The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Microstimulation Activates a Handful of Muscle Synergies
Open accessAbstract
SUMMARY Muscle synergies have been proposed as a mechanism to simplify movement control. Whether these coactivation patterns have any physiological reality within the nervous system remains unknown. Here we applied electrical microstimulation to motor cortical areas of rhesus macaques to evoke hand movements. Movements tended to converge towards particular postures, driven by synchronous bursts of muscle activity. Across stimulation sites, the muscle activations were reducible to linear sums of a few basic patterns—each corresponding to a muscle synergy evident in voluntary reach, grasp, and transport movements made by the animal. These synergies were represented non-uniformly over the cortical surface. We argue that the brain exploits these properties of synergies—postural equivalence, low dimensionality, and topographical representation—to simplify motor planning, even for complex hand movements.
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Cites
Learning the parts of objects by non-negative matrix factorization
Lee, D. D., & Seung, H. S. (1999) · Nature · doi:10.1038/44565 · Cited by 13,868
Combinations of muscle synergies in the construction of a natural motor behavior
d'Avella, A., Saltiel, P., & Bizzi, E. (2003) · Nature Neuroscience · doi:10.1038/nn1010 · Cited by 1,344
Self-citationPostural Hand Synergies for Tool Use
Santello, M., Flanders, M., & Soechting, J. F. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-23-10105.1998 · Cited by 1,215
Complex Movements Evoked by Microstimulation of Precentral Cortex
Graziano, M. S. A., Taylor, C. S. R., & Moore, T. (2002) · Neuron · doi:10.1016/s0896-6273(02)00698-0 · Cited by 921
Computations Underlying the Execution of Movement: A Biological Perspective
Bizzi, E., Mussa-Ivaldi, F. A., & Giszter, S. (1991) · Science · doi:10.1126/science.1857964 · Cited by 677
Self-citationThe construction of movement by the spinal cord
Tresch, M. C., Saltiel, P., & Bizzi, E. (1999) · Nature Neuroscience · doi:10.1038/5721 · Cited by 617
Self-citationConstraints on Somatotopic Organization in the Primary Motor Cortex
Schieber, M. H. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.86.5.2125 · Cited by 596
Subdivisions of primary motor cortex based on cortico-motoneuronal cells
Rathelot, J.-A., & Strick, P. L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808362106 · Cited by 584
Muscle Synergies Characterizing Human Postural Responses
Torres-Oviedo, G., & Ting, L. H. (2007) · Journal of Neurophysiology · doi:10.1152/jn.01360.2006 · Cited by 551
Convergent force fields organized in the frog's spinal cord
Giszter, S., Mussa-Ivaldi, F., & Bizzi, E. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-02-00467.1993 · Cited by 544
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Flexible neural control of motor units
Marshall, N. J., Glaser, J. I., Trautmann, E. M., Amematsro, E. A., Perkins, S. M., Shadlen, M. N., Abbott, L. F., Cunningham, J. P., & Churchland, M. M. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01165-8 · Cited by 107
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Re-establishing the merits of electrical brain stimulation
Desmurget, M., Song, Z., Mottolese, C., & Sirigu, A. (2013) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2013.07.002 · Cited by 90
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Metadata
- Authors
- Overduin, S. A., d’Avella, A., Carmena, J. M., & Bizzi, E.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2012-12
- Volume
- 76
- Issue
- 6
- Pages
- 1071-1077
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2057820870
- Cited by
- 287
- References
- 36
- FWCI
- 11.82
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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