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Functional Properties of Cortical Feedback Projections to the Olfactory Bulb
Open accessAbstract
Summary Sensory perception is not a simple feed-forward process and higher brain areas can actively modulate information processing in “lower” areas. We used optogenetic methods to examine how cortical feedback projections affect circuits in the first olfactory processing stage, the olfactory bulb. Selective activation of back projections from the anterior olfactory nucleus/cortex (AON) revealed functional glutamatergic synaptic connections on several types of bulbar interneurons. Unexpectedly, AON axons also directly depolarized mitral cells, enough to elicit spikes reliably in a time window of a few milliseconds. Mitral cells received strong disynaptic inhibition, a third of which arises in the glomerular layer. Activating feedback axons in vivo led to suppression of spontaneous as well as odor-evoked activity of mitral cells, sometimes preceded by a temporally-precise increase in firing probability. Our study indicates that cortical feedback can shape the activity of bulbar output neurons by enabling precisely timed spikes and enforcing broad inhibition to suppress background activity.
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Petreanu, L., Huber, D., Sobczyk, A., & Svoboda, K. (2007) · Nature Neuroscience · doi:10.1038/nn1891 · Cited by 930
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Metadata
- Authors
- Markopoulos, F., Rokni, D., Gire, D. H., & Murthy, V. N.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2012-12
- Volume
- 76
- Issue
- 6
- Pages
- 1175-1188
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2003068184
- Cited by
- 225
- References
- 1
- FWCI
- 9.03
- Type
- journal article
- Language
- en
- Open access
- bronze
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