The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
Differential Control of Learning and Anxiety along the Dorsoventral Axis of the Dentate Gyrus
Open accessAbstract
The dentate gyrus (DG), in addition to its role in learning and memory, is increasingly implicated in the pathophysiology of anxiety disorders. Here, we show that, dependent on their position along the dorso-ventral axis of the hippocampus, DG granule cells (GCs) control specific features of anxiety and contextual learning. Using optogenetic techniques to either elevate or decrease GC activity, we demonstrate that GCs in the dorsal DG control exploratory drive and encoding, not retrieval, of contextual fear memories. In contrast, elevating the activity of GCs in the ventral DG has no effect on contextual learning but powerfully suppresses innate anxiety. These results suggest that strategies aimed at modulating the excitability of the ventral DG may be beneficial for the treatment of anxiety disorders.
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“The hippocampus itself appears to have a dorsal-ventral functional gradient, with the dorsal hippocampus encoding context more specifically, while the ventral hippocampus (vHPC) includes affective information as well [37].”
From Prefrontal cortex, amygdala, and threat processing: implications for PTSD (2022) · cites this paper as [37]
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“The canonical role of the hippocampus in threat circuitry is to encode context-specific information of a threat trace, as it is crucial for an organism to be able to distinguish threats as belonging to a particular context.”
From Prefrontal cortex, amygdala, and threat processing: implications for PTSD (2022) · cites this paper as [37]
In the citing paper
“Studies have shown that different parts of the hippocampus serve these different functions, with the dorsal hippocampus supporting spatial navigation learning and memory, and the ventral hippocampus as important for anxiety and stress regulation (Fanselow and Dong, 2010; Kheirbek et al., 2013).”
From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Kheirbek et al., 2013
In the citing paper
“however, direct photostimulation of ventral dentate gyrus granule cells has been in fact found to suppress anxiety-like behaviors in the EPM and OFT91.”
From Resolving the neural circuits of anxiety (2015) · cites this paper as [91]
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Cites
Millisecond-timescale, genetically targeted optical control of neural activity
Boyden, E. S., Zhang, F., Bamberg, E., Nagel, G., & Deisseroth, K. A. (2005) · Nature Neuroscience · doi:10.1038/nn1525 · Cited by 5,015
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Self-citationDeep Brain Stimulation for Treatment-Resistant Depression
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Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
van Praag, H., Kempermann, G., & Gage, F. H. (1999) · Nature Neuroscience · doi:10.1038/6368 · Cited by 3,880
Are the Dorsal and Ventral Hippocampus Functionally Distinct Structures?
Fanselow, M. S., & Dong, H.-W. (2010) · Neuron · doi:10.1016/j.neuron.2009.11.031 · Cited by 3,358
Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.
Phillips, R. G., & LeDoux, J. E. (1992) · Behavioral Neuroscience · doi:10.1037/0735-7044.106.2.274 · Cited by 3,292
Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus
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The human hippocampus and spatial and episodic memory
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STRESS AND HIPPOCAMPAL PLASTICITY
McEwen, B. S. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.105 · Cited by 2,087
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Functional organization of the hippocampal longitudinal axis
Strange, B. A., Witter, M. P., Lein, E. S., & Moser, E. I. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3785 · Cited by 1,738
Optogenetics: 10 years of microbial opsins in neuroscience
Deisseroth, K. A. (2015) · Nature Neuroscience · doi:10.1038/nn.4091 · Cited by 1,335
Madisen, L., Garner, A. R., Shimaoka, D., Chuong, A. S., Klapoetke, N. C., Li, L., van der Bourg, A., Niino, Y., Egolf, L., Monetti, C., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.02.022 · Cited by 1,114
Self-citationAdult hippocampal neurogenesis and cognitive flexibility — linking memory and mood
Anacker, C., & Hen, R. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.45 · Cited by 1,014
Self-citationIn vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9
Swiech, L., Heidenreich, M., Banerjee, A., Habib, N., Li, Y., Trombetta, J., Sur, M., & Zhang, F. (2015) · Nature Biotechnology · doi:10.1038/nbt.3055 · Cited by 772
Metadata
- Authors
- Kheirbek, M. A., Drew, L. J., Burghardt, N. S., Costantini, D. O., Tannenholz, L., Ahmari, S. E., Zeng, H., Fenton, A. A., & Hen, R.
- Affiliations
- New York State Psychiatric Institute (US)
- Allen Institute for Brain Science (US)
- SUNY Downstate Health Sciences University (US)
- Corresponding author
- Hen, René
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 77
- Issue
- 5
- Pages
- 955-968
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC3595120
- OpenAlex
- W2069281265
- Semantic Scholar
- 3c538be529a4c5c54e7172e30f4e8504564c6a8d
- Cited by
- 713
- References
- 67
- Citations by year
- 2026: 29 · 2025: 62 · 2024: 46 · 2023: 39 · 2022: 63 · 2021: 59 · 2020: 67 · 2019: 74 · 2018: 65 · 2017: 50 · 2016: 46 · 2015: 43 · 2014: 51 · 2013: 19
- FWCI
- 28.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of Mental Health (R37MH068542, K01MH099371, T32MH015174, K08MH087718)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- dentate gyrus, granule cells, dorsal-ventral axis, anxiety, contextual fear memory, contextual learning, memory encoding, memory retrieval, hippocampus, anxiety disorders, optogenetics
- MeSH terms
- Animals, Anxiety, Avoidance Learning, Behavior, Animal, Conditioning, Psychological, Fear, Immunohistochemistry, Learning, Male, Mental Recall, Stereotaxic Techniques, Dentate Gyrus, Mice, Optical Fibers, Opsins, Electrophysiological Phenomena, In Vitro Techniques
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