Cited by 143Sleep and Wakefulness ResearchMemory and Neural MechanismsNeuroscience and Neuropharmacology Research

Sleep deprivation during a specific 3-hour time window post-training impairs hippocampal synaptic plasticity and memory

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Prince, Toni-Moi, Wimmer, Mathieu, Choi, Jennifer, Havekes, Robbert, Aton, Sara, Abel, Ted·2014·Neurobiology of Learning and Memory

Abstract

Sleep deprivation disrupts hippocampal function and plasticity. In particular, long-term memory consolidation is impaired by sleep deprivation, suggesting that a specific critical period exists following learning during which sleep is necessary. To elucidate the impact of sleep deprivation on long-term memory consolidation and synaptic plasticity, long-term memory was assessed when mice were sleep deprived following training in the hippocampus-dependent object place recognition task. We found that 3h of sleep deprivation significantly impaired memory when deprivation began 1h after training. In contrast, 3 h of deprivation beginning immediately post-training did not impair spatial memory. Furthermore, a 3-h sleep deprivation beginning 1h after training impaired hippocampal long-term potentiation (LTP), whereas sleep deprivation immediately after training did not affect LTP. Together, our findings define a specific 3-h critical period, extending from 1 to 4h after training, during which sleep deprivation impairs hippocampal function.

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  • Sleep deprivation can affect hippocampal synaptic plasticity during defined timeframes.

    “and that sleep deprivation can affect hippocampal synaptic plasticity during defined timeframes.78,79”

    From Sleep Deprivation and Circadian Disruption (2015) · cites this paper as [78]

  • Hippocampal network activity changes during sleep-dependent memory consolidation.

    “showing that hippocampal network activity changes during sleep-dependent memory consolidation”

    From Sleep Deprivation and Circadian Disruption (2015) · cites this paper as [78]

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Authors
Prince, T.-M., Wimmer, M., Choi, J., Havekes, R., Aton, S., & Abel, T.
Affiliations
  • University of Pennsylvania (US)
  • University of Michigan (US)
Corresponding author
Abel, Ted
Venue
Neurobiology of Learning and Memory
Publisher
Elsevier BV
Published
2014-03
Volume
109
Pages
122-130
ISSN
1074-7427 (ISSN-L)
OpenAlex
W2033136528
Cited by
142
References
72
Citations by year
2026: 7 · 2025: 11 · 2024: 14 · 2023: 8 · 2022: 17 · 2021: 13 · 2020: 18 · 2019: 9 · 2018: 12 · 2017: 12 · 2016: 6 · 2015: 7 · 2014: 8
FWCI
6.13
Type
journal article
Language
en
Open access
Locations
  • Neurobiology of Learning and Memory (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Funders
  • Johns Hopkins University
  • Kissei
  • National Institutes of Health
  • Centers for Disease Control and Prevention
  • National Institute on Aging (P01AG017628)
  • National Heart, Lung, and Blood Institute (T32HL007953)
  • National Institute of Mental Health (DP2MH104119)
  • National Eye Institute (K99EY021503)
  • National Institute of General Medical Sciences (T32GM007517, K12GM081259)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
sleep deprivation, hippocampus, synaptic plasticity, long-term potentiation, memory consolidation, spatial memory, critical period, mice
MeSH terms
Animals, Hippocampus, Male, Mice, Inbred C57BL, Sleep Deprivation, Space Perception, Time Factors, Long-Term Potentiation, Recognition, Psychology, Mice, Memory, Long-Term

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