Sleep to Upscale, Sleep to Downscale: Balancing Homeostasis and Plasticity
Open accessAbstract
The synaptic homeostasis hypothesis of sleep proposes that slow wave sleep (SWS) causes downscaling of synaptic networks potentiated during information uptake in prior wakefulness. Two studies in Neuron challenge this mechanism. Chauvette et al. (2012) show that SWS mediates an up- rather than downregulation of excitatory postsynaptic potential responses. Grosmark et al. (2012) find that downscaling in hippocampal networks might be mediated through REM sleep theta rather than SWS.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
SWS is linked to synaptic potentiation rather than down-scaling.
“suggesting that SWS is linked to synaptic potentiation rather than down-scaling (118).”
From About Sleep's Role in Memory (2013) · cites this paper as [118]
The SWS-related enhancement in synaptic strength is a calcium-dependent postsynaptic mechanism requiring the hyperpolarizing down-state of the slow oscillation and coactivation of AMPA and NMDA receptors.
“Further experiments in vitro confirmed that the SWS-related enhancement in synaptic strength is a calciumdependent postsynaptic mechanism which requires (i) the hyperpolarizing down-state of the slow oscillation and (ii) the coactivation of AMPA and NMDA receptors”
From About Sleep's Role in Memory (2013) · cites this paper as [118]
REM sleep theta is involved not only in unspecific synaptic downscaling but also in reorganizing and shaping hippocampal memory representations.
“These data suggest that REM sleep theta is not only involved in an unspecific synaptic downscaling but also in reorganizing and shaping hippocampal memory representations (118).”
From About Sleep's Role in Memory (2013) · cites this paper as [118]
Cites
Huber, R., Felice Ghilardi, M., Massimini, M., & Tononi, G. (2004) · Nature · doi:10.1038/nature02663 · Cited by 1,854 · see citing works
Vyazovskiy, V. V., Cirelli, C., Pfister-Genskow, M., Faraguna, U., & Tononi, G. (2008) · Nature Neuroscience · doi:10.1038/nn2035 · Cited by 837 · see citing works
Sleep Enhances Plasticity in the Developing Visual Cortex
Frank, M. G., Issa, N. P., & Stryker, M. P. (2001) · Neuron · doi:10.1016/s0896-6273(01)00279-3 · Cited by 523 · see citing works
Sleep selectively enhances memory expected to be of future relevance
Wilhelm, I., Diekelmann, S., Molzow, I., Ayoub, A., Mölle, M., & Born, J. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3575-10.2011 · Cited by 397 · see citing works
The sequential hypothesis of the function of sleep
Giuditta, A., Ambrosini, M. V., Montagnese, P., Mandile, P., Cotugno, M., Zucconi, G. G., & Vescia, S. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(95)00012-i · Cited by 382 · see citing works
Slow oscillations orchestrating fast oscillations and memory consolidation
Mölle, M., & Born, J. (2011) · Progress in Brain Research · doi:10.1016/b978-0-444-53839-0.00007-7 · Cited by 270 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Rasch, B., & Born, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00032.2012 · Cited by 2,783 · see citing works
Self-citationSleep promotes branch-specific formation of dendritic spines after learning
Yang, G., Lai, C. S. W., Cichon, J., Ma, L., Li, W., & Gan, W.-B. (2014) · Science · doi:10.1126/science.1249098 · Cited by 616 · see citing works
Varga, A. W., Wohlleber, M. E., Giménez, S., Romero, S., Alonso, J. F., Ducca, E. L., Kam, K., Lewis, C., Tanzi, E. B., Tweardy, S., et al. (2016) · SLEEP · doi:10.5665/sleep.6240 · Cited by 203 · see citing works
Prince, T.-M., Wimmer, M., Choi, J., Havekes, R., Aton, S., & Abel, T. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.11.021 · Cited by 142 · see citing works
Plasticity during sleep is linked to specific regulation of cortical circuit activity
Niethard, N., Burgalossi, A., & Born, J. (2017) · Frontiers in Neural Circuits · doi:10.3389/fncir.2017.00065 · Cited by 89 · see citing works
Central Nervous Insulin Signaling in Sleep-Associated Memory Formation and Neuroendocrine Regulation
Feld, G. B., Wilhem, I., Benedict, C., Rüdel, B., Klameth, C., Born, J., & Hallschmid, M. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.312 · Cited by 36 · see citing works
Self-citation
- Authors
- Born, J., & Feld, G. B.
- Affiliations
- University of Tübingen (DE)
- ORCID
- Feld, Gordon B.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2012-09
- Volume
- 75
- Issue
- 6
- Pages
- 933-935
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2043738025
- Cited by
- 73
- References
- 6
- Citations by year
- 2025: 5 · 2024: 4 · 2023: 5 · 2022: 3 · 2021: 7 · 2020: 5 · 2019: 4 · 2018: 4 · 2017: 6 · 2016: 6 · 2015: 7 · 2014: 7 · 2013: 10
- FWCI
- 3.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- synaptic homeostasis hypothesis, slow-wave sleep, REM sleep, synaptic plasticity, synaptic downscaling, hippocampus, excitatory postsynaptic potentials, theta oscillations, memory consolidation
- MeSH terms
- Animals, Evoked Potentials, Male, Neuronal Plasticity, Neurons, Sleep, Sleep, REM, Somatosensory Cortex, Thalamus, Theta Rhythm, Long-Term Potentiation, CA1 Region, Hippocampal
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
