Central Nervous Insulin Signaling in Sleep-Associated Memory Formation and Neuroendocrine Regulation
Open accessAbstract
The neurochemical underpinnings of sleep's contribution to the establishment and maintenance of memory traces are largely unexplored. Considering that intranasal insulin administration to the CNS improves memory functions in healthy and memory-impaired humans, we tested whether brain insulin signaling and sleep interact to enhance memory consolidation in healthy participants. We investigated the effect of intranasal insulin on sleep-associated neurophysiological and neuroendocrine parameters and memory consolidation in 16 men and 16 women (aged 18-30 years), who learned a declarative word-pair task and a procedural finger sequence tapping task in the evening before intranasal insulin (160 IU) or placebo administration and 8 h of nocturnal sleep. On the subsequent evening, they learned interfering word-pairs and a new finger sequence before retrieving the original memories. Insulin increased growth hormone concentrations in the first night-half and EEG delta power during the second 90 min of non-rapid-eye-movement sleep. Insulin treatment impaired the acquisition of new contents in both the declarative and procedural memory systems on the next day, whereas retrieval of original memories was unchanged. Results indicate that sleep-associated memory consolidation is not a primary mediator of insulin's acute memory-improving effect, but that the peptide acts on mechanisms that diminish the subsequent encoding of novel information. Thus, by inhibiting processes of active forgetting during sleep, central nervous insulin might reduce the interfering influence of encoding new information.
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IN insulin administration before nocturnal sleep did not induce major changes in polysomnographically assessed sleep architecture in humans.
“Although IN insulin administration before nocturnal sleep did not induce major changes in polysomnographically assessed sleep architecture in humans, 45,46”
From Intranasal insulin (2021) · cites this paper as [45]
In the same study, growth hormone concentrations showed a pronounced treatment-induced surge that was independent of the subject's sex.
“growth hormone concentrations showed a pronounced treatment-induced surge that was independent of the subject's sex.”
From Intranasal insulin (2021) · cites this paper as [45]
Women displayed a trend to improved learning of new word-pairs in the insulin vs placebo condition.
“although women displayed a trend to improved learning of new word-pairs in the insulin vs. placebo condition; see below).45”
From Intranasal insulin (2021) · cites this paper as [45]
IN insulin compared to placebo enhances EEG delta power during the second 90 minutes of NREM sleep in young, healthy men.
“EEG delta power during the second 90 minutes of NREM sleep was found to be enhanced by IN insulin compared to placebo in young, healthy men.45”
From Intranasal insulin (2021) · cites this paper as [45]
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- Authors
- Feld, G. B., Wilhem, I., Benedict, C., Rüdel, B., Klameth, C., Born, J., & Hallschmid, M.
- Affiliations
- University of Tübingen (DE)
- University Children's Hospital Zurich (CH)
- Uppsala University (SE)
- German Center for Diabetes Research (DE)
- Corresponding author
- Hallschmid, Manfred
- Venue
- Neuropsychopharmacology
- Published
- 2015-10-08
- Volume
- 41
- Issue
- 6
- Pages
- 1540-1550
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC4832015
- OpenAlex
- W2325925647
- Cited by
- 36
- References
- 68
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 5 · 2022: 3 · 2021: 5 · 2020: 2 · 2019: 4 · 2018: 6 · 2017: 3 · 2016: 1
- FWCI
- 2.00
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neuropsychopharmacology (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Uppsala University Publications (Uppsala University) (submittedVersion, other-oa)
- Site cant be reached (submittedVersion, cc-by)
- PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion, cc-by)
- Funders
- Deutsche Forschungsgemeinschaft (SFB654, 01GI0925)
- Bundesministerium für Bildung und Forschung (01GI0925, DZD e.V.; 01GI0925)
- Universität zu Lübeck
- Novo Nordisk Fonden (NNF14OC0009349)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- insulin signaling, sleep, memory consolidation, intranasal insulin, neuroendocrine regulation, growth hormone, EEG delta power, NREM sleep, declarative memory, procedural memory, memory interference, memory encoding
- MeSH terms
- Memory Consolidation, Administration, Intranasal, Adolescent, Adult, Blood Glucose, Brain, Delta Rhythm, Double-Blind Method, Female, Humans, Insulin, Male, Sleep, Cross-Over Studies, Young Adult
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