Sleep deprivation during a specific 3-hour time window post-training impairs hippocampal synaptic plasticity and memory
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Sleep deprivation disrupts hippocampal function and plasticity. In particular, long-term memory consolidation is impaired by sleep deprivation, suggesting that a specific critical period exists following learning during which sleep is necessary. To elucidate the impact of sleep deprivation on long-term memory consolidation and synaptic plasticity, long-term memory was assessed when mice were sleep deprived following training in the hippocampus-dependent object place recognition task. We found that 3h of sleep deprivation significantly impaired memory when deprivation began 1h after training. In contrast, 3 h of deprivation beginning immediately post-training did not impair spatial memory. Furthermore, a 3-h sleep deprivation beginning 1h after training impaired hippocampal long-term potentiation (LTP), whereas sleep deprivation immediately after training did not affect LTP. Together, our findings define a specific 3-h critical period, extending from 1 to 4h after training, during which sleep deprivation impairs hippocampal function.
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Sleep deprivation can affect hippocampal synaptic plasticity during defined timeframes.
“and that sleep deprivation can affect hippocampal synaptic plasticity during defined timeframes.78,79”
From Sleep Deprivation and Circadian Disruption (2015) · cites this paper as [78]
Hippocampal network activity changes during sleep-dependent memory consolidation.
“showing that hippocampal network activity changes during sleep-dependent memory consolidation”
From Sleep Deprivation and Circadian Disruption (2015) · cites this paper as [78]
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- Authors
- Prince, T.-M., Wimmer, M., Choi, J., Havekes, R., Aton, S., & Abel, T.
- Affiliations
- University of Pennsylvania (US)
- University of Michigan (US)
- Corresponding author
- Abel, Ted
- Venue
- Neurobiology of Learning and Memory
- Publisher
- Elsevier BV
- Published
- 2014-03
- Volume
- 109
- Pages
- 122-130
- ISSN
- 1074-7427 (ISSN-L)
- PMC
- PMC3966473
- OpenAlex
- W2033136528
- Cited by
- 142
- References
- 72
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 14 · 2023: 8 · 2022: 17 · 2021: 13 · 2020: 18 · 2019: 9 · 2018: 12 · 2017: 12 · 2016: 6 · 2015: 7 · 2014: 8
- FWCI
- 6.13
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neurobiology of Learning and Memory (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Funders
- Johns Hopkins University
- Kissei
- National Institutes of Health
- Centers for Disease Control and Prevention
- National Institute on Aging (P01AG017628)
- National Heart, Lung, and Blood Institute (T32HL007953)
- National Institute of Mental Health (DP2MH104119)
- National Eye Institute (K99EY021503)
- National Institute of General Medical Sciences (T32GM007517, K12GM081259)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- sleep deprivation, hippocampus, synaptic plasticity, long-term potentiation, memory consolidation, spatial memory, critical period, mice
- MeSH terms
- Animals, Hippocampus, Male, Mice, Inbred C57BL, Sleep Deprivation, Space Perception, Time Factors, Long-Term Potentiation, Recognition, Psychology, Mice, Memory, Long-Term
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