy · doi:10.1038/mt.2011.103 · Cited by 182
Beltran, W. A., Boye, S. L., Boye, S. E., Chiodo, V. A., Lewin, A. S., Hauswirth, W. W., & Aguirre, G. D. (2010) · Gene Therapy · doi:10.1038/gt.2010.56 · Cited by 96 · cited 2×
“Viruses that deliver optogenetic tools can have off-target effects and may elicit inflammatory responses (Beltran et al., 2010).”
Background
Cited by
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
Szymański, W., Beierle, J. M., Kistemaker, H. A. V., Velema, W. A., & Feringa, B. L. (2013) · Chemical Reviews · doi:10.1021/cr300179f · Cited by 1,239
A Roadmap to Success in Photopharmacology
Broichhagen, J., Frank, J. A., & Trauner, D. (2015) · Accounts of Chemical Research · doi:10.1021/acs.accounts.5b00129 · Cited by 730
Self-citationEmerging Targets in Photopharmacology
Lerch, M. M., Hansen, M. J., van Dam, G. M., Szymanski, W., & Feringa, B. L. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201601931 · Cited by 675
Functional architecture of the retina: Development and disease
Hoon, M., Okawa, H., Della Santina, L., & Wong, R. O. L. (2014) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2014.06.003 · Cited by 585
Advances and opportunities in the exciting world of azobenzenes
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Metadata
- Authors
- Polosukhina, A., Litt, J., Tochitsky, I., Nemargut, J., Sychev, Y., De Kouchkovsky, I., Huang, T., Borges, K., Trauner, D., Van Gelder, R. N., & Kramer, R. H.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2012-07
- Volume
- 75
- Issue
- 2
- Pages
- 271-282
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2158094776
- Cited by
- 238
- References
- 6
- FWCI
- 9.41
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Polosukhina, A., Litt, J., Tochitsky, I., Nemargut, J., Sychev, Y., De Kouchkovsky, I., Huang, T., Borges, K., Trauner, D., Van Gelder, R. N., & Kramer, R. H. (2012). Photochemical Restoration of Visual Responses in Blind Mice. Neuron. https://doi.org/10.1016/j.neuron.2012.05.022
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
